42 results on '"Histamine receptors -- Physiological aspects"'
Search Results
2. Martin-Luther-Universitat Halle-Wittenberg Researcher Details Findings in Pharmaceuticals (Function and Role of Histamine H1 Receptor in the Mammalian Heart)
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Pharmacology, Experimental ,Heart -- Physiological aspects ,Mammals -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Health - Abstract
2023 JUN 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on pharmaceuticals are presented in a new report. According to [...]
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- 2023
3. Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity
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Cenac, Nicolas, Altier, Christophe, Motta, Jean-Paul, d'Aldebert, Emilie, Galeano, Sophie, Zamponi, Gerald W., and Vergnolle, Nathalie
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Cations -- Physiological aspects ,Cations -- Research ,Cellular signal transduction -- Research ,Histamine receptors -- Physiological aspects ,Histamine receptors -- Research ,Viscera -- Physiological aspects ,Viscera -- Research ,Irritable bowel syndrome -- Development and progression ,Irritable bowel syndrome -- Models ,Irritable bowel syndrome -- Research ,Health - Published
- 2010
4. Hypoxic ventilatory response during light and dark periods and the involvement of histamine H1 receptor in mice
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Ohshima, Yasuyoshi, Iwase, Michiko, Izumizaki, Masahiko, Ishiguro, Takashi, Kanamaru, Mitsuko, Nakayama, Hideaki, Gejyo, Fumitake, and Homma, Ikuo
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Hypoxia -- Physiological aspects ,Pulmonary ventilation -- Evaluation ,Histamine receptors -- Physiological aspects ,Circadian rhythms -- Influence ,Muridae -- Physiological aspects ,Biological sciences - Abstract
Ventilation oscillates throughout a day in parallel with oscillations in metabolic rate. Histamine affects ventilation and the balance of the energy metabolism via H1 receptors in the brain. We tested the hypothesis that the ventilatory response to hypoxia varies between light and dark periods and that histamine H1 receptors are required for the circadian variation, using wild-type (WT) and histamine H1 receptor knockout (H1RKO) mice. Mice were exposed to hypoxic gas (7% [O.sub.2] + 3% [CO.sub.2] in [N.sub.2]) during light and dark periods. Ventilation initially increased and then declined. In WT mice, minute ventilation ([V.sub.E]) during hypoxia was higher in the dark period than in the light period, which was an upward shift along with the baseline ventilation. Hypoxia decreased the metabolic rate, whereas [O.sub.2] consumption ([VO.sub.2]) and [CO.sub.2] excretion were higher in the dark period than in the light period. However, in H1RKO mice, changes in VE during hypoxia between light and dark periods were minimal, because [V.sub.E] was increased relative to [VO.sub.2], particularly in the light period. In H1RKO mice, the H[CO.sub.3] concentration and base excess values were increased in arterial blood, and the level of ketone bodies was increased in the serum, indicating that metabolic acidosis occurred. Respiratory compensation takes part in the [V.sub.E] increase relative to [Vo.sub.2] during hypoxia. These results suggested that changes in [V.sub.E] during hypoxia vary between light and dark periods and that H1 receptors play a role in circadian variation in VE through control of the acid-base status and metabolism in mice. H1 receptor knockout mice; hypoxia; ventilation; metabolism; circadian variation
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- 2007
5. Constitutive activity of the histamine [H.sub.3] receptor
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Arrang, Jean-Michel, Morisset, Severine, and Gbahou, Florence
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Histamine receptors -- Physiological aspects ,Histamine receptors -- Properties ,Biological sciences ,Chemistry ,Pharmaceuticals and cosmetics industries - Abstract
Constitutive activity has been mainly recorded for numerous overexpressed and/or mutated receptors. The histamine [H.sub.3] receptor ([H.sub.3]R) is a target of choice to study the physiological relevance of this process. In rodent brain, postsynaptic [H.sub.3]Rs show high constitutive activity, and presynaptic [H.sub.3] autoreceptors that show constitutive activity have a predominant role in inhibiting the activity of histamine neurons. [H.sub.3]R inverse agonists abrogate this constitutive brake and enhance histamine release in vivo. Some of these inverse agonists have entered clinical trials for the treatment of cognitive and food intake disorders. Studies performed in vitro and in vivo with proxyfan show that this [H.sub.3]R ligand is a 'protean agonist'--that is, a ligand with a spectrum of activity ranging from full agonism to full inverse agonism depending on the level of [H.sub.3]R constitutive activity. Consistent with its physiological and therapeutic relevance, the constitutive activity of [H.sub.3]R thus has a major function in the brain and regulates the activity of [H.sub.3]R-targeted drugs.
