Search

Your search keyword '"Herpin, Patrick"' showing total 154 results
Start Over Author "Herpin, Patrick"
154 results on '"Herpin, Patrick"'

5. Carnitine palmitoyltranferase I (CPT I) activity and its regulation by malonyl-CoA are modulated by age and cold exposure in skeletal muscle mitochondria from newborn pigs

Author

Schmidt, Isabelle and Herpin, Patrick

Subjects
Mitochondria -- Research, Swine -- Research, Oxidation, Physiological -- Research, Fatty acids -- Research, Food/cooking/nutrition
Abstract

Whole-body lipid utilization is progressively enhanced during the first postnatal day in pigs, especially during cold exposure and muscular shivering thermogenesis. This study was designed to examine early postnatal changes in fatty acid oxidation potential, carnitine palmitoyltransferase I activity and regulation by malonyl-CoA in skeletal muscle mitochondria isolated from newborn and 5-d-old piglets. At 5 d of life, pigs were maintained for a 4-h period in thermoneutral (30 [degrees] C) or cold (20 [degrees] C) conditions. Intermyofibrillar and subsarcolemmal mitochondria were isolated from longissimus dorsi and rhomboideus muscles. In subsarcolemmal mitochondria, carnitine palmitoyltransferase I activity increased with age (P < 0.01) and was 80% lower (P < 0.001) than in intermyofibrillar mitochondria. Intermyofibrillar mitochondria had high enzyme activities and fatty acid oxidation potential from birth. The fatty acids 16:0, 18:1(n-9) and 18:2(n-6) were oxidized at a higher rate than 18:0 (-37%) and 8:0 (-55%). Sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition and malonyl-CoA levels decreased by 47% (P < 0.05) and 33% (P < 0.01) with age, respectively. After 4 h of cold exposure, sensitivity of carnitine palmitoyltransferase I to malonyl-CoA was unaffected in the rhomboideus and tended to be greater (P < 0.06) in longissimus dorsi muscle. Malonyl-CoA levels were lower (P < 0.05) in the rhomboideus and were unaffected in longissimus dorsi muscle. These results demonstrate that fatty acid oxidation is effective from birth in isolated intermyofibrillar mitochondria. The postnatal enhancement of fatty acid utilization observed in vivo can be explained, at least in part, by a rise in carnitine palmitoyltransferase I activity in subsarcolemmal mitochondria and a modulation of its activity by malonyl-CoA in intermyofibrillar mitochondria. KEY WORDS: * pigs * skeletal muscle * fatty acid oxidation * carnitine palmitoyltransferase I * malonyl-CoA

Published
1998

7. Effect of the level of asphyxia during delivery on viability at birth and early postnatal vitality of newborn pigs

Author

Herpin, Patrick, Dividich, Jean Le, Hulin, Jean Claude, Fillaut, Martine, Marco, Francoise de, and Bertin, Roseline

Subjects
Swine -- Research, Asphyxia -- Research, Parturition -- Complications, Zoology and wildlife conservation
Abstract

Newborn pigs (n = 117) were used to provide information on the relationships of degree of asphyxia during delivery, viability at birth, and some striking aspects of postnatal vitality including survival, interval between birth and first udder contact and between birth and first suckling, rectal temperature at 24 h of life ([RT.sub.24]), and growth rate over the first 10 d of life. The degree of asphyxia at birth was estimated from cord blood pC[O.sub.2], pH, and lactate levels. Onset of respiration, heart rate, skin color, and attempts to stand during the first minute after birth were used to estimate the viability score. Neonatal asphyxia, i.e., decreased blood pH and increased blood pC[O.sub.2] and lactate, was associated with the production of unusually high levels of catecholamines. The degree of asphyxia increased with late position in the birth order (P < .01) and was higher in piglets born posteriorly (P < .05). Further, the average blood pC[O.sub.2] within a litter increased (P < .05) with litter size. There was an inverse relationship between the degree of asphyxia and the viability score (P < .001). Highly viable piglets reached the udder more rapidly (P < .001) and had a higher [RT.sub.24] (P < .001) than those of low viability. Plasma glucose concentrations increased with blood pC[O.sub.2] and plasma epinephrine concentrations (P < .001). Neonatal asphyxia reduced postnatal vitality by delaying the first contact with the udder (P < .03) and was associated with a lower [RT.sub.24] (P < .05), growth rate (P < .001), and survival over 10 d (P < 0.06). These variables, i.e., interval between birth and first udder contact, [RT.sub.24], and growth rate, were correlated with birth weight (P < .001); [RT.sub.24] was also shown to decrease (P < .001) with the time taken to reach the udder. Overall, results suggest that piglets suffering from asphyxia during delivery are less viable at birth and less prone to adapt to extra-uterine life. Key Words: Asphyxia, Parturition, Piglets, Viability, Postnatal Vitality

