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19 results on '"Hedberg, Mikael"'

2. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Author

Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, van Erp, Theo G.M., Walton, Esther, Hibar, Derrek P., Schmaal, Lianne, Jiang, Wenhao, Glahn, David C., Pearlson, Godfrey D., Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Yamamori, Hidenaga, Bustillo, Juan R., Clark, Vincent P., Mueller, Bryon A., Cahn, Wiepke, de Zwarte, Sonja M.C., Hulshoff Pol, Hilleke E., Kahn, René S., Ophoff, Roel A., van Haren, Neeltje E.M., Andreassen, Ole A., Dale, Anders M., Doan, Nhat Trung, Gurholt, Tiril P., Hartberg, Cecilie B., Haukvik, Unn K., Jørgensen, Kjetil N., Lagerberg, Trine V., Melle, Ingrid, Westlye, Lars T., Gruber, Oliver, Kraemer, Bernd, Richter, Anja, Zilles, David, Calhoun, Vince D., Crespo-Facorro, Benedicto, Roiz-Santiañez, Roberto, Tordesillas-Gutiérrez, Diana, Loughland, Carmel, Carr, Vaughan J., Catts, Stanley, Cropley, Vanessa L., Fullerton, Janice M., Green, Melissa J., Henskens, Frans A., Jablensky, Assen, Lenroot, Rhoshel K., Mowry, Bryan J., Michie, Patricia T., Pantelis, Christos, Quidé, Yann, Schall, Ulrich, Scott, Rodney J., Cairns, Murray J., Seal, Marc, Tooney, Paul A., Rasser, Paul E., Cooper, Gavin, Shannon Weickert, Cynthia, Weickert, Thomas W., Morris, Derek W., Hong, Elliot, Kochunov, Peter, Beard, Lauren M., Gur, Raquel E., Gur, Ruben C., Satterthwaite, Theodore D., Wolf, Daniel H., Belger, Aysenil, Brown, Gregory G., Ford, Judith M., Macciardi, Fabio, Mathalon, Daniel H., O’Leary, Daniel S., Potkin, Steven G., Preda, Adrian, Voyvodic, James, Lim, Kelvin O., McEwen, Sarah, Yang, Fude, Tan, Yunlong, Tan, Shuping, Wang, Zhiren, Fan, Fengmei, Chen, Jingxu, Xiang, Hong, Tang, Shiyou, Guo, Hua, Wan, Ping, Wei, Dong, Bockholt, Henry J., Ehrlich, Stefan, Wolthusen, Rick P.F., King, Margaret D., Shoemaker, Jody M., Sponheim, Scott R., De Haan, Lieuwe, Koenders, Laura, Machielsen, Marise W., van Amelsvoort, Therese, Veltman, Dick J., Assogna, Francesca, Banaj, Nerisa, de Rossi, Pietro, Iorio, Mariangela, Piras, Fabrizio, Spalletta, Gianfranco, McKenna, Peter J., Pomarol-Clotet, Edith, Salvador, Raymond, Corvin, Aiden, Donohoe, Gary, Kelly, Sinead, Whelan, Christopher D., Dickie, Erin W., Rotenberg, David, Voineskos, Aristotle N., Ciufolini, Simone, Radua, Joaquim, Dazzan, Paola, Murray, Robin, Reis Marques, Tiago, Simmons, Andrew, Borgwardt, Stefan, Egloff, Laura, Harrisberger, Fabienne, Riecher-Rössler, Anita, Smieskova, Renata, Alpert, Kathryn I., Wang, Lei, Jönsson, Erik G., Koops, Sanne, Sommer, Iris E.C., Bertolino, Alessandro, Bonvino, Aurora, Di Giorgio, Annabella, Neilson, Emma, Mayer, Andrew R., Stephen, Julia M., Kwon, Jun Soo, Yun, Je-Yeon, Cannon, Dara M., McDonald, Colm, Lebedeva, Irina, Tomyshev, Alexander S., Akhadov, Tolibjohn, Kaleda, Vasily, Busatto, Geraldo F., Rosa, Pedro G.P., Serpa, Mauricio H., Zanetti, Marcus V., Hoschl, Cyril, Skoch, Antonin, Spaniel, Filip, Tomecek, David, Hagenaars, Saskia P., McIntosh, Andrew M., Whalley, Heather C., Lawrie, Stephen M., Knöchel, Christian, Oertel-Knöchel, Viola, Stäblein, Michael, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Uhlmann, Anne, Lopez-Jaramillo, Carlos, Dima, Danai, McMahon, Agnes, Faskowitz, Joshua I., Gutman, Boris A., Jahanshad, Neda, Thompson, Paul M., and Turner, Jessica A.

