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2. Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era

Author

Gerhardt, Felix, Fiessler, Eva, Olsson, Karen M., Kayser, Moritz Z., Kovacs, Gabor, Gall, Henning, Ghofrani, H. Ardeschir, Badr Eslam, Roza, Lang, Irene M., Benjamin, Nicola, Grünig, Ekkehard, Halank, Michael, Lange, Tobias J., Ulrich, Silvia, Leuchte, Hanno, Held, Matthias, Klose, Hans, Ewert, Ralf, Wilkens, Heinrike, Pizarro, Carmen, Skowasch, Dirk, Wissmüller, Max, Hellmich, Martin, Olschewski, Horst, Hoeper, Marius M., and Rosenkranz, Stephan

Published
2024
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3. 'GOLD or lower limit of normal definition? a comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study'

Author

Güder Gülmisal, Brenner Susanne, Angermann Christiane E, Ertl Georg, Held Matthias, Sachs Alfred P, Lammers Jan-Willem, Zanen Pieter, Hoes Arno W, Störk Stefan, and Rutten Frans H

Subjects
COPD diagnosis, lower limit of normal, GOLD, validation, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background The Global initiative for chronic Obstructive Lung Disease (GOLD) defines COPD as a fixed post-bronchodilator ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) below 0.7. Age-dependent cut-off values below the lower fifth percentile (LLN) of this ratio derived from the general population have been proposed as an alternative. We wanted to assess the diagnostic accuracy and prognostic capability of the GOLD and LLN definition when compared to an expert-based diagnosis. Methods In a prospective cohort study, 405 patients aged ≥ 65 years with a general practitioner's diagnosis of COPD were recruited and followed up for 4.5 (median; quartiles 3.9; 5.1) years. Prevalence rates of COPD according to GOLD and three LLN definitions and diagnostic performance measurements were calculated. The reference standard was the diagnosis of COPD of an expert panel that used all available diagnostic information, including spirometry and bodyplethysmography. Results Compared to the expert panel diagnosis, 'GOLD-COPD' misclassified 69 (28%) patients, and the three LLNs misclassified 114 (46%), 96 (39%), and 98 (40%) patients, respectively. The GOLD classification led to more false positives, the LLNs to more false negative diagnoses. The main predictors beyond the FEV1/FVC ratio for an expert diagnosis of COPD were the FEV1 % predicted, and the residual volume/total lung capacity ratio (RV/TLC). Adding FEV1 and RV/TLC to GOLD or LLN improved the diagnostic accuracy, resulting in a significant reduction of up to 50% of the number of misdiagnoses. The expert diagnosis of COPD better predicts exacerbations, hospitalizations and mortality than GOLD or LLN. Conclusions GOLD criteria over-diagnose COPD, while LLN definitions under-diagnose COPD in elderly patients as compared to an expert panel diagnosis. Incorporating FEV1 and RV/TLC into the GOLD-COPD or LLN-based definition brings both definitions closer to expert panel diagnosis of COPD, and to daily clinical practice.

Published
2012
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4. How to interpret algorithmically constructed topical structures of research specialties? A case study comparing an internal and an external mapping of the topical structure of invasion biology

Author

Held, Matthias and Velden, Theresa

Subjects
Computer Science - Digital Libraries, Physics - Physics and Society
Abstract

In our paper we seek to address a shortcoming in the scientometric literature, namely that, given the proliferation of algorithmic approaches to topic detection from bibliometric data, there is a relative lack of studies that validate and create a deeper understanding of the topical structures these algorithmic approaches generate. To take a closer look at this issue, we investigate the results of the new Leiden algorithm when applied to the direct citation network of a field-level data set. We compare this internal perspective which is constructed from the citation links within a data set of 30,000 publications in invasion biology, with an external perspective onto the topic structures in this research specialty, which is based on a global science map in form of the CWTS microfield classification underlying the Leiden Ranking. We present an initial comparative analysis of the results and lay out our next steps that will involve engaging with domain experts to examine how the algorithmically identified topics relate to understandings of topics and topical perspectives that operate within this research specialty., Comment: conference Paper, 10 pages, 3 figures

Published
2019

5. Microarrays in ecological research: A case study of a cDNA microarray for plant-herbivore interactions

Author

Gase Klaus, Held Matthias, and Baldwin Ian T

Subjects
Ecology, QH540-549.5
Abstract

Abstract Background Microarray technology allows researchers to simultaneously monitor changes in the expression ratios (ERs) of hundreds of genes and has thereby revolutionized most of biology. Although this technique has the potential of elucidating early stages in an organism's phenotypic response to complex ecological interactions, to date, it has not been fully incorporated into ecological research. This is partially due to a lack of simple procedures of handling and analyzing the expression ratio (ER) data produced from microarrays. Results We describe an analysis of the sources of variation in ERs from 73 hybridized cDNA microarrays, each with 234 herbivory-elicited genes from the model ecological expression system, Nicotiana attenuata, using procedures that are commonly used in ecologic research. Each gene is represented by two independently labeled PCR products and each product was arrayed in quadruplicate. We present a robust method of normalizing and analyzing ERs based on arbitrary thresholds and statistical criteria, and characterize a "norm of reaction" of ERs for 6 genes (4 of known function, 2 of unknown) with different ERs as determined across all analyzed arrays to provide a biologically-informed alternative to the use of arbitrary expression ratios in determining significance of expression. These gene-specific ERs and their variance (gene CV) were used to calculate array-based variances (array CV), which, in turn, were used to study the effects of array age, probe cDNA quantity and quality, and quality of spotted PCR products as estimates of technical variation. Cluster analysis and a Principal Component Analysis (PCA) were used to reveal associations among the transcriptional "imprints" of arrays hybridized with cDNA probes derived from mRNA from N. attenuata plants variously elicited and attacked by different herbivore species and from three congeners: N. quadrivalis, N. longiflora and N. clevelandii. Additionally, the PCA revealed the contribution of individual gene ERs to the associations among arrays. Conclusions While the costs of 'boutique' array fabrication are rapidly declining, familiar methods for the analysis of the data they create are still missing. The case history illustrated here demonstrates the ease with which this powerful technology can be adapted to ecological research.