Published
1996

8. Utilization of colostral energy by the newborn pig

Author

Le Dividich, Jean, Herpin, Patrick, and Rosario-Ludovino, Rui Manuel

Subjects
Colostrum -- Research, Swine -- Food and nutrition, Bioenergetics -- Research, Zoology and wildlife conservation
Abstract

Twenty-five newborn pigs were used to evaluate the energy utilization of sow colostrum by pigs maintained for 24 h in respiratory chambers at an environmental temperature of 33 [degrees] C. Within a litter, five neonatal pigs were obtained before nursing and allotted on the basis of initial body weight (IBW) at 3 h of age to one of the five treatments: killed, fed intragastrically 6, 12, or 18 g of sow colostrum/kg IBW per meal, or fasted. A total of 24 meals at 60-min intervals was provided and pigs were killed 1 h after the last meal. Heat production (HP) was measured by indirect calorimetry and energy retention (ER) was calculated by metabolizable energy (ME) -- HP. A balance technique was used to determine nitrogen (N) retention, and comparative slaughter technique (CST) was used to determine fat accretion and glycogen mobilization. The ME intake increased quadratically (P [is less than] .01) with the level of colostrum intake. The efficiency of ME for ER was 91 [+ or -] 4%. Nitrogen absorbed was utilized with an efficiency of 89 [+ or -] 3% for N retention, and the estimated energy cost of 1 kcal of protein synthesized was 1.11 [+ or -] .11 kcal. Thermoneutral maintenance ME requirement was low (68.5 kcal [center dot] kg avg B[W.sup.-1] [center dot] .24 [h.sup.-1]) because of the low activity of pigs. Fasting heat production (FHP) measured by calorimetry and CST amounted to 56.4 and 60.4 kcal [center dot] kg avg B[W.sup.-1] [center dot] 24 [h.sup.-1], respectively. Estimates of the contribution of glycogen and protein catabolism to FHP were 83.0 and 6.8%, respectively. Results suggest that a realistic recommendation of colostrum intake during the first postnatal day would be approximately 280 g/kg BW. The calculated available energy supplied by colostrum meets 60% of the energy required for HP in typical birth environment conditions of 18 to 21 [degrees] C.

Published
1994

12. Unusual metabolic characteristics in skeletal muscles of transgenic rabbits for human lipoprotein lipase

Author

Viglietta Céline, Herpin Patrick, Damon Marie, Jadhao Sanjay B, Gondret Florence, Houdebine Louis-Marie, and Hocquette Jean-François

Subjects
Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background The lipoprotein lipase (LPL) hydrolyses circulating triacylglycerol-rich lipoproteins. Thereby, LPL acts as a metabolic gate-keeper for fatty acids partitioning between adipose tissue for storage and skeletal muscle primarily for energy use. Transgenic mice that markedly over-express LPL exclusively in muscle, show increases not only in LPL activity, but also in oxidative enzyme activities and in number of mitochondria, together with an impaired glucose tolerance. However, the role of LPL in intracellular nutrient pathways remains uncertain. To examine differences in muscle nutrient uptake and fatty acid oxidative pattern, transgenic rabbits harboring a DNA fragment of the human LPL gene (hLPL) and their wild-type littermates were compared for two muscles of different metabolic type, and for perirenal fat. Results Analyses of skeletal muscles and adipose tissue showed the expression of the hLPL DNA fragment in tissues of the hLPL group only. Unexpectedly, the activity level of LPL in both tissues was similar in the two groups. Nevertheless, mitochondrial fatty acid oxidation rate, measured ex vivo using [1-14C]oleate as substrate, was lower in hLPL rabbits than in wild-type rabbits for the two muscles under study. Both insulin-sensitive glucose transporter GLUT4 and muscle fatty acid binding protein (H-FABP) contents were higher in hLPL rabbits than in wild-type littermates for the pure oxidative semimembranosus proprius muscle, but differences between groups did not reach significance when considering the fast-twitch glycolytic longissimus muscle. Variations in both glucose uptake potential, intra-cytoplasmic binding of fatty acids, and lipid oxidation rate observed in hLPL rabbits compared with their wild-type littermates, were not followed by any modifications in tissue lipid content, body fat, and plasma levels in energy-yielding metabolites. Conclusions Expression of intracellular binding proteins for both fatty acids and glucose, and their following oxidation rates in skeletal muscles of hLPL rabbits were not fully consistent with the physiology rules. The modifications observed in muscle metabolic properties might not be directly associated with any LPL-linked pathways, but resulted likely of transgene random insertion into rabbit organism close to any regulatory genes. Our findings enlighten the risks for undesirable phenotypic modifications in micro-injected animals and difficulties of biotechnology in mammals larger than mice.

