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1. Extracorporeal cardiopulmonary resuscitation versus standard treatment for refractory out-of-hospital cardiac arrest: a Bayesian meta-analysis

Author

Heuts, Samuel, Ubben, Johannes F. H., Kawczynski, Michal J., Gabrio, Andrea, Suverein, Martje M., Delnoij, Thijs S. R., Kavalkova, Petra, Rob, Daniel, Komárek, Arnošt, van der Horst, Iwan C. C., Maessen, Jos G., Yannopoulos, Demetris, Bělohlávek, Jan, Lorusso, Roberto, and van de Poll, Marcel C. G.

Published
2024
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3. Characteristics and Outcomes of Prolonged Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Surgery: The Post-Cardiotomy Extracorporeal Life Support (PELS-1) Cohort Study

Author

Bunge, Jeroen J. H., Mariani, Silvia, Meuwese, Christiaan, van Bussel, Bas C. T., Di Mauro, Michele, Wiedeman, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J. R., Gommers, Diederik, Dos Reis Miranda, Dinis, Lorusso, Roberto, Heuts, Samuel, Ravaux, Justine, Schaefer, Anne-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Sriranjan, Kogulan, Mazzeffi, Michael A, Vedadi, Nazli, Di Eusanio, Marco, Sorokin, Vitaly, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Grus, Tomas, and Solinas, Marco

Published
2024
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4. Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial

Author

Ubben, Johannes F.H., Heuts, Samuel, Delnoij, Thijs S.R., Suverein, Martje M., Hermanides, Renicus C., Otterspoor, Luuk C., Kraemer, Carlos V. Elzo, Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Dos Reis Miranda, Dinis, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C.C., Winkens, Bjorn, Maessen, Jos G., Lorusso, Roberto, and van de Poll, Marcel C.G.

Published
2024
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5. The impact of high versus standard enteral protein provision on functional recovery following intensive care admission: Protocol for a pre-planned secondary Bayesian analysis of the PRECISe trial

Author

Heuts, Samuel, de Heer, Pieter, Gabrio, Andrea, Bels, Julia L.M., Lee, Zheng-Yii, Stoppe, Christian, van Kuijk, Sander, Beishuizen, Albertus, de Bie-Dekker, Ashley, Fraipont, Vincent, Lamote, Stoffel, Ledoux, Didier, Scheeren, Clarissa, De Waele, Elisabeth, van Zanten, Arthur, Mesotten, Dieter, and van de Poll, Marcel C.G.

Published
2024
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8. Features and outcomes of female and male patients requiring postcardiotomy extracorporeal life support

Author

Heuts, Samuel, Conci, Luca, Szalkiewicz, Philipp, Lehmann, Sven, Khalil, Jawad, Obadia, Jean-Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Reis Miranda, Dinis Dos, Sriranjan, Kogulan, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Ramanathan, Kollengode, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Grus, Tomas, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Ravaux, Justine Mafalda, van Bussel, Bas C.T., De Piero, Maria Elena, van Kruijk, Sander M.J., Schaefer, Anne-Kristin, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Published
2024
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10. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study

Author

Ravaux, Justine, Schaefer, Ann-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Miranda, Dinis Dos Reis, Sriranjan, Kogulan, Mazzeffi, Michael A., Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Sorokin, Vitaly, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Wang, I-wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Published
2023
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11. Association of High-Sensitivity Cardiac Troponin T With 30-Day and 5-Year Mortality After Cardiac Surgery

Author

Pölzl, Leo, Engler, Clemens, Sterzinger, Philipp, Lohmann, Ronja, Nägele, Felix, Hirsch, Jakob, Graber, Michael, Eder, Jonas, Reinstadler, Sebastian, Sappler, Nikolay, Kilo, Juliane, Tancevski, Ivan, Bachmann, Sebastian, Abfalterer, Hannes, Ruttmann-Ulmer, Elfriede, Ulmer, Hanno, Griesmacher, Andrea, Heuts, Samuel, Thielmann, Matthias, Bauer, Axel, Grimm, Michael, Bonaros, Nikolaos, Holfeld, Johannes, and Gollmann-Tepeköylü, Can

Published
2023
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12. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Ravaux, Justine, di Mauro, Michele, Schaefer, Ann-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Reis Miranda, Dinis Dos, Buscher, Hergen, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, Maclaren, Graeme, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Heuts, Samuel, Mariani, Silvia, van Bussel, Bas C.T., Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Published
2023
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13. On-Support and Post-Weaning Mortality in Post-Cardiotomy Extracorporeal Membrane Oxygenation