Published
2004
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6. Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial

Author

White, R James, Jerjes-Sanchez, Carlos, Bohns Meyer, Gisela Martina, Pulido, Tomas, Sepulveda, Pablo, Wang, Kuo Yang, Grünig, Ekkehard, Hiremath, Shirish, Yu, Zaixin, Gangcheng, Zhang, Yip, Wei Luen James, Zhang, Shuyang, Khan, Akram, Deng, CQ, Grover, Rob, Tapson, Victor F, Svetliza, Graciela Noemi, Lescano, Adrian Jose, Bortman, Guillermo Roberto, Diez, Fabian Antonio, Botta, Christian Edgardo, Fitzgerald, John, Feenstra, Eelke, Kermeen, Fiona Dawn, Keogh, Anne Margaret, Williams, Trevor John, Yousseff, Peter Paul, Ng, Benjamin Joh-Han, Smallwood, David McNaughton, Dwyer, Nathan Brent, Brown, Martin Russell, Lang, Irene M, Steringer-Mascherbauer, Regina, Arakaki, Jaquelina Sonoe Ota, Campos, Frederico Thadeu Assis Figueiredo, de Amorim Correa, Ricardo, de Souza, Rogerio, Bohns Meyer, Gisela M, Moreira, Maria Auxiliadora Carmo, Yoo, Hugo Hyung Bok, Lapa, Monica Silveira, Swiston, John, Hirani, Naushad, Mehta, Sanjay, Michelakis, Evangelos, Sepulveda, Pablo Andres, Blancaire, Monica Maria Zagolin, Liu, Jimming, Shuyang, Zhang, Pan, Lei, Chunde, Bao, Qun, Yi, Xiaoshu, Cheng, Zaixin, Yu, Li, Xinli, Hua, Yao, Zhu, Xianyang, Chen, Yundai, Zhaozhong, Cheng, Yang, Yuanhua, Daxin, Zhou, Jieyan, Shen, Nielsen-Kudsk, Jens Erik, Carlsen, Jorn, Bourdin, Arnaud, Hachulla, Eric, Dromer, Claire, Chaouat, Ari, Reynaud-Gauber, Martine, Seronde, Marie-France, Klose, Hans, Halank, Michael, Hoffken, Gert, Ewert, Ralf, Rosenkranz, Stephan, Grunig, Ekkehard, Kruger, Ulrich, Kronsbein, Juliane, Hauptmeier, Barbara Monika, Koch, Andrea, Held, Matthias, Lange, Tobias Johannes, Neurohr, Claus, Wilkens, Heinrike, Wilhelm Wirtz, Hubert Rolf, Konstantinides, Stavros, Argyropoulou-Pataka, Paraskevi, Orfanos, Stylianos, Kerkar, Prafulla Gopinath, Suresh, Pujar Venkateshacharya, Baxi, Hemang Ashwinkumar, Oomman, Abraham, Abhaichand, Rajpal Kanaklal, Arjun, Padma Kumar Edla, Chopra, Vijay, Mehrotra, Rahul, Rajput, Rajeev Kumar, and Sawhney, Jitendra Pal Singh

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Trials and Supportive Activities, Rare Diseases, Patient Safety, Digestive Diseases, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Administration, Oral, Adolescent, Adult, Aged, Antihypertensive Agents, Double-Blind Method, Epoprostenol, Female, Humans, Male, Middle Aged, Placebos, Pulmonary Arterial Hypertension, Young Adult, FREEDOM-EV Investigators, clinical study, combination therapy, oral treprostinil, pulmonary arterial hypertension, sequential therapy, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate the effect of oral treprostinil compared with placebo on time to first adjudicated clinical worsening event in participants with PAH who recently began approved oral monotherapy.Methods: In this event-driven, double-blind study, we randomly allocated 690 participants (1:1 ratio) with PAH to receive placebo or oral treprostinil extended-release tablets three times daily. Eligible participants were using approved oral monotherapy for over 30 days before randomization and had a 6-minute-walk distance 150 m or greater. The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of inhaled or parenteral prostacyclin therapy; disease progression; or unsatisfactory long-term clinical response.Measurements and Main Results: Clinical worsening occurred in 26% of the oral treprostinil group compared with 36% of placebo participants (hazard ratio, 0.74; 95% confidence interval, 0.56-0.97; P = 0.028). Key measures of disease status, including functional class, Borg dyspnea score, and N-terminal pro-brain natriuretic peptide, all favored oral treprostinil treatment at Week 24 and beyond. A noninvasive risk stratification analysis demonstrated that oral treprostinil-assigned participants had a substantially higher mortality risk at baseline but achieved a lower risk profile from Study Weeks 12-60. The most common adverse events in the oral treprostinil group were headache, diarrhea, flushing, nausea, and vomiting.Conclusions: In participants with PAH, addition of oral treprostinil to approved oral monotherapy reduced the risk of clinical worsening.Clinical trial registered with www.clinicaltrials.gov (NCT01560624).

