1. Accumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome
- Author
-
Wängberg, B, Ahlman, H, Tylén, U, Nilsson, O, Hermodsson, S, and Hellstrand, K
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Immunology ,Aetiology ,2.1 Biological and endogenous factors ,Cancer ,Cytotoxicity ,Immunologic ,Embolization ,Therapeutic ,Hepatic Artery ,Humans ,Intestinal Neoplasms ,Killer Cells ,Natural ,Liver Neoplasms ,Lymphocytes ,Malignant Carcinoid Syndrome ,Phenotype ,NK CELLS ,CARCINOID TUMORS ,HEPATIC ARTERY EMBOLIZATION ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients.
- Published
- 1995