Author

Mariani, Silvia, Schaefer, Anne-Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Conci, Luca, Szalkiewicz, Philipp, De Piero, Maria Elena, Heuts, Samuel, Ravaux, Justine, van der Horst, Iwan C.C., Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Whitman, Glenn, Shekar, Kiran, Wiedemann, Dominik, and Lorusso, Roberto

Published
2023
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16. Benefit of isolated surgical valve repair or replacement for functional tricuspid regurgitation and long-term outcomes stratified by the TRI-SCORE.

Author

Dreyfus, Julien, Juarez-Casso, Fernando, Sala, Alessandra, Carnero-Alcazar, Manuel, Eixerés-Esteve, Andrea, Bohbot, Yohann, Bazire, Baptiste, Flagiello, Michele, Riant, Elisabeth, Mbaki, Yannick, Tomasi, Jacques, Senage, Thomas, Idrissi, Kenza Rahmouni El, Coisne, Augustin, Eyharts, Damien, Doguet, Fabien, Viau, Florence, Eggenspieler, Florian, Heuts, Samuel, and Nia, Peyman Sardari

Subjects
TRICUSPID valve insufficiency, PATIENT selection, RANDOMIZED controlled trials, SURVIVAL rate, TRICUSPID valve surgery, DEATH rate
Abstract

Background and Aims Severe tricuspid regurgitation is associated with increased mortality rates, but benefit of its correction and ideal timing are not clearly determined. This study aimed to identify patient subsets who might benefit from the surgery. Methods In TRIGISTRY, an international cohort study of consecutive patients with severe isolated functional tricuspid regurgitation (33 centres, 10 countries), survival rates up to 10 years were compared between patients who underwent isolated tricuspid valve surgery (repair or replacement) and those conservatively managed, overall and according to TRI-SCORE category (low: ≤3, intermediate: 4–5, and high: ≥6). Results One thousand and two hundred seventeen were managed conservatively, and 551 underwent isolated tricuspid valve surgery (200 repairs and 351 replacements). TRI-SCORE distribution was 33% low, 32% intermediate, and 35% high. At 10 years, survival rates were similar between surgical and conservative management [41% vs. 36%; hazard ratio (HR).97; 95% confidence interval (CI).88–1.08, P =.57]. Surgery improved survival compared with conservative management in the low TRI-SCORE category (72% vs. 44%; HR.27; 95% CI.20–.37, P <.0001), but not in the intermediate (36% vs. 37%; HR 1.17; 95%CI.98–1.40, P =.09) or high categories (20% vs. 24%; HR 1.06; 95% CI.91–1.25, P =.45). Both repair and replacement improved survival in the low TRI-SCORE category (84% and 61% vs. 44%; HR.11; 95% CI.06–.19, P <.0001, and HR.65; 95% CI.47–.90, P =.009). Repair showed benefit in the intermediate category (59% vs. 37%; HR.49; 95% CI.35–.68, P <.0001) while replacement was possibly harmful (25% vs. 37%; HR 1.43; 95% CI 1.18–1.72, P =.0002). Conclusions Higher survival rates were observed with repair than replacement and benefit of intervention declined as TRI-SCORE increased with no benefit of any type of surgery in the high TRI-SCORE category. These results emphasize the importance of timely intervention and patient selection to achieve the best outcomes and the need for randomized controlled trials. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Short- and long-term outcomes in isolated vs. hybrid thoracoscopic ablation in patients with atrial fibrillation: a systematic review and reconstructed individual patient data meta-analysis.

Author

Aerts, Luca, Kawczynski, Michal J, Bidar, Elham, Luermans, Justin G L, Chaldoupi, Sevasti-Maria, Meir, Mark La, Kowalewski, Mariusz, Maessen, Jos G, Heuts, Samuel, and Maesen, Bart