Published
2018
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3. Experimental and computational evaluations of parallel spillway outlets

Author

Hedberg, Mikael and Hedberg, Mikael

Abstract

Experiments and computational simulations have been performed as part of a larger project to instil trust in computational methods for design of hydraulics flows in spillways. Presented in this licenciate is one manuscript and two conference papers. The first conference paper details experiments done at Älvkarleby of a multiple outlet spillway model with an inlet channel specifically designed to contain interesting hydraulic features. The results indicate that simulations agree well with experiments. In the second conference paper acoustic doppler velocimetry measurements (ADV) were done and compared to simulations of a racetrack flume with a fish passageway at Älvkarleby. The results showed agreement but due to inlet conditions of the experiment some discrepancies were noticed. The manuscript presents experiments of a wider range of flow in the experimental flume of the first conference paper, with additional ADV measurements. Preliminary conclusions are that discrepancies can be due to inlet conditions. A short summary of further work is included.

Published
2023

4. Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research

Author

Kong, Xiang-Zhen, Francks, Clyde, Allen, Nicholas B., Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Howells, Fleur M., Ames, David, Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G, Kaleda, Vasily, Kelly, Clare, Andreassen, Ole A., Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Vasquez, Alejandro Arias, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Liu, Jia, Armstrong, Nicola J., Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Malpas, Charles B., Asherson, Phil, Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Maniega, Susana Muñoz, Bergo, Felipe, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Nerland, Stener, Bastin, Mark E., Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Orr, Catherine, Batalla, Albert, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Radua, Joaquim, Bauer, Jochen, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Schmaal, Lianne, Baune, Bernhard T, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Sinha, Rajita, Baur-Streubel, Ramona, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Strike, Lachlan T., Biederman, Joseph, Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Erp, Theo G. M., Blaine, Sara K., Heuvel, Odile A., Meer, Dennis, Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Boedhoe, Premika, Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., White, Tonya, Bøen, Erlend, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Zhen, Zonglei, Bose, Anushree, Zhu, Xing-xing, Ziegler, Georg C., Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bralten, Janita, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Brandeis, Daniel, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brem, Silvia, Mathias, Samuel R., Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Cannon, Dara M., Guadalupe, Tulio, Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Clark, Vincent P., Abé, Christoph, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, Bruttopilo, Sara Ambrosino, Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W, Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Akudjedu, Theophilus N., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Förster, Katharina, Aleman, Andre, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Grabe, Hans Jörgen, Alhusaini, Saud, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Carmen Valdés Hernández, Maria, Alhusaini, Saud, Del Carmen Valdés Hernández, Maria, Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., van Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Allen, Nicholas B., Howells, Fleur M., Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G., Kaleda, Vasily, Ames, David, Kelly, Clare, Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Andreassen, Ole A., Kuntsi, Jonna, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Vasquez, Alejandro Arias, Liu, Jia, Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Armstrong, Nicola J., Malpas, Charles B., Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Asherson, Phil, Maniega, Susana Muñoz, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Bergo, Felipe, Nerland, Stener, Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Bastin, Mark E., Orr, Catherine, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, von Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Batalla, Albert, Radua, Joaquim, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Bauer, Jochen, Schmaal, Lianne, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Baune, Bernhard T., Sinha, Rajita, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Baur-Streubel, Ramona, Strike, Lachlan T., Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Biederman, Joseph, van Erp, Theo G. M., van den Heuvel, Odile A., van der Meer, Dennis, van Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Blaine, Sara K., Voineskos, Aristotle N., Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., Boedhoe, Premika, White, Tonya, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Bøen, Erlend, Zhen, Zonglei, Zhu, Xing-Xing, Ziegler, Georg C., de Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bose, Anushree, Francks, Clyde, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Bralten, Janita, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brandeis, Daniel, Kong, Xiang-Zhen, Brem, Silvia, Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Mathias, Samuel R., Cannon, Dara M., Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-Lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Guadalupe, Tulio, Clark, Vincent P., Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, de Bruttopilo, Sara Ambrosino, Abé, Christoph, de Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W., Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Akudjedu, Theophilus N., Förster, Katharina, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, do Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Aleman, Andre, Grabe, Hans Jörgen, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Ontwikkelingspsychologie (Psychologie, FMG), Adult Psychiatry, APH - Mental Health, ANS - Compulsivity, Impulsivity & Attention, Child and Adolescent Psychiatry & Psychosocial Care, Child Psychiatry, ANS - Cellular & Molecular Mechanisms, Laboratory Genetic Metabolic Diseases, Paediatrics, General Paediatrics, ARD - Amsterdam Reproduction and Development, Paediatric Pulmonology, Graduate School, and APH - Digital Health

