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142 results on '"Hillmann, Axel"'

2. Analysis of Osteosarcoma Cell Lines and Patient Tissue Using a 3D In Vivo Tumor Model—Possible Effects of Punicalagin

Author

Dorn, Anna Rebecca, primary, Neff, Sara, additional, Hupp, Sophia, additional, Engelhardt, Melissa, additional, Pion, Eric, additional, Lenze, Ulrich, additional, Knebel, Carolin, additional, Duprée, Anna, additional, Schewe, Simone, additional, Weber, Markus, additional, Wulbrand, Christian, additional, Hillmann, Axel, additional, Weber, Florian, additional, Clarke, Phillip, additional, Kainz, Philipp, additional, Aung, Thiha, additional, and Haerteis, Silke, additional

Published
2024
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6. How Relevant Is the Parallax Effect on Low Centered Pelvic Radiographs in Total Hip Arthroplasty

Author

Weber, Markus, Meyer, Matthias, Von Kunow, Frederik, Füchtmeier, Bernd, Hillmann, Axel, and Wulbrand, Christian

Subjects
ddc:610, total hip arthroplasty, cup position, parallax effect, 610 Medizin, Medicine (miscellaneous)
Abstract

The correct cup position in total hip arthroplasty (THA) is usually assessed on anteroposterior low centered pelvic radiographs, harboring the risk of misinterpretation due to projection of a three-dimensional geometry on a two-dimensional plane. In the current study, we evaluate the effect of this parallax effect on the cup inclination and anteversion in THA. In the course of a prospective clinical trial, 116 standardized low centered pelvic radiographs, as routinely obtained after THA, were evaluated regarding the impact of central beam deviation on the cup inclination and anteversion angles. Measurements of the horizontal and vertical beam offset with two different methods of parallax correction were compared with each other. Furthermore, the effect of parallax correction on the accuracy ofmeasuring the cup position was investigated. The mean difference between the two parallax correction methods was 0.2° ± 0.1° (from 0° to 0.4°) for the cup inclination and 0.1° ± 0.1° (from −0.1° to 0.2°) for the anteversion. For a typically intended cup position of a 45° inclination and 15° anteversion, the parallax effect led to a mean error of −1.5° ± 0.3° for the inclination and 0.6° ± 1.0° for the anteversion. Central beam deviation resulted in a projected higher cup inclination up to 3.7°, and this effect was more prominent in cups with higher anteversion. In contrast, the projected inclination decreased due to the parallax effect up to 3.2°, especially in cups with high inclination. The parallax effect on routinely obtained low centered pelvic radiographs is low and not clinically relevant due to the compensating effect of simultaneous medial and caudal central beam deviation.

Published
2023
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7. SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line

Author

Stöckl, Sabine, Lindner, Georg, Li, Shushan, Schuster, Philipp, Haferkamp, Sebastian, Wagner, Ferdinand, Prodinger, Peter M., Multhoff, Gabriele, Boxberg, Melanie, Hillmann, Axel, Bauer, Richard J., and Grässel, Susanne

Subjects
musculoskeletal diseases, endocrine system, animal structures, 610 Medizin, Apoptosis, Article, lcsh:Chemistry, Cell Movement, Cell Line, Tumor, Chlorocebus aethiops, Matrix Metalloproteinase 13, Animals, Humans, SOX9, transcription factor, chondrosarcoma, polyploidy, MMP13, CRISPR/Cas9, lcsh:QH301-705.5, Vero Cells, Cell Proliferation, ddc:610, SOX9 Transcription Factor, musculoskeletal system, Oncolytic Viruses, lcsh:Biology (General), lcsh:QD1-999, embryonic structures
Abstract

As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies. Our study shows an increase in SOX9 expression in chondrosarcoma compared to normal cartilage, but a decrease when the tumors are finally defined as dedifferentiated chondrosarcoma (DDCS). In DDCS, SOX9 is almost completely absent in the non-chondroid, dedifferentiated compartments. CRISPR/Cas9-mediated knockout of SOX9 in a human chondrosarcoma cell line (HTB94) results in reduced proliferation, clonogenicity and migration, accompanied by an inability to activate MMP13. In contrast, adhesion, apoptosis and polyploidy formation are favored after SOX9 deletion, probably involving BCL2 and survivin. The siRNA-mediated SOX9 knockdown partially confirmed these results, suggesting the need for a certain SOX9 threshold for particular cancer-related events. To increase the efficacy of chondrosarcoma therapies, potential therapeutic approaches were analyzed in SOX9 knockout cells. Here, we found an increased impact of doxorubicin, but a reduced sensitivity for oncolytic virus treatment. Our observations present novel insight into the role of SOX9 in chondrosarcoma biology and could thereby help to overcome the obstacle of drug resistance and limited therapy options.

Published
2020

12. SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line

Author

Stöckl, Sabine, primary, Lindner, Georg, additional, Li, Shushan, additional, Schuster, Philipp, additional, Haferkamp, Sebastian, additional, Wagner, Ferdinand, additional, Prodinger, Peter M., additional, Multhoff, Gabriele, additional, Boxberg, Melanie, additional, Hillmann, Axel, additional, Bauer, Richard J., additional, and Grässel, Susanne, additional

Published
2020
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17. Sox9 affects cell survival in a chondrosarcoma cell line via Bcl-2- and Survivin-mediated mechanisms

Author

Stöckl, Sabine, Göttl, Claudia, Hillmann, Axel, and Grässel, Susanne

Subjects
chondrosarcoma, ddc: 610, 610 Medical sciences, Medicine, Sox9
Abstract

Objectives: Chondrosarcoma is the second most common form of primary malignant bone tumors overall, but is the most common form in adults. Accumulating evidence from recent studies point to a critical role of Sox9, the master transcription factor for chondrogenesis, as a proto-oncogene in plenty of [for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)

Published
2019

20. Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group

Author

Ozaki, Toshifumi, Flege, Silke, Liljenqvist, Ulf, Hillmann, Axel, Delling, Gunter, Salzer-Kuntschik, Mechthild, Jurgens, Heribert, Kotz, Rainer, Winkelmann, Winfried, and Bielack, Stefan S.

