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3. Development of a decision analytical framework to prioritise operating room capacity: lessons learnt from an empirical example on delayed elective surgeries during the COVID-19 pandemic in a hospital in the Netherlands

Author

Hein G Gooszen, Maroeska M Rovers, Mirre Scholte, Camiel Rosman, Janneke PC Grutters, Niek Stadhouders, Stan RW Wijn, Sanne JJPM Metsemakers, Robin J Vermeulen, Ron van der Pennen, Bart JJM Berden, Tim M Govers, Charlotte Michels, Milica Jevdjevic, Ilse Spenkelink, Niels van den Berkmortel, Casper Tax, Michiel Sedelaar, Sebastiaan van der Goes, Tony van Tienen, Rudolph Poolman, Jelle Ruurda, and Paul van Leest

Subjects
Medicine
Abstract

Objective To develop a prioritisation framework to support priority setting for elective surgeries after COVID-19 based on the impact on patient well-being and cost.Design We developed decision analytical models to estimate the consequences of delayed elective surgical procedures (eg, total hip replacement, bariatric surgery or septoplasty).Setting The framework was applied to a large hospital in the Netherlands.Outcome measures Quality measures impacts on quality of life and costs were taken into account and combined to calculate net monetary losses per week delay, which quantifies the total loss for society expressed in monetary terms. Net monetary losses were weighted by operating times.Results We studied 13 common elective procedures from four specialties. Highest loss in quality of life due to delayed surgery was found for total hip replacement (utility loss of 0.27, ie, 99 days lost in perfect health); the lowest for arthroscopic partial meniscectomy (utility loss of 0.05, ie, 18 days lost in perfect health). Costs of surgical delay per patient were highest for bariatric surgery (€31/pp per week) and lowest for arthroscopic partial meniscectomy (−€2/pp per week). Weighted by operating room (OR) time bariatric surgery provides most value (€1.19/pp per OR minute) and arthroscopic partial meniscectomy provides the least value (€0.34/pp per OR minute). In a large hospital the net monetary loss due to prolonged waiting times was €700 840 after the first COVID-19 wave, an increase of 506% compared with the year before.Conclusions This surgical prioritisation framework can be tailored to specific centres and countries to support priority setting for delayed elective operations during and after the COVID-19 pandemic, both in and between surgical disciplines. In the long-term, the framework can contribute to the efficient distribution of OR time and will therefore add to the discussion on appropriate use of healthcare budgets. The online framework can be accessed via: https://stanwijn.shinyapps.io/priORitize/.

Published
2022
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5. Superiority of Step-up Approach vs Open Necrosectomy in Long-term Follow-up of Patients With Necrotizing Pancreatitis

Author

Hollemans, Robbert A., Bakker, Olaf J., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bruno, Marco J., Buskens, Erik, Dejong, Cornelis H., van Duijvendijk, Peter, van Eijck, Casper H., Fockens, Paul, van Goor, Harry, van Grevenstein, Wilhelmina M., van der Harst, Erwin, Heisterkamp, Joos, Hesselink, Eric J., Hofker, Sijbrand, Houdijk, Alexander P., Karsten, Tom, Kruyt, Philip M., van Laarhoven, Cornelis J., Laméris, Johan S., van Leeuwen, Maarten S., Manusama, Eric R., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., van Ramshorst, Bert, Roos, Daphne, Rosman, Camiel, Schaapherder, Alexander F., van der Schelling, George P., Timmer, Robin, Verdonk, Robert C., de Wit, Ralph J., Gooszen, Hein G., Besselink, Marc G., and van Santvoort, Hjalmar C.

Published
2019
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6. Robust single-parameter quantized charge pumping

Author

Kaestner, B., Kashcheyevs, V., Hein, G., Pierz, K., Siegner, U., and Schumacher, H. W.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

This paper investigates a scheme for quantized charge pumping based on single-parameter modulation. The device was realized in an AlGaAs-GaAs gated nanowire. We find a remarkable robustness of the quantized regime against variations in the driving signal, which increases with applied rf power. This feature together with its simple configuration makes this device a potential module for a scalable source of quantized current., Comment: Submitted to Appl. Phys. Lett

Published
2008
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7. Single-parameter non-adiabatic quantized charge pumping

Author

Kaestner, B., Kashcheyevs, V., Amakawa, S., Li, L., Blumenthal, M. D., Janssen, T. J. B. M., Hein, G., Pierz, K., Weimann, T., Siegner, U., and Schumacher, H. W.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Controlled charge pumping in an AlGaAs/GaAs gated nanowire by single-parameter modulation is studied experimentally and theoretically. Transfer of integral multiples of the elementary charge per modulation cycle is clearly demonstrated. A simple theoretical model shows that such a quantized current can be generated via loading and unloading of a dynamic quasi-bound state. It demonstrates that non-adiabatic blockade of unwanted tunnel events can obliterate the requirement of having at least two phase-shifted periodic signals to realize quantized pumping. The simple configuration without multiple pumping signals might find wide application in metrological experiments and quantum electronics., Comment: 4 pages, 4 figures

Published
2007
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9. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

Manusama, Eric R, Hadithi, Mohammed, Rosman, Camiel, Schaapherder, Alexander F, Schoon, Erik J, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C, Bakker, Olaf J, Besselink, Marc G, Boermeester, Marja A, Bollen, Thomas L, Bosscha, Koop, Bouwense, Stefan A, Bruno, Marco J, Cappendijk, Vincent C, Consten, Esther C, Dejong, Cornelis H, van Eijck, Casper H, Erkelens, Willemien G, van Goor, Harry, van Grevenstein, Wilhelmina M U, Haveman, Jan-Willem, Hofker, Sijbrand H, Jansen, Jeroen M, Laméris, Johan S, van Lienden, Krijn P, Meijssen, Maarten A, Mulder, Chris J, Nieuwenhuijs, Vincent B, Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J, Römkens, Tessa E, Scheepers, Joris J, Schepers, Nicolien J, Schwartz, Matthijs P, Seerden, Tom, Spanier, B W Marcel, Straathof, Jan Willem A, Strijker, Marin, Timmer, Robin, Venneman, Niels G, Vleggaar, Frank P, Voermans, Rogier P, Witteman, Ben J, Gooszen, Hein G, Dijkgraaf, Marcel G, and Fockens, Paul