Published
2004
Full Text
View/download PDF

15. Quels descripteurs phénotypiques pour caractériser la qualité de la viande de porc ?

Author

Herpin, Patrick, Gondret, Florence, Lebret, Bénédicte, Systèmes d'élevage, nutrition animale et humaine (SENAH), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

16. Numéro spécial 'Elevage bio'. Avant-propos

Author

Guyomard, Herve, Coudurier, Bernard, Herpin, Patrick, Collège de Direction (CODIR), Institut National de la Recherche Agronomique (INRA), and Jean-Marc Perez

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2009

17. Vingt ans de recherche et d’innovation en productions animales à l’INRA

Author

Charley, Bernard, Chemineau, Philippe, Boichard, Didier, Meynard, Jean Marc, Aumont, Gilles, Herpin, Patrick, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Station de Génétique Quantitative et Appliquée (SGQA), Département Sciences pour l'Action et le Développement (DEPT SAD), Département Santé Animale (DEPT SA), Laboratoire de Microbioologie, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Bernard Charley, Patrick Herpin, Jean-Marc Perez, and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
AMENITE ENVIRONNEMENTALE DE L'ELEVAGE, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, BIOLOGIE DES POPULATIONS, IMPACT ENVIRONNEMENTAL DE L'ELEVAGE, GENETIQUE ANIMALE, SECURITE SANITAIRE DES ALIMENTS, GENETIQUE DE L'ANIMAL D'ELEVAGE, CONDUITE DE TROUPEAU, ANIMAL D' ELEVAGE, MAITRISE DE LA REPRODUCTION ANIMALE
Abstract

National audience; A l’occasion de son 20ème anniversaire, la revue INRA Productions Animales a décidé de publier un numéro spécial sur « 20 ans de recherches en productions animales à l’INRA ». Son objectif est de retracer, à travers quelques exemples significatifs, des résultats scientifiques majeurs de l’INRA en productions animales, qui ont déjà pour la plupart un impact avéré en élevage. Les avancées spectaculaires de la biologie et des approches systémiques au cours des dernières décennies, tant conceptuelles que méthodologiques, ont eu de très nombreuses répercussions sur les recherches en productions animales, qu’il serait impossible de détailler de façon exhaustive dans le cadre de ce seul numéro. C’est pourquoi nous avons choisi de présenter à grands traits certaines de ces avancées dans cette brève introduction, avant d’en proposer plusieurs illustrations dans les articles de ce numéro.

Published
2008

18. Special issue 'Porcherie verte'. Foreword

Author

Herpin, Patrick, Perez, Jean-Marc, Département Physiologie Animale et Systèmes d'Elevage (PHASE), Institut National de la Recherche Agronomique (INRA), and Michel Bonneau

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2008

19. Expression of uncoupling proteins and mitochondrial activity are dependent on muscular fibre type in rabbits and chickens

Author

Joubert, Romain, Collin, Anne, Berri, Cécile, Lefaucheur, Louis, Vincent, Annie, Fillaut, Martine, Ecolan, Patrick, Mur, Ludivine, Godet, Estelle, Crochet, Sabine, Bordeau, Thierry, Skiba-Cassy, Sandrine, Tesseraud, Sophie, Herpin, Patrick, Damon, Marie, Unité de Recherches Avicoles (URA), Institut National de la Recherche Agronomique (INRA), Systèmes d'Elevage, Nutrition Animale et Humaine (SENAH), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Nutrition, Aquaculture et Génomique (NUAGE), Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Laboratoire de Microbioologie, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