Subjects
Osteosarcoma -- Care and treatment, Bone cancer -- Care and treatment, Chemotherapy -- Usage, Radiotherapy -- Usage, Health
Published
2002

24. Pelvic Ewing sarcoma: a retrospective analysis of 241 cases

Author

Hoffmann, Christiane, Ahrens, Susanne, Dunst, Jurgen, Hillmann, Axel, Winkelmann, Winfried, Craft, Alan, Gobel, Ulrich, Rube, Christian, Voute, Paul A., Harms, Dieter, and Jurgens, Herbert

Subjects
Ewing's sarcoma -- Prognosis, Pelvic cancer -- Prognosis, Health
Published
1999

25. Walking ability during daily life in patients with osteoarthritis of the knee or the hip and lumbar spinal stenosis: a cross sectional study

Author

Hillmann Axel, Ringling Michael, Schubert Tim, Müller Carsten, Brandes Mirko, Winter Corinna C, Rosenbaum Dieter, and Schulte Tobias L

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Degenerative musculoskeletal disorders are among the most frequent diseases occurring in adulthood, often impairing patients' functional mobility and physical activity. The aim of the present study was to investigate and compare the impact of three frequent degenerative musculoskeletal disorders -- knee osteoarthritis (knee OA), hip osteoarthritis (hip OA) and lumbar spinal stenosis (LSS) -- on patients' walking ability. Methods The study included 120 participants, with 30 in each patient group and 30 healthy control individuals. A uniaxial accelerometer, the StepWatch™ Activity Monitor (Orthocare Innovations, Seattle, Washington, USA), was used to determine the volume (number of gait cycles per day) and intensity (gait cycles per minute) of walking ability. Non-parametric testing was used for all statistical analyses. Results Both the volume and the intensity of walking ability were significantly lower among the patients in comparison with the healthy control individuals (p < 0.001). Patients with LSS spent 0.4 (IQR 2.8) min/day doing moderately intense walking (>50 gait cycles/min), which was significantly lower in comparison with patients with knee and hip OA at 2.5 (IQR 4.4) and 3.4 (IQR 16.1) min/day, respectively (p < 0.001). No correlations between demographic or anthropometric data and walking ability were found. No technical problems or measuring errors occurred with any of the measurements. Conclusions Patients with degenerative musculoskeletal disorders suffer limitations in their walking ability. Objective assessment of walking ability appeared to be an easy and feasible tool for measuring such limitations as it provides baseline data and objective information that are more precise than the patients' own subjective estimates. In everyday practice, objective activity assessment can provide feedback for clinicians regarding patients' performance during everyday life and the extent to which this confirms the results of clinical investigations. The method can also be used as a way of encouraging patients to develop a more active lifestyle.

Published
2010
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32. Giant Cell Tumor of the Spine

Author

Ozaki, Toshifumi, primary, Liljenqvist, Ulf, additional, Halm, Henry, additional, Hillmann, Axel, additional, Gosheger, Georg, additional, and Winkelmann, Winfried, additional

Published
2002
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40. Genetic imbalances revealed by comparative genomic hybridization in Ewing tumors

Author

Ozaki, Toshifumi, primary, Paulussen, Michael, additional, Poremba, Christopher, additional, Brinkschmidt, Christian, additional, Rerin, Julio, additional, Ahrens, Susanne, additional, Hoffmann, Christiane, additional, Hillmann, Axel, additional, Wai, Daniel, additional, Schaefer, Karl-Ludwig, additional, Boecker, Werner, additional, Juergens, Heribert, additional, Winkelmann, Winfried, additional, and Dockhorn-Dworniczak, Barbara, additional

Published
2001
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42. Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)

Author

Van Valen, Frans, primary, Fulda, Simone, additional, Truckenbrod, Borna, additional, Eckervogt, Vera, additional, Sonnemann, Jürgen, additional, Hillmann, Axel, additional, Rödl, Robert, additional, Hoffmann, Christiane, additional, Winkelmann, Winfried, additional, Schäfer, Lutz, additional, Dockhorn-Dworniczak, Barbara, additional, Wessel, Torsten, additional, Boos, Joachim, additional, Debatin, Klaus-Michael, additional, and Jürgens, Herbert, additional

Published
2000
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43. Pelvic Ewing sarcoma

Author

Hoffmann, Christiane, primary, Ahrens, Susanne, additional, Dunst, J�rgen, additional, Hillmann, Axel, additional, Winkelmann, Winfried, additional, Craft, Alan, additional, G�bel, Ulrich, additional, R�be, Christian, additional, Vo�te, Paul A., additional, Harms, Dieter, additional, and J�rgens, Herbert, additional

Published
1999
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44. Limb Salvage and Outcome of Osteosarcoma

Author

Lindner, Norbert J., primary, Ramm, Oliver, additional, Hillmann, Axel, additional, Roedl, Robert, additional, Gosheger, Georg, additional, Brinkschmidt, Christian, additional, Juergens, Heribert, additional, and Winkelmann, Winfried, additional

Published
1999
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46. Chondrosarcoma of the Pelvis

Author

Ozaki, Toshifumi, primary, Hillmann, Axel, additional, Lindner, Norbert, additional, Blasius, Sebastian, additional, and Winkelmann, Winfried, additional

Published
1997
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