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Hepatitis B Immune Globulin in Prevention of Hepatitis B among Hospital Staff Members
- Source :
- Journal of Infectious Diseases. 135:473-477
- Publication Year :
- 1977
- Publisher :
- Oxford University Press (OUP), 1977.
-
Abstract
- In a double-blind trial of hospital staff members at risk of contracting hepatitis B, 110 subjects received hepatitis B immune globulin or immune serum globulin prophylactically. An additional 125 individuals working in the same locations were unwilling to participate in the trial and received no prophylaxis. During the study period of 28 months, 13 cases of clinical hepatitis B occurred in the untreated group, whereas only three cases occurred among the subjects who received prophylaxis. In a hemodialysis center at Sahlgren's Hospital, Gateborg, Sweden, the annual attack rate of clinical hepatitis B among staff members was 5%-8% (12-19 cases per year) during the period 1968-1972 despite considerable hygienic measures to decrease the incidence of infection.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Attack rate
Prevalence
Immunoglobulins
Antibodies, Viral
Internal medicine
medicine
Humans
Immunology and Allergy
Sweden
Hepatitis
Clinical Trials as Topic
Hepatitis B Surface Antigens
Hepatitis B immune globulin
biology
business.industry
Incidence (epidemiology)
Hepatitis B
medicine.disease
Personnel, Hospital
Infectious Diseases
Immunology
biology.protein
Female
Hemodialysis
Antibody
business
medicine.drug
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....aabd6f9b59e05671eec28f226226a59c