Published
2018
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11. Contributors

Author

Abbas, Abbas E., primary, Adams, David B., additional, Aggarwal, Piyush, additional, Ahmed, Bestoun H., additional, Albanese, Craig, additional, Albert, Matthew R., additional, Ali, Abubaker, additional, Alicuben, Evan, additional, Allaix, Marco E., additional, Altman, Ashley, additional, Ando, Hisami, additional, Andolfi, Ciro, additional, Annamalai, Alagappan, additional, Asare, Elliot A., additional, Asti, Emanuele, additional, Auchincloss, Hugh G., additional, Babic, Benjamin, additional, Baker, Talia B., additional, Ball, Chad G., additional, Barbetta, Arianna, additional, Barlow, John M., additional, Barr, Justin, additional, Barreto, Juan Camilo, additional, Barry, Linda, additional, Beal, Eliza W., additional, Beard, Kristin Wilson, additional, Beck, David E., additional, Behrns, Kevin E., additional, Bellevue, Oliver C., additional, Bellorin-Marin, Omar E., additional, Bergman, Jacques, additional, Berry, James, additional, Besselink, Marc G.H., additional, Bharucha, Adil E., additional, Bilchik, Anton J., additional, Bildzukewicz, Nikolai A., additional, Bingham, Jason, additional, Birnbaum, Elisa, additional, Black, Sylvester M., additional, Blackmon, Shanda H., additional, Bleier, Joshua I.S., additional, Bodzin, Adam S., additional, Boland, C. Richard, additional, Bolton, John, additional, Bolton, Nathan, additional, Bonavina, Luigi, additional, Bonds, Morgan, additional, Bouwense, Stefan A.W., additional, Boys, Joshua A., additional, Bravo-Infante, Raquel, additional, Bremner, Ross M., additional, Brenner, Bruce M., additional, Brown, Shaun R., additional, Callery, Mark P., additional, Cameron, John L., additional, Camilleri, Michael, additional, Campbell, Jacob, additional, Cassim, Riaz, additional, Castillo-Angeles, Manuel, additional, Cauley, Christy, additional, Cavaness, Keith M., additional, Cerfolio, Robert J., additional, Champagne, Bradley J., additional, Chandrasoma, Parakrama, additional, Chang, Alex L., additional, Chapman, Christopher G., additional, Chapman, William C., additional, Cheek, Susannah, additional, Chen, Harvey S., additional, Cho, Clifford S., additional, Choi, Eric T., additional, Choi, Eugene A., additional, Chojnacki, Karen A., additional, Choti, Michael A., additional, Christie, Ian, additional, Chua, Heidi, additional, Church, James M., additional, Cioffi, Jessica L., additional, Clark, Susannah, additional, Clavien, Pierre-Alain, additional, Cloud, Adam, additional, Colavita, Paul D., additional, Colquhoun, Steven D., additional, Conway, William, additional, Cools-Lartigue, Jonathan, additional, Coosemans, Willy, additional, Cornwell, Edward E., additional, Costantini, Mario, additional, Coyle, Yvonne, additional, Craig, Daniel A., additional, Croome, Kristopher P., additional, Cullen, Joseph J., additional, D'Andrea, Anthony P., additional, Dassopoulos, Themistocles, additional, Davila, Marta L., additional, Davila, Raquel E., additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Dempsey, Daniel T., additional, dePrisco, Gregory, additional, Depypere, Lieven, additional, Dietz, David W., additional, Dillhoff, Mary E., additional, DiNorcia, Joseph, additional, Doane, Stephen M., additional, Dogeas, Epameinondas, additional, Dozois, Eric J., additional, Dumon, Kristoffel, additional, Dunn, Stephen P., additional, Dunst, Christy M., additional, Dussel, John N., additional, Dyer, Matthew, additional, Efron, Jonathan, additional, El-Gohary, Yousef, additional, Lakis, Mustapha El, additional, Ellison, E. Christopher, additional, Ellsmere, James, additional, Essani, Rahila, additional, Evans, Douglas B., additional, Fang, Sandy H., additional, Fasen, Geoffrey, additional, Fernando, Hiran C., additional, Ferri, Lorenzo, additional, Fichera, Alessandro, additional, Finck, Christine, additional, Fisher, Oliver M., additional, Fleshman, James W., additional, Fong, Yuman, additional, Foreman, Michael L., additional, Francone, Todd D., additional, Franko, Edward R., additional, French, Daniel, additional, Fuchs, Hans Friedrich, additional, Fuchs, Karl Hermann, additional, Funaki, Brian, additional, Funk, Geoffrey A., additional, Fusco, Joseph, additional, Gaitonde, Shrawan G., additional, Gajjar, Aakash H., additional, Garcia-Aguilar, Julio, additional, Gearhart, Susan, additional, Geller, David A., additional, Ghobadi, Comeron, additional, Gilbert, Sebastien, additional, Giles, David, additional, Gillaspie, Erin, additional, Girotti, Micah, additional, Gittes, George K., additional, Goodman, Michael D., additional, Gooszen, Hein G., additional, Gores, Gregory J., additional, Griffin, James F., additional, Griffin, S. Michael, additional, Grimm, Leander, additional, Grochola, L.F., additional, Habib, Fahim, additional, Hanks, John B., additional, Harris, James E., additional, Hartwig, Matthew G., additional, Hassan, Imran, additional, Hedrick, Traci L., additional, Hicks, Terry C., additional, Hodin, Richard, additional, Hofstetter, Wayne L., additional, Hogg, Melissa, additional, Hu, Yue-Yung, additional, Hungness, Eric S., additional, Hunt, Steven R., additional, Huseynova, Khumara, additional, Hyman, Neil H., additional, Iannitti, David A., additional, Indes, Jeffrey, additional, Jenkins, Megan, additional, Jensen, Todd, additional, Jeziorczak, Paul M., additional, Jilani, Danial, additional, Jiménez-Toscano, Marta, additional, Jobe, Blair A., additional, Johnston, Lily E., additional, Kahrilas, Peter J., additional, Kalady, Matthew F., additional, Kassira, Noor, additional, Katkhouda, Namir, additional, Katz, Philip O., additional, Keller, Deborah S., additional, Kelley, Matthew P., additional, Kennedy, Gregory D., additional, Kent, Tara Sotsky, additional, Kia, Leila, additional, Kibbe, Melina R., additional, Kim, John, additional, King, Alice, additional, Kiran, Ravi P., additional, Kirton, Orlando C., additional, Klein, Andrew, additional, Klein, Eric N., additional, Kohn, Geoffrey P., additional, Kovell, Robert Caleb, additional, Kozol, Robert, additional, Lacy, Antonio M., additional, Ladner, Daniela P., additional, Lagarde, S.M., additional, Laituri, Carrie A., additional, Landmann, Alessandra, additional, Lee, Janet T., additional, Lee, Lawrence L., additional, Leinicke, Jennifer A., additional, Lerut, Toni, additional, Levi, David M., additional, Li, Chao, additional, Liang, Yu, additional, Lichliter, Andrew