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2 results on '"Hidalgo-García, Laura (0000-0002-5529-171X)"'

1. Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572

Author

Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Diez-Echave, Patricia (0000-0003-4493-3091), Martín-Cabrejas, Izaskun (0000-0002-7913-0291), Garrido-Mesa, José (0000-0001-6420-9055), Langa, Susana (0000-0003-2729-219X), Vezza, Teresa (0000-0002-9780-0180), Landete, José María [0000-0002-5147-3989], Hidalgo-García, Laura (0000-0002-5529-171X), Algieri, Francesca (0000-0002-0262-4867), Mayer, Melinda J. (0000-0002-8764-2836), Narbad, Arjan (0000-0003-2968-7558), García Lafuente, Ana María (0000-0002-5147-3145), Medina, Margarita (0000-0001-9692-4977), Rodríguez-Nogales, Alba (0000-0003-1927-0628), Rodríguez-Cabezas, María Elena (0000-0001-9085-8147), Gálvez, Julio (0000-0001-6876-3782), Arqués, Juan L (0000-0002-8548-0183), Diez-Echave, Patricia, Martín-Cabrejas, Izaskun, Garrido-Mesa, José, Langa, Susana, Vezza, Teresa, Landete, José María, Hidalgo-García, Laura, Algieri, Francesca, Mayer, Melinda J., Narbad, Arjan, García Lafuente, Ana María, Medina, Margarita, Rodríguez-Nogales, Alba, Rodríguez-Cabezas, María Elena, Gálvez, Julio, Arques Orobón, Juan Luis, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Diez-Echave, Patricia (0000-0003-4493-3091), Martín-Cabrejas, Izaskun (0000-0002-7913-0291), Garrido-Mesa, José (0000-0001-6420-9055), Langa, Susana (0000-0003-2729-219X), Vezza, Teresa (0000-0002-9780-0180), Landete, José María [0000-0002-5147-3989], Hidalgo-García, Laura (0000-0002-5529-171X), Algieri, Francesca (0000-0002-0262-4867), Mayer, Melinda J. (0000-0002-8764-2836), Narbad, Arjan (0000-0003-2968-7558), García Lafuente, Ana María (0000-0002-5147-3145), Medina, Margarita (0000-0001-9692-4977), Rodríguez-Nogales, Alba (0000-0003-1927-0628), Rodríguez-Cabezas, María Elena (0000-0001-9085-8147), Gálvez, Julio (0000-0001-6876-3782), Arqués, Juan L (0000-0002-8548-0183), Diez-Echave, Patricia, Martín-Cabrejas, Izaskun, Garrido-Mesa, José, Langa, Susana, Vezza, Teresa, Landete, José María, Hidalgo-García, Laura, Algieri, Francesca, Mayer, Melinda J., Narbad, Arjan, García Lafuente, Ana María, Medina, Margarita, Rodríguez-Nogales, Alba, Rodríguez-Cabezas, María Elena, Gálvez, Julio, and Arques Orobón, Juan Luis

Abstract

Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.