Abstract

Aims Both isolated thoracoscopic and hybrid thoracoscopic atrial fibrillation (AF) ablation techniques have demonstrated favourable outcomes in the management of patients with (long-standing) persistent AF, as compared with catheter ablation. However, it is currently unknown whether there is a difference in short- and long-term outcomes when comparing these two minimally invasive surgical AF ablation procedures. Therefore, a systematic review and meta-analysis were performed to investigate these two techniques, with a specific emphasis on long-term freedom from atrial tachyarrhythmias (ATAs). Methods and results A systematic search through PubMed, EMBASE, and the Cochrane Library databases was performed. All studies reporting on short-term outcomes were included in the meta-analysis. A pooled analysis of long-term freedom from ATA was performed based on Kaplan–Meier (KM) curve-derived individual patient data. Reconstructed individual time-to-event data were analysed in a multivariable Cox frailty model with adjustments for age, sex, type of AF, duration of AF history, and study variable (frailty term in the frailty Cox model). In total, 53 studies were included in the meta-analysis, encompassing 4950 patients. There were no differences in major short-term outcomes (mortality or stroke) between isolated thoracoscopic and hybrid thoracoscopic ablation. A total of 18 studies reported KM curves for long-term freedom from ATA, comprising 2038 patients. Adjusted analysis revealed that hybrid ablation was significantly associated with greater freedom from ATA [adjusted hazard ratio (aHR) = 0.59, 95% confidence interval (CI): 0.43–0.83, P < 0.001] compared with isolated thoracoscopic ablation. Additionally, older age (aHR = 1.07, 95% CI: 1.03–1.12, P = 0.002) and a higher percentage of male patients (aHR = 1.02, 95% CI: 1.01–1.03, P < 0.001) were significantly associated with lower long-term freedom from ATA recurrence. Conclusion Hybrid thoracoscopic AF ablation is associated with a greater long-term freedom from ATA when compared with isolated thoracoscopic ablation, without differences in complications. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Permanent pacemaker implantation after combined mitral- and tricuspid valve surgery: a nationwide multicentre study.

Author

Olsthoorn, Jules R, Tjien, Andrew Tjon Joek, Heuts, Samuel, Bouwmeester, Sjoerd, Houterman, Saskia, Roefs, Maaike M, Koene, Bart, Singh, Sandeep, Boon, Rody, Tonino, Pim, Verberkmoes, Niels, and Registration, Cardiothoracic Surgery and Pacemaker/ICD Registration Committees of the Netherlands Heart

Subjects
MITRAL valve surgery, CORONARY artery bypass, CORONARY artery surgery, ATRIAL septum, ATRIAL septal defects, TRICUSPID valve surgery
Abstract

OBJECTIVES The threshold to perform concomitant tricuspid valve (TV) repair during primary mitral valve (MV) surgery has decreased, based on recent randomized evidence. Based on these developments, the indication for TV repair during MV surgery is expected to increase further. However, concerns have been raised regarding the risk of permanent pacemaker implantation (PPI) during a concomitant procedure. Therefore, we aim to assess the incidence of PPI in combined MV and TV surgery in a nationwide registry. METHODS The current study uniquely cross-linked the Cardiothoracic and Pacemaker/ICD registry of the Netherlands Heart Registration. Patients undergoing primary MV and TV surgery (± atrial septal defect closure, rhythm surgery, coronary artery bypass grafting) between 1 January and 31 December2021 were included. The primary outcome was PPI within 30 days after surgery. Subgroup analyses were performed for isolated MV and TV surgery and MV repair. The association between concomitant TV surgery and PPI was assessed using multivariable binary logistic regression analyses. RESULTS A total of 1060 patients (n  = 833 MV, n  = 227 MV + TV) were included. The overall incidence of PPI was 4.3%. No significant difference in PPI between MV and MV + TV surgery were found (3.7% vs 6.6%, P  = 0.06). Concomitant TV surgery was not an independent risk factor for PPI after surgery after adjustment for covariates. These results were robust after sensitivity analyses. CONCLUSIONS The current study was not able to find a statistical difference between the PPI rate in MV surgery patients and MV + TV surgery patients. Extension of the waiting period prior to PPI, may result in decreased PPI rates. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Routine Protamine Administration for Bleeding in Transcatheter Aortic Valve Implantation: The ACE-PROTAVI Randomized Clinical Trial.