H., additional, Lichliter, Warren E., additional, Lightner, Amy L., additional, Lile, Deacon J., additional, Lillemoe, Keith D., additional, Lin, Jules, additional, Lin, Shu S., additional, Lipham, John C., additional, Litle, Virginia R., additional, Lodhia, Nayna A., additional, Longo, Walter E., additional, Lord, Reginald V.N., additional, Louie, Brian E., additional, Low, Donald E., additional, Lowe, Val J., additional, Luc, Jessica G.Y., additional, Luketich, James D., additional, Ma, Yanling, additional, MacCarty, Robert L., additional, MacDonald, Blair, additional, Madoff, Robert D., additional, Magge, Deepa, additional, Maheshwari, Anurag, additional, Mahmoud, Najjia N., additional, Mahvi, David A., additional, Mahvi, David M., additional, Mak, Grace Z., additional, Mansfield, Sara A., additional, Manzano, Maricarmen, additional, Maron, David J., additional, Mathew, Melvy S., additional, Mathis, Kellie L., additional, Matthews, Jeffrey B., additional, McFadden, David W., additional, Merchea, Amit, additional, Messaris, Evangelos, additional, Miller, Daniel L., additional, Miller, Heidi J., additional, Millis, J. Michael, additional, Mittal, Sumeet K., additional, Molena, Daniela, additional, Montgomery, Stephanie C., additional, Moore, Ryan, additional, Morgan, Katherine A., additional, Mortenson, Melinda M., additional, Mulholland, Michael W., additional, Mulvihill, Michael S., additional, Mutch, Matthew, additional, Nafteux, Philippe Robert, additional, Nagaraju, Arun, additional, Nagorney, David M., additional, Nathan, Hari, additional, Natoli, Karen R., additional, Navuluri, Rakesh, additional, Nissen, Nicholas N., additional, Nobel, Tamar B., additional, Noordman, B.J., additional, Norton, Jeffrey A., additional, Novitsky, Yuri W., additional, Nussbaum, Michael S., additional, Nyberg, Scott L., additional, Oelschlager, Brant K., additional, Oh, Daniel S., additional, Otero-Piñeiro, Ana, additional, Oto, Aytekin, additional, Pachter, H. Leon, additional, Paidas, Charles N., additional, Palazzo, Francesco, additional, Paniccia, Alessandro, additional, Papaconstantinou, Harry T., additional, Pappas, Theodore N., additional, Pappou, Emmanouil P., additional, Parikh, Manish, additional, Paruch, Jennifer L., additional, Patel, Asish D., additional, Patel, Mikin, additional, Patti, Marco G., additional, Paulson, Emily Carter, additional, Pawlik, Timothy M., additional, Payne, Isaac, additional, Pemberton, John H., additional, Pendola, Michael, additional, Perez, Alexander, additional, Pernar, Luise I.M., additional, Peters, Walter R., additional, Petrowsky, Henrik, additional, Peyre, Christian G., additional, Phillips, Alexander W., additional, Pillai, Lashmikumar, additional, Plummer, Joseph M., additional, Pointer, David T., additional, Poruk, Katherine E., additional, Posner, Mitchell C., additional, Postier, Russell, additional, Prachand, Vivek N., additional, Pritts, Timothy A., additional, Quatrino, Gregory, additional, Ranka, Sagar, additional, Rattner, David W., additional, Reavis, Kevin M., additional, Reddy, Vikram B., additional, Remzi, Feza H., additional, Ricciardi, Rocco, additional, Rice, Thomas W., additional, Richman, Aaron, additional, Rider, Paul, additional, Roberts, John Paul, additional, Roberts, Patricia L., additional, Roggin, Kevin K., additional, Roll, Garrett Richard, additional, Rona, Kais, additional, Rosen, Charles B., additional, Ross, Samuel Wade, additional, Roth, J. Scott, additional, Rushing, Amy P., additional, Safar, Bashar, additional, Saldinger, Pierre F., additional, Samakar, Kamran, additional, Sandhu, Kulmeet K., additional, Schaheen, Lara W., additional, Schirmer, Bruce, additional, Schneider, Andrew, additional, Schulick, Richard D., additional, Schwab, Ben, additional, Scurci, Stephanie, additional, Senagore, Anthony, additional, Shah, Adil A., additional, Shah, Shimul A., additional, Shames, Brian, additional, Shanmugan, Skandan, additional, Shapiro, David S., additional, Silviera, Matthew, additional, Slakey, Douglas P., additional, Sloan, Joshua, additional, Smallwood, Nathan, additional, Smith, Shane P., additional, Smithers, B. Mark, additional, Smoot, Rory L., additional, Soares, Kevin C., additional, Soffer, Edy, additional, Solomina, Julia, additional, Soper, Nathaniel J., additional, Spechler, Stuart Jon, additional, Sridhar, Praveen, additional, Steele, Scott R., additional, Sternbach, Joel M., additional, Stevenson, Christina E., additional, Strong, Scott A., additional, Sucandy, Iswanto, additional, Sundaram, Magesh, additional, Sundaresan, Sudhir, additional, Swanstrom, Lee L., additional, Sylla, Patricia, additional, Takada, Tadahiro, additional, Talbot, Ethan, additional, Tam, Vernissia, additional, Tamm, Eric P., additional, Tatarian, Talar, additional, Tavakkoli, Ali, additional, Te, Helen S., additional, Teitelbaum, Ezra N., additional, Ternent, Charles A., additional, Thompson, Jon S., additional, Thomson, Iain, additional, Thorson, Alan G., additional, Thorson, Chad M., additional, Totten, Crystal F., additional, Truty, Mark J., additional, Tsai, Susan, additional, Tseng, Jennifer, additional, Tullius, Tom, additional, Tzakis, Andreas G., additional, van Lanschot, J.J.B., additional, van Santvoort, Hjalmar C., additional, Van Veer, Hans, additional, Vega, Jorge A., additional, Velanovich, Vic, additional, Vogler, Sarah A., additional, Wang, Huamin, additional, Ward, Mark A., additional, Warner, Brad W., additional, Warner, Susanne G., additional, Watson, Thomas J., additional, Waxman, Irving, additional, Webster-Lake, Carissa, additional, Wei, Benjamin, additional, Weiser, Martin R., additional, Wells, Dennis, additional, Wells, Katerina, additional, Welton, Mark Lane, additional, Wen, Yuxiang, additional, Wendling, Mark R., additional, Wesson, Hadley K.H., additional, Wexner, Steven D., additional, White, Rebekah R., additional, Whitlow, Charles B., additional, Wijnhoven, B.P.L., additional, Wilkes, Justin, additional, Wilson, Rickesha L., additional, Witkowski, Piotr, additional, Wolfgang, Christopher L., additional, Worrell, Stephanie G., additional, Yang, Jian, additional, Yeo, Charles J., additional, Yeung, Ching, additional, Yung, Evan E., additional, Zafar, Syed Nabeel, additional, Zaninotto, Giovanni, additional, Zeh, Herbert, additional, Zehetner, Joerg, additional, Zenilman, Michael E., additional, Zimmerman, Pamela, additional, and Zuccaro, Gregory, additional