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- 2007
6. Decreased intracellular calcium mediates the histamine [H.sub.3]-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. (Pharmacology)
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Silver, Randi B., Poonwasi, Kumar S., Seyedi, Nahid, Wilson, Sandy J., Lovenberg, Timothy W., and Levi, Roberto
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Histamine receptors -- Physiological aspects ,Calcium in the body -- Physiological aspects ,Exocytosis -- Physiological aspects ,Science and technology - Abstract
Activation of presynatic histamine [H.sub.3] receptors ([H.sub.3]R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and ischemic conditions. Analogous to the effects of [[alpha].sub.2]-adrenoceptors, which also act prejunctionally to inhibit norepinephrine release, [H.sub.3]R-mediated antiexocytotic effects could result from a decreased [Ca.sup.2+] influx into nerve endings. We tested this hypothesis in sympathetic nerve terminals isolated from guinea pig heart (cardiac synaptosomes) and in a model human neuronal cell line (SH-SY5Y), which we stably transfected with human [H.sub.3]R cDNA (SH-SY5Y-[H.sub.3]). We found that reducing [Ca.sup.2+] influx in response to membrane depolarization by inhibiting N-type [Ca.sup.2+] channels with [omega]-conotoxin ([omega]-CTX) greatly attenuated the exocytosis of [[sup.3]H]norepinephrine from both SH-SY5Y and SH-SY5Y-[H.sub.3] cells, as well as the exocytosis of endogenous norepinephrine from cardiac synaptosomes. Similar to [omega]-CTX, activation of [H.sub.3]R with the selective [H.sub.3]R-agonist imetit also reduced both the rise in intracellular [Ca.sup.2+] concentration ([Ca.sub.i]) and norepinephrine exocytosis in response to membrane depolarization. The selective [H.sub.3]R antagonist thioperamide prevented this effect of imetit. In the parent SH-SY5Y cells lacking [H.sub.3]R, imetit affected neither the rise in [Ca.sub.i] nor [[sup.3]H]norepinephrine exocytosis, demonstrating that the presence of [H.sub.3]R is a prerequisite for a decrease in [Ca.sub.i] in response to imetit and that [H.sub.3]R activation modulates norepinephrine exocytosis by limiting the magnitude of the increase in [Ca.sub.i]. Inasmuch as excessive norepinephrine exocytosis is a leading cause of cardiac dysfunction and arrhythmias during acute myocardial ischemia, attenuation of norepinephrine release by [H.sub.3]R agonists may offer a novel therapeutic approach to this condition.
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- 2002
7. Novel insights into histamine H2 receptor biology
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Del Valle, John and Gantz, Ira
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Histamine receptors -- Physiological aspects ,Gastrointestinal system -- Motility ,Intestines -- Secretions ,G proteins -- Physiological aspects ,Cellular signal transduction -- Physiological aspects ,Amines -- Physiological aspects ,Biological sciences - Abstract
The histamine H2 receptor agonist exhibits multiple biological actions. For example, it plays an important role in the regulation of gastric acid secretion as well as gastrointestinal motility. This biogenic amine receptor is also involved in the regulation of secretion in the intestines and proliferation of the cells. The H2 receptor demonstrates the ability to activate multiple G proteins. However, its potential role in cell growth is still uncertain and therefore requires additional investigative studies.
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- 1997
8. Gender affects rats' central nervous system histaminergic responses to dietary manipulation
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Mercer, L. Preston, Kelley, Danita S., Bundrant, Holly M., Haq, Akram-Ul, and Humphries, Laurie L.
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Central nervous system -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Animal nutrition -- Research ,Dimorphism (Animals) -- Physiological aspects ,Food/cooking/nutrition - Abstract
The histaminergic system (histamine and its [H.sub.1]-receptor) of the central nervous system has been implicated in control of food intake. The reported studies were designed to examine the effects of food restriction and very low (1%) protein diets on central nervous system [H.sub.1]-receptors in male and female rats. In a series of experiments, groups of rats were freely fed a 25% protein diet, a 1% protein diet, or fed the 25% protein diet at 4 g/100 g body weight for 14-20 d. When freely fed 25% protein diets, females had higher whole-brain [H.sub.1]-receptor binding than males on d I (female 122.36 [+ or -] 4.53 and male 65.78 [+ or -] 3.82 pmol/g protein; P < 0.001). Changing diets affected central [H.sub.1]-receptor binding in both males and females (P < 0.003). When rats were fed both restricted levels of food and 1% protein diets, the receptor binding of males increased by d 5 whereas that of females decreased by d 5 (P < 0.001). When fed 1% protein diets, females had decreased [H.sub.1]-receptor binding (98.4 [+ or -] 2.38 pmol/g protein) and that in males increased to 119.81 [+ or -] 5.09 pmol/g protein. After 15 d, females had eaten significantly more food than males: females 166 [+ or -] 4.9 g, males 124 [+ or -] 1.9 g (P < 0.0007). Males had a significantly greater weight loss than females: males -28.8 [+ or -] 2.6 g, females -17.08 [+ or -] 0.97 g (P < 0.0007). When fed restricted diets, females had decreased [H.sub.1]-receptor binding (93.81 [+ or -] 5.58 pmol/g) whereas binding in males increased to 111.27 [+ or -] 8.55 pmol/g. Preliminary saturation binding studies indicated that restricted food intake lowered receptor density (females consuming 25% protein: 715 [+ or -] 30 pmol/g protein; female restricted: 467 [+ or -] 28 pmol/g protein, P < 0.05), while 1% protein increased receptor sensitivity, i.e., lowered [K.sub.D] (males consuming 25% protein: 15.3 [+ or -] 1.8 nmol; males fed low protein: 2.8 [+ or -] 0.27 nmol). This study suggests that dietary manipulation affects central [H.sub.1]-receptor binding in a gender-specific manner, thereby modulating central histaminergic activity during food or protein deficit. INDEXING KEY WORDS: * receptor * growth * histamine * rats * gender * diet
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- 1996
9. Characterization of the effects of histamine on porcine tracheobronchial lymph vessels
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Reeder, Laurie B., DeFilippi, Vincent J., and Ferguson, Mark K.
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Histamine -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Lymphoid tissue -- Physiological aspects ,Vascular smooth muscle -- Physiological aspects ,Vasoconstriction -- Physiological aspects ,Endothelium-derived relaxing factors -- Physiological aspects ,Biological sciences - Abstract
The effects of endothelium-derived relaxing factor (EDRF) on the response of lymphatic vascular smooth muscles to histaminergic (H) receptor activation and inhibition were analyzed in porcine tracheobronchial lymph vessel rings. The histamine-mediated release of EDRF into the lymphatic vessels is vital for the regulation of lymph flow in porcine tracheobronchial lymph vessels. Administration of dipenhydramine in tracheobronchial lymph vessels inhibited the H1-specific contractile activity of histamine. Furthermore, the release of EDRF in lymphatic vessels is mediated by H1 receptors.