20. La recherche du bien-être animal

Author

Veissier, Isabelle, Donnars, Catherine, Beaumont, Catherine, Boissy, Alain, Burgat, Florence, Cario, Laurent, Herpin, Patrick, Lévy, Frédéric, Unité de Recherches sur les Herbivores (URH), Institut National de la Recherche Agronomique (INRA), Mission communication MICOM, Unité de Recherches Avicoles (URA), Transformations Sociales et Politiques liées aux Vivants (TSV), Laboratoire de Microbioologie, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, Laboratoire de Microbiologie, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Université de Bourgogne (UB), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.SOCIO] Humanities and Social Sciences/Sociology, ComputingMilieux_MISCELLANEOUS, BIEN-ETRE ANIMAL, RELATION HOMME-ANIMAL
Abstract

National audience

Published
2007

21. Number of intramuscular adipocytes and fatty acid binding protein-4 content are significant indicators of intramuscular fat level in crossbred Large White x Duroc pigs

Author

Damon, Marie, Louveau, Isabelle, Lefaucheur, Louis, Lebret, Bénédicte, Vincent, Annie, Le Roy, Pascale, Sanchez, Marie Pierre, Herpin, Patrick, Gondret, Florence, ProdInra, Migration, Systèmes d'Elevage, Nutrition Animale et Humaine (SENAH), Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), Génétique Animale (GARen), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Ecole Nationale Supérieure Agronomique de Rennes, Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Laboratoire de Microbioologie, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies, [SDV.SA.SPA] Life Sciences [q-bio]/Agricultural sciences/Animal production studies, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

22. Estimation of the effects of realized selection in Large White population from 1977 to 1998 on body composition and physiological state at birth using frozen semen

Author

Canario, Laurianne, Tribout, Thierry, Thomas, Francoise, David, Chrystele, Gogué, Jean-Marcel, Herpin, Patrick, Bidanel, Jean Pierre, Père, Marie-Christine, Le Dividich, Jean, Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Systèmes d'Elevage, Nutrition Animale et Humaine (SENAH), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Domaine expérimental Bourges-La Sapinière (BOURGES), Laboratoire de Microbioologie, and Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)

Subjects
analyse statistique, composition corporelle, sperme, [SDV]Life Sciences [q-bio], naissance, race porcine large white, insémination artificielle, sélection animale, sus scrofa, [INFO]Computer Science [cs], porcelet, europe, race, ComputingMilieux_MISCELLANEOUS, porc
Abstract

National audience

Published
2005

23. Environmental and hormonal regulation of energy metabolism in early development of the pig

Author

Herpin, Patrick, Louveau, Isabelle, Damon, Marie, Le Dividich, Jean, Systèmes d'Elevage, Nutrition Animale et Humaine (SENAH), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, D.G. Burrin, H.J. Mersmann, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], NOUVEAU-NE, [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

24. Ca2+- activated myosin-ATPases, creatine and adenylate kinases regulate mitochondrial function according to myofibre type in rabbit

Author

Guéguen, N., Lefaucheur, Louis, Ecolan, P.04Fillaut, M., Herpin, Patrick, Systèmes d'Elevage, Nutrition Animale et Humaine (SENAH), Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), ProdInra, Migration, and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], ADP, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

25. Efect of breed and body weight on thermoregulatory abilities of European (Piétrain X (Landrace X Large White)) and Chinese (Meishan) piglets at birth

Author

Herpin, Patrick, Vincent, Annie, Damon, Marie, Unité mixte de recherche veau et porc (UMR VP), Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2004

26. Effect of feeding of Yucca schidigera (DK Powder) to the sow on piglet blood oxygenation and survival

Author

Herpin, Patrick, Vincent, Annie, Cheeke, P.R., ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies, [SDV.SA.SPA] Life Sciences [q-bio]/Agricultural sciences/Animal production studies, ComputingMilieux_MISCELLANEOUS, RELATION MERE-JEUNE
Abstract

International audience

Published
2004

27. Unusual metabolic characteristics in skeletal muscles of transgenic rabbits for human lipoprotein lipase

Author

Gondret, Florence, Jadhao, S.B., Damon, Marie, Herpin, Patrick, Viglietta, Céline, Houdebine, Louis, Hocquette, Jean-François, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Unité de Recherches sur les Herbivores (URH), Institut National de la Recherche Agronomique (INRA), Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
métabolisme lipidique, glut 4, transgène, acide gras, transport du glucose, [SDV]Life Sciences [q-bio], Research, h fabp, muscle squelettique, homme, lcsh:Nutritional diseases. Deficiency diseases, protéine de liaison des acides gras, lipoprotéine lipase, [INFO]Computer Science [cs], lapin, lcsh:RC620-627
Abstract