Subjects
P‐hacking, Datasets as Topic, Publication bias, 0302 clinical medicine, 130 000 Cognitive Neurology & Memory, Statistics, team science, Brain asymmetry, Multicenter Studies as Topic, Cervell, Research Articles, Cerebral Cortex, Radiological and Ultrasound Technology, P-hacking, 05 social sciences, Brain, Cerebral cortex, Middle Aged, Magnetic Resonance Imaging, Discoveries in science, Escorça cerebral, Neurology, Biaix de publicació, Anatomy, Psychology, Research Article, Neuroinformatics, Adult, Adolescent, Neuroimaging, Descobriments científics, 050105 experimental psychology, Statistical power, 03 medical and health sciences, Young Adult, Magnetic resonance imaging, Imatges per ressonància magnètica, multisite collaboration, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, ddc:610, reproducibility, Aged, publication bias, Reproducibility, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Perspective (graphical), Reproducibility of Results, Brain Cortical Thickness, Research data, Sample size determination, Dades de recerca, Neurology (clinical), Scale (map), Developmental Psychopathology, 030217 neurology & neurosurgery
Abstract

The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p‐hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left–right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta‐analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an “ideal publishing environment,” that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically‐used sample sizes., Region‐wise effect sizes and reproducibility rates of hemispheric asymmetry effects. In general, effects with higher effect sizes showed higher reproducibility, given the same conditions (e.g., sample size and data heterogeneity).

Published
2022
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5. Publisher Correction:Common brain disorders are associated with heritable patterns of apparent aging of the brain (Nature Neuroscience, (2019), 22, 10, (1617-1623), 10.1038/s41593-019-0471-7)

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J., Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K., Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L., Buitelaar, Jan, Celius, Elisabeth G., Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M., de Quervain, Dominique J.F., Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S., Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K., Harbo, Hanne F., Hartman, Catharina A., Heslenfeld, Dirk, Hoekstra, Pieter J., Høgestøl, Einar A., Jernigan, Terry L., Jonassen, Rune, Jönsson, Erik G., Farde, Lars, Engberg, Göran, Erhardt, Sophie, Schwieler, Lilly, Piehl, Fredrik, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K., Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J., Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B., Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne Marthe, Selbæk, Geir, Shadrin, Alexey A., Smeland, Olav B., Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Ulrichsen, Kristine M., Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., and Westlye, Lars T.

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

In the version of this