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- 1996
10. Impaired locomotor activity and explanatory behavior in mice lacking histamine H1 receptors
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Inoue, Isao, Yanai, Kazuhiko, Kitamura, Daisuke, Taniuchi, Ichiro, Kobayashi, Takashi, Niimura, Kaku, Watanabe, Takehiko, and Watanabe, Takeshi
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Histamine receptors -- Physiological aspects ,Mice -- Physiological aspects ,Science and technology - Abstract
From pharmacological studies using histamine antagonists and agonists, it has been demonstrated that histamine modulates many physiological functions of the hypothalamus, such as arousal state, locomotor activity, feeding, and drinking. Three kinds of receptors ([H.sub.1], [H.sub.2], and [H.sub.3]) mediate these actions. To define the contribution of the histamine [H.sub.1] receptors (H1R) to behavior, mutant mice lacking the H1R were generated by homologous recombination. In brains of homozygous mutant mice, no specific binding of [3H]pyrilamine was seen. [3H]Doxepin has two saturable binding sites with higher and lower affinities in brains of wild-type mice, but H1R-deficient mice showed only the weak labeling of [3H]doxepin that corresponds to lower-affinity binding sites. Mutant mice develop normally, but absence of H1R significantly increased the ratio of ambulation during the light period to the total ambulation for 24 hr in an accustomed environment. In addition, mutant mice significantly reduced exploratory behavior of ambulation and rearings in a new environment. These results indicate that through H1R, histamine is involved in circadian rhythm of locomotor activity and exploratory behavior as a neurotransmitter.
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- 1996
11. Histamine activates phospholipase C in human airway epithelial cells via a phorbol ester-sensitive pathway
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Rugolo, M., Barzanti, F., Gruenert, D.C., and Hrelia, S.
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Histamine receptors -- Physiological aspects ,Nasal fossa -- Physiological aspects ,Epithelial cells -- Physiological aspects ,Phospholipases -- Physiological aspects ,Cystic fibrosis -- Physiological aspects ,Biological sciences - Abstract
The 9HTEo- tracheal epithelium cell lines and the CFNPE9o- nasal epithelium cell lines of cystic fibrosis patients were analyzed to determine the cellular signaling mechanism that is triggered by histamine. Histamine-induced intracellular Ca2+ mobilization in airway epithelial cells is mediated by the presence of histamine receptors that are linked by pertussis toxin-insensitive G proteins to phospholipase C.
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- 1996
12. Histamine H2 receptor activates adenylate cyclase and PLC via separate GTP-dependent pathways
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Wang, L., Gantz, I., and DelValle, J.
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Histamine -- Physiological aspects ,Adenylate cyclase -- Physiological aspects ,G proteins -- Physiological aspects ,Cellular signal transduction -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Phospholipases -- Physiological aspects ,Biological sciences - Abstract
Isolated cell membranes from purified canine parietal and rat hepatoma cells with histamine H2 receptors were analyzed to determine the effects of histamine on adenylate cyclase (AC) and phospholipase C (PLC) signaling. PLC and AC were activated by histamine H2 receptors by utilizing two guanosine triphosphate (GTP)-dependent pathways. The histamine-induced activation of PLC by GTP-dependent pathway is sensitive to cholera toxin. However, histamine activation of PLC is not affected by AC and cyclic adenosine monophosphate generation.
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- 1996
13. Inverse agonism of histamine H2 antagonists accounts for upregulation of spontaneously active histamine H2 receptors
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Smit, Martine J., Leurs, Rob, Alewijnse, Astrid E., Blauw, Joeri, Van Nieuw Amerongen, Gerard P., Van De Vrede, Yvonne, Roovers, Edwin, and Timmerman, Henk
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Histamine receptors -- Physiological aspects ,Genetic regulation -- Analysis ,Science and technology - Abstract
Histamine [H.sub.2] receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure to the [H.sub.2] antagonists cimetidine and ranitidine. This effect appears to be [H.sub.2] receptor-mediated as no change in receptor density was observed after [H.sub.1] or [H.sub.3] antagonist treatment or after incubation with the structural analogue of cimetidine, VUF 8299, which has no [H.sub.2] antagonistic effects. By using transfected CHO cells expressing different densities of wild-type [H.sub.2] receptors or an uncoupled [H.sub.2][Leu.sup.124]Ala receptor, the histamine [H.sub.2] receptor was found to display considerable agonist-independent [H.sub.2] receptor activity. Cimetidine and ranitidine, which both induce [H.sub.2] receptor upregulation, actually functioned as inverse agonists in those cell lines displaying spontaneous agonist-independent [H.sub.2] receptor activity. Burimamide, on the other hand, was shown to act as a neutral antagonist and did as expected not induce [H.sub.2] receptor upregulation after long-term exposure. The displayed inverse agonism of [H.sub.2] antagonists appears to be a mechanistic basis for the observed [H.sub.2] antagonist-induced [H.sub.2] receptor upregulation in transfected CHO cells. These observations shed new light on the pharmacological classification of the [H.sub.2] antagonists and may offer a plausible explanation for the observed development of tolerance after prolonged clinical use.
