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The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

Authors :
t Hart, L.M.
Fritsche, A.
Nijpels, G.
van Leeuwen, N.
Donnelly, L.A.
Dekker, J.M.
Alssema, M.
Fadista, J.
Carlotti, F.
Gjesing, A.P.
Palmer, C.N.
van Haeften, T.W.
Herzberg-Schafer, S.A.
Simonis-Bik, A.M.
Houwing-Duistermaat, J.J.
Helmer, Q.
Deelen, J.
Guigas, B.
Hansen, T.
Machicao, F.
Willemsen, G.
Heine, R.J.
Kramer, M.H.
Holst, J.J.
de Koning, E.J.
Haring, H.U.
Pedersen, O.
Groop, L.
de Geus, E.J.
Slagboom, P.E.
Boomsma, D.I.
Eekhoff, E.M.
Pearson, E.R.
Diamant, M.
t Hart, L.M.
Fritsche, A.
Nijpels, G.
van Leeuwen, N.
Donnelly, L.A.
Dekker, J.M.
Alssema, M.
Fadista, J.
Carlotti, F.
Gjesing, A.P.
Palmer, C.N.
van Haeften, T.W.
Herzberg-Schafer, S.A.
Simonis-Bik, A.M.
Houwing-Duistermaat, J.J.
Helmer, Q.
Deelen, J.
Guigas, B.
Hansen, T.
Machicao, F.
Willemsen, G.
Heine, R.J.
Kramer, M.H.
Holst, J.J.
de Koning, E.J.
Haring, H.U.
Pedersen, O.
Groop, L.
de Geus, E.J.
Slagboom, P.E.
Boomsma, D.I.
Eekhoff, E.M.
Pearson, E.R.
Diamant, M.
Source :
Diabetes vol.62 (2013) nr.9 p.3275-3281 [ISSN 0012-1797]
Publication Year :
2013

Abstract

The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances beta-cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P<br />The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances beta-cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P

Details

Database :
OAIster
Journal :
Diabetes vol.62 (2013) nr.9 p.3275-3281 [ISSN 0012-1797]
Notes :
DOI: 10.2337/db13-0227, Diabetes vol.62 (2013) nr.9 p.3275-3281 [ISSN 0012-1797], English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn931049884
Document Type :
Electronic Resource

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