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Three Groups of SPF Wistar rats were fed on radiation-sterilized, autoclave-sterilized and ordinarily autoclave-treated SPF food respectively. During 1½ years experimentation no significant differences between the groups were found with regards to general health, grow rate, feed consumption and reproduction performance. Mutagenic effects were not demonstrated either at autopsies or at a dominant lethal mutation test.

Formålet med dette forsøg var at undersøge virkningen af foderets selen- og vitamin E indhold på søernes frugtbarhed og pattegrisenes levedygtighed og vækst. Endvidere at undersøge koncentrationen af selen (Se) og vitamin E i råmælk, somælk og blod i relation til foderet. Der forekom enkelte dødsfald blandt grisene, som kunne sættes i forbindelse med enten lavt Se-indhold eller lavt vitamin E indhold i foderet. Der blev desuden konstateret flere brunst- og drægtighedsproblemer hos søer, derfik foder med det lave indhold af vitamin E end hos søer i de andre grupper. En forøgelse af Se-indholdet fra 30 til 60 µg pr. kg foder gav en fordobling af indholdet i råmælk og i somælk. En forøgelse af vitamin E indholdet i foderet fra ca. 20 mg til ca. 45 mg pr. kg foder gav 4 gange forøgelse i råmælk og somælk. Der blev konstateret tilsvarende virkninger af Se og vitamin E i foderet på indholdet i blodet.

1. Pigs, 28 castrated males and 32 females were weaned at 3 weeks old. Males were killed at about 85 kg bodyweight. Females remained in the 4 experimental groups and were mated at the first oestrus after 7 months of age. Two from each group were mated for a total of 4 litters. Altogether 165 pigs of the 2nd generation were killed at about 85 kg bodyweight. The main component of the diets was barley grown in soil which had previously produced crops of very low selenium content. The area was divided into 2 and half was treated with Se before the barley was sown. Of the 4 experimental groups 2 got diets low in Se, 0.03 mg/kg, with vitamin E 15 IU/kg. One of those diets was supplemented with vitamin E to give 45 IU/kg. The other 2 diets had Se 0.06 mg/kg and vitamin E 15 or 45 IU/kg. Sodium selenite as fertilizer increased Se in the barley from 0.01 to 0.05/106. The higher concentration of Se or vitamin E was not significantly associated with milk yield of the sow, litter size, birthweight or Hb. There was a tendency for milk yield to increase for sows receiving higher Se and vitamin E and litter size was slightly higher from sows receiving higher vitamin E. The content of Se and vitamin E was much higher in colostrum, range 53 to 108 mu g/kg between the 4 groups, than in milk, 13 to 27 mu g/kg, and additions of Se and vitamin E to the diet was associated with their marked increases in both colostrum and milk. There was a moderately improving effect of a high Se concentration in feed on growth rate and feed utilization. Low dietary Se and vitamin E were followed by increased mortality rate in piglets; iron toxicity following Fe treatment was observed in piglets given low dietary vitamin E. Signs characteristic of Pale Soft Exudative (PSE) meat were not observed in the deprived pigs.ADDITIONAL ABSTRACT:In this study of the effect of 2 levels of dietary Se (0.03 and 0.06 mg/kg feed) with and without vitamin E supplement (30 IU/kg feed) on the growth and reproduction of pi

1. Pigs, 28 castrated males and 32 females were weaned at 3 weeks old. Males were killed at about 85 kg bodyweight. Females remained in the 4 experimental groups and were mated at the first oestrus after 7 months of age. Two from each group were mated for a total of 4 litters. Altogether 165 pigs of the 2nd generation were killed at about 85 kg bodyweight. The main component of the diets was barley grown in soil which had previously produced crops of very low selenium content. The area was divided into 2 and half was treated with Se before the barley was sown. Of the 4 experimental groups 2 got diets low in Se, 0.03 mg/kg, with vitamin E 15 IU/kg. One of those diets was supplemented with vitamin E to give 45 IU/kg. The other 2 diets had Se 0.06 mg/kg and vitamin E 15 or 45 IU/kg. Sodium selenite as fertilizer increased Se in the barley from 0.01 to 0.05/106. The higher concentration of Se or vitamin E was not significantly associated with milk yield of the sow, litter size, birthweight or Hb. There was a tendency for milk yield to increase for sows receiving higher Se and vitamin E and litter size was slightly higher from sows receiving higher vitamin E. The content of Se and vitamin E was much higher in colostrum, range 53 to 108 mu g/kg between the 4 groups, than in milk, 13 to 27 mu g/kg, and additions of Se and vitamin E to the diet was associated with their marked increases in both colostrum and milk. There was a moderately improving effect of a high Se concentration in feed on growth rate and feed utilization. Low dietary Se and vitamin E were followed by increased mortality rate in piglets; iron toxicity following Fe treatment was observed in piglets given low dietary vitamin E. Signs characteristic of Pale Soft Exudative (PSE) meat were not observed in the deprived pigs.ADDITIONAL ABSTRACT:In this study of the effect of 2 levels of dietary Se (0.03 and 0.06 mg/kg feed) with and without vitamin E supplement (30 IU/kg feed) on the growth and reproduction of pi