146,413 results on '"Holm, A"'
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2. Crossing that Line: Kentucky, the Ohio River, and Slavery's Border
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Holm, April
- Published
- 2023
3. Shapeshifting Subjects: Gloria Anzaldúa’s Naguala and Border Arte by Kelli D. Zaytoun (review)
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Holm, Andrea Hernández
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- 2023
4. Proceedings of the 2022 Annual Meeting of the Canadian Mathematics Education Study Group = Actes de la Rencontre Annuelle 2022 du Groupe Canadien d'Étude en Didactique des Mathématiques (45th, Virtual, May 27-29, 2022)
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Canadian Mathematics Education Study Group (CMESG), Jennifer Holm, and Charlotte Megroureche
- Abstract
Another year of COVID-19 meant another virtual meeting but the Canadian Mathematics Education Study Group/Groupe Canadien d'Étude en Didactique des Mathématiques (CMESG/GCEDM) made the best of the situation and found ways to learn together and share connections. Having learned a lot from the 2021 virtual meeting, the executive was able to once again offer a virtual program that, although reduced from the normal offerings, ensured an opportunity for spirited discussions, meaningful learning, and celebrating the newest members. The 45th annual meeting took place May 27-29, 2022. These proceedings contain one plenary lecture, six working groups, and ten new PhD reports. Seventeen papers are included in these proceedings--two papers are written in both French and English; three papers are written in French; and the remainder are written in English.
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- 2024
5. Bonds of Salvation: How Christianity Inspired and Limited American Abolitionism by Ben Wright (review)
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Holm, April
- Published
- 2022
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6. Plasma dynamics in thin domains
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Holm, Darryl D., Hu, Ruiao, and Street, Oliver D.
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Physics - Plasma Physics ,Mathematical Physics - Abstract
In the present work, we study the geometric structures of the Rotating Shallow Water Magnetohydrodynamics (RSW-MHD) equations through a Lie group invariant Euler-Poincar\'e variational principle. In this geometric framework, we derive new, structure-preserving stochastic RSW-MHD models by introducing stochastic perturbations to the Lie-Poisson structure of the deterministic RSW-MHD equations. The resulting stochastic RSW-MHD equations provide new capabilities for potential application to uncertainty quantification and data assimilation, for example, in space plasma (space weather) and solar physics, particularly in solar tachocline dynamics., Comment: 1st draft, comments welcome
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- 2025
7. Intermittent molecular motion and first passage statistics for the NMR relaxation of confined water
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Gravelle, Simon, Coasne, Benoit, Holm, Christian, and Schlaich, Alexander
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Condensed Matter - Soft Condensed Matter ,Physics - Chemical Physics ,Physics - Computational Physics - Abstract
The structure and dynamics of fluids confined in nanoporous media differ from those in bulk, which can be probed using NMR relaxation measurements. We here show, using atomistic molecular dynamics simulations of water in a slit nanopore, that the behavior of the NMR relaxation rate, R1, with varying surface interaction and confinement strength can be estimated from the exchange statistics of fluid molecules between the adsorbed surface layer and the bulk region, where molecules undergo intermittent dynamics. We employ first return passage time calculations to quantify the molecular exchange statistics, thereby linking microscopic parameters of the confined fluid-such as adsorption time, pore size, and diffusion coefficient-to the NMR relaxation rate. This approach allows to predict and interpret the molecular relaxation of fluids at interfaces using merely concepts of statistical mechanics and can be generalized to closed and open geometries.
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- 2025
8. Gleaning gravitational amplitudes -- a double copy for canceling dilatons
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Johansson, Henrik and Vazquez-Holm, Ingrid
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
Scattering amplitudes in general relativity can be conveniently computed using the double copy, which relates them to Yang-Mills amplitudes. However, unwanted dilatons are sourced by massive scalar matter, which must be removed from the double copy in order to match the long range gravitational interactions. In this paper, we study how to automatically cancel out the dilatons by finding a suitable double-copy prescription in terms of gauge-theory fields, effectively treating the new contributions as ghosts that subtract out the unwanted states. At tree level, we find that an asymmetric double copy can reproduce the dilaton graphs in general dimension, which we explicitly verify up to six external massive scalars. Considering a one-loop four-point example, the same asymmetric double copy needs to be supplemented by the subtraction of bubble graphs that originate both from the axion and a residual dilaton term., Comment: 45 pages + refs, 4 tables
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- 2025
9. Equivariant cohomological rigidity for four-dimensional Hamiltonian $\mathbf{S^1}$-manifolds
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Holm, Tara S., Kessler, Liat, and Tolman, Susan
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Mathematics - Symplectic Geometry ,Mathematics - Differential Geometry ,53D35 (55N91, 53D20, 57S15) - Abstract
For manifolds equipped with group actions, we have the following natural question: To what extent does the equivariant cohomology determine the equivariant diffeotype? We resolve this question for Hamiltonian circle actions on compact, connected symplectic four-manifolds. They are equivariantly diffeomorphic if and only if their equivariant cohomology rings are isomorphic as algebras over the equivariant cohomology of a point. In fact, we prove a stronger claim: each isomorphism between their equivariant cohomology rings is induced by an equivariant diffeomorphism., Comment: 23 pages, 6 figures
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- 2024
10. A nanolaser with extreme dielectric confinement
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Xiong, Meng, Yu, Yi, Berdnikov, Yury, Borregaard, Simon Klinck, Dubré, Adrian Holm, Semenova, Elizaveta, Yvind, Kresten, and Mørk, Jesper
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Physics - Optics - Abstract
The interaction between light and matter can be enhanced by spatially concentrating the light field to boost the photon energy density and increasing the photon dwell time to prolong energy transfer between light and matter. Traditionally, strong spatial light localization has been achieved using plasmonics, which, despite its effectiveness, entails ohmic losses. Recent advances in nanostructured dielectrics offer an avenue for achieving strong light confinement without metallic losses. However, previous studies primarily focused on minimizing the optical mode volume without adequately addressing light-matter interactions. Here, we develop a nanolaser that simultaneously localizes the electromagnetic field and excited carriers within the same region of a dielectric nanobridge. This extreme dielectric confinement of both light and matter achieves a mode volume below the diffraction limit and a subwavelength carrier volume without the introduction of lateral quantum confinement, enabling continuous-wave lasing at room-temperature. Moreover, we observe a strong correlation between the mode field and carrier distribution, and unexpectedly, the enhanced mode field localization automatically leads to more pronounced carrier localization, promoting self-alignment of light and matter, which significantly reduces the laser threshold. We quantify the intensified light-matter interaction with a newly proposed interaction volume, which generalizes the concept of mode volume to a broad class of active media. Our work lays the ground for developing ultra-efficient optoelectronic devices by greatly enhancing light-matter interactions through advanced material nanostructuring.