Published
2019
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12. Acute Pancreatitis

Author

Bouwense, Stefan A.W., primary, Gooszen, Hein G., additional, van Santvoort, Hjalmar C., additional, and Besselink, Marc G.H., additional

Published
2019
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14. Risk of Recurrent Pancreatitis and Progression to Chronic Pancreatitis After a First Episode of Acute Pancreatitis

Author

Ahmed Ali, Usama, Issa, Yama, Hagenaars, Julia C., Bakker, Olaf J., van Goor, Harry, Nieuwenhuijs, Vincent B., Bollen, Thomas L., van Ramshorst, Bert, Witteman, Ben J., Brink, Menno A., Schaapherder, Alexander F., Dejong, Cornelis H., Spanier, B.W. Marcel, Heisterkamp, Joos, van der Harst, Erwin, van Eijck, Casper H., Besselink, Marc G., Gooszen, Hein G., van Santvoort, Hjalmar C., and Boermeester, Marja A.

Published
2016
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15. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial

Author

da Costa, David W, Bouwense, Stefan A, Schepers, Nicolien J, Besselink, Marc G, van Santvoort, Hjalmar C, van Brunschot, Sandra, Bakker, Olaf J, Bollen, Thomas L, Dejong, Cornelis H, van Goor, Harry, Boermeester, Marja A, Bruno, Marco J, van Eijck, Casper H, Timmer, Robin, Weusten, Bas L, Consten, Esther C, Brink, Menno A, Spanier, B W Marcel, Bilgen, Ernst Jan Spillenaar, Nieuwenhuijs, Vincent B, Hofker, H Sijbrand, Rosman, Camiel, Voorburg, Annet M, Bosscha, Koop, van Duijvendijk, Peter, Gerritsen, Jos J, Heisterkamp, Joos, de Hingh, Ignace H, Witteman, Ben J, Kruyt, Philip M, Scheepers, Joris J, Molenaar, I Quintus, Schaapherder, Alexander F, Manusama, Eric R, van der Waaij, Laurens A, van Unen, Jacco, Dijkgraaf, Marcel G, van Ramshorst, Bert, Gooszen, Hein G, and Boerma, Djamila

Published
2015
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18. Registration of LCS ‘Valiant’ hard red winter wheat

Author

Baenziger, P. S., primary, Masterson, S. D., additional, Boehm, J. D., additional, Belamkar, V., additional, Barnett, M. D., additional, Rose, D. J., additional, Xu, L., additional, Wegulo, S. N., additional, Regassa, T., additional, Easterly, A. C., additional, Creech, C. F., additional, Santra, D. K., additional, Kruger, G. R., additional, Hergert, G. W., additional, Klein, R. N., additional, Jin, Y., additional, Kolmer, J., additional, Chen, M.‐S., additional, Hein, G. L., additional, Bowden, R. L., additional, Guttieri, M. J., additional, Bai, G., additional, Salah, I. El‐Basyoni, additional, and Poland, J., additional

Published
2022
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21. Severity score-based study of predictors and clinical correlates of Post-COVID Syndrome (PCS) in Germany