Published
2021

2. Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572

Author

Margarita Medina, Patricia Diez-Echave, Arjan Narbad, Ana García-Lafuente, Melinda J. Mayer, José Garrido-Mesa, José María Landete, Julio Gálvez, Juan Luis Arqués, Laura Hidalgo-García, Teresa Vezza, Alba Rodríguez-Nogales, María Elena Rodríguez-Cabezas, Francesca Algieri, Izaskun Martín-Cabrejas, Susana Langa, [Diez-Echave,P, Garrido-Mesa,J, Vezza,T, Hidalgo-García,L, Algieri,F, Rodríguez-Nogales,A, Rodríguez-Cabezas,ME, Gálvez,J] Centro de Investigaciones Biomédicas en Red–Enfermedades Hepáticas y Digestivas (CIBER-EHD), Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain. [Diez-Echave,P, Gálvez,J] Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain. [Martín-Cabrejas,I, Langa,S, Landete,JM, Medina,M, Arqués,JL] Departamento Tecnología de Alimentos, INIA-CSIC, Madrid, Spain. [Mayer,MJ, Narbad,A] Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich, UK. [García-Lafuente,A] Centro para la Calidad de los Alimentos, INIA-CISC, Soria, Spain., This work was supported by project no. RTA2017-00002-00-00 from the Spanish Ministry of Science and Innovation, by the Junta de Andalucía (CTS 164) and Instituto de Salud Carlos III (PI19/01058) with funds from the European Union., Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Diez-Echave, Patricia (0000-0003-4493-3091), Martín-Cabrejas, Izaskun (0000-0002-7913-0291), Garrido-Mesa, José (0000-0001-6420-9055), Langa, Susana (0000-0003-2729-219X), Vezza, Teresa (0000-0002-9780-0180), Landete, José M (0000-0002-5147-3989), Hidalgo-García, Laura (0000-0002-5529-171X), Algieri, Francesca (0000-0002-0262-4867), Mayer, Melinda J (0000-0002-8764-2836), Narbad, Arjan (0000-0003-2968-7558), García-Lafuente, Ana (0000-0002-5147-3145), Medina, Margarita (0000-0001-9692-4977), Rodríguez-Nogales, Alba (0000-0003-1927-0628), Rodríguez-Cabezas, María Elena (0000-0001-9085-8147), Gálvez, Julio (0000-0001-6876-3782), and Arqués, Juan L (0000-0002-8548-0183)

Subjects
Male, 0301 basic medicine, Limosilactobacillus reuteri, Colonic model, Probiotic, Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Lactobacillaceae::Lactobacillus::Lactobacillus reuteri [Medical Subject Headings], law.invention, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mice, Anatomy::Cells::Cells, Cultured::Cell Line [Medical Subject Headings], law, Inmunomodulación, Chemicals and Drugs::Organic Chemicals::Aldehydes::Glyceraldehyde [Medical Subject Headings], Organisms::Eukaryota::Animals [Medical Subject Headings], Technology and Food and Beverages::Food and Beverages::Food::Dairy Products [Medical Subject Headings], TX341-641, Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Acyclic::Alkanes::Propane [Medical Subject Headings], Chemicals and Drugs::Carbohydrates::Polysaccharides::Glucans::Dextrans::Dextran Sulfate [Medical Subject Headings], Nutrition and Dietetics, Strain (chemistry), In vitro toxicology, Antimicrobial compound, Reuterin, Anatomy::Cells::Myeloid Cells::Macrophages [Medical Subject Headings], Sulfato de Dextran, Línea Celular, Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::Probiotics [Medical Subject Headings], Sodium, 030106 microbiology, Lactobacillus reuteri, chemistry.chemical_element, Check Tags::Male [Medical Subject Headings], In Vitro Techniques, Protectores contra radiación, Glyceraldehyde, Microbiology, Protective effect, Immunomodulation, Propane, 03 medical and health sciences, In vivo, Animals, Humans, Macrófagos, Inflammation, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Nutrition. Foods and food supply, Macrophages, Probiotics, Probióticos, Dextran sulphate sodium, In vitro, Diseases::Animal Diseases::Disease Models, Animal [Medical Subject Headings], Gastrointestinal Tract, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, chemistry, Dextran sulphate, DSS-induced colitic model, Anatomy::Digestive System::Gastrointestinal Tract [Medical Subject Headings], Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL [Medical Subject Headings], Cell line, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Food Science
Abstract

18 Pág. Departamento de Tecnología de Alimentos​​, Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain., This work was supported by project no. RTA2017-00002-00-00 from the Spanish Ministry of Science and Innovation, by the Junta de Andalucía (CTS 164) and Instituto de Salud Carlos III (PI19/01058) with funds from the European Union

Published
2021
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