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- 2024
11. Warfare Ignited Price Contagion Dynamics in Early Modern Europe
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Esmaili, Emile, Puma, Michael J., Ludlow, Francis, Holm, Poul, and Jobbova, Eva
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Economics - Econometrics - Abstract
Economic historians have long studied market integration and contagion dynamics during periods of warfare and global stress, but there is a lack of model-based evidence on these phenomena. This paper uses an econometric contagion model, the Diebold-Yilmaz framework, to examine the dynamics of economic shocks across European markets in the early modern period. Our findings suggest that key periods of violent conflicts significantly increased food price spillover across cities, causing widespread disruptions across Europe. We also demonstrate the ability of this framework to capture relevant historical dynamics between the main trade centers of the period., Comment: 20 pages
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- 2024
12. Tilting in $Q$-shaped derived categories
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Gratz, Sira, Holm, Henrik, Jorgensen, Peter, and Stevenson, Greg
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Mathematics - Representation Theory ,Mathematics - Rings and Algebras ,16E35, 18E35, 18G80, 18N40 - Abstract
The main result of this paper is that there is sometimes a triangulated equivalence between $D_Q( A )$, the $Q$-shaped derived category of an algebra $A$, and $D( B )$, the classic derived category of a different algebra $B$. By construction, $D_Q( A )$ consists of $Q$-shaped diagrams of $A$-modules for a suitable small category $Q$. Our result concerns the case where $Q$ consists of shifts of indecomposable projective modules over a self-injective $\mathbb{Z}$-graded algebra $\Lambda$. A notable special case is the result by Iyama, Kato, and Miyachi that $D_N( A )$, the $N$-derived category of $A$, is triangulated equivalent to $D( T_{ N-1 }A )$, the classic derived category of $T_{ N-1 }( A )$, which denotes upper diagonal $( N-1 ) \times ( N-1 )$-matrices over $A$. Several other special cases will also be discussed., Comment: Reference added. 10 pages
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- 2024
13. Danoliteracy of Generative, Large Language Models
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Holm, Søren Vejlgaard, Hansen, Lars Kai, and Nielsen, Martin Carsten
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,I.2.7 - Abstract
The language technology moonshot moment of Generative, Large Language Models (GLLMs) was not limited to English: These models brought a surge of technological applications, investments and hype to low-resource languages as well. However, the capabilities of these models in languages such as Danish were until recently difficult to verify beyond qualitative demonstrations due to a lack of applicable evaluation corpora. We present a GLLM benchmark to evaluate Danoliteracy, a measure of Danish language and cultural competency, across eight diverse scenarios such Danish citizenship tests and abstractive social media question answering. This limited-size benchmark is found to produce a robust ranking that correlates to human feedback at $\rho \sim 0.8$ with GPT-4 and Claude Opus models achieving the highest rankings. Analyzing these model results across scenarios, we find one strong underlying factor explaining $95\%$ of scenario performance variance for GLLMs in Danish, suggesting a $g$ factor of model consistency in language adaption., Comment: 16 pages, 13 figures, submitted to: NoDaLiDa/Baltic-HLT 2025
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- 2024
14. ProMQA: Question Answering Dataset for Multimodal Procedural Activity Understanding
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Hasegawa, Kimihiro, Imrattanatrai, Wiradee, Cheng, Zhi-Qi, Asada, Masaki, Holm, Susan, Wang, Yuran, Fukuda, Ken, and Mitamura, Teruko
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Computer Science - Computation and Language - Abstract
Multimodal systems have great potential to assist humans in procedural activities, where people follow instructions to achieve their goals. Despite diverse application scenarios, systems are typically evaluated on traditional classification tasks, e.g., action recognition or temporal action segmentation. In this paper, we present a novel evaluation dataset, ProMQA, to measure system advancements in application-oriented scenarios. ProMQA consists of 401 multimodal procedural QA pairs on user recording of procedural activities coupled with their corresponding instruction. For QA annotation, we take a cost-effective human-LLM collaborative approach, where the existing annotation is augmented with LLM-generated QA pairs that are later verified by humans. We then provide the benchmark results to set the baseline performance on ProMQA. Our experiment reveals a significant gap between human performance and that of current systems, including competitive proprietary multimodal models. We hope our dataset sheds light on new aspects of models' multimodal understanding capabilities., Comment: 18 pages, 11 figures
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- 2024
15. Non-commutative friezes and their determinants, the non-commutative Laurent phenomenon for weak friezes, and frieze gluing
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Cuntz, Michael, Holm, Thorsten, and Jorgensen, Peter
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Mathematics - Combinatorics ,05E99, 13F60, 51M20 - Abstract
This paper studies a non-commutative generalisation of Coxeter friezes due to Berenstein and Retakh. It generalises several earlier results to this situation: A formula for frieze determinants, a $T$-path formula expressing the Laurent phenomenon, and results on gluing friezes together. One of our tools is a non-commutative version of the weak friezes introduced by Canakci and Jorgensen., Comment: Updated references. 26 pages and 16 figures
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- 2024
16. Collective variables of neural networks: empirical time evolution and scaling laws
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Tovey, Samuel, Krippendorf, Sven, Spannowsky, Michael, Nikolaou, Konstantin, and Holm, Christian
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Computer Science - Machine Learning ,Physics - Computational Physics - Abstract
This work presents a novel means for understanding learning dynamics and scaling relations in neural networks. We show that certain measures on the spectrum of the empirical neural tangent kernel, specifically entropy and trace, yield insight into the representations learned by a neural network and how these can be improved through architecture scaling. These results are demonstrated first on test cases before being shown on more complex networks, including transformers, auto-encoders, graph neural networks, and reinforcement learning studies. In testing on a wide range of architectures, we highlight the universal nature of training dynamics and further discuss how it can be used to understand the mechanisms behind learning in neural networks. We identify two such dominant mechanisms present throughout machine learning training. The first, information compression, is seen through a reduction in the entropy of the NTK spectrum during training, and occurs predominantly in small neural networks. The second, coined structure formation, is seen through an increasing entropy and thus, the creation of structure in the neural network representations beyond the prior established by the network at initialization. Due to the ubiquity of the latter in deep neural network architectures and its flexibility in the creation of feature-rich representations, we argue that this form of evolution of the network's entropy be considered the onset of a deep learning regime., Comment: 11 pages, 3 figures
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- 2024
17. Balanced Air-Biased Detection of Terahertz Waveforms
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Ohrt, Alexander Holm, Nagy, Olivér, Löscher, Robin, Saraceno, Clara J., Zhou, Binbin, and Jepsen, Peter Uhd
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Physics - Optics - Abstract
A novel balanced air-biased coherent detection scheme for capturing ultrabroadband terahertz (THz) waveforms is implemented. The balanced detection scheme allows for coherent detection at the full repetition rate of the laser system without requiring bias modulation, signal generators, or lock-in amplifiers while doubling the dynamic range and quadrupling the signal-to-noise ratio compared to conventional air-biased coherent detection. These advantages are achieved by rotating the bias electrodes by 90{\deg} relative to the conventional scheme. With a 1 kHz driving laser, the scheme enables sub-second, high-fidelity waveform acquisition with a continuously moving delay stage, demonstrated by collecting 200 waveforms in 100 s. The balanced detection scheme paves the way for much faster and higher quality 2D ultrabroadband terahertz spectroscopy., Comment: 4 pages, 4 figures
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- 2024
- Full Text
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18. The MDW H{\alpha} Sky Survey: Data Release 0
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Aftab, Noor, Xunhe, Zhang, Mittelman, David R., di Cicco, Dennis, Walker, Sean, Sliski, David H., Homa, Julia, Holm-Hansen, Colin, Putman, Mary, Schiminovich, David, Henden, Arne, and Walker, Gary
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The Mittelman-di Cicco-Walker (MDW) H$\alpha$ Sky Survey is an autonomously-operated and ongoing all-sky imaging survey in the narrowband H$\alpha$ wavelength. The survey was founded by amateur astronomers, and is presented here in its first stage of refinement for rigorous scientific use. Each field is exposed through an H$\alpha$ filter with a 3nm bandwidth for a total of four hours, with a pixel scale of 3.2 arcsec. Here, we introduce the first Data Release of the MDW H$\alpha$ Survey (Data Release 0, or DR0), spanning 238 fields in the region of Orion (~3100 deg$^2$). DR0 includes: calibrated mean fields, star-removed mean fields, a point source catalog matched to Data Release 1 of the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS1) and the INT Galactic Plane Survey (IGAPS), and mosaics.