Author

Vriesendorp, Pieter A., Nanayakkara, Shane, Heuts, Samuel, Ball, Jocasta, Chandrasekar, Jaya, Dick, Ronald, Haji, Kawa, Htun, Nay Min, McGaw, David, Noaman, Samer, Palmer, Sonny, Cairo, Sesto, Shulman, Mark, Lin, Enjarn, Hastings, Stuart, Waldron, Benedict, Proimos, George, Soon, Kean H., Yudi, Matias B., and Zimmet, Adam

Published
2024
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21. Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial

Author

Medische Staf Intensive Care, Ubben, Johannes F.H., Heuts, Samuel, Delnoij, Thijs S.R., Suverein, Martje M., Hermanides, Renicus C., Otterspoor, Luuk C., Kraemer, Carlos V.Elzo, Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Dos Reis Miranda, Dinis, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C.C., Winkens, Bjorn, Maessen, Jos G., Lorusso, Roberto, van de Poll, Marcel C.G., Medische Staf Intensive Care, Ubben, Johannes F.H., Heuts, Samuel, Delnoij, Thijs S.R., Suverein, Martje M., Hermanides, Renicus C., Otterspoor, Luuk C., Kraemer, Carlos V.Elzo, Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Dos Reis Miranda, Dinis, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C.C., Winkens, Bjorn, Maessen, Jos G., Lorusso, Roberto, and van de Poll, Marcel C.G.

Published
2024

22. Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation:A secondary analysis of the INCEPTION-trial

Author

Ubben, Johannes F.H., Heuts, Samuel, Delnoij, Thijs S.R., Suverein, Martje M., Hermanides, Renicus C., Otterspoor, Luuk C., Kraemer, Carlos V.Elzo, Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Dos Reis Miranda, Dinis, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C.C., Winkens, Bjorn, Maessen, Jos G., Lorusso, Roberto, van de Poll, Marcel C.G., Ubben, Johannes F.H., Heuts, Samuel, Delnoij, Thijs S.R., Suverein, Martje M., Hermanides, Renicus C., Otterspoor, Luuk C., Kraemer, Carlos V.Elzo, Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Dos Reis Miranda, Dinis, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C.C., Winkens, Bjorn, Maessen, Jos G., Lorusso, Roberto, and van de Poll, Marcel C.G.

Abstract

Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used as a supportive treatment for refractory out-of-hospital cardiac arrest (OHCA). Still, there is a paucity of data evaluating favorable and unfavorable prognostic characteristics in patients considered for ECPR. Methods: We performed a previously unplanned post-hoc analysis of the multicenter randomized controlled INCEPTION-trial. The study group consisted of patients receiving ECPR, irrespective of initial group randomization. The patients were divided into favorable survivors (cerebral performance category [CPC] 1–2) and unfavorable or non-survivors (CPC 3–5).Results: In the initial INCEPTION-trial, 134 patients were randomized. ECPR treatment was started in 46 (66%) of 70 patients in the ECPR treatment arm and 3 (4%) of 74 patients in the conventional treatment arm. No statistically significant differences in baseline characteristics, medical history, or causes of arrest were observed between survivors (n = 5) and non-survivors (n = 44). More patients in the surviving group had a shockable rhythm at the time of cannulation (60% vs. 14%, p = 0.037), underwent more defibrillation attempts (13 vs. 6, p = 0.002), and received higher dosages of amiodarone (450 mg vs 375 mg, p = 0.047) despite similar durations of resuscitation maneuvers. Furthermore, non-survivors more frequently had post-ECPR implantation adverse events. Conclusion: The persistence of ventricular arrhythmia is a favorable prognostic factor in patients with refractory OHCA undergoing an ECPR-based treatment. Future studies are warranted to confirm this finding and to establish additional prognostic factors. Clinical trial Registration: clinicaltrials.gov

Published
2024

23. The prognostic impact of unplanned invasive coronary angiography following coronary artery bypass grafting.

Author

Heuts, Samuel, Bova, Roberto, Romeo, Jamie L R, Vriesendorp, Pieter A, Horst, Iwan C C van der, Segers, Patrique, Maessen, Jos G, Gollmann-Tepeköylü, Can, Hof, Arnoud W J van 't, Bidar, Elham, and Lux, Arpad

Subjects
*CORONARY artery bypass, *CORONARY artery surgery, *CORONARY angiography, *MYOCARDIAL revascularization, *MYOCARDIAL ischemia
Abstract