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- 1996
14. Does the histaminergic system mediate bombesin/GRP-induced suppression of food intake?
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Merali, Zul and Banks, Kate
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Ingestion -- Research ,Histamine receptors -- Physiological aspects ,Bombesin -- Analysis ,Biological sciences - Abstract
A study of the effects of selective H3-receptor agonists such as R-alpha-methyl histamine (alpha-MH) and Imetit on bombesin (BN)-or cholecystokinin (CCK)-induced satiety reveals that BN induces satiety by promoting histaminergic activity at unknown locations and that the BN effects on food intake are lowered by H3-receptor agoinsts by preventing histamine secretion. Satiety inhibition by H3-receptor agonists is dose-dependent and selective to BN and is absent when the activation is by CCK. The inhibitory effects of the agonists are prevented by H3-receptor antagonists.
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- 1994
15. Histamine H2 receptors and histidine decarboxylase in normal and leukemic human monocytes and macrophages
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Mirossay, Ladislav, Chastre, Eric, Callebert, Jacques, Launay, Jean-Marie, Housset, Bruno, Zimber, Amazia, Abita, Jean-Pierre, and Gespach, Christian
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Histamine receptors -- Physiological aspects ,Monocytes -- Physiological aspects ,Macrophages -- Physiological aspects ,Biological sciences - Abstract
A study of the regulation of spontaneous and retinoic-induced differentiation of normal and leukemic human monocytes and macrophages by histamine H2 receptors and histamine decarboxylase reveals that histamines control the various autocrine, paracrine and intracrine mechanisms that regulate immune and inflammatory phagocytic responses in peripheral blood and tissues. The all-trans-retinoic acid (RA)-induced differentiation of normal human monocytes and of THP-1 leukemic monocytes into macrophages results in PMA-induced inhibition of H2O2 formation and attenuated cAMP production by histamine, mediated by RA-induced H2 R gene expression.
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- 1994
16. Manipulation of central nervous system histamine or histaminergic receptors (H1) affects food intake in rats
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Mercer, L. Preston, Kelley, Danita Saxon, Humphries, Laurie L., and Dunn, Jon D.
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Histamine -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Rats -- Physiological aspects ,Central nervous system -- Physiological aspects ,Ingestion -- Physiological aspects ,Food/cooking/nutrition - Abstract
The reported studies were designed to examine relationships between central nervous system histamine, histaminergic receptors ([H.sub.1]) and food intake in rats. The hypothesis being tested was as follows: 'One component of the neuroregulation of food intake involves histaminergic activity in the hypothalamus as influenced by variation of histamine levels and/or [H.sub.1] receptor concentrations.' We performed combinations of dietary, surgical and pharmacological treatments on male or female rats. We fed groups of male or female rats diets containing either 4 g casein/100 g diet (low protein diet) or 25 g casein/100 g diet (normal protein). Rats with surgical ablation of the paraventricular nucleus did not decrease food intake when fed the low protein diet, whereas adrenalectomized rats did. Increasing central histamine levels decreased food intake, whereas decreasing central histamine increased food intake. Rats injected with histaminergic ([H.sub.1]) antagonists lost the ability to detect low protein diet in short-term experiments and had improved efficiency of weight gain. Rats that were fed the low protein diet or pair-fed the normal protein diet had greater [H.sub.1] receptor concentrations in whole brain preparations when compared with rats fed the normal protein diet. No differences were noted due to gender. Thus, manipulation of histamine levels affected food intake as hypothesized, i.e., increasing central histamine decreased food in rats fed the normal protein diet, whereas decreasing central histamine or blockade of [H.sub.1] receptors increased food intake in rats fed the low protein diet.
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- 1994
17. Effect of histamine on rat gastric H+-K+-ATPase alpha-subunit expression
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Tari, Akira, Yamamoto, Gohso, Yonei, Yoshikazu, Sumii, Masaharu, Sumii, Koji, Haruma, Ken, Kajiyama, Goro, Wu, Vincent, Sachs, George, and Walsh, John H.
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Stomach -- Secretions ,Histamine receptors -- Physiological aspects ,Biological sciences - Abstract
Studies on rat gastric H+-K+-ATPase alpha subunit reveal that H2 receptor activation leads to histamine stimulation of H+-K+-ATPase alpha subunit activity. Famotidine, which enhances gastric pH and serum gastrin, reduces the H2 receptor action. It also reduces the level of H+-K+-ATPase mRNA.
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- 1994
18. Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women
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Bytautiene, Egle, Vedernikov, Yuri P., Saade, George R., Romero, Roberto, and Garfield, Robert E.
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Myometrium -- Health aspects ,Myometrium -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Pregnant women -- Health aspects ,Obstetrics -- Research ,Health - Abstract
Research has been conducted on histamine. The role of histamine in uterine tissue's plastic and tonic contractive activity has been investigated, and the results have demonstrated that histamine inhibits tonic and increases spontaneous uterine tissue contractions.
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- 2003
19. Enhancement of antibiotic concentrations in gastric mucosa by H2-receptor antagonist: implications for treatment of Helicobacter pylori infections
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Westblom, T. Ulf and Duriex, Dennis E.
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Cimetidine -- Health aspects ,Histamine receptors -- Physiological aspects ,Gastritis -- Models ,Clindamycin -- Physiological aspects ,Helicobacter infections -- Drug therapy ,Gastritis -- Drug therapy ,Gastritis -- Causes of ,Health - Abstract
Antral gastritis is an inflammatory disease involving the portion of the stomach near its junction with the esophagus. It is becoming increasingly clear that the bacterium Helicobacter pylori plays an important role in the development of this disease. Hence, many treatment strategies have incorporated administration of one or several antibiotic medications. Although multiple-drug regimens have yielded high eradication rates, results have been much poorer with single-agent treatments. This may be due to the emergence of antibiotic resistance, antagonistic effects of gastric acid on the therapeutic actions of the drug, or less than optimal concentrations of the antibiotic at the gastric mucosa (the lining of the stomach) where the bacterial infection is present. To evaluate the effects of decreasing gastric acidity on mucosal antibiotic activity, an experiment was carried out in guinea pigs (an animal model of gastrointestinal function that has been shown to be very similar to human). Animals were pretreated with the histamine H2 receptor blocker cimetidine, which caused a reduction in gastric acid secretion; the guinea pigs were then treated with the antibiotic clindamycin. Blood samples as well as tissue sections were taken from the gastric antrum several times after drug treatment, and analyzed for antibiotic levels. Blood levels of clindamycin were similar to those that occur in the absence of cimetidine; however, following pretreatment with cimetidine, mucosal antibiotic concentrations were increased by as much as 10-fold (compared with normal levels of gastric acidity). Agents that reduce acidity may serve as useful adjuncts to antibiotic therapy for gastritis, particularly when single-antibiotic treatment is used. (Consumer Summary produced by Reliance Medical Information, Inc.)