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- 2024
19. CO2-induced Drastic Decharging of Dielectric Surfaces in Aqueous Suspensions
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Vogel, Peter, Beyer, David, Holm, Christian, and Palberg, Thomas
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Materials Science - Abstract
We study the influence of airborne CO2 on the charge state of carboxylate stabilized polymer latex particles suspended in aqueous electrolytes. We combine conductometric experiments interpreted in terms of Hessinger's conductivity model with Poisson-Boltzmann cell (PBC) model calculations with charge regulation boundary conditions. Without CO2, a minority of the weakly acidic surface groups are dissociated and only a fraction of the total number of counter-ions actually contribute to conductivity. The remaining counter-ions exchange freely with added other ions like Na+, K+ or Cs+. From the PBC-calculations we infer a corresponding pKa of 4.26 as well as a renormalized charge in reasonably good agreement with the number of freely mobile counter-ions. Equilibration of salt- and CO2-free suspensions against ambient air leads to a drastic de-charging, which exceeds by far the expected effects of to dissolved CO2 and its dissociation products. Further, no counter-ion-exchange is observed. To reproduce the experimental findings, we have to assume an effective pKa of 6.48. This direct influence of CO2 on the state of surface group dissociation explains our recent finding of a CO2-induced decrease of the {\zeta}-potential and supports the suggestion of an additional charge regulation caused by molecular CO2. Given the importance of charged surfaces in contact with aqueous electrolytes, we anticipate that our observations bear substantial theoretical challenges and important implications for applications ranging from desalination to bio-membranes., Comment: Submitted to Soft Matter, regular article, 22 pages, 6 figures, 65 references, supplementary material of 8 pages with 7 figures
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- 2024
20. Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity
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Huang, Yun, Sulek, Karolina, Stinson, Sara E., Holm, Louise Aas, Kim, Min, Trost, Kajetan, Hooshmand, Kourosh, Lund, Morten Asp Vonsild, Fonvig, Cilius E., Juel, Helene Bæk, Nielsen, Trine, Ängquist, Lars, Rossing, Peter, Thiele, Maja, Krag, Aleksander, Holm, Jens-Christian, Legido-Quigley, Cristina, and Hansen, Torben
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- 2025
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21. The Connection between Distance Learning Profiles and Achievement Emotions in Secondary Mathematics Education
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Anni Sydänmaanlakka, Jokke Häsä, Marja E. Holm, and Markku S. Hannula
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During the COVID-19 pandemic, distance learning became the dominant form of education, utilizing a variety of technological resources to activate students and facilitate independent learning. In this study, latent profile analysis was used to identify different distance learning profiles and analysis of covariance was used to analyze the relationships between identified profiles and students' (n = 552) achievement emotions in Finnish upper secondary schools (n = 18). The results supported a four-profile model contrasting teaching practices against student involvement: the largest profile (32.97%) was characterized as "deactivating-distracted," followed by "deactivating-engaged" (24.92%) and "activating-engaged" (24.64%), with the smallest profile (17.57%) being "activating-distracted." Here, activation refers to teaching practices with a focus on student participation and school support, whereas distraction reflects students' involvement in the distance learning environment. Notably, the "activating-engaged" profile exhibited the most positive achievement emotions, while the "deactivating-distracted" profile was associated with the most negative emotions. These results highlight the importance of active participation, promoting engagement, and the need for support in distance learning contexts to foster students' positive achievement emotions.
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- 2025
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22. Creep and Damage Processes in Cyclically Loaded Model of Turbine Rotor
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Altenbach, Holm, Breslavsky, Dmytro, Senko, Alyona, Tatarinova, Oksana, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Altenbach, Holm, editor, Gao, Xiao-Wei, editor, Syngellakis, Stavros, editor, Cheng, Alexander H.-D., editor, Lampart, Piotr, editor, and Tkachuk, Anton, editor
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- 2025
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23. Geometric Theory of Perturbation Dynamics Around Non-equilibrium Fluid Flows
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Holm, Darryl D., Hu, Ruiao, Street, Oliver D., Crisan, Dan, Series Editor, Golden, Ken, Series Editor, Holm, Darryl D., Series Editor, Lewis, Mark, Series Editor, Nishiura, Yasumasa, Series Editor, Tribbia, Joseph, Series Editor, Zubelli, Jorge Passamani, Series Editor, Chapron, Bertrand, editor, Mémin, Etienne, editor, and Coughlan, Jane-Lisa, editor
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- 2025
- Full Text
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24. Collisions of Burgers Bores with Nonlinear Waves
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Dombret, Albert, Holm, Darryl D., Hu, Ruiao, Street, Oliver D., Wang, Hanchun, Crisan, Dan, Series Editor, Golden, Ken, Series Editor, Holm, Darryl D., Series Editor, Lewis, Mark, Series Editor, Nishiura, Yasumasa, Series Editor, Tribbia, Joseph, Series Editor, Zubelli, Jorge Passamani, Series Editor, Chapron, Bertrand, editor, Mémin, Etienne, editor, and Coughlan, Jane-Lisa, editor
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- 2025
- Full Text
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25. Civilians and Cities in a Western Borderland
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Holm, April E.