Open in new tab Download slide OBJECTIVES Myocardial ischaemia following coronary artery bypass grafting (CABG) is a potentially devastating complication. Nevertheless, the incidence, aetiology and prognostic relevance of unplanned coronary angiography (uCAG) remain understudied. We aimed to investigate the prevalence and outcome of patients undergoing urgent, uCAG in the postoperative period following CABG. METHODS We screened all patients undergoing isolated elective CABG in an academic referral centre between 2016 and 2021 and identified patients undergoing uCAG within 30 days of surgery. For uCAG patients, a distinction was made between patients undergoing re-revascularization (REV) and patients receiving conservative management (CON). The primary outcomes were 30-day mortality and unadjusted and adjusted long-term survival. Secondary outcomes were the indication for and prevalence of uCAG and urgent revascularization. RESULTS Of the 1918 patients undergoing isolated CABG, 78 individuals needed uCAG (4.1%), of whom 45 underwent immediate revascularization (REV group; 2.3% overall, 57% within the uCAG group, median age 69.9 years) and 33 were treated conservatively (CONS group; 1.7% overall, 42% within the uCAG group, median age 69.1 years). Patients undergoing uCAG (n  = 78) had a higher 30-day mortality than patients not undergoing uCAG (n  = 1840, 30-day mortality: 9.0% vs 0.4%, P  < 0.001). Long-term survival was significantly decreased in patients undergoing uCAG in both unadjusted (hazard ratio 2.20, 95% confidence interval 1.30–3.73) and EuroSCORE-, age- and sex-adjusted models (hazard ratio uCAG 2.03, 95% confidence interval 1.16–3.56). CONCLUSIONS Unplanned postoperative coronary angiography is performed in 4.1% of isolated CABG procedures, and patients in need of such urgent invasive evaluation are subjected to decreased short- and long-term survival. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Outcomes of Mitral Valve Regurgitation Management after Expert Multidisciplinary Valve Team Evaluation.

Author

Welman, Myrthe J. M., Streukens, Sebastian A. F., Mephtah, Anass, Hoebers, Loes P., Vainer, Jindrich, Theunissen, Ralph, Heuts, Samuel, Maessen, Jos G., Segers, Patrique, Vernooy, Kevin, van 't Hof, Arnoud W. J., Sardari Nia, Peyman, and Vriesendorp, Pieter A.

Subjects
MITRAL valve, SURVIVAL rate, WATCHFUL waiting, SURVIVAL analysis (Biometry), DRUG therapy, MITRAL valve insufficiency
Abstract

Background/Objectives: Mitral regurgitation (MR) affects millions worldwide, necessitating timely intervention. There are significant clinical challenges in the conservative management of MR, leaving a knowledge gap regarding the impact of multidisciplinary decision-making on treatment outcomes. This study aimed to provide insights into the impact of multidisciplinary decision-making on the survival outcomes of MR patients, focusing on conservative approaches. Methods: This study retrospectively analyzes 1365 patients evaluated by an expert multidisciplinary heart team (MDT) in a single center from 2015 to 2022. Treatments included surgery, catheter-based interventions, and conservative management. Propensity matching was utilized to compare surgery and conservative approaches. Results: Surgical intervention was associated with superior long-term survival outcomes compared to conservative and catheter-based treatments, particularly for degenerative MR (DMR). Survival rates of patients deemed by the MDT to have non-severe DMR were comparable to surgical patients (HR 1.07, 95% CI: 0.37–3.12, p = 0.90). However, non-severe functional MR (FMR) patients trended towards elevated mortality risk (HR 1.77, 95% CI: 0.94–3.31, p = 0.07). Pharmacological treatment for DMR was associated with significantly higher mortality compared to surgery (HR 8.0, 95% CI: 1.78–36.03, p = 0.001). Functional MR patients treated pharmacologically exhibited a non-significantly higher mortality risk compared to surgical intervention (HR 1.93, 95% CI: 0.77–4.77, p = 0.20). Conclusions: Survival analysis revealed significant benefits for surgical intervention, contrasting with elevated mortality risks associated with conservative management. "Watchful waiting" may be appropriate for non-severe DMR, while FMR may require closer monitoring. Further research is needed to assess the impact of regular follow-up or delayed surgery on survival rates, as pharmacological therapy has limited long-term efficacy for DMR. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Hybrid atrial fibrillation ablation

Author

van der Heijden, Claudia A. J., primary, Aerts, Luca, additional, Chaldoupi, Sevasti-Marisevi, additional, van Cruchten, Cas, additional, Kawczynski, Michal, additional, Heuts, Samuel, additional, Bidar, Elham, additional, Luermans, Justin G. L. M., additional, and Maesen, Bart, additional

Published
2024
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27. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study