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- 1991
20. Gastroesophageal reflux disease: selecting optimal therapy
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Robinson, Malcolm
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Gastroesophageal reflux -- Care and treatment ,Histamine receptors -- Physiological aspects ,Adenosine triphosphatase -- Health aspects ,Health - Published
- 1994
21. What Makes Us Itch?
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Pruritus -- Physiological aspects ,Pruritus -- Health aspects ,Pruritus -- Care and treatment ,Touch -- Psychological aspects ,Touch -- Physiological aspects ,Histamine receptors -- Health aspects ,Histamine receptors -- Physiological aspects - Abstract
To listen to this broadcast, click here: http://www.npr.org/templates/story/story.php?storyId=14386632 JOE PALCA, host: From NPR News, this is TALK OF THE NATION: SCIENCE FRIDAY. I'm Joe Palca. Up now, most of the […]
- Published
- 2007
22. Effects of histamine type 2-receptor antagonists cimetidine and famotidine on left ventricular systolic function in chronic congestive heart failure
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Solomon, Scott D., Wolff, Simonetta, Jarboe, Linda A., Wolfe, M. Michael, and Lee, Richard T.
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Histamine receptors -- Physiological aspects ,Cimetidine -- Physiological aspects ,Famotidine -- Physiological aspects ,Heart -- Contraction ,Health - Abstract
Twelve patients with stable congestive heart failure and left ventricular dysfunction were enrolled in a double-blind, randomized crossover trial of famotidine, cimetidine and placebo to determine whether histamine type 2 ([H.sub.2]) antagonists adversely affect left ventricular systolic performance. Two-dimensional echocardiograms were obtained at baseline, after 4 days of oral treatment with standard doses of famotidine and cimetidine, and placebo, and at the conclusion of the trial. The baseline mean ejection fraction was 19 [+ or -] 7%. The changes in ejection fraction were +2 [+ or -] 11% (9S% confidence interval [CI] -5 to 9%) with famotidine, +3 [+ or -] 10% (95% CI -3 to 10%) with cimetidine, and -3 [+ or -] 7% (95% CI -8 to 2%) with placebo. There were no significant differences in changes in ejection fraction among the 3 experimental treatments (p = 0.22; analysis of variance). The changes in end-systolic wall stress/ volume ratios from baseline were +6 [+ or -] 21% (9S% CI -6 to 18%) for famotidine, +8 [+ or -] 29% (9S% CI - 8 to 25%) for cimetidine, and +2% [+ or -] 29% (95% CI -15 to 18%) for placebo (p = 0.69; analysis of variance). No patient had a worsening of symptoms during therapy. Despite previous reports that [H.sub.2] antagonists may depress left ventricular systolic function, at standard doses these agents result in no decrease in left ventricular systolic function in patients with chronic congestive heart failure. (Am J Cardiol 1993;72:1163-1166)
- Published
- 1993
23. Histamine-2 receptor antagonists do not alter serum ethanol levels in fed, nonalcoholic men
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Raufman, Jean-Pierre, Notar-Francesco, Vincent, Raffaniello, Robert D., and Straus, Eugene W.
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Alcohol -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Antihistamines -- Physiological aspects ,Health - Abstract
* Objective: To determine whether the four histamine-2 receptor antagonists currently available for the treatment of acid-peptic disorders in the United States alter serum ethanol levels after moderate alcohol consumption. * Design: Prospective, randomized crossover design comparing the effects of histamine-2 receptor antagonists and no treatment on serum ethanol levels. Each participant served as his own control. * Participants: Twenty-five healthy nonalcoholic men (21 to 35 years old); two participants were withdrawn before starting the study. * Setting: University medical center. * Intervention: Cimetidine (400 mg twice daily), famotidine (20 mg twice daily), nizatidine (150 mg twice daily), ranitidine (1 50 mg twice daily), and no treatment for 7 days. After the last dose of medication, participants ate a standard meal; 1 hour later they drank ethanol (0.3 g/kg body weight in 500 mL of orange juice) over 8 minutes. * Measurements: Simultaneous measurements of breath and serum (headspace gas chromatography) ethanol were made before and 10, 20, 30, 45, 60, 90, 120, 150, and 180 minutes after ingestion of ethanol. * Results: Peak ethanol levels did not differ (mmol/L; mean [+ or -] SE) after cimetidine (3.0 [+ or -] 0.3), famotidine (2.9 [+ or -] 0.3), nizatidine (2.9 [+ or -] 0.3), ranitidine (3.1 [+ or -] 0.4), and no treatment (2.9 [+ or -] 0.4). Similarly, there was no difference in the area under the curve (mmol/L) . h; mean [+ or -] SE) after cimetidine (4.3 [+ or -] 0.5), famotidine (3.8 [+ or -] 0.4), nizatidine (4.2 [+ or -] 0.5), ranitidine (3.9 [+ or -]- 0.4), and no treatment (4.0 [+ or -]- 0.5). * Conclusions: In healthy nonalcoholic men, the histamine-2 receptor antagonists currently available in the United States do not alter serum ethanol levels following moderate alcohol consumption after an evening meal., Histamine-2 (H-2) receptor antagonists may not affect blood levels of ethanol, or alcohol, in nonalcoholic men after moderate consumption of alcohol on a full stomach. Patients suffering from peptic-acid diseases are often treated with H-2 receptor antagonists. Twenty-three healthy nonalcoholic men between 21 and 35 years old were treated for seven days each with 400 milligrams (mg) of cimetidine twice a day, 20 mg of famotidine twice a day, 150 mg of nizatidine twice a day and 150 mg of rantidine twice a day and no treatment. Maximum blood levels of ethanol did not differ significantly during any of the treatments. Average blood levels of ethanol also did not differ significantly during any of the treatments. Some H-2 receptor antagonists are planned over-the-counter sale. Their affect on blood levels of ethanol is an important factor in evaluating the safety of these drugs.