Author

Bahmer, T, primary, Borzikowsky, C, additional, Lieb, W, additional, Horn, A, additional, Krist, L, additional, Fricke, J, additional, Scheibenbogen, C, additional, Rabe, K F, additional, Maetzler, W, additional, Maetzler, C, additional, Laudien, M, additional, Frank, D, additional, Ballhausen, S, additional, Viebke, A, additional, Hermes, A, additional, Muljukov, O, additional, Haeusler, K G, additional, El Mokhtari, N E, additional, Witzenrath, M, additional, Zoller, T, additional, Vehreschild, J J, additional, Hopff, S, additional, Anton, G, additional, Krefting, D, additional, Reinke, L, additional, Hein, G, additional, Montellano, F A, additional, Kohls, M, additional, Morbach, C, additional, Störk, S, additional, Reese, J, additional, Keil, T, additional, Heuschmann, P, additional, Krawczak, M, additional, and Schreiber, S, additional

Published
2022
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24. Medikamentöse Therapie

Author

Bolten, W., Krüger, K., Kaiser, H., Keysser, M., Genth, E., Häntzschel, H., Ehlert, A., Wald, A., Kladny, B., Specker, C., Uhlemann, C., Gromnica-Ihle, E., Reinhold-Keller, E., Hein, G., Neeck, G., Michels, H., Nüsslein, H., Schwartz, H., Braun, J., Wollenhaupt, J., Ringe, J. D., Schneider, M., Schwartz-Eywill, M., Oelzner, O., Herzer, P., Keel, P., Dreher, R., Wassenberg, S., Wollina, U., Keitel, W., Rüther, W., Vorbrüggen, W., Zenz, M., Pantel, M., Keysser, G., Fischer-Betz, R., and Deutsche Gesellschaft für Rheumatologie e.V.

Published
2007
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27. Knochenerkrankungen

Author

Hein, G. E., Steinbeck, Gerhard, editor, Paumgartner, Gustav, editor, Brandt, T., editor, Göke, B., editor, Greten, N., editor, Hiddemann, W., editor, Lode, H., editor, Mann, K., editor, Riess, H., editor, Risler, T., editor, Schattenkirchner, M., editor, Seeger, W., editor, and Wehling, M., editor

Published
2005
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28. Development of a decision analytical framework to prioritise operating room capacity: lessons learnt from an empirical example on delayed elective surgeries during the COVID-19 pandemic in a hospital in the Netherlands

Author

Rovers, Maroeska M, primary, Wijn, Stan RW, additional, Grutters, Janneke PC, additional, Metsemakers, Sanne JJPM, additional, Vermeulen, Robin J, additional, van der Pennen, Ron, additional, Berden, Bart JJM, additional, Gooszen, Hein G, additional, Scholte, Mirre, additional, and Govers, Tim M, additional

Published
2022
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32. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Author

van Grinsven, Janneke, van Brunschot, Sandra, Bakker, Olaf J., Bollen, Thomas L., Boermeester, Marja A., Bruno, Marco J., Dejong, Cornelis H., Dijkgraaf, Marcel G., van Eijck, Casper H., Fockens, Paul, van Goor, Harry, Gooszen, Hein G., Horvath, Karen D., van Lienden, Krijn P., van Santvoort, Hjalmar C., Besselink, Marc G., Abdelhafez, M, Andersson, R, Andren-Sandberg, A, Ashley, S, van Baal, M, Baron, T, Bassi, C, Bradley, E, Buchler, M, Cappendijk, V, Carter, R, Charnley, R, Coelho, D, Connor, S, Dellinger, P, Dervenis, C, Deviere, J, Doctor, N, Dudeja, V, En-qiang, M, Escourrou, J, Fagenholz, P, Farkas, G, Forsmark, C, Freeman, M, Freeny, P, French, J, Friess, H, Gardner, T, Goetzinger, P, Haveman, J, Hofker, S, Imrie, C, Isaji, S, Isenmann, R, Klar, E, Laméris, J, Lerch, M, Lévy, P, Lillemoe, K, Löhr, M, Mayerle, J, Mayumi, T, Mittal, A, Moessner, J, Morgan, D, Mortele, K, Nealon, W, Neoptolemos, J, Nieuwenhuijs, V, Nordback, I, Olah, A, Oppong, K, Padbury, R, Papachristou, G, Parks, R, Poley, J, Radenkovic, D, Raraty, M, Rau, B, Rebours, V, Rische, S, Runzi, M, Sainani, N, Sarr, M, Schaapherder, S, Seewald, S, Seifert, H, Shimosegawa, T, Silverman, S, Singh, V, Siriwardena, A, Steinberg, W, Sutton, R, Takeda, K, Timmer, R, Vege, S, Voermans, R, de Waele, J, Wang, Ch, Warshaw, A, Werner, J, Weusten, B, Whitcomb, D, Wig, J, Windsor, J, and Zyromski, N

Published
2015
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35. Registration of LCS 'Valiant' hard red winter wheat.

Author

Baenziger, P. S., Masterson, S. D., Boehm, J. D., Belamkar, V., Barnett, M. D., Rose, D. J., Xu, L., Wegulo, S. N., Regassa, T., Easterly, A. C., Creech, C. F., Santra, D. K., Kruger, G. R., Hergert, G. W., Klein, R. N., Jin, Y., Kolmer, J., Chen, M.‐S., Hein, G. L., and Bowden, R. L.