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- 2018
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26. A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
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Thomas, Tom, Friedrich, Matthias, Rich-Griffin, Charlotte, Pohin, Mathilde, Agarwal, Devika, Pakpoor, Julia, Lee, Carl, Tandon, Ruchi, Rendek, Aniko, Aschenbrenner, Dominik, Jainarayanan, Ashwin, Voda, Alexandru, Siu, Jacqueline, Sanches-Peres, Raphael, Nee, Eloise, Sathananthan, Dharshan, Kotliar, Dylan, Todd, Peter, Kiourlappou, Maria, Gartner, Lisa, Ilott, Nicholas, Issa, Fadi, Hester, Joanna, Turner, Jason, Nayar, Saba, Mackerodt, Jonas, Zhang, Fan, Jonsson, Anna, Brenner, Michael, Raychaudhuri, Soumya, Kulicke, Ruth, Ramsdell, Danielle, Stransky, Nicolas, Pagliarini, Ray, Bielecki, Piotr, Spies, Noah, Marsden, Brian, Taylor, Stephen, Wagner, Allon, Klenerman, Paul, Walsh, Alissa, Coles, Mark, Jostins-Dean, Luke, Powrie, Fiona, Filer, Andrew, Travis, Simon, Uhlig, Holm, Dendrou, Calliope, and Buckley, Christopher
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Humans ,Single-Cell Analysis ,Adalimumab ,Inflammatory Bowel Diseases ,Crohn Disease ,Longitudinal Studies ,Colitis ,Ulcerative ,Tumor Necrosis Factor-alpha ,Transcriptome ,Female ,Adult ,Male ,Interferons ,Signal Transduction ,Arthritis ,Rheumatoid - Abstract
Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment response. We describe a therapeutic atlas for Crohns disease (CD) and ulcerative colitis (UC) following adalimumab, an anti-tumour necrosis factor (anti-TNF) treatment. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies (41 subjects), revealing disease-specific differences. A systems biology-spatial analysis identified granuloma signatures in CD and interferon (IFN)-response signatures localising to T cell aggregates and epithelial damage in CD and UC. Pretreatment differences in epithelial and myeloid compartments were associated with remission outcomes in both diseases. Longitudinal comparisons demonstrated disease progression in nonremission: myeloid and T cell perturbations in CD and increased multi-cellular IFN signalling in UC. IFN signalling was also observed in rheumatoid arthritis (RA) synovium with a lymphoid pathotype. Our therapeutic atlas represents the largest cellular census of perturbation with the most common biologic treatment, anti-TNF, across multiple inflammatory diseases.
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- 2024
27. Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature.
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Holtz, Andrew, Van Weyenbergh, Johan, Hong, Samuel, Cuypers, Lize, OToole, Áine, Dudas, Gytis, Gerdol, Marco, Potter, Barney, Ntoumi, Francine, Mapanguy, Claujens, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Van Holm, Bram, Menezes, Soraya, Soubotko, Katja, Van Pottelbergh, Gijs, Wollants, Elke, Vermeersch, Pieter, Jacob, Ann-Sophie, Maes, Brigitte, Obbels, Dagmar, Matheeussen, Veerle, Martens, Geert, Gras, Jérémie, Verhasselt, Bruno, Laffut, Wim, Vael, Carl, Goegebuer, Truus, van der Kant, Rob, Rousseau, Frederic, Schymkowitz, Joost, Serrano, Luis, Delgado, Javier, Wenseleers, Tom, Bours, Vincent, André, Emmanuel, Suchard, Marc, Rambaut, Andrew, Dellicour, Simon, Maes, Piet, Durkin, Keith, and Baele, Guy
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COVID-19 ,Disease spread ,Genomic epidemiology ,Phylodynamics ,Phylogeography ,SARS-CoV-2 ,Humans ,SARS-CoV-2 ,COVID-19 ,Spike Glycoprotein ,Coronavirus ,Aged ,Male ,Travel ,Belgium ,Middle Aged ,Female ,Adult ,Phylogeography ,Nasopharynx - Abstract
We investigate the emergence, mutation profile, and dissemination of SARS-CoV-2 lineage B.1.214.2, first identified in Belgium in January 2021. This variant, featuring a 3-amino acid insertion in the spike protein similar to the Omicron variant, was speculated to enhance transmissibility or immune evasion. Initially detected in international travelers, it substantially transmitted in Central Africa, Belgium, Switzerland, and France, peaking in April 2021. Our travel-aware phylogeographic analysis, incorporating travel history, estimated the origin to the Republic of the Congo, with primary European entry through France and Belgium, and multiple smaller introductions during the epidemic. We correlate its spread with human travel patterns and air passenger data. Further, upon reviewing national reports of SARS-CoV-2 outbreaks in Belgian nursing homes, we found this strain caused moderately severe outcomes (8.7% case fatality ratio). A distinct nasopharyngeal immune response was observed in elderly patients, characterized by 80% unique signatures, higher B- and T-cell activation, increased type I IFN signaling, and reduced NK, Th17, and complement system activation, compared to similar outbreaks. This unique immune response may explain the variants epidemiological behavior and underscores the need for nasal vaccine strategies against emerging variants.
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- 2024
28. Emerging multiscale insights on microbial carbon use efficiency in the land carbon cycle
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He, Xianjin, Abs, Elsa, Allison, Steven D, Tao, Feng, Huang, Yuanyuan, Manzoni, Stefano, Abramoff, Rose, Bruni, Elisa, Bowring, Simon PK, Chakrawal, Arjun, Ciais, Philippe, Elsgaard, Lars, Friedlingstein, Pierre, Georgiou, Katerina, Hugelius, Gustaf, Holm, Lasse Busk, Li, Wei, Luo, Yiqi, Marmasse, Gaëlle, Nunan, Naoise, Qiu, Chunjing, Sitch, Stephen, Wang, Ying-Ping, and Goll, Daniel S
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Agricultural ,Veterinary and Food Sciences ,Biological Sciences ,Forestry Sciences ,Life on Land ,Carbon Cycle ,Soil Microbiology ,Carbon ,Soil ,Ecosystem ,Bacteria - Abstract
Microbial carbon use efficiency (CUE) affects the fate and storage of carbon in terrestrial ecosystems, but its global importance remains uncertain. Accurately modeling and predicting CUE on a global scale is challenging due to inconsistencies in measurement techniques and the complex interactions of climatic, edaphic, and biological factors across scales. The link between microbial CUE and soil organic carbon relies on the stabilization of microbial necromass within soil aggregates or its association with minerals, necessitating an integration of microbial and stabilization processes in modeling approaches. In this perspective, we propose a comprehensive framework that integrates diverse data sources, ranging from genomic information to traditional soil carbon assessments, to refine carbon cycle models by incorporating variations in CUE, thereby enhancing our understanding of the microbial contribution to carbon cycling.
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- 2024
29. Peptide Classification from Statistical Analysis of Nanopore Translocation Experiments
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Hoßbach, Julian, Tovey, Samuel, Ensslen, Tobias, Behrends, Jan C., and Holm, Christian
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Physics - Biological Physics - Abstract
Protein characterization using nanopore-based devices promises to be a breakthrough method in basic research, diagnostics, and analytics. Current research includes the use of machine learning to achieve this task. In this work, a comprehensive statistical analysis of nanopore current signals is performed and demonstrated to be sufficient for classifying up to 42 peptides with over 70 % accuracy. Two sets of features, the statistical moments and the catch22 set, are compared both in their representations and after training small classifier neural networks. We demonstrate that complex features of the events, captured in both the catch22 set and the central moments, are key in classifying peptides with otherwise similar mean currents. These results highlight the efficacy of purely statistical analysis of nanopore data and suggest a path forward for more sophisticated classification techniques.