Published
2020

8. Risk stratification and response to therapy in patients with pulmonary arterial hypertension and comorbidities: A COMPERA analysis

Author

Rosenkranz, Stephan, Pausch, Christine, Coghlan, John G., Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Vizza, Carmine Dario, Gall, Henning, Distler, Oliver, Delcroix, Marion, Ghofrani, Hossain A., Ewert, Ralf, Kabitz, Hans-Joachim, Skowasch, Dirk, Behr, Juergen, Milger, Katrin, Halank, Michael, Wilkens, Heinrike, Seyfarth, Hans-Jürgen, Held, Matthias, Scelsi, Laura, Neurohr, Claus, Vonk-Noordegraaf, Anton, Ulrich, Silvia, Klose, Hans, Claussen, Martin, Eisenmann, Stephan, Schmidt, Kai-Helge, Remppis, Bjoern Andrew, Skride, Andris, Jureviciene, Elena, Gumbiene, Lina, Miliauskas, Skaidrius, Löffler-Ragg, Judith, Lange, Tobias J., Olsson, Karen M., Hoeper, Marius M., and Opitz, Christian

Published
2023
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12. Phenotyping of idiopathic pulmonary arterial hypertension: a registry analysis

Author

Hoeper, Marius M, Dwivedi, Krit, Pausch, Christine, Lewis, Robert A, Olsson, Karen M, Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Vizza, Carmine Dario, Gall, Henning, Distler, Oliver, Opitz, Christian, Gibbs, John Simon R, Delcroix, Marion, Park, Da-Hee, Ghofrani, Hossein Ardeschir, Ewert, Ralf, Kaemmerer, Harald, Kabitz, Hans-Joachim, Skowasch, Dirk, Behr, Juergen, Milger, Katrin, Lange, Tobias J, Wilkens, Heinrike, Seyfarth, Hans-Jürgen, Held, Matthias, Dumitrescu, Daniel, Tsangaris, Iraklis, Vonk-Noordegraaf, Anton, Ulrich, Silvia, Klose, Hans, Claussen, Martin, Eisenmann, Stephan, Schmidt, Kai-Helge, Swift, Andrew J, Thompson, Alfred A Roger, Elliot, Charlie A, Rosenkranz, Stephan, Condliffe, Robin, Kiely, David G, and Halank, Michael

Published
2022
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15. Early switch to oral anticoagulation in patients with acute intermediate-risk pulmonary embolism (PEITHO-2): a multinational, multicentre, single-arm, phase 4 trial

Author

Antonio, Jaime, Freire, Abelaira, Ageno, Walter, Akin, Ibrahim, Anusic, Toni, Barco, Stefano, Becker, Dorothea, Bertoletti, Laurent, Bettoni, Giuseppe, Binder, Harald, Brodmann, Marianne, Bouvaist, Hélène, Carels, Regina, Cuccia, Claudio, Couturaud, Francis, Dellas, Claudia, Di Pasquale, Giuseppe, Dimopoulos, Konstantinos, Dürschmied, Daniel, Empen, Klaus, Enea, Iolanda, Faggiano, Pompilio, Ferrari, Emile, Ficker, Joachim, Galiè, Nazzareno, Galvani, Marcello, Genth-Zotz, Sabine, Giannakoulas, George, Girard, Philippe, Gorbulev, Stanislav, Ghuysen, Alexandre, Held, Matthias, Hobohm, Lukas, Huisman, Menno V., Jiménez, David, Klok, Frederikus A., Konstantinides, Stavros V., Kozak, Matija, Kronfeld, Kai, Lang, Irene Marthe, Lankeit, Mareike, Lehmacher, Walter, Miguel, Concepcion Patricia Lopez, Martin, Nadine, Mavromanoli, Anna, Meneveau, Nicolas, Meyer, Guy, Münzel, Thomas, Palazzini, Massimiliano, Pareznik, Roman, Petris, Antoniu Octavian, Piovaccari, Giancarlo, Quitzau, Kurt, Parepa, Irinel Raluca, Martin, Purificacion Ramirez, Righini, Marc, Salvi, Aldo, Schellong, Sebastian, Schmidt, Kai-Helge, Schmidtmann, Irene, Toenges, Gerrit, Todea, Silviu Bogdan, Torbicki, Adam, Valerio, Luca, Vanassche, Thomas, Verschuren, Franck, Vida-Simiti, Luminita Animarie, Wolf-Pütz, Anamaria, Klok, Frederikus A, Mavromanoli, Anna C, Duerschmied, Daniel, Huisman, Menno V, and Konstantinides, Stavros V

Published
2021
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16. Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial

Author

Behr, Jürgen, Kreuter, Michael, Johow, Johannes, Rabe, Klaus F, Bonella, Francesco, Bonnet, Reiner, Grohe, Christian, Held, Matthias, Wilkens, Heinrike, Hammerl, Peter, Koschel, Dirk, Blaas, Stefan, Wirtz, Hubert, Ficker, Joachim H, Neumeister, Wolfgang, Schönfeld, Nicolaus, Claussen, Martin, Kneidinger, Nikolaus, Frankenberger, Marion, Hummler, Simone, Kahn, Nicolas, Tello, Silke, Freise, Julia, Welte, Tobias, Neuser, Petra, Günther, Andreas, Schade-Brittinger, Carmen, Aminossadati, Behnaz, Nasemann, Christian, Yahiaoui, Soraya, Dupuy Backofen, Christoph, Hahmann, Maik, Wittenberg, Michael, Drakopanagiotakis, Fotis, von der Beck, Daniel, Ghofrani, Stefanie, Heinemann, Sabine, Krauss, Ekaterina, Rethorn, Hella, Koch, Andrea, Leuschner, Gabriela, Matthes, Sandhya, Neurohr, Claus, Veit, Tobias, Milger-Kneidinger, Katrin, Herth, Felix, Benstz, Julia, Bahmer, Thomas, Biller, Heike, Waschki, Benjamin, Apel, Rosa-Marie, Costabel, Ulrich, Börner, Eva, Wessendorf, Thomas, Arnrich, Margret, Ilie, Lacramioara, Wald, Alexandra, Seyfarth, Hans-Jürgen, Reinhardt, Christian, Cinar, Atif, Vogler, Markus, Huhn, Siegfried Matthias, Richter, Jaqueline, Neff, Ulrich, Blum, Torsten Gerriet, Vesenbeckh, Silvan, Boch, Christian, Semper, Hannes, Wilke, Andreas, Pfeifer, Michael, Schweda, Annette, Krill, Angelika, Lensch, Christian, Joa, Franziska, Schröder, Barbara, Plaßmeier, Annabel, Baron, Stefan, Froehling, Klaus Peter, Prasse, Antje, and Schönfeld, Nicolas