Background The lipoprotein lipase (LPL) hydrolyses circulating triacylglycerol-rich lipoproteins. Thereby, LPL acts as a metabolic gate-keeper for fatty acids partitioning between adipose tissue for storage and skeletal muscle primarily for energy use. Transgenic mice that markedly over-express LPL exclusively in muscle, show increases not only in LPL activity, but also in oxidative enzyme activities and in number of mitochondria, together with an impaired glucose tolerance. However, the role of LPL in intracellular nutrient pathways remains uncertain. To examine differences in muscle nutrient uptake and fatty acid oxidative pattern, transgenic rabbits harboring a DNA fragment of the human LPL gene (hLPL) and their wild-type littermates were compared for two muscles of different metabolic type, and for perirenal fat. Results Analyses of skeletal muscles and adipose tissue showed the expression of the hLPL DNA fragment in tissues of the hLPL group only. Unexpectedly, the activity level of LPL in both tissues was similar in the two groups. Nevertheless, mitochondrial fatty acid oxidation rate, measured ex vivo using [1-14C]oleate as substrate, was lower in hLPL rabbits than in wild-type rabbits for the two muscles under study. Both insulin-sensitive glucose transporter GLUT4 and muscle fatty acid binding protein (H-FABP) contents were higher in hLPL rabbits than in wild-type littermates for the pure oxidative semimembranosus proprius muscle, but differences between groups did not reach significance when considering the fast-twitch glycolytic longissimus muscle. Variations in both glucose uptake potential, intra-cytoplasmic binding of fatty acids, and lipid oxidation rate observed in hLPL rabbits compared with their wild-type littermates, were not followed by any modifications in tissue lipid content, body fat, and plasma levels in energy-yielding metabolites. Conclusions Expression of intracellular binding proteins for both fatty acids and glucose, and their following oxidation rates in skeletal muscles of hLPL rabbits were not fully consistent with the physiology rules. The modifications observed in muscle metabolic properties might not be directly associated with any LPL-linked pathways, but resulted likely of transgene random insertion into rabbit organism close to any regulatory genes. Our findings enlighten the risks for undesirable phenotypic modifications in micro-injected animals and difficulties of biotechnology in mammals larger than mice.

Published
2004

28. La mitochondrie, carrefour métabolique pour l'utilisation des acides gras : importance chez l'homme et chez l'animal

Author

Morio, Béatrice, Hocquette, Jean-François, Herpin, Patrick, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), Unité de Recherches sur les Herbivores (URH), Unité mixte de recherche veau et porc (UMR VP), Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2003

29. Dossier : Quel avenir pour les filières animales ? Avant-propos

Author

Herpin, Patrick, Département Elevage et Nutrition des Animaux (ENA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs]
Abstract

National audience; Dans le cadre d’une journée d’animation scientifique, le Département Elevage et Nutrition des Animaux de l’INRA a organisé le 25 mars 2003 à l’INAPG une conférence-débat sur l’avenir des filières animales.

Published
2003

30. Comparaison de porcs présentant des teneurs extrêmes en lipides dans le muscle longissimus. 2- Capacités de stockage et d'utilisation des lipides intramusculaires

Author

Damon, Marie, Gondret, Florence, Vincent, Annie, Louveau, Isabelle, Lebret, Bénédicte, Lefaucheur, Louis, Mourot, Jacques, Le Roy, Pascale, Herpin, Patrick, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, ComputingMilieux_MISCELLANEOUS
Abstract

"Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "; National audience

Published
2002

31. Comparaison de porcs présentant des teneurs extrêmes en lipides dans le muscle longissimus

Author

Lebret, Bénédicte, Louveau, Isabelle, Damon, Marie, Gondret, Florence, Lefaucheur, Louis, Mourot, Jacques, Herpin, Patrick, Le Roy, Pascale, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Station de Génétique Quantitative et Appliquée (SGQA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2002

32. Differential effect of triiodothyronine on mitochondrial energy coupling in piglet glycolytic and oxidative muscles

Author

Damon, Marie, Lombardi, A., Vincent, Annie, Fillaut, Martine, Herpin, Patrick, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], T3, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2002