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- 2024
30. Kinetic and Equilibrium Shapes of Cylindrical Grain Boundaries
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Qiu, Anqi, Qiu, Caihao, Chesser, Ian, Han, Jian, Srolovitz, David, and Holm, Elizabeth
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Condensed Matter - Materials Science - Abstract
In this work, we investigate the shape evolution of rotated, embedded, initially cylindrical grains (with [001] cylinder axis) in Ni under an applied synthetic driving force via molecular dynamics simulations and a continuum, disconnection-based grain boundary migration model. For some initial misorientations, the expanding grains form well-defined, faceted shapes, while for others the shapes remain cylindrical. The embedded grains tend to rotate during grain boundary migration, with the direction of rotation dependent on initial misorientation and direction of growth (expand/shrink). The kinetic shapes, which are bounded by low mobility grain boundary planes, differ from equilibrium shapes (bounded by low energy grain boundaries). The multi-mode disconnection model-based predictions are consistent with the molecular dynamics results for faceting tendency, kinetic grain shape, and grain rotation as a function of misorientation and whether the grains are expanding or contracting. This demonstrates that grain boundary migration and associated grain rotation are mediated by disconnection flow along grain boundaries., Comment: 40 pages, 18 figures
- Published
- 2024
31. 31 Lectures on Geometric Mechanics
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Holm, Darryl D.
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Physics - Classical Physics ,Mathematical Physics ,Mathematics - Dynamical Systems ,Physics - Plasma Physics - Abstract
These lecture notes in geometric mechanics are meant to convey insight through clear definitions and workable examples. The lecture format adopted here is intended to convey the immediacy of the taught course and to be useful as a basis for other courses. The lecture notes comprise: AP = Applications of Pure maths, e.g., Noether's theorem: Lie group symmetry of Hamilton's variational principle implies conservation laws for its equations of motion.\smallskip PA = Purifications of Applied maths, e.g., Euler fluid dynamics describes geodesic flow on the manifold of smooth invertible maps acting on the domain of flow. \smallskip Both AP and PA appear here, though the difference is not mentioned. It is left to the reader to decide whether it was AP or PA in each of the lectures containing well over sixty solved exercises. An aspect of modern applications emphasised here is the use of the composition of evolutionary maps for multi-physics, multi-timescale interactions including waves interacting with flows in the Euler--Poincar\'e framework in geophysical fluid dynamics (GFD) for ocean and atmosphere dynamics, and in magnetohydrodynamics (MHD) for applications in plasma physics such as magnetic confinement fusion (MFC) and astrophysical processes such as Alfv\'en waves and gravity waves propagating on the Solar tachocline. The topics covered in each lecture can also be gleaned from its table of contents listed at the onset of each lecture., Comment: Textbook in the form of 31 consecutive lectures. arXiv admin note: substantial text overlap with arXiv:0708.1585
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- 2024
32. Comparing two different types of stochastic parametrisation in geophysical flow
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Holm, Darryl, Pan, Wei, and Woodfield, James
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Physics - Fluid Dynamics ,Mathematical Physics - Abstract
This paper investigates the effects of stochastic variations in bathymetry on the solutions of the thermal quasigeostrophic (TQG) equations. These stochastic perturbations generate a variety of different types of ensemble spread in the solution behaviour whilst also preserving the deterministic Lie Poisson structure and Casimir conservation laws. We numerically compare the solution sensitivity, to another type of structure-preserving stochastic perturbation where instead of bathymetry, the velocity is stochastically perturbed.
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- 2024
33. Evidence chain for time-reversal symmetry-breaking kagome superconductivity
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Deng, Hanbin, Liu, Guowei, Guguchia, Z., Yang, Tianyu, Liu, Jinjin, Wang, Zhiwei, Xie, Yaofeng, Shao, Sen, Ma, Haiyang, Liège, William, Bourdarot, Frédéric, Yan, Xiao-Yu, Qin, Hailang, Mielke III, C., Khasanov, R., Luetkens, H., Wu, Xianxin, Chang, Guoqing, Liu, Jianpeng, Christensen, Morten Holm, Kreisel, Andreas, Andersen, Brian Møller, Huang, Wen, Zhao, Yue, Bourges, Philippe, Yao, Yugui, Dai, Pengcheng, and Yin, Jia-Xin
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science - Abstract
Superconductivity and magnetism are antagonistic quantum matter, while their intertwining has long been considered in frustrated-lattice systems1-3. In this work, we utilize scanning tunneling microscopy and muon spin resonance to discover time-reversal symmetry-breaking superconductivity in kagome metal Cs(V,Ta)3Sb5, where the Cooper pairing exhibits magnetism and is modulated by it. In the magnetic channel, we observe spontaneous internal magnetism in a full-gap superconducting state. Under perturbations of inverse magnetic fields, we detect a time-reversal asymmetrical interference of Bogoliubov quasi-particles at a circular vector. At this vector, the pairing gap spontaneously modulates, which is distinct from pair density waves occurring at a point vector and consistent with the theoretical proposal of unusual interference effect under time-reversal symmetry-breaking. The correlation between internal magnetism, Bogoliubov quasi-particles, and pairing modulation provides a chain of experimental clues for time-reversal symmetry-breaking kagome superconductivity., Comment: To appear in Nature Materials (2024)
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- 2024
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34. SANGRIA: Surgical Video Scene Graph Optimization for Surgical Workflow Prediction
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Köksal, Çağhan, Ghazaei, Ghazal, Holm, Felix, Farshad, Azade, and Navab, Nassir
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
Graph-based holistic scene representations facilitate surgical workflow understanding and have recently demonstrated significant success. However, this task is often hindered by the limited availability of densely annotated surgical scene data. In this work, we introduce an end-to-end framework for the generation and optimization of surgical scene graphs on a downstream task. Our approach leverages the flexibility of graph-based spectral clustering and the generalization capability of foundation models to generate unsupervised scene graphs with learnable properties. We reinforce the initial spatial graph with sparse temporal connections using local matches between consecutive frames to predict temporally consistent clusters across a temporal neighborhood. By jointly optimizing the spatiotemporal relations and node features of the dynamic scene graph with the downstream task of phase segmentation, we address the costly and annotation-burdensome task of semantic scene comprehension and scene graph generation in surgical videos using only weak surgical phase labels. Further, by incorporating effective intermediate scene representation disentanglement steps within the pipeline, our solution outperforms the SOTA on the CATARACTS dataset by 8% accuracy and 10% F1 score in surgical workflow recognition, Comment: 9 pages, 3 figures, 3 tables, MICCAI GRAIL Workshop paper