Published
2021
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18. Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry

Author

Hoeper, Marius M., Pausch, Christine, Grünig, Ekkehard, Klose, Hans, Staehler, Gerd, Huscher, Doerte, Pittrow, David, Olsson, Karen M., Vizza, Carmine Dario, Gall, Henning, Benjamin, Nicola, Distler, Oliver, Opitz, Christian, Gibbs, J. Simon R., Delcroix, Marion, Ghofrani, H. Ardeschir, Rosenkranz, Stephan, Ewert, Ralf, Kaemmerer, Harald, Lange, Tobias J., Kabitz, Hans-Joachim, Skowasch, Dirk, Skride, Andris, Jureviciene, Elena, Paleviciute, Egle, Miliauskas, Skaidrius, Claussen, Martin, Behr, Juergen, Milger, Katrin, Halank, Michael, Wilkens, Heinrike, Wirtz, Hubert, Pfeuffer-Jovic, Elena, Harbaum, Lars, Scholtz, Werner, Dumitrescu, Daniel, Bruch, Leonhard, Coghlan, Gerry, Neurohr, Claus, Tsangaris, Iraklis, Gorenflo, Matthias, Scelsi, Laura, Vonk-Noordegraaf, Anton, Ulrich, Silvia, and Held, Matthias

Published
2020
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20. Diagnose Algorithmus der pulmonalen Hypertonie und Screening-Verfahren

Author

Tello, Khodr, additional, Richter, Manuel J., additional, Kremer, Nils, additional, Gall, Henning, additional, Egenlauf, Benjamin, additional, Sorichter, Stephan, additional, Heberling, Melanie, additional, Douschan, Philipp, additional, Hager, Alfred, additional, Yogeswaran, Athiththan, additional, Behr, Jürgen, additional, Xanthouli, Panagiota, additional, and Held, Matthias, additional

Published
2023
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21. Pulmonale Hypertonie assoziiert mit Lungenerkrankungen

Author

Halank, Michael, primary, Zeder, Katarina E., primary, Sommer, Natascha, primary, Kneidinger, Nikolaus, primary, Behr, Jürgen, primary, Ulrich, Silvia, additional, Held, Matthias, additional, Köhler, Thomas, additional, Foris, Vasile, additional, Heberling, Melanie, additional, Neurohr, Claus, additional, Ronczka, Julia, additional, Holt, Stephan, additional, and Skowasch, Dirk, additional

Published
2023
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22. Chronisch thromboembolische pulmonale Hypertonie (Gruppe 4)

Author

Guth, Stefan, additional, Wilkens, Heinrike, additional, Halank, Michael, additional, Held, Matthias, additional, Hobohm, Lukas, additional, Konstantinides, Stavros, additional, Omlor, Albert, additional, Seyfarth, Hans-Jürgen, additional, Schäfers, Hans-Joachim, additional, Mayer, Eckhard, additional, and Wiedenroth, Christoph B., additional

Published
2023
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24. Treatment strategies and survival of patients with connective tissue disease and pulmonary arterial hypertension: a COMPERA analysis.

Author

Distler, Oliver, Ofner, Christian, Huscher, Dörte, Jordan, Suzana, Ulrich, Silvia, Stähler, Gerd, Grünig, Ekkehard, Held, Matthias, Ghofrani, H Ardeschir, Claussen, Martin, Lange, Tobias J, Klose, Hans, Rosenkranz, Stephan, Vonk-Noordegraaf, Anton, Vizza, C Dario, Delcroix, Marion, Opitz, Christian, Pausch, Christine, Scelsi, Laura, and Neurohr, Claus

Subjects
COMBINATION drug therapy, SURVIVAL rate, RESEARCH funding, LONG-term health care, FISHER exact test, TREATMENT effectiveness, DESCRIPTIVE statistics, SYSTEMIC lupus erythematosus, MANN Whitney U Test, CHI-squared test, CONNECTIVE tissue diseases, PHOSPHODIESTERASE inhibitors, SYSTEMIC scleroderma, PULMONARY arterial hypertension, COMPARATIVE studies, DATA analysis software, ENDOTHELINS, CELL receptors, CHEMICAL inhibitors
Abstract

Objectives Pulmonary arterial hypertension (PAH) occurs in various connective tissue diseases (CTDs). We sought to assess contemporary treatment patterns and survival of patients with various forms of CTD-PAH. Methods We analysed data from COMPERA, a European pulmonary hypertension registry, to describe treatment strategies and survival in patients with newly diagnosed PAH associated with SSc, SLE, MCTD, UCTD and other types of CTD. All-cause mortality was analysed according to the underlying CTD. For patients with SSc-PAH, we also assessed survival according to initial therapy with endothelin receptor antagonists (ERAs), phosphodiesterase type 5 inhibitors (PDE5is) or a combination of these two drug classes. Results This analysis included 607 patients with CTD-PAH. Survival estimates at 1, 3 and 5 years for SSc-PAH (n  = 390) were 85%, 59% and 42%; for SLE-PAH (n  = 34) they were 97%, 77% and 61%; for MCTD-PAH (n  = 33) they were 97%, 70% and 59%; for UCTD-PAH (n  = 60) they were 88%, 67% and 52%; and for other CTD-PAH (n  = 90) they were 92%, 69% and 55%, respectively. After multivariable adjustment, the survival of patients with SSc-PAH was significantly worse compared with the other conditions (P  = 0.001). In these patients, the survival estimates were significantly better with initial ERA–PDE5i combination therapy than with initial ERA or PDE5i monotherapy (P  = 0.016 and P  = 0.012, respectively). Conclusions Mortality remains high in patients with CTD-PAH, especially for patients with SSc-PAH. However, for patients with SSc-PAH, our results suggest that long-term survival may be improved with initial ERA–PDE5i combination therapy compared with initial monotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Treatment strategies and survival of patients with connective tissue disease and pulmonary arterial hypertension: A COMPERA analysis