- Published
- 1993
24. Gastroesophageal reflux disease in adults: pathophysiology, diagnosis, and management
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Rex, Douglas K.
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Gastroesophageal reflux -- Care and treatment ,Histamine receptors -- Physiological aspects ,Omeprazole -- Physiological aspects ,Antacids -- Physiological aspects ,Esophagitis -- Care and treatment - Abstract
Gastroesophageal reflux disease (GERD) refers to symptoms or tissue damage that result from gastroesophageal reflux. Reflux esophagitis is a subset of GERD and implies the presence of esophageal inflammation, ie, esophageal erosions that are visible endoscopically, or nonerosive inflammation that can be documented by biopsies. Heartburn is the most common and specific symptom of GERD. In some patients, chest pain or respiratory symptoms may be the only presenting signs. In patients aged, Gastroesophageal reflux occurs commonly in normal persons. Patients who have either symptoms or tissue damage resulting from reflux are said to have gastroesophageal reflux disease (GERD). "Reflux esophagitis" is often [...]
- Published
- 1992
25. Localization and quantification of histamine in injured skin as parameters for the timing of wounds.
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Fu Chen Zhong and Zhu Ziazhen
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Skin -- Injuries ,Histamine receptors -- Physiological aspects ,Mast cells -- Physiological aspects - Published
- 1991
26. Clinical review of histamine-2 receptor antagonists
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Lipsy, Robert J., Fennerty, Brian, and Fagan, Timothy C.
- Subjects
Histamine receptors -- Physiological aspects ,Antiulcer drugs -- Physiological aspects ,Antihistamines -- Health aspects ,Histamine -- Physiological aspects ,Health - Abstract
Histamine is a natural substance that increases stomach secretion, dilates capillaries, or small blood vessels, and contracts the bronchi and bronchioles, the muscular tube-like structures branching from the trachea, or windpipe, to the lungs. Histamine specifically binds or attaches to protein sites on the cell membrane called histamine receptors. Although there are various types of histamine receptors, the receptor involved in many of histamine's cellular reactions is the histamine-2 or H2 receptor. Agents that block the H2 receptor are called H2 receptor antagonists, and have been shown to be clinically useful. H2 receptor antagonists are used to treat several conditions: ulcers of the stomach and duodenum, the first part of the small intestine; gastroesophageal reflux, the backflow of stomach contents from the stomach to the esophagus; and hypersecretory states, conditions of increased release of substances, such as acid from the stomach. The H2 receptor antagonists have also been used prophylactically to prevent stress-related ulcers and the recurrence of stomach and duodenal ulcers. The H2 receptor antagonists approved for clinical use include cimetidine, famotidine, ranitidine, and nizatidine; their effectiveness, adverse drug reactions, and interactions with other drugs are reviewed. Because these agents differ with respect to drug interactions and adverse effects, clinicians should consider these factors when choosing H2 receptor antagonists for their patients. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1990
27. Coupling of histamine [H.sub.3] receptors to neuronal [Na.sup.+]/[H.sup.+] exchange: A novel protective mechanism in myocardial ischemia
- Author
-
Silver, Randi B., Mackins, Christina J., Smith, Neil C.E., Koritchneva, Irina L., Lefkowitz, Kara, Lovenberg, Timothy W., and Levi, Roberto
- Subjects
Histamine receptors -- Physiological aspects ,Coronary heart disease -- Physiological aspects ,Neurons -- Physiological aspects ,Noradrenaline -- Physiological aspects ,Sodium in the body -- Physiological aspects ,Arrhythmia -- Physiological aspects ,Ion exchange -- Physiological aspects ,Acidosis -- Physiological aspects ,Science and technology - Abstract
In myocardial ischemia, adrenergic nerves release excessive amounts of norepinephrine (NE), causing dysfunction and arrhythmias. With anoxia and the concomitant ATP depletion, vesicular storage of NE is impaired, resulting in accumulation of free NE in the axoplasm of sympathetic nerves. Intraneuronal acidosis activates the [Na.sup.+]/[H.sup.+] exchanger (NHE), leading to increased [Na.sup.+] entry in the nerve terminals. These conditions favor availability of the NE transporter to the axoplasmic side of the membrane, causing massive carrier-mediated efflux of free NE. Neuronal NHE activation is pivotal in this process; NHE inhibitors attenuate carrier-mediated NE release. We previously reported that activation of histamine [H.sub.3] receptors ([H.sub.3]R) on cardiac sympathetic nerves also reduces carrier-mediated NE release and alleviates arrhythmias. Thus, [H.sub.3]R activation may be negatively coupled to NHE. We tested this hypothesis in individual human SKNMC neuroblastoma cells stably transfected with [H.sub.3]R cDNA, loaded with the intracellular pH (p[H.sub.i]) indicator BCECF. These cells possess amiloride-sensitive NHE. NHE activity was measured as the rate of [Na.sup.+]-dependent p[H.sub.i] recovery in response to an acute acid pulse ([NH.sub.4]CI). We found that the selective [H.sub.3]R-agonist imetit markedly diminished NHE activity, and so did the amiloride derivative EIPA. The selective [H.sub.3]R antagonist thioperamide abolished the imetit-induced NHE attenuation. Thus, our results provide a link between [H.sub.3]R and NHE, which may limit the excessive release of NE during protracted myocardial ischemia. Our previous and present findings uncover a novel mechanism of cardioprotection: NHE inhibition in cardiac adrenergic neurons as a means to prevent ischemic arrhythmias associated with carrier-mediated NE release.