Author

Mariani, Silvia, primary, Wang, I-wen, additional, van Bussel, Bas C.T., additional, Heuts, Samuel, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, van der Horst, Iwan C.C., additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Ramanathan, Kollengode, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, MacLaren, Graeme, additional, Sorokin, Vitaly, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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29. Stroke reduction by cerebral embolic protection devices in transcatheter aortic valve implantation: a systematic review and Bayesian meta-analysis

Author

Heuts, Samuel, primary, Gabrio, Andrea, additional, Veenstra, Leo, additional, Maesen, Bart, additional, Kats, Suzanne, additional, Maessen, Jos G, additional, Walton, Antony S, additional, Nanayakkara, Shane, additional, Lansky, Alexandra J, additional, van 't Hof, Arnoud W J, additional, and Vriesendorp, Pieter A, additional

Published
2023
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31. Early extracorporeal CPR for refractory out-of-hospital cardiac arrest – A pre-planned per-protocol analysis of the INCEPTION-trial

Author

Ubben, Johannes F.H., primary, Suverein, Martje M., additional, Delnoij, Thijs S.R., additional, Heuts, Samuel, additional, Winkens, Bjorn, additional, Gabrio, Andrea, additional, van der Horst, Iwan C.C., additional, Maessen, Jos G., additional, Lorusso, Roberto, additional, and van de Poll, Marcel C.G., additional

Published
2023
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32. The impact of high versus standard enteral protein provision on functional recovery following Intensive Care admission: Protocol for a pre-planned secondary Bayesian analysis of the PRECISe trial.

Author

Heuts, Samuel, primary, de Heer, Pieter, additional, Gabrio, Andrea, additional, Bels, Julia LM., additional, Lee, Zheng-Yii, additional, Stoppe, Christian, additional, van Kuijk, Sander, additional, Beishuizen, Albertus, additional, de Bie-Dekker, Ashley, additional, Fraipont, Vincent, additional, Lamote, Stoffel, additional, Ledoux, Didier, additional, Scheeren, Clarissa, additional, De Waele, Elisabeth, additional, van Zanten, Arthur, additional, Mesotten, Dieter, additional, and van de Poll, Marcel CG., additional

Published
2023
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33. On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation

Author

Mariani, Silvia, primary, Schaefer, Anne-Kristin, additional, van Bussel, Bas C.T., additional, Di Mauro, Michele, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, De Piero, Maria Elena, additional, Heuts, Samuel, additional, Ravaux, Justine, additional, van der Horst, Iwan C.C., additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Whitman, Glenn, additional, Shekar, Kiran, additional, Wiedemann, Dominik, additional, Lorusso, Roberto, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Dos Reis Miranda, Dinis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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34. A Bayesian re-analysis of the INCEPTION-trial

Author

Heuts, Samuel, primary, van de Koolwijk, Anina F, additional, Gabrio, Andrea, additional, Ubben, Johannes F H, additional, van der Horst, Iwan C C, additional, Delnoij, Thijs S R, additional, Suverein, Martje M, additional, Maessen, Jos G, additional, Lorusso, Roberto, additional, and van de Poll, Marcel C G, additional

Published
2023
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41. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults: The PELS‐1 Multicenter Cohort Study

Author

Mariani, Silvia, primary, Heuts, Samuel, additional, van Bussel, Bas C. T., additional, Di Mauro, Michele, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J. H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Marco L. Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I‐wen, additional, Jung, Jae‐Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn J. R., additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Anne‐Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean‐Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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42. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Heuts, Samuel, primary, Mariani, Silvia, additional, van Bussel, Bas C.T., additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Sriranjan, Kogulan, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Mazzeffi, Michael A., additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Sorokin, Vitaly, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, di Mauro, Michele, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Reis Miranda, Dinis Dos, additional, Buscher, Hergen, additional, Herr, Daniel, additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Maclaren, Graeme, additional, Ramanathan, Ram, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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46. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults:The PELS-1 Multicenter Cohort Study