33. Mise au point d'un protocole d'analyse du transcriptome musculaire appliquée à l'étude de la qualité de la viande de porc

Author

Damon, Marie, Liaubet, Laurence, Vincent, Annie, Herpin, Patrick, Hatey, François, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2002

34. Comparaison de porc présentant des teneurs extrêmes en lipides dans le muscle Longissimus. 1- Performances de croissance et qualité des carcasses et des viandes

Author

Lebret, Bénédicte, Louveau, Isabelle, Damon, Marie, Gondret, Florence, Lefaucheur, Louis, Mourot, Jacques, Herpin, Patrick, Le Roy, Pascale, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, and Unité mixte de recherche veau et porc

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2002

35. Effects of a transgene containing a DNA fragment of the human LPL gene on muscle oxidative metabolism in the rabbit

Author

Gondret, Florence, Jadhao, S.B., Herpin, Patrick, Damon, Marie, Vincent, Annie, Vighetta, C., Houdebine, Louis, Hocquette, Jean-François, Station de recherches porcines, Institut National de la Recherche Agronomique (INRA), Unité de Recherches sur les Herbivores (URH), Unité biologie du développement et biotechnologie, and École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], EXPRESSION DE GENES, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2001

36. Mise en place des caractéristiques contractiles et métaboliques des fibres musculaires chez le porc : mécanismes et effets des facteurs d'élevage

Author

Lefaucheur, Louis, Damon, Marie, Herpin, Patrick, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

37. Recherche et études des gènes impliqués dans la qualité de la viande de porc à travers l'analyse du transcriptome

Author

Damon, Marie, Gondret, Florence, Lefaucheur, Louis, Louveau, Isabelle, Herpin, Patrick, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

38. Maîtrise de la teneur en lipides intramusculaires chez le porc et le lapin

Author

Mourot, Jacques, Gondret, Florence, Louveau, Isabelle, Lefaucheur, Louis, Herpin, Patrick, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

39. Fonction mitochondriale et biologie du muscle

Author

Herpin, Patrick, Chevalier, J., GABELLO, G., ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], SITE WEB, [INFO]Computer Science [cs], [INFO] Computer Science [cs]
Abstract

*INRA UMR Veau et Porc Rennes (FRA) Diffusion du document : INRA UMR Veau et Porc Rennes (FRA); National audience

Published
2001

40. Les actions de recherche engagées dans le programme transversal 'Fonction mitochondriale et biologie du muscle'

Author

Herpin, Patrick, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], BIOLOGIE DU MUSCLE, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], BIOLOGIE, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

41. IGF-1, IGF-binding proteins, GH and IGF-1 receptors in hypothyroid and hyperthyroid neonatal pigs

Author

Louveau, Isabelle, Herpin, Patrick, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2001

42. L'expression du gène de la lipoprotéine lipase humaine modifie le potentiel de transport des nutriments chez le lapin en croissance

Author

Hocquette, Jean-François, Herpin, Patrick, Damon, Marie, Houdebine, Louis, Gondret, Florence, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

43. Teneur en lipides intramusculaires chez le lapin : contribution relative des différentes voies métaboliques des tissus musculaires

Author

Gondret, Florence, Hocquette, Jean-François, Herpin, Patrick, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Unité de Recherches sur les Herbivores (URH), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

44. Maîtrise de la teneur en lipides intramusculaires chez le porc et le lapin

Author

Gondret, Florence, Louveau, Isabelle, Damon, Marie, Lefaucheur, Louis, Herpin, Patrick, Mourot, Jacques, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

45. Caractérisation et expression des isoformes de la carnitine palmitoyl transférase I dans le muscle de porcelet

Author

Damon, Marie, Vincent, Annie, Herpin, Patrick, Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2000

46. Effect of birth weight on thermoregulatory abilities of Chinese (Meishan) and European (Large x Pietrain) newborn piglets

Author

Herpin, Patrick, Hulin, J.C., Unité mixte de recherche veau et porc (UMR VP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS, POIDS DE NAISSANCE
Abstract

International audience

Published
2000

47. Yucca gives smaller piglets a better start

Author

Herpin, Patrick, Demaegdt, G., ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
ALIMENT PREMIER AGE, [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ALIMENTATION PORCINE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2000