Author

Distler, Oliver, primary, Ofner, Christian, additional, Huscher, Dörte, additional, Jordan, Suzana, additional, Ulrich, Silvia, additional, Stähler, Gerd, additional, Grünig, Ekkehard, additional, Held, Matthias, additional, Ghofrani, H Ardeschir, additional, Claussen, Martin, additional, Lange, Tobias J, additional, Klose, Hans, additional, Rosenkranz, Stephan, additional, Vonk-Noordegraaf, Anton, additional, Vizza, C Dario, additional, Delcroix, Marion, additional, Opitz, Christian, additional, Pausch, Christine, additional, Scelsi, Laura, additional, Neurohr, Claus, additional, Olsson, Karen M, additional, Coghlan, J Gerry, additional, Halank, Michael, additional, Skowasch, Dirk, additional, Behr, Jürgen, additional, Milger, Katrin, additional, Remppis, Bjoern Andrew, additional, Skride, Andris, additional, Jureviciene, Elena, additional, Gumbiene, Lina, additional, Miliauskas, Skaidrius, additional, Löffler-Ragg, Judith, additional, Wilkens, Heinrike, additional, Pittrow, David, additional, Hoeper, Marius M, additional, and Ewert, Ralf, additional

Published
2023
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28. Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification

Author

Pallares Robles, Alejandro, primary, ten Cate, Vincent, additional, Lenz, Michael, additional, Schulz, Andreas, additional, Prochaska, Jürgen H., additional, Rapp, Steffen, additional, Koeck, Thomas, additional, Leineweber, Kirsten, additional, Heitmeier, Stefan, additional, Opitz, Christian F., additional, Held, Matthias, additional, Espinola-Klein, Christine, additional, Lackner, Karl J., additional, Münzel, Thomas, additional, Konstantinides, Stavros V., additional, ten Cate-Hoek, Arina, additional, ten Cate, Hugo, additional, and Wild, Philipp S., additional

Published
2023
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30. Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study

Author

Ghofrani, Hossein-Ardeschir, Simonneau, Gérald, D'Armini, Andrea M, Fedullo, Peter, Howard, Luke S, Jaïs, Xavier, Jenkins, David P, Jing, Zhi-Cheng, Madani, Michael M, Martin, Nicolas, Mayer, Eckhard, Papadakis, Kelly, Richard, Dominik, Kim, Nick H, Lang, Irene, Kähler, Christian, Delcroix, Marion, Bshouty, Zoheir, Sepulveda Varela, Pablo, Jing, Zhi-Cheng, Yang, Yuanhua, Liu, Jinming, Zhang, Gangcheng, Zhang, Nuofu, Mi, Yuhong, Zhu, Xianyang, Jansa, Pavel, Jaïs, Xavier, Prévot, Grégoire, Bouvaist, Hélène, Sanchez, Olivier, Grimminger, Friedrich, Held, Matthias, Wilkens, Heinrike, Rosenkranz, Stephan, Grünig, Ekkehard, Karlócai, Kristóf, Temesvári, András, Edes, Istvan, Aidietienė, Sigita, Miliauskas, Skaidrius, Pulido Zamudio, Tomas Rene, Jerjes Sanchez, Carlos, Vonk Noordegraaf, Anton, Lewczuk, Jerzy, Podolec, Piotr, Kasprzak, Jarosław, Mularek-Kubzdela, Tatiana, Grzywna, Ryszard, Dheda, Keertan, Moiseeva, Olga, Chernyavskiy, Alexander, Shipulin, Vladimir, Barbarash, Olga, Martynyuk, Tamila, Kim, Hyung-Kwan, Park, Jun-Bean, Lee, Jae Seung, Speich, Rudolf, Ulrich, Silvia, Aubert, John-David, Phrommintikul, Arintaya, Jaimchariyatam, Nattapong, Sompradeekul, Suree, Onen, Zeynep Pinar, Okumus, Gulfer, Solovey, Lyubomyr, Gavrysyuk, Volodymyr, Howard, Luke, Pepke-Zaba, Joanna, Condliffe, Robin, McConnell, John, Kerr, Kim, Nguyen, Lan Hieu, and Pham, Nguyen Vinh

Abstract

Macitentan is beneficial for long-term treatment of pulmonary arterial hypertension. The microvasculopathy of chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension are similar.