- Published
- 2001
28. Is histamine the final neurotransmitter in the entrainment of circadian rhythms in mammals?
- Author
-
Jacobs, Edwin H., Yamatodani, Atsushi, and Timmerman, Henk
- Subjects
Pharmaceutical research -- Reports ,Circadian rhythms -- Effect of chemicals on ,Histamine receptors -- Physiological aspects ,Neurotransmitters -- Research ,Biological sciences ,Chemistry ,Pharmaceuticals and cosmetics industries - Abstract
Adaptation of circadian rhythms to the environmental light-dark cycle is necessary for the survival of organisms. This synchronization or entrainment is only caused by light (photic input) during the dark period, according to the internal biological clock of an organism. During the light period, internal factors (non-photic input), rather than light, are able to entrain circadian rhythms. In this article, the data that implicate the neurotransmitter system for histamine in circadian entrainment are reviewed. Furthermore, we speculate that histamine receptors are the final gate at which both photic and non-photic entrainment mechanisms converge before sending a resetting signal to the intracellular biological clock.
- Published
- 2000
29. Research Data from University of Occupational and Environmental Health Update Understanding of Glucose Intolerance
- Subjects
Dextrose -- Physiological aspects ,Histamine -- Physiological aspects ,Glucose -- Physiological aspects ,Glucose metabolism -- Physiological aspects ,Universities and colleges -- Japan -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Health - Abstract
New investigation results, 'Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice,' are detailed in a study published in The American Journal of [...]
- Published
- 2011
30. New Findings from Hannover Veterinary and Medical University Update Understanding of Ethylamines (Histamine Receptor Expression in the Gastrointestinal Tract of Dogs)
- Subjects
Histamine -- Physiological aspects ,Gastrointestinal system -- Physiological aspects ,Irritable bowel syndrome -- Research -- Physiological aspects ,Gastrointestinal diseases -- Research -- Physiological aspects ,Histamine receptors -- Physiological aspects ,RNA -- Physiological aspects ,Health - Abstract
2017 FEB 13 (VerticalNews) -- By a News Reporter-Staff News Editor at Veterinary Research Week -- Investigators discuss new findings in Ethylamines. According to news reporting originating from Hannover, Germany, [...]
- Published
- 2017
31. Easy as 1,2,3? Histamine receptors and gastric acid. (Commentaries: Heliocobacter pylori)
- Author
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Beales, I.L.P.
- Subjects
Gastric acid -- Physiological aspects ,Helicobacter pylori -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Health ,Physiological aspects - Abstract
N-alpha-methyl-histamine, which is produced in the gastric mucosa by Helicobacter pylori, is a potent [H.sub.2] receptor agonist as well as a [H.sub.3] receptor agonist It is over 80 years since [...]
- Published
- 2002
32. Findings from M.S. Tichenor and Co-Researchers Provides New Data on Medicinal Chemistry (Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators)
- Subjects
Histamine -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Health - Abstract
2016 FEB 5 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Health and Medicine have been published. According to news [...]
- Published
- 2016
33. Studies from Jagiellonian University Update Current Data on Autacoids (Human Eosinophils - Potential Pharmacological Model Applied in Human Histamine H-4 Receptor Research)
- Subjects
Histamine -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Health ,Jagiellonian University - Abstract
2015 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Biological Factors. According to news reporting originating from [...]
- Published
- 2015
34. Histamine [H.sub.1] receptors mediate the anorectic action of the pancreatic hormone amylin
- Author
-
Mollet, A., Lutz, T.A., Meier, S., Riediger, T., Rushing, P.A., and Scharrer, E.
- Subjects
Histamine receptors -- Physiological aspects ,Body weight -- Physiological aspects ,Ingestion -- Physiological aspects ,Biological sciences - Abstract
Histamine [H.sub.1] receptors mediate the anorectic action of the pancreatic hormone amylin. Am J Physiol Regulatory Integrative Comp Physiol 281: R1442-R1448, 2001.--We investigated the role of histamine [H.sub.1] receptors in mediating the anorectic effect of intraperitoneally injected amylin (5 and 20 [micro]g/kg), the amylin agonist salmon calcitonin (sCT; 10 [micro]g/kg), leptin (1.3 mg/kg), and cholecystokinin (CCK; 20 [micro]g/kg). The experiments were performed with mice lacking functional [H.sub.1] receptors ([H.sub.1]Rko) and wild-type (WT) controls. The mice were also injected with the [H.sub.3] antagonist thioperamide (20 mg/kg), which reduces feeding by enhancing the release of endogenous histamine through presynaptic [H.sub.3] receptors. The feeding-suppressive effect of thioperamide was abolished in [H.sub.1]Rko mice. The anorectic effects of amylin and sCT were significantly reduced in 12-h food-deprived [H.sub.1]Rko mice compared with WT mice [1-h food intake: WT-NaCl 0.51 [+ or -] 0.05 g vs. WT-amylin (5 [micro]g/kg) 0.30 [+ or -] 0.06 g (P < 0.01); [H.sub.1]Rko-NaCl 0.45 [+ or -] 0.05 g vs. [H.sub.1]Rko-amylin 0.40 [+ or -] 0.04 g; WT-NaCl 0.40 [+ or -] 0.09 g vs. WT-sCT (10 [micro]g/kg) 0.14 [+ or -] 0.10 g (P < 0.05); [H.sub.1]Rko-NaCl 0.44 [+ or -] 0.08 g vs. [H.sub.1]Rko-sCT 0.50 [+ or -] 0.06 g]. The anorectic effect of leptin was absent in ad libitum-fed [H.sub.1]Rko mice, whereas CCK equally reduced feeding in WT and [H.sub.1]Rko animals. This suggests that the histaminergic system is involved in mediating the anorectic effects of peripheral amylin and sCT via histamine [H.sub.1] receptors. The same applies to leptin but not to CCK. [H.sub.1]Rko mice showed significantly increased body weight gain compared with WT mice, supporting the role of endogenous histamine in the regulation of feeding and body weight. food intake; histamine [H.sub.1] receptor knockout mice; thioperamide; salmon calcitonin; leptin; cholecystokinin