Subjects
WINTER wheat, WHEAT, BREAD quality, PLANT selection, GRAIN yields, NATURAL immunity
Abstract

Historically cultivars developed jointly by the University of Nebraska‐Lincoln and USDA‐ARS wheat (Triticum aestivum L.) improvement project tend to be late and better adapted to the northern Great Plains. LCS 'Valiant' (Reg. no. CV‐1196, PI 693223; tested as NE10478‐1) was released based on the merits of its earliness, agronomic performance, relevant disease resistances, and end‐use quality characteristics and its adaptation to the central Great Plains. As such, the line was licensed to Limagrain Cereal Seeds for their ability to market outside of Nebraska. LCS Valiant hard red winter wheat was released in March 2020 by the developing institutions and the licensee. NE10478‐1 was a selection in 2011 for uniformity and grain yield from NE10478, which was derived from the cross NI03418/'Camelot'. The pedigree of NI03418 is W91‐248/NE95544 (=McVey 78015/NE88521)//'Thunderbird'. The final cross of NE10478 was made in 2004. The F1 generation was grown in Yuma, AZ, in 2005, and the F2 to F3 generations were advanced as bulks at Mead, NE, in 2006–2007 or sent for Hessian fly resistance screening by the USDA. In 2007, single F3‐derived F4 rows were planted for selection. There was no further selection in NE10478 other than to remove off‐types thereafter until 2011 when heads were selected to increase uniformity. LCS Valiant was evaluated in replicated trials thereafter. It has excellent winter survival, acceptable reactions to many of the common diseases in its target area, and good end‐use quality for bread making. Core Ideas: Valiant is an early hard red winter wheat adapted to the central Great Plains for dryland production. Valiant has excellent winter survival and stem rust resistance and good Hessian fly resistance. The end‐use quality for bread making of Valiant is very good. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Die beeinträchtigte psychische Gesundheit von medizinischem Personal in einer deutschen anästhesiologischen Klinik ist unabhängig von unmittelbarer SARS-CoV-2-Exposition - eine Längsschnitt-Beobachtungsstudie

Author

Schmid, B, Schulz, SM, Schuler, M, Göpfert, D, Hein, G, Heuschmann, P, Wurmb, T, Pauli, P, Meybohm, P, and Rittner, HL

Subjects
critical care, medizinisches Personal, ddc: 610, healthcare workers, Intensivmedizin, psychische Gesundheit, COVID-19, anesthesia, mental health, Anästhesie
Abstract

Background: The study aimed to assess the mental well-being of healthcare professionals at a German department of anesthesiology and critical care with a specialized ICU for treatment of COVID-19 patients during the first two peaks of the 2020 pandemic, and identifying risk and protective factors.Methods: A single-center longitudinal, online-based survey was conducted in healthcare workers from a department of anesthesiology and critical care in Bavaria, the most affected federal state in Germany at the time of assessment. Validated scores for depression, anxiety, somatic disorders, burnout, resilience, and self-management were used and complemented by questions about perceived COVID-19-related stressors. In parallel, patient characteristics in the ICU were collected.Results: 24 and 23 critically ill COVID-19 patients were treated during both observation periods in April/May and November/December 2020, respectively. 87.5% and 78.2% of patients had moderate to severe acute respiratory distress syndrome. From March 6, 2020 onwards, the hospital had switched to a command and control-based hospital incident command system (HICS) and increased work forces. Point prevalence of depression-like symptoms (13.6% and 12.8%) and burnout (21.6% and 17.4%) in the department's healthcare professionals was high. Exposure to SARS-CoV-2 did not increase psychological burden. Consequences of the lockdown were rated as highly distressing by a majority of all ICU personnel. High self-reported trait resilience was protective against signs of depression, generalized anxiety, and burnout.Conclusions: During the pandemic, healthcare professionals have been suffering from increased psychological distress compared to reference data for both the general population and ICU personnel. General effects of the lockdown appear more relevant than actual COVID-19 patient contact. High trait resilience has a protective effect, yet vulnerable individuals may require specific support. Prevention against potential after effects of the lockdown, and in particular measures allowing to avoid another lockdown, appear warranted. Hintergrund: Die Studie hatte zum Ziel, die psychische Gesundheit der anästhesiologischen Mitarbeiterinnen und Mitarbeiter einer Universitätsklinik mit einer auf COVID-19 spezialisierten Intensivstation während der ersten beiden Wellen der Pandemie im Frühjahr und Herbst 2020 zu untersuchen und sowohl Risikofaktoren als auch protektive Faktoren zu identifizieren.Methoden: Es wurde eine monozentrische, Web-basierte Umfrage unter medizinischen Angestellten der Klinik für Anästhesiologie, Universitätsklinikum Würzburg, durchgeführt. Hierzu wurden validierte Tests zu den Domänen Depressivität, Ängstlichkeit, somatoforme Störungen, Burnout, Resilienz und Selbstmanagement verwendet und des Weiteren offene Fragen zu subjektiv belastenden, COVID-19-assoziierten Faktoren gestellt. Zusätzlich wurden Charakteristika der in den Umfragezeiträumen behandelten Patientinnen und Patienten sowie Informationen zum Krankenhausmanagement während der Pandemie erfasst.Ergebnisse: In den beiden Erhebungszeiträumen wurden 24 bzw. 23 kritisch kranke COVID-19-Patientinnen und -Patienten behandelt. 87.5% bzw. 78.2% der Patientinnen und Patienten litten an einer moderaten bis schweren Form des adulten akuten Lungenversagens. Ab dem 6. März 2020 implementierte die Klinik eine streng hierarchische Notfall-Einsatzleitung, um tagesaktuell auf die Dynamik der Pandemie reagieren zu können, und die personellen Ressourcen wurden erhöht. Punktprävalenzen von Depressivität (13,6% und 12.8%) und Burnout (21,3% und 17.4%) bei den Studienteilnehmerinnen und -teilnehmern waren hoch. Die unmittelbare psychische Belastung war unabhängig von einer Exposition gegenüber SARS-CoV-2. Die Auswirkungen der Ausgangsbeschränkungen wurden von einer Mehrheit der Untersuchten als stark beeinträchtigend beschrieben. Hohe Resilienz schien protektiv zu wirken gegen Anzeichen von Depressivität, generalisierter Angst und Burnout.Schlussfolgerungen: Im Verlauf der ersten Monate der Pandemie litt das medizinische Personal unter erhöhter psychischer Belastung verglichen mit früheren Vergleichsdaten sowohl der Allgemeinbevölkerung als auch von Personal auf Intensivstationen. Die allgemeinen Auswirkungen der Ausgangsbeschränkungen schienen hierbei einen größeren Einfluss gehabt zu haben als der tatsächliche Kontakt mit COVID-19-Patientinnen und -Patienten. Ausgeprägte Resilienz hatte einen positiven Effekt. Allerdings könnten anfällige Mitarbeiterinnen und Mitarbeiter unter Umständen gezielte Unterstützung benötigen. Zudem sind vorbeugende Maßnahmen gegen mögliche Nachwirkungen der Pandemie-Beschränkungen sowie alle Maßnahmen, die geeignet erscheinen, einen weiteren Lockdown zu verhindern, sinnvoll.