Author

Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Abstract

Background Extracorporeal membrane oxygenation (ECMO) has been increasingly used for postcardiotomy cardiogenic shock, but without a concomitant reduction in observed in-hospital mortality. Long-term outcomes are unknown. This study describes patients' characteristics, in-hospital outcome, and 10-year survival after postcardiotomy ECMO. Variables associated with in-hospital and postdischarge mortality are investigated and reported. Methods and Results The retrospective international multicenter observational PELS-1 (Postcardiotomy Extracorporeal Life Support) study includes data on adults requiring ECMO for postcardiotomy cardiogenic shock between 2000 and 2020 from 34 centers. Variables associated with mortality were estimated preoperatively, intraoperatively, during ECMO, and after the occurrence of any complications, and then analyzed at different time points during a patient's clinical course, through mixed Cox proportional hazards models containing fixed and random effects. Follow-up was established by institutional chart review or contacting patients. This analysis included 2058 patients (59% were men; median [interquartile range] age, 65.0 [55.0-72.0] years). In-hospital mortality was 60.5%. Independent variables associated with in-hospital mortality were age (hazard ratio [HR], 1.02 [95% CI, 1.01-1.02]) and preoperative cardiac arrest (HR, 1.41 [95% CI, 1.15-1.73]). In the subgroup of hospital survivors, the overall 1-, 2-, 5-, and 10-year survival rates were 89.5% (95% CI, 87.0%-92.0%), 85.4% (95% CI, 82.5%-88.3%), 76.4% (95% CI, 72.5%-80.5%), and 65.9% (95% CI, 60.3%-72.0%), respectively. Variables associated with postdischarge mortality included older age, atrial fibrillation, emergency surgery, type of surgery, postoperative acute kidney injury, and postoperative septic shock. Conclusions In adults, in-hospital mortality after postcardiotomy ECMO remains high; however, two-thirds of those who are discharged from hospital survive up to 10 years. Patien

Published
2023

47. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation:A descriptive multicenter observational study

Author

Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, Miranda, Dinis Dos Reis, Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, and Miranda, Dinis Dos Reis

Abstract

Objectives: Postcardiotomy extracorporeal membrane oxygenation (ECMO) can be initiated intraoperatively or postoperatively based on indications, settings, patient profile, and conditions. The topic of implantation timing only recently gained attention from the clinical community. We compare patient characteristics as well as in-hospital and long-term survival between intraoperative and postoperative ECMO.Methods: The retrospective, multicenter, observational Postcardiotomy Extracorporeal Life Support (PELS-1) study includes adults who required ECMO due to postcardiotomy shock between 2000 and 2020. We compared patients who received ECMO in the operating theater (intraoperative) with those in the intensive care unit (postoperative) on in-hospital and postdischarge outcomes. Results: We studied 2003 patients (women: 41.1%; median age: 65 years; interquartile range [IQR], 55.0-72.0). Intraoperative ECMO patients (n = 1287) compared with postoperative ECMO patients (n = 716) had worse preoperative risk profiles. Cardiogenic shock (45.3%), right ventricular failure (15.9%), and cardiac arrest (14.3%) were the main indications for postoperative ECMO initiation, with cannulation occurring after (median) 1 day (IQR, 1-3 days). Compared with intraoperative application, patients who received postoperative ECMO showed more complications, cardiac reoperations (intraoperative: 19.7%; postoperative: 24.8%, P = .011), percutaneous coronary interventions (intraoperative: 1.8%; postoperative: 3.6%, P = .026), and had greater in-hospital mortality (intraoperative: 57.5%; postoperative: 64.5%, P = .002). Among hospital survivors, ECMO duration was shorter after intraoperative ECMO (median, 104; IQR, 67.8-164.2 hours) compared with postoperative ECMO (median, 139.7; IQR, 95.8-192 hours, P < .001), whereas postdischarge long-term survival was similar between the 2 groups (P = .86). Conclusions: Intraopera

Published
2023

50. Sheathless Versus Sheathed Intra-Aortic Balloon Pump Implantation in Patients Undergoing Cardiac Surgery

Author

Heuts, Samuel, primary, Lorusso, Roberto, additional, di Mauro, Michele, additional, Jiritano, Federica, additional, Scrofani, Roberto, additional, Antona, Carlo, additional, Dato, Guglielmo Actis, additional, Centofanti, Paolo, additional, Ferrarese, Sandro, additional, Matteucci, Matteo, additional, Miceli, Antonio, additional, Glauber, Mattia, additional, Vizzardi, Enrico, additional, Sponga, Sandro, additional, Vendramin, Igor, additional, Garatti, Andrea, additional, de Vincentiis, Carlo, additional, De Bonis, Michele, additional, Pieri, Marina, additional, Troise, Giovanni, additional, Tomba, Margherita Dalla, additional, and Serraino, Giuseppe Filiberto, additional

Published
2023
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