- Published
- 2001
35. Do histamine-2 receptor antagonists influence the metabolism of ethanol?
- Author
-
Levitt, Michael D.
- Subjects
Histamine receptors -- Physiological aspects ,Antihistamines -- Physiological aspects ,Alcohol metabolism -- Physiological aspects ,Health - Abstract
The effect of histamine-2 (H-2) receptor antagonists on the metabolism of ethanol, or alcohol, is controversial. H-2 receptor antagonists are a group of drugs mainly used to treat patients suffering from acid-peptic diseases. A research study found that commercially available H-2 receptor antagonists did not affect the metabolism of alcohol. One concern is that H-2 receptor antagonists can unexpectedly increase blood levels of alcohol after ingestion of large amounts of alcohol. Part of this controversy is fueled by the debate over the metabolism of alcohol. After imbibing alcohol, a certain portion may be metabolized by the mucosal lining of the stomach. All of the alcohol that reaches the peripheral circulation is metabolized by the liver. H-2 receptor antagonists may affect the metabolism of alcohol because they inhibit gastric metabolism.
- Published
- 1993
36. Acid suppression: how much is needed?
- Author
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Colin-Jones, D.G.
- Subjects
Omeprazole -- Evaluation ,Histamine receptors -- Physiological aspects ,Antihistamines -- Health aspects ,Esophagitis -- Drug therapy ,Gastric acid -- Physiological aspects ,Ulcers -- Drug therapy - Published
- 1990
37. Histamine-2 receptor antagonist stimulates immune system in cancer
- Subjects
Immunotherapy -- Research ,Stomach cancer -- Physiological aspects ,Histamine receptors -- Physiological aspects ,Business ,Health care industry - Abstract
Histamine-2 receptor antagonists show promise for adoptive immunotherapy in cancer patients, report Korean researchers. K.B. Hahm et al., from the Yonsei University College of Medicine in Seoul, South Korea, compared [...]
- Published
- 1995
38. Investigators at Semmelweis University, Department of Medicine release new data on life sciences
- Subjects
Histidine -- Reports ,Histidine -- Physiological aspects ,Histamine receptors -- Reports ,Histamine receptors -- Physiological aspects ,Histamine -- Reports ,Histamine -- Physiological aspects ,Universities and colleges -- Reports ,Universities and colleges -- Physiological aspects - Abstract
Investigators publish new data in the report 'Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors.' According to recent research published in [...]
- Published
- 2009
39. Research results from Texas A&M University, Health Science Center update knowledge of physiology
- Subjects
Phosphotransferases -- Physiological aspects ,Phosphotransferases -- Research ,Histamine receptors -- Physiological aspects ,Histamine receptors -- Research ,Histamine -- Physiological aspects ,Histamine -- Research ,Universities and colleges -- Physiological aspects ,Universities and colleges -- Research ,Biotechnology industry ,Pharmaceuticals and cosmetics industries - Abstract
Research findings, 'Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway,' are discussed in a new report. According to recent research [...]
- Published
- 2008
40. Recent findings from Technical University Munchen, Department of Human Biology highlight research in physiology
- Subjects
Drugs -- Research ,Drugs -- Reports ,Drugs -- Physiological aspects ,Histamine receptors -- Reports ,Histamine receptors -- Physiological aspects ,Histamine -- Reports ,Histamine -- Physiological aspects ,Universities and colleges -- Reports ,Universities and colleges -- Physiological aspects - Abstract
Current study results from the report, 'Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors,' have been published (see also Physiology). "Histamine [...]
- Published
- 2007
41. Drug treatment of obesity reviewed
- Subjects
Health -- Reports ,Health -- Physiological aspects ,Obesity -- Drug therapy ,Obesity -- Reports ,Obesity -- Physiological aspects ,Weight reducing preparations -- Reports ,Weight reducing preparations -- Physiological aspects ,Drugs -- Reports ,Drugs -- Physiological aspects ,Dopamine receptors -- Reports ,Dopamine receptors -- Physiological aspects ,Histamine receptors -- Reports ,Histamine receptors -- Physiological aspects - Abstract
A researcher reviews the drug treatment of obesity on a recent issue of Psychiatric Clinics of North America. According to a study from the United States, "As new drugs are [...]
- Published
- 2005
42. Loratadine and ventricular tachycardia
- Author
-
Good, Arnold P., Rockwood, Robert, and Schad, Paul
- Subjects
Ventricular tachycardia -- Drug therapy ,Histamine receptors -- Physiological aspects ,Health - Published
- 1994
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