Published
2021

46. Predicting a 'difficult cholecystectomy' after mild gallstone pancreatitis

Author

Robbert A. Hollemans, Stefan A.W. Bouwense, Hjalmar C. van Santvoort, Sijbrand Hofker, Marc G. Besselink, Hein G. Gooszen, Djamila Boerma, David W da Costa, Thomas L. Bollen, Nicolien J. Schepers, Harry van Goor, Esther C. J. Consten, Gastroenterology & Hepatology, ​Robotics and image-guided minimally-invasive surgery (ROBOTICS), Surgery, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, and CCA - Cancer Treatment and Quality of Life

Subjects
Male, Time Factors, SURGERY, medicine.medical_treatment, Gallstones, 030230 surgery, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Cholangiography, Postoperative Complications, Randomized controlled trial, law, Risk Factors, Medicine, BILE-DUCT INJURIES, LAPAROSCOPIC CHOLECYSTECTOMY, DELAYED-CHOLECYSTECTOMY, Prospective Studies, Prospective cohort study, Vas score, Netherlands, medicine.diagnostic_test, Gastroenterology, Middle Aged, TIME, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Treatment Outcome, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, CHOLANGIOGRAPHY, Visual analogue scale, Operative Time, Risk Assessment, Time-to-Treatment, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Sex Factors, Humans, Cholecystectomy, Aged, Hepatology, business.industry, ACUTE CHOLECYSTITIS, medicine.disease, Confidence interval, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], CONVERSION, Pancreatitis, BILIARY PANCREATITIS, EXPERIENCE, business
Abstract

Background: Cholecystectomy after gallstone pancreatitis may be technically demanding. The aim of this study was to investigate risk factors for a difficult cholecystectomy after mild pancreatitis.Methods: This was a prospective study within a randomized controlled trial on the timing of cholecystectomy after mild gallstone pancreatitis. Difficulty of cholecystectomy was scored on a 0 to 10 visual analogue scale (VAS) by the senior attending surgeon. The primary outcome 'difficult cholecystectomy' was defined by presence of one or more of the following features: a VAS score >= 8, duration of surgery > 75 minutes, conversion or subtotal cholecystectomy.Results: 249 patients were included in the primary analysis. A difficult cholecystectomy occurred in 82 patients (33%). In the 'same-admission cholecystectomy' group 29 of 112 cholecystectomies were difficult (26%) versus 49 of 127 patients (39%) who underwent surgery after 2 weeks (p = 0.037). After multivariable analysis, male sex (OR 1.80, 95% confidence interval [CI] 1.04-3.13; p = 0.037), prior sphincterotomy (OR 1.79, 95% CI 1.01-3.16; p = 0.046), and delaying cholecystectomy for at least two weeks (OR 1.81, 95% CI 1.04-3.16; p = 0.036) were independent predictors of a difficult cholecystectomy.Conclusion: Surgeons should anticipate a difficult cholecystectomy after mild gallstone pancreatitis in case of male sex, prior sphincterotomy and delayed cholecystectomy.

Published
2019

47. Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis

Author

Olaf J. Bakker, Marc G. Besselink, Nicolien J. Schepers, Marco J. Bruno, Hein G. Gooszen, Thomas L. Bollen, Hjalmar C. van Santvoort, Usama Ahmed Ali, Gastroenterology & Hepatology, Surgery, AGEM - Re-generation and cancer of the digestive system, AGEM - Digestive immunity, and Graduate School

Subjects
0301 basic medicine, medicine.medical_specialty, business.industry, Gastroenterology, Necrotising pancreatitis, medicine.disease, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Post-hoc analysis, medicine, Acute pancreatitis, Pancreatitis, 030211 gastroenterology & hepatology, Infected necrosis, In patient, Respiratory system, Pancreas, business
Abstract

ObjectiveIn patients with pancreatitis, early persisting organ failure is believed to be the most important cause of mortality. This study investigates the relation between the timing (onset and duration) of organ failure and mortality and its association with infected pancreatic necrosis in patients with necrotising pancreatitis.DesignWe performed a post hoc analysis of a prospective database of 639 patients with necrotising pancreatitis from 21 hospitals. We evaluated the onset, duration and type of organ failure (ie, respiratory, cardiovascular and renal failure) and its association with mortality and infected pancreatic necrosis.ResultsIn total, 240 of 639 (38%) patients with necrotising pancreatitis developed organ failure. Persistent organ failure (ie, any type or combination) started in the first week in 51% of patients with 42% mortality, in 13% during the second week with 46% mortality and in 36% after the second week with 29% mortality. Mortality in patients with persistent multiple organ failure lasting ConclusionIn patients with necrotising pancreatitis, early persistent organ failure is not associated with increased mortality when compared with persistent organ failure which develops further on during the disease course. Furthermore, no association was found between the duration of organ failure and mortality.