Published
2024
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33. Anxiety, Depression, and Health-Related QOL in Patients Diagnosed with PAH or CTEPH

Author

Pfeuffer, Elena, Krannich, Holger, Halank, Michael, Wilkens, Heinrike, Kolb, Philipp, Jany, Berthold, and Held, Matthias

Subjects
Depression (Mood disorder) -- Risk factors -- Research, Pulmonary hypertension -- Complications and side effects -- Psychological aspects -- Care and treatment -- Patient outcomes -- Research, Anxiety -- Risk factors -- Research, Quality of life -- Health aspects -- Research, Health
Abstract

Background Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are life-threatening diseases with a high burden of symptoms. Although depression, anxiety, and reduced health related quality of life (HRQOL) have also been reported, a comparative analysis which explores these traits and their underlying factors was lacking. Methods A retrospective analysis of depression, anxiety, and health related QOL was conducted using a Hospital anxiety and depression scale (HADS) as well as the SF-36 HRQOL questionnaire. Results from these tools were compared with haemodynamic and functional parameters in 70 PAH and 23 CTEPH outpatients from a German tertiary care center specializing in pulmonary hypertension. Results Although HRQOL was reduced in both cohorts of patients, individuals diagnosed with CTEPH scored lower in nearly all SF-36 parameters. Significance was noted in both 'mental health' (p = 0.01) and 'mental component summary score' (MCS) (p = 0.02). Depression was also more frequent in patients with CTEPH (56%) than in patients with PAH (30%), (p = 0.03). Overall, depression and anxiety correlated with most SF-36 scales in both PAH and CTEPH. In CTEPH, depression also correlated with the Borg Dyspnea Scale (r = 0.44, p = 0.01). These patients also had significantly lower pCO.sub.2 levels than the PAH cohort reflecting more severe ventilation/perfusion mismatch. All other haemodynamic and functional parameters did not differ across the groups. Conclusion While both cohorts of patients suffer from a reduced HRQOL as well as depression and anxiety, decreases in mental health parameters are more pronounced in the CTEPH cohort. This suggests a strong effort to improve early detection, especially in dyspneic patients with classical risk factors for CTEPH and PAH and argues for mental illness interventions alongside routine clinical care provided to patients diagnosed with PAH or CTEPH., Author(s): Elena Pfeuffer [sup.1] [sup.2] , Holger Krannich [sup.3] , Michael Halank [sup.4] , Heinrike Wilkens [sup.5] , Philipp Kolb [sup.6] , Berthold Jany [sup.1] , Matthias Held [sup.1] Author [...]

Published
2017
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35. Cardiopulmonary exercise testing in the follow-up after acute pulmonary embolism

Author

Farmakis, Ioannis T., primary, Valerio, Luca, additional, Barco, Stefano, additional, Alsheimer, Eva, additional, Ewert, Ralf, additional, Giannakoulas, George, additional, Hobohm, Lukas, additional, Keller, Karsten, additional, Mavromanoli, Anna C., additional, Rosenkranz, Stephan, additional, Morris, Timothy A., additional, Konstantinides, Stavros V., additional, Held, Matthias, additional, and Dumitrescu, Daniel, additional

Published
2023
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37. Material Trajectories

Author

Perraudin, Léa, Winkler, Clemens, Mareis, Claudia, Held, Matthias, Perraudin, Léa, Winkler, Clemens, Mareis, Claudia, and Held, Matthias

Abstract

This edited volume is the outcome of the 2021 Annual Conference of the German Society for Design Theory and Research (DGTF), organized in cooperation with the Cluster of Excellence “Matters of Activity. Image Space Material” at the Humboldt-Universität zu Berlin and the weißensee kunsthochschule berlin. The constellation of these three institutions shaped the theme of the conference, “Material Trajectories. Designing with Care” as they all have a long history of exploring the possibilities and complications of design and material culture in theory and practice. This book is thus conceived as a collaborative attempt by interdisciplinary scholars and design practitioners to explore the foundations of a new material culture. It is about exploring and problematizing material trajectories and entanglements, as well as opening up new and different ways of designing with modesty, complicity, and care.

Published
2023

38. Cardiopulmonary exercise testing during follow-up after acute pulmonary embolism

Author

Farmakis, Ioannis T; https://orcid.org/0000-0002-0586-6386, Valerio, Luca; https://orcid.org/0000-0003-4466-0724, Barco, Stefano; https://orcid.org/0000-0002-2618-347X, Alsheimer, Eva, Ewert, Ralf, Giannakoulas, George; https://orcid.org/0000-0001-7491-6319, Hobohm, Lukas; https://orcid.org/0000-0002-4312-0366, Keller, Karsten; https://orcid.org/0000-0002-0820-9584, Mavromanoli, Anna C, Rosenkranz, Stephan, Morris, Timothy A; https://orcid.org/0000-0002-5122-9193, Konstantinides, Stavros V; https://orcid.org/0000-0001-6359-7279, Held, Matthias, Dumitrescu, Daniel, Farmakis, Ioannis T; https://orcid.org/0000-0002-0586-6386, Valerio, Luca; https://orcid.org/0000-0003-4466-0724, Barco, Stefano; https://orcid.org/0000-0002-2618-347X, Alsheimer, Eva, Ewert, Ralf, Giannakoulas, George; https://orcid.org/0000-0001-7491-6319, Hobohm, Lukas; https://orcid.org/0000-0002-4312-0366, Keller, Karsten; https://orcid.org/0000-0002-0820-9584, Mavromanoli, Anna C, Rosenkranz, Stephan, Morris, Timothy A; https://orcid.org/0000-0002-5122-9193, Konstantinides, Stavros V; https://orcid.org/0000-0001-6359-7279, Held, Matthias, and Dumitrescu, Daniel