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- 2024
35. Central nervous system involvement in Waldenström macroglobulinemia: a comparative population-based study of Bing-Neel syndrome and histological transformation
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Østergaard, Simon, Munksgaard, Lars, Hammer, Troels, Nielsen, Torsten Holm, Pedersen, Mette Ølgod, and Gjerdrum, Lise Mette Rahbek
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- 2025
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36. Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses
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Laurie, Steven, Steyaert, Wouter, de Boer, Elke, Polavarapu, Kiran, Schuermans, Nika, Sommer, Anna K., Demidov, German, Ellwanger, Kornelia, Paramonov, Ida, Thomas, Coline, Aretz, Stefan, Baets, Jonathan, Benetti, Elisa, Bullich, Gemma, Chinnery, Patrick F., Clayton-Smith, Jill, Cohen, Enzo, Danis, Daniel, de Sainte Agathe, Jean-Madeleine, Denommé-Pichon, Anne-Sophie, Diaz-Manera, Jordi, Efthymiou, Stephanie, Faivre, Laurence, Fernandez-Callejo, Marcos, Freeberg, Mallory, Garcia-Pelaez, José, Guillot-Noel, Lena, Haack, Tobias B., Hanna, Mike, Hengel, Holger, Horvath, Rita, Houlden, Henry, Jackson, Adam, Johansson, Lennart, Johari, Mridul, Kamsteeg, Erik-Jan, Kellner, Melanie, Kleefstra, Tjitske, Lacombe, Didier, Lochmüller, Hanns, López-Martín, Estrella, Macaya, Alfons, Marcé-Grau, Anna, Maver, Aleš, Morsy, Heba, Muntoni, Francesco, Musacchia, Francesco, Nelson, Isabelle, Nigro, Vincenzo, Olimpio, Catarina, Oliveira, Carla, Paulasová Schwabová, Jaroslava, Pauly, Martje G., Peterlin, Borut, Peters, Sophia, Pfundt, Rolph, Piluso, Giulio, Piscia, Davide, Posada, Manuel, Reich, Selina, Renieri, Alessandra, Ryba, Lukas, Šablauskas, Karolis, Savarese, Marco, Schöls, Ludger, Schütz, Leon, Steinke-Lange, Verena, Stevanin, Giovanni, Straub, Volker, Sturm, Marc, Swertz, Morris A., Tartaglia, Marco, te Paske, Iris B. A. W., Thompson, Rachel, Torella, Annalaura, Trainor, Christina, Udd, Bjarne, Van de Vondel, Liedewei, van de Warrenburg, Bart, van Reeuwijk, Jeroen, Vandrovcova, Jana, Vitobello, Antonio, Vos, Janet, Vyhnálková, Emílie, Wijngaard, Robin, Wilke, Carlo, William, Doreen, Xu, Jishu, Yaldiz, Burcu, Zalatnai, Luca, Zurek, Birte, Brookes, Anthony J., Evangelista, Teresinha, Gilissen, Christian, Graessner, Holm, Hoogerbrugge, Nicoline, Ossowski, Stephan, Riess, Olaf, Schüle, Rebecca, Synofzik, Matthis, Verloes, Alain, Matalonga, Leslie, Brunner, Han G., Lohmann, Katja, de Voer, Richarda M., Töpf, Ana, Vissers, Lisenka E.L.M., Beltran, Sergi, and Hoischen, Alexander
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- 2025
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37. Optimizing hydrophilic drug incorporation into SEDDS using dry reverse micelles: a comparative study of preparation methods
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Lindner, Sera, Ricci, Fabrizio, Sandmeier, Matthias, Holm, René, Michalowski, Cecilia Bohns, Washburn, Nathaniel, Sun, Dajun, Di Pretoro, Giustino, and Bernkop-Schnürch, Andreas
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- 2025
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38. The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap
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Jonker, Anneliene H., Tataru, Elena-Alexandra, Graessner, Holm, Dimmock, David, Jaffe, Adam, Baynam, Gareth, Davies, James, Mitkus, Shruti, Iliach, Oxana, Horgan, Rich, Augustine, Erika F., Bateman-House, Alison, Pasmooij, Anna Maria Gerdina, Yu, Tim, Synofzik, Matthis, Douville, Julie, Lapteva, Larissa, Brooks, Philip John, O’Connor, Daniel, and Aartsma-Rus, Annemieke
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- 2025
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39. Hydrophobic ion pairing: lipophilicity improvement of anionic macromolecules by divalent cation mediated complex formation
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Lindner, Sera, Ricci, Fabrizio, Holm, René, Sun, Dajun, Washburn, Nathaniel, Michalowski, Cecilia Bohns, Di Pretoro, Giustino, and Bernkop-Schnürch, Andreas
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- 2024
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40. Thunderstorm ground enhancements in Finland: observations using spectroscopic radiation detectors
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Leppänen, Ari-Pekka, Peräjärvi, Kari, Paatero, Jussi, Joutsenvaara, Jari, Hannula, Antti, Hepoaho, Arttu, Holm, Philip, Ilander, Tarja, and Kärkkäinen, Jouni
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- 2024
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41. Mutational heterogeneity in large B-cell lymphoma: insights from paired biopsies
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Hersby, Ditte Stampe, Schejbel, Lone, Breinholt, Marie Fredslund, Høgdall, Estrid, Nørgaard, Peter, Nielsen, Torsten Holm, Pedersen, Lars Møller, and Gang, Anne Ortved
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- 2024
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42. Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy
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Zheng, Sean L., Henry, Albert, Cannie, Douglas, Lee, Michael, Miller, David, McGurk, Kathryn A., Bond, Isabelle, Xu, Xiao, Issa, Hanane, Francis, Catherine, De Marvao, Antonio, Theotokis, Pantazis I., Buchan, Rachel J., Speed, Doug, Abner, Erik, Adams, Lance, Aragam, Krishna G., Ärnlöv, Johan, Raja, Anna Axelsson, Backman, Joshua D., Baksi, John, Barton, Paul J. R., Biddinger, Kiran J., Boersma, Eric, Brandimarto, Jeffrey, Brunak, Søren, Bundgaard, Henning, Carey, David J., Charron, Philippe, Cook, James P., Cook, Stuart A., Denaxas, Spiros, Deleuze, Jean-François, Doney, Alexander S., Elliott, Perry, Erikstrup, Christian, Esko, Tõnu, Farber-Eger, Eric H., Finan, Chris, Garnier, Sophie, Ghouse, Jonas, Giedraitis, Vilmantas, Guðbjartsson, Daniel F., Haggerty, Christopher M., Halliday, Brian P., Helgadottir, Anna, Hemingway, Harry, Hillege, Hans L., Kardys, Isabella, Lind, Lars, Lindgren, Cecilia M., Lowery, Brandon D., Manisty, Charlotte, Margulies, Kenneth B., Moon, James C., Mordi, Ify R., Morley, Michael P., Morris, Andrew D., Morris, Andrew P., Morton, Lori, Noursadeghi, Mahdad, Ostrowski, Sisse R., Owens, Anjali T., Palmer, Colin N. A., Pantazis, Antonis, Pedersen, Ole B. V., Prasad, Sanjay K., Shekhar, Akshay, Smelser, Diane T., Srinivasan, Sundararajan, Stefansson, Kari, Sveinbjörnsson, Garðar, Syrris, Petros, Tammesoo, Mari-Liis, Tayal, Upasana, Teder-Laving, Maris, Thorgeirsson, Guðmundur, Thorsteinsdottir, Unnur, Tragante, Vinicius, Trégouët, David-Alexandre, Treibel, Thomas A., Ullum, Henrik, Valdes, Ana M., van Setten, Jessica, van Vugt, Marion, Veluchamy, Abirami, Verschuren, W. M. Monique, Villard, Eric, Yang, Yifan, Asselbergs, Folkert W., Cappola, Thomas P., Dube, Marie-Pierre, Dunn, Michael E., Ellinor, Patrick T., Hingorani, Aroon D., Lang, Chim C., Samani, Nilesh J., Shah, Svati H., Smith, J. Gustav, Vasan, Ramachandran S., O’Regan, Declan P., Holm, Hilma, Noseda, Michela, Wells, Quinn, Ware, James S., and Lumbers, R. Thomas