Published
2019

48. Superiority of Step-up Approach vs Open Necrosectomy in Long-term Follow-up of Patients With Necrotizing Pancreatitis

Author

Cornelis H. C. Dejong, Joos Heisterkamp, Erik Buskens, Philip M Kruyt, Maarten S. van Leeuwen, Robbert A. Hollemans, Marja A. Boermeester, Ralph J. de Wit, Camiel Rosman, Wilhelmina M U van Grevenstein, Sijbrand Hofker, Eric R. Manusama, I. Quintus Molenaar, Vincent B. Nieuwenhuijs, Daphne Roos, George P. van der Schelling, Marco J. Bruno, Marc G. Besselink, Koop Bosscha, Peter van Duijvendijk, Johan S. Laméris, Cornelis J. H. M. van Laarhoven, Robert C. Verdonk, Thomas L. Bollen, Paul Fockens, Olaf J. Bakker, Hein G. Gooszen, Harry van Goor, Alexander P. Houdijk, Alexander F. Schaapherder, Erwin van der Harst, Hjalmar C. van Santvoort, Robin Timmer, Tom M. Karsten, Casper H.J. van Eijck, Eric J. Hesselink, Bert van Ramshorst, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Value, Affordability and Sustainability (VALUE), Methods in Medicines evaluation & Outcomes research (M2O), Gastroenterology & Hepatology, APH - Methodology, AII - Infectious diseases, AGEM - Digestive immunity, Gastroenterology and Hepatology, and AGEM - Re-generation and cancer of the digestive system

Subjects
0301 basic medicine, Time Factors, GUIDELINES, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Quality of life, Randomized controlled trial, Interquartile range, law, Recurrence, QUALITY-OF-LIFE, Minimally Invasive, Clinical endpoint, Digestive System Surgical Procedures, Pancreatic Surgery, Pain, Postoperative, Pancreatitis, Acute Necrotizing, NECROSIS, Gastroenterology, Health Care Costs, Progression-Free Survival, Survival Rate, FECAL ELASTASE-1, Drainage, 030211 gastroenterology & hepatology, Reoperation, medicine.medical_specialty, SF-36, CLASSIFICATION, Infected Necrosis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, EQ-5D, Internal medicine, medicine, Journal Article, MANAGEMENT, Humans, Incisional Hernia, Pancreas, Hepatology, business.industry, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], 030104 developmental biology, STATES, Quality of Life, Pancreatitis, Exocrine Pancreatic Insufficiency, business, SF-36 HEALTH SURVEY, Follow-Up Studies
Abstract

BACKGROUND & AIMS: In a 2010 randomized trial (the PANTER trial), a surgical step-up approach for infected necrotizing pancreatitis was found to reduce the composite endpoint of death or major complications compared with open necrosectomy; 35% of patients were successfully treated with simple catheter drainage only. There is concern, however, that minimally invasive treatment increases the need for reinterventions for residual peripancreatic necrotic collections and other complications during the long term. We therefore performed a long-term follow-up study. METHODS: We reevaluated all the 73 patients (of the 88 patients randomly assigned to groups) who were still alive after the index admission, at a mean 86 months (+/- 11 months) of follow-up. We collected data on all clinical and health care resource utilization endpoints through this follow-up period. The primary endpoint was death or major complications (the same as for the PANTER trial). We also measured exocrine insufficiency, quality of life (using the Short Form-36 and EuroQol 5 dimensions forms), and Izbicki pain scores. RESULTS: From index admission to long-term follow-up, 19 patients (44%) died or had major complications in the step-up group compared with 33 patients (73%) in the open-necrosectomy group (P = .005). Significantly lower proportions of patients in the step-up group had incisional hernias (23% vs 53%; P = .004), pancreatic exocrine insufficiency (29% vs 56%; P = .03), or endocrine insufficiency (40% vs 64%; P = .05). There were no significant differences between groups in proportions of patients requiring additional drainage procedures (11% vs 13%; P = .99) or pancreatic surgery (11% vs 5%; P = .43), or in recurrent acute pancreatitis, chronic pancreatitis, Izbicki pain scores, or medical costs. Quality of life increased during follow-up without a significant difference between groups. CONCLUSIONS: In an analysis of long-term outcomes of trial participants, we found the step-up approach for necrotizing pancreatitis to be superior to open necrosectomy, without increased risk of reinterventions.

Published
2019

50. Impact of global Fxr deficiency on experimental acute pancreatitis and genetic variation in the FXR locus in human acute pancreatitis.

Author

Rian M Nijmeijer, Frank G Schaap, Alexander J J Smits, Andreas E Kremer, Louis M A Akkermans, Alfons B A Kroese, Ger T Rijkers, Marguerite E I Schipper, André Verheem, Cisca Wijmenga, Hein G Gooszen, and Karel J van Erpecum

Subjects
Medicine, Science
Abstract

BackgroundInfectious complications often occur in acute pancreatitis, related to impaired intestinal barrier function, with prolonged disease course and even mortality as a result. The bile salt nuclear receptor farnesoid X receptor (FXR), which is expressed in the ileum, liver and other organs including the pancreas, exhibits anti-inflammatory effects by inhibiting NF-κB activation and is implicated in maintaining intestinal barrier integrity and preventing bacterial overgrowth and translocation. Here we explore, with the aid of complementary animal and human experiments, the potential role of FXR in acute pancreatitis.MethodsExperimental acute pancreatitis was induced using the CCK-analogue cerulein in wild-type and Fxr-/- mice. Severity of acute pancreatitis was assessed using histology and a semi-quantitative scoring system. Ileal permeability was analyzed in vitro by Ussing chambers and an in vivo permeability assay. Gene expression of Fxr and Fxr target genes was studied by quantitative RT-PCR. Serum FGF19 levels were determined by ELISA in acute pancreatitis patients and healthy volunteers. A genetic association study in 387 acute pancreatitis patients and 853 controls was performed using 9 tagging single nucleotide polymorphisms (SNPs) covering the complete FXR gene and two additional functional SNPs.ResultsIn wild-type mice with acute pancreatitis, ileal transepithelial resistance was reduced and ileal mRNA expression of Fxr target genes Fgf15, SHP, and IBABP was decreased. Nevertheless, Fxr-/- mice did not exhibit a more severe acute pancreatitis than wild-type mice. In patients with acute pancreatitis, FGF19 levels were lower than in controls. However, there were no associations of FXR SNPs or haplotypes with susceptibility to acute pancreatitis, or its course, outcome or etiology.ConclusionWe found no evidence for a major role of FXR in acute human or murine pancreatitis. The observed altered Fxr activity during the course of disease may be a secondary phenomenon.

Published
2014
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