Abstract

BACKGROUND Cardiopulmonary exercise testing (CPET) may provide prognostically valuable information during follow-up after pulmonary embolism (PE). Our objective was to investigate the association of patterns and degree of exercise limitation, as assessed by CPET, with clinical, echocardiographic and laboratory abnormalities and quality of life (QoL) after PE. METHODS In a prospective cohort study of unselected consecutive all-comers with PE, survivors of the index acute event underwent 3- and 12-month follow-ups, including CPET. We defined cardiopulmonary limitation as ventilatory inefficiency or insufficient cardiocirculatory reserve. Deconditioning was defined as peak O$_{2}$ uptake (V'$_{O_{2}}$ ) <80% with no other abnormality. RESULTS Overall, 396 patients were included. At 3 months, prevalence of cardiopulmonary limitation and deconditioning was 50.1% (34.7% mild/moderate; 15.4% severe) and 12.1%, respectively; at 12 months, it was 44.8% (29.1% mild/moderate; 15.7% severe) and 14.9%, respectively. Cardiopulmonary limitation and its severity were associated with age (OR per decade 2.05, 95% CI 1.65-2.55), history of chronic lung disease (OR 2.72, 95% CI 1.06-6.97), smoking (OR 5.87, 95% CI 2.44-14.15) and intermediate- or high-risk acute PE (OR 4.36, 95% CI 1.92-9.94). Severe cardiopulmonary limitation at 3 months was associated with the prospectively defined, combined clinical-haemodynamic end-point of "post-PE impairment" (OR 6.40, 95% CI 2.35-18.45) and with poor disease-specific and generic health-related QoL. CONCLUSIONS Abnormal exercise capacity of cardiopulmonary origin is frequent after PE, being associated with clinical and haemodynamic impairment as well as long-term QoL reduction. CPET can be considered for selected patients with persisting symptoms after acute PE to identify candidates for closer follow-up and possible therapeutic interventions.

Published
2023

39. Trends in COVID-19-associated mortality in patients with pulmonary hypertension: a COMPERA analysis

Author

Schmidt, Kai-Helge, Milger, Katrin; https://orcid.org/0000-0003-2914-8773, Pausch, Christine; https://orcid.org/0000-0002-1866-9015, Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Gall, Henning; https://orcid.org/0000-0001-7016-7373, Distler, Oliver; https://orcid.org/0000-0002-0546-8310, Skowasch, Dirk, Halank, Michael, Wilkens, Heinrike, Held, Matthias, Klose, Hans, Hoeper, Marius M; https://orcid.org/0000-0001-9086-2293, Schmidt, Kai-Helge, Milger, Katrin; https://orcid.org/0000-0003-2914-8773, Pausch, Christine; https://orcid.org/0000-0002-1866-9015, Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Gall, Henning; https://orcid.org/0000-0001-7016-7373, Distler, Oliver; https://orcid.org/0000-0002-0546-8310, Skowasch, Dirk, Halank, Michael, Wilkens, Heinrike, Held, Matthias, Klose, Hans, and Hoeper, Marius M; https://orcid.org/0000-0001-9086-2293

Abstract

In patients with pulmonary hypertension, the mortality rate associated with COVID-19 has declined sharply with the emergence of the Omicron variants https://bit.ly/42OMsfj

Published
2023

40. The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry

Author

Kreuter, Michael, Swigris, Jeff, Pittrow, David, Geier, Silke, Klotsche, Jens, Prasse, Antje, Wirtz, Hubert, Koschel, Dirk, Andreas, Stefan, Claussen, Martin, Grohé, Christian, Wilkens, Henrike, Hagmeyer, Lars, Skowasch, Dirk, Meyer, Joachim F., Kirschner, Joachim, Gläser, Sven, Kahn, Nicolas, Welte, Tobias, Neurohr, Claus, Schwaiblmair, Martin, Held, Matthias, Bahmer, Thomas, Oqueka, Tim, Frankenberger, Marion, and Behr, Jürgen

Published
2019
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41. Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment

Author

Kahnert, Kathrin, Andreas, Stefan, Kellerer, Christina, Lutter, Johanna I., Lucke, Tanja, Yildirim, Önder, Lehmann, Mareike, Seissler, Jochen, Behr, Jürgen, Frankenberger, Marion, Bals, Robert, Watz, Henrik, Welte, Tobias, Trudzinski, Franziska C., Vogelmeier, Claus F., Alter, Peter, Jörres, Rudolf A., Bahmer, Thomas, Bewig, Burkhard, Ewert, Ralf, Stubbe, Beate, Ficker, Joachim H., Grohé, Christian, Held, Matthias, Henke, Markus, Herth, Felix, Kirsten, Anne-Marie, Koczulla, Rembert, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Herzmann, Christian, Pfeifer, Michael, Randerath, Winfried J., Seeger, Werner, Studnicka, Michael, Taube, Christian, Timmermann, Hartmut, Schmeck, Bernd, Vogelmeier, Claus, and Wirtz, Hubert

Subjects
Male, Epidemiology, Science, Vital Capacity, Medizin, Article, Body Mass Index, Cohort Studies, Pulmonary Disease, Chronic Obstructive, Sex Factors, Forced Expiratory Volume, Diabetes Mellitus, Humans, Hypoglycemic Agents, Lung, Aged, Multidisciplinary, Smoking, Age Factors, Middle Aged, respiratory system, Metformin, respiratory tract diseases, Pulmonary Emphysema, Pulmonary Diffusing Capacity, Medicine, Female, Drug therapy
Abstract

We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging effects of metformin. Patients of GOLD grades 1–4 of the COSYCONET cohort with follow-up data of up to 4.5 y were included. The annual decline in lung function (FEV1, FVC) and CO diffusing capacity (KCO, TLCO) in %predicted at baseline was evaluated for associations with age, sex, BMI, pack-years, smoking status, baseline lung function, exacerbation risk, respiratory symptoms, cardiac disease, as well as metformin-containing therapy compared to patients without diabetes and metformin. Among 2741 patients, 1541 (mean age 64.4 y, 601 female) fulfilled the inclusion criteria. In the group with metformin treatment vs. non-diabetes the mean annual decline in KCO and TLCO was significantly lower (0.2 vs 2.3, 0.8 vs. 2.8%predicted, respectively; p 1 and FVC. These results were confirmed using multiple regression and propensity score analyses. Our findings demonstrate an association between the annual decline of lung diffusing capacity and the intake of metformin in patients with COPD consistent with the hypothesis of anti-aging effects of metformin as reflected in a surrogate marker of emphysema.