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- 2024
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43. Pre-clinical and clinical trials for anesthesia in neonates: gaps and future directions
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Barton, Katherine, Yellowman, R. Dexter, Holm, Tara, Beaulieu, Forrest, Zuckerberg, Gabriel, Gwal, Kriti, Setty, Bindu N., Janitz, Emily, and Hwang, Misun
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- 2024
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44. Reducing Antibiotic Prescriptions for Urinary Tract Infection in Nursing Homes Using a Complex Tailored Intervention Targeting Nursing Home Staff: Protocol for a Cluster Randomized Controlled Trial
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Arnold, Sif Helene, Jensen, Jette Nygaard, Kousgaard, Marius Brostrøm, Siersma, Volkert, Bjerrum, Lars, and Holm, Anne
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundUrinary tract infection (UTI) is the most common reason for antibiotic prescription in nursing homes. Overprescription causes antibiotic-related harms in those who are treated and others residing within the nursing home. The diagnostic process in nursing homes is complicated with both challenging issues related to the elderly population and the nursing home setting. A physician rarely visits a nursing home for suspected UTI. Consequently, the knowledge of UTI and communication skills of staff influence the diagnosis. ObjectiveThe objective of this study is to describe a cluster randomized controlled trial with a tailored complex intervention for improving the knowledge of UTI and communication skills of nursing home staff in order to decrease the number of antibiotic prescriptions for UTI in nursing home residents, without changing hospitalization and mortality. MethodsThe study describes an open-label cluster randomized controlled trial with two parallel groups and a 1:1 allocation ratio. Twenty-two eligible nursing homes are sampled from the Capital Region of Denmark, corresponding to 1274 nursing home residents. The intervention group receives a dialogue tool, and all nursing home staff attend a workshop on UTI. The main outcomes of the study are the antibiotic prescription rate for UTI, all-cause hospitalization, all-cause mortality, and suspected UTI during the trial period. ResultsThe trial ended in April 2019. Data have been collected and are being analyzed. We expect the results of the trial to be published in a peer-reviewed journal in the fall of 2020. ConclusionsThe greatest strengths of this study are the randomized design, tailored development of the intervention, and access to medical records. The potential limitations are the hierarchy in the prescription process, Hawthorne effect, and biased access to data on signs and symptoms through a UTI diary. The results of this trial could offer a strategy to overcome some of the challenges of increased antibiotic resistance and could have implications in terms of how to handle cases of suspected UTI. Trial RegistrationClinicalTrials.gov NCT03715062; https://clinicaltrials.gov/ct2/show/NCT03715062 International Registered Report Identifier (IRRID)DERR1-10.2196/17710
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- 2020
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45. Washed Away: Incorporating Bank Erosion into Highway Risk Assessments
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Davidson, S. L., Marin-Esteve, B., Weatherly, H., Scordo, E., Holm, K., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Lu, Xinzheng, Series Editor, Rujikiatkamjorn, Cholachat, editor, Xue, Jianfeng, editor, and Indraratna, Buddhima, editor
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- 2025
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46. Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
- Author
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Kurmasheva, Naziia, Said, Aida, Wong, Boaz, Kinderman, Priscilla, Han, Xiaoying, Rahimic, Anna H. F., Kress, Alena, Carter-Timofte, Madalina E., Holm, Emilia, van der Horst, Demi, Kollmann, Christoph F., Liu, Zhenlong, Wang, Chen, Hoang, Huy-Dung, Kovalenko, Elina, Chrysopoulou, Maria, Twayana, Krishna Sundar, Ottosen, Rasmus N., Svenningsen, Esben B., Begnini, Fabio, Kiib, Anders E., Kromm, Florian E. H., Weiss, Hauke J., Di Carlo, Daniele, Muscolini, Michela, Higgins, Maureen, van der Heijden, Mirte, Arulanandam, Rozanne, Bardoul, Angelina, Tong, Tong, Ozsvar, Attila, Hou, Wen-Hsien, Schack, Vivien R., Holm, Christian K., Zheng, Yunan, Ruzek, Melanie, Kalucka, Joanna, de la Vega, Laureano, Elgaher, Walid A. M., Korshoej, Anders R., Lin, Rongtuan, Hiscott, John, Poulsen, Thomas B., O’Neill, Luke A., Roy, Dominic G., Rinschen, Markus M., van Montfoort, Nadine, Diallo, Jean-Simon, Farin, Henner F., Alain, Tommy, and Olagnier, David
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- 2024
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47. Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
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Bradfeld, Jonathan P., Kember, Rachel L., Ulrich, Anna, Balkhiyarova, Zhanna, Alyass, Akram, Aris, Izzuddin M., Bell, Joshua A., Broadaway, K. Alaine, Chen, Zhanghua, Chai, Jin-Fang, Davies, Neil M., Fernandez-Orth, Dietmar, Bustamante, Mariona, Fore, Ruby, Ganguli, Amitavo, Heiskala, Anni, Hottenga, Jouke-Jan, Íñiguez, Carmen, Kobes, Sayuko, Leinonen, Jaakko, Lowry, Estelle, Lyytikainen, Leo-Pekka, Mahajan, Anubha, Pitkänen, Niina, Schnurr, Theresia M., Have, Christian Theil, Strachan, David P., Thiering, Elisabeth, Vogelezang, Suzanne, Wade, Kaitlin H., Wang, Carol A., Wong, Andrew, Holm, Louise Aas, Chesi, Alessandra, Choong, Catherine, Cruz, Miguel, Elliott, Paul, Franks, Steve, Frithiof-Bøjsøe, Christine, Gauderman, W. James, Glessner, Joseph T., Gilsanz, Vicente, Griesman, Kendra, Hanson, Robert L., Kaakinen, Marika, Kalkwarf, Heidi, Kelly, Andrea, Kindler, Joseph, Kähönen, Mika, Lanca, Carla, Lappe, Joan, Lee, Nanette R., McCormack, Shana, Mentch, Frank D., Mitchell, Jonathan A., Mononen, Nina, Niinikoski, Harri, Oken, Emily, Pahkala, Katja, Sim, Xueling, Teo, Yik-Ying, Baier, Leslie J., van Beijsterveldt, Toos, Adair, Linda S., Boomsma, Dorret I., de Geus, Eco, Guxens, Mònica, Eriksson, Johan G., Felix, Janine F., Gilliland, Frank D., Hansen, Torben, Hardy, Rebecca, Hivert, Marie-France, Holm, Jens-Christian, Jaddoe, Vincent W. V., Järvelin, Marjo-Riitta, Lehtimäki, Terho, Mackey, David A., Meyre, David, Mohlke, Karen L., Mykkänen, Juha, Oberfeld, Sharon, Pennell, Craig E., Perry, John R. B., Raitakari, Olli, Rivadeneira, Fernando, Saw, Seang-Mei, Sebert, Sylvain, Shepherd, John A., Standl, Marie, Sørensen, Thorkild I. A., Timpson, Nicholas J., Torrent, Maties, Willemsen, Gonneke, Hypponen, Elina, Power, Chris, McCarthy, Mark I., Freathy, Rachel M., Widén, Elisabeth, Hakonarson, Hakon, Prokopenko, Inga, Voight, Benjamin F., Zemel, Babette S., Grant, Struan F. A., and Cousminer, Diana L.
