1. The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway
- Author
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t Hart, L.M., Fritsche, A., Nijpels, G., van Leeuwen, N., Donnelly, L.A., Dekker, J.M., Alssema, M., Fadista, J., Carlotti, F., Gjesing, A.P., Palmer, C.N., van Haeften, T.W., Herzberg-Schafer, S.A., Simonis-Bik, A.M., Houwing-Duistermaat, J.J., Helmer, Q., Deelen, J., Guigas, B., Hansen, T., Machicao, F., Willemsen, G., Heine, R.J., Kramer, M.H., Holst, J.J., de Koning, E.J., Haring, H.U., Pedersen, O., Groop, L., de Geus, E.J., Slagboom, P.E., Boomsma, D.I., Eekhoff, E.M., Pearson, E.R., Diamant, M., t Hart, L.M., Fritsche, A., Nijpels, G., van Leeuwen, N., Donnelly, L.A., Dekker, J.M., Alssema, M., Fadista, J., Carlotti, F., Gjesing, A.P., Palmer, C.N., van Haeften, T.W., Herzberg-Schafer, S.A., Simonis-Bik, A.M., Houwing-Duistermaat, J.J., Helmer, Q., Deelen, J., Guigas, B., Hansen, T., Machicao, F., Willemsen, G., Heine, R.J., Kramer, M.H., Holst, J.J., de Koning, E.J., Haring, H.U., Pedersen, O., Groop, L., de Geus, E.J., Slagboom, P.E., Boomsma, D.I., Eekhoff, E.M., Pearson, E.R., and Diamant, M.
- Abstract
The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances beta-cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P, The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances beta-cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P
- Published
- 2013