48. Le programme Asteroger : vers un outil multifonctionnel pour les productions animales

Author

Hatey, François, Martin, Patrice, Douaire, Madeleine, Le Gac, Florence, Dambrine, Ginette, Herpin, Patrick, Monget, Philippe, Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), Institut National de la Recherche Agronomique (INRA), Génétique Animale (GARen), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Ecole Nationale Supérieure Agronomique de Rennes, Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement (SCRIBE), Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Station de recherches porcines, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences
Abstract

"Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "; National audience

Published
2000

49. Métabolisme énergétique des muscles squelettiques chez les animaux producteurs de viande

Author

Hocquette, Jean-François, Ortigues Marty, Isabelle, Damon, Marie, Herpin, Patrick, Geay, Y., Station de recherches sur la nutrition des herbivores, Institut National de la Recherche Agronomique (INRA), Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences
Abstract

National audience; In meat-producing animals, skeletal muscle is a tissue of major economic importance. Its main physiological functions are thermogenesis, posture and physical activity. Each of these and muscle growth present specific energy requirements, which may be responsible for competitions between the different metabolic pathways of the utilisation of energy-yielding nutrients. These metabolic regulations modify the efficiencies of ATP production and utilisation, as well as some muscle characteristics which are essential for meat quality. For example, a more glycolytic muscle metabolism is associated with a better utilisation of glucose, a higher sensitivity of muscle to insulin, an increased muscle development, a reduction in its energy expenditure and an increase in its glycogen content. Improvement of muscle growth through genetic selection induces a less oxidative muscle metabolism associated with a lower intramuscular lipid content. A rise in the supply of energy-yielding nutrients is in favour of protein, glycogen and intramuscular lipid deposition. Nevertheless, an excess in energy may be responsible for an enhanced resistance of muscle to insulin which then favours carcass adiposity. The turnover and the partition of nutrients among the intramuscular anabolic (lipogenesis, glycogenesis) and catabolic (glycolysis, lipolysis, oxidation) pathways remain to be investigated. Physical activity of animals and cold adaptation modify muscle characteristics in favour of oxidative metabolism. The issue which remains to be addressed today is to determine whether the optimisation of the efficiency of ATP production and utilisation is compatible with the improvement of meat quality, especially through its glycogen and intramuscular lipid contents.; Le muscle est d’importance économique majeure chez les animaux producteurs de viande. Ses principales fonctions physiologiques sont la thermogenèse, la posture et l’activité physique de l’animal. Ces fonctions et la croissance du muscle ont des besoins spécifiques en énergie, entraînant parfois des compétitions pour l’utilisation des différents nutriments. Ces régulations métaboliques modifient les efficacités de production et d’utilisation de l’ATP, et certaines caractéristiques musculaires déterminantes pour les qualités de la viande. Par exemple, un métabolisme musculaire plus glycolytique est associé à une meilleure utilisation du glucose, à une plus grande sensibilité du muscle à l’insuline, à un développement accru du muscle, à une réduction de ses dépenses énergétiques, et à une augmentation de sa teneur en glycogène. L’amélioration de la croissance musculaire par la sélection génétique induit un métabolisme musculaire moins oxydatif avec, comme conséquence, moins de lipides intramusculaires. Une augmentation des apports énergétiques favorise les dépôts de protéines, de glycogène et de lipides intramusculaires. Toutefois, des apports excessifs induisent une résistance du muscle à l’insuline favorisant le développement des tissus adipeux de la carcasse. Le turnover des nutriments et leur répartition entre les voies anaboliques (lipogenèse, glycogenèse) ou cataboliques (glycolyse, lipolyse, oxydation) intramusculaires restent à préciser. L’activité physique des animaux et la lutte contre le froid modifient les caractéristiques musculaires en favorisant le métabolisme oxydatif. La question qui se pose aujourd’hui est donc : l’optimisation des efficacités de production et d’utilisation de l’ATP est-elle compatible avec l’amélioration des qualités de la viande, déterminées notamment par les taux de glycogène et de lipides intramusculaires ?

Published
2000

50. Effect of oxygen inhalation at birth on the reduction of early postnatal mortality in pigs

Author

Herpin, Patrick, Hulin, J.C., Fillaut, Martine, ProdInra, Migration, Unité mixte de recherche veau et porc (UMR VP), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2000

Catalog

Books, media, physical & digital resources
See catalog results