Published
2022

44. Know thy tools! Limits of popular algorithms used for topic reconstruction

Author

Held, Matthias

Subjects
qualitative and quantitative approaches, 310 Sammlungen allgemeiner Statistiken, concept definitions, algorithms, science mapping
Abstract

To reconstruct topics in bibliometric networks, one must use algorithms. Specifically, researchers often apply algorithms from the class of network community detection algorithms (such as the Louvain algorithm) that are general-purpose algorithms not intentionally programmed for a bibliometric task. Each algorithm has specific properties “inscribed,” which distinguish it from the others. It can thus be assumed that different algorithms are more or less suitable for a given bibliometric task. However, the suitability of a specific algorithm when it is applied for topic reconstruction is rarely reflected upon. Why choose this algorithm and not another? In this study, I assess the suitability of four community detection algorithms for topic reconstruction, by first deriving the properties of the phenomenon to be reconstructed—topics—and comparing if these match with the properties of the algorithms. The results suggest that the previous use of these algorithms for bibliometric purposes cannot be justified by their specific suitability for this task.

Published
2022
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45. Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study

Author

Konstantinides, Stavros V., Barco, Stefano, Rosenkranz, Stephan, Lankeit, Mareike, Held, Matthias, Gerhardt, Felix, Bruch, Leonard, Ewert, Ralf, Faehling, Martin, Freise, Julia, Ghofrani, Hossein-Ardeschir, Grünig, Ekkehard, Halank, Michael, Heydenreich, Nadine, Hoeper, Marius M., Leuchte, Hanno H., Mayer, Eckhard, Meyer, F. Joachim, Neurohr, Claus, Opitz, Christian, Pinto, Antonio, Seyfarth, Hans-Jürgen, Wachter, Rolf, Zäpf, Bianca, Wilkens, Heinrike, Binder, Harald, and Wild, Philipp S.

Published
2016
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47. Prognostic Relevance of Cardiopulmonary Exercise Testing for Patients with Chronic Thromboembolic Pulmonary Hypertension

Author

Ewert, Ralf, primary, Ittermann, Till, additional, Schmitt, Delia, additional, Pfeuffer-Jovic, Elena, additional, Stucke, Johannes, additional, Tausche, Kristin, additional, Halank, Michael, additional, Winkler, Jörg, additional, Hoheisel, Andreas, additional, Stubbe, Beate, additional, Heine, Alexander, additional, Seyfarth, Hans-Jürgen, additional, Opitz, Christian, additional, Habedank, Dirk, additional, Wensel, Roland, additional, and Held, Matthias, additional

Published
2022
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49. COVID-19 patients share common, corticosteroid-independent features of impaired host immunity to pathogenic molds

Author

Tappe, Beeke, primary, Lauruschkat, Chris D., additional, Strobel, Lea, additional, Pantaleón García, Jezreel, additional, Kurzai, Oliver, additional, Rebhan, Silke, additional, Kraus, Sabrina, additional, Pfeuffer-Jovic, Elena, additional, Bussemer, Lydia, additional, Possler, Lotte, additional, Held, Matthias, additional, Hünniger, Kerstin, additional, Kniemeyer, Olaf, additional, Schäuble, Sascha, additional, Brakhage, Axel A., additional, Panagiotou, Gianni, additional, White, P. Lewis, additional, Einsele, Hermann, additional, Löffler, Jürgen, additional, and Wurster, Sebastian, additional

Published
2022
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50. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort

Author

von Siemens, Sarah Marietta, Perneczky, Robert, Waschki, Benjamin, Lutter, Johanna I, Welte, Tobias, Jörres, Rudolf A, Kahnert, Kathrin, group, COSYCONET study, Andreas, Stefan, Bals, Robert, Behr, Jürgen, Vogelmeier, Claus F, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Gogol, Manfred, Grohé, Christian, Hauck, Rainer, Held, Matthias, Jany, Berthold, Henke, Markus, Herth, Felix, Höffken, Gerd, Katus, Hugo A, Kirsten, Anne-Marie, Watz, Henrik, Koczulla, Rembert, Kenn, Klaus, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Lange, Christoph, Kauffmann-Guerrero, Diego, Zabel, Peter, Pfeifer, Michael, Randerath, Winfried J, Seeger, Werner, Studnicka, Michael, Taube, Christian, Teschler, Helmut, Timmermann, Hartmut, Virchow, J Christian, Vogelmeier, Claus, Alter, Peter, Wagner, Ulrich, Wirtz, Hubert, Trudzinski, Franziska C, and Söhler, Sandra

Subjects
Male, medicine.medical_specialty, epidemiology [Cognitive Dysfunction], psychology [Pulmonary Disease, Chronic Obstructive], Medizin, Comorbidity, Cohort Studies, 03 medical and health sciences, FEV1/FVC ratio, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Cognition, epidemiology [Pulmonary Disease, Chronic Obstructive], Surveys and Questionnaires, medicine, Dementia, Humans, COPD, Cognitive Dysfunction, ddc:610, Cognitive skill, Path analysis (statistics), Aged, lcsh:RC705-779, business.industry, Research, physiology [Cognition], diagnosis [Pulmonary Disease, Chronic Obstructive], lcsh:Diseases of the respiratory system, Middle Aged, medicine.disease, Mental Status and Dementia Tests, humanities, Cross-Sectional Studies, Cognitive impairment, diagnosis [Cognitive Dysfunction], 030228 respiratory system, Cohort, Physical therapy, Female, psychology [Cognitive Dysfunction], business, 030217 neurology & neurosurgery, Cognitive load
Abstract

Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1–4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George‘s respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.

Published
2022
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