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- 2024
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48. Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
- Author
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Kurmasheva, Naziia, Said, Aida, Wong, Boaz, Kinderman, Priscilla, Han, Xiaoying, Rahimic, Anna H. F., Kress, Alena, Carter-Timofte, Madalina E., Holm, Emilia, van der Horst, Demi, Kollmann, Christoph F., Liu, Zhenlong, Wang, Chen, Hoang, Huy-Dung, Kovalenko, Elina, Chrysopoulou, Maria, Twayana, Krishna Sundar, Ottosen, Rasmus N., Svenningsen, Esben B., Begnini, Fabio, Kiib, Anders E., Kromm, Florian E. H., Weiss, Hauke J., Di Carlo, Daniele, Muscolini, Michela, Higgins, Maureen, van der Heijden, Mirte, Arulanandam, Rozanne, Bardoul, Angelina, Tong, Tong, Ozsvar, Attila, Hou, Wen-Hsien, Schack, Vivien R., Holm, Christian K., Zheng, Yunan, Ruzek, Melanie, Kalucka, Joanna, de la Vega, Laureano, Elgaher, Walid A. M., Korshoej, Anders R., Lin, Rongtuan, Hiscott, John, Poulsen, Thomas B., O’Neill, Luke A., Roy, Dominic G., Rinschen, Markus M., van Montfoort, Nadine, Diallo, Jean-Simon, Farin, Henner F., Alain, Tommy, and Olagnier, David
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- 2024
- Full Text
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49. Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
- Author
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Bradfield, Jonathan P., Kember, Rachel L., Ulrich, Anna, Balkhiyarova, Zhanna, Alyass, Akram, Aris, Izzuddin M., Bell, Joshua A., Broadaway, K. Alaine, Chen, Zhanghua, Chai, Jin-Fang, Davies, Neil M., Fernandez-Orth, Dietmar, Bustamante, Mariona, Fore, Ruby, Ganguli, Amitavo, Heiskala, Anni, Hottenga, Jouke-Jan, Íñiguez, Carmen, Kobes, Sayuko, Leinonen, Jaakko, Lowry, Estelle, Lyytikainen, Leo-Pekka, Mahajan, Anubha, Pitkänen, Niina, Schnurr, Theresia M., Have, Christian Theil, Strachan, David P., Thiering, Elisabeth, Vogelezang, Suzanne, Wade, Kaitlin H., Wang, Carol A., Wong, Andrew, Holm, Louise Aas, Chesi, Alessandra, Choong, Catherine, Cruz, Miguel, Elliott, Paul, Franks, Steve, Frithioff-Bøjsøe, Christine, Gauderman, W. James, Glessner, Joseph T., Gilsanz, Vicente, Griesman, Kendra, Hanson, Robert L., Kaakinen, Marika, Kalkwarf, Heidi, Kelly, Andrea, Kindler, Joseph, Kähönen, Mika, Lanca, Carla, Lappe, Joan, Lee, Nanette R., McCormack, Shana, Mentch, Frank D., Mitchell, Jonathan A., Mononen, Nina, Niinikoski, Harri, Oken, Emily, Pahkala, Katja, Sim, Xueling, Teo, Yik-Ying, Baier, Leslie J., van Beijsterveldt, Toos, Adair, Linda S., Boomsma, Dorret I., de Geus, Eco, Guxens, Mònica, Eriksson, Johan G., Felix, Janine F., Gilliland, Frank D., Biobank, Penn Medicine, Hansen, Torben, Hardy, Rebecca, Hivert, Marie-France, Holm, Jens-Christian, Jaddoe, Vincent W. V., Järvelin, Marjo-Riitta, Lehtimäki, Terho, Mackey, David A., Meyre, David, Mohlke, Karen L., Mykkänen, Juha, Oberfield, Sharon, Pennell, Craig E., Perry, John R. B., Raitakari, Olli, Rivadeneira, Fernando, Saw, Seang-Mei, Sebert, Sylvain, Shepherd, John A., Standl, Marie, Sørensen, Thorkild I. A., Timpson, Nicholas J., Torrent, Maties, Willemsen, Gonneke, Hypponen, Elina, Power, Chris, McCarthy, Mark I., Freathy, Rachel M., Widén, Elisabeth, Hakonarson, Hakon, Prokopenko, Inga, Voight, Benjamin F., Zemel, Babette S., Grant, Struan F. A., and Cousminer, Diana L.
- Published
- 2024
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50. Energy landscape interpretation of universal linearly increasing absorption with frequency
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Holm, Sverre and Bergli, Joakim
- Subjects
Condensed Matter - Soft Condensed Matter ,Condensed Matter - Materials Science - Abstract
Absorption of elastic waves in complex media is commonly found to increase linearly with frequency, for both longitudinal and shear waves. This ubiquitous property is observed in media such as rocks, unconsolidated sediments, and human tissue. Absorption is due to relaxation processes at the level of atomic scales and up to the sub-micron scale of biological materials. The effect of these processes is usually expressed as an integral over relaxation frequencies or relaxation times. Here we argue that these processes are thermally activated. Unusual for ultrasonics and seismics, we can therefore transform the expression for absorption from the frequency or time domains to an integral over an activation energy landscape weighted by an energy distribution. The universal power-law property surprisingly corresponds to a flat activation energy landscape. This is the solution which maximizes entropy or randomness. Therefore the linearly increasing absorption corresponds to the energy landscape with the fewest possible constraints., Comment: 9 pages, 4 figures
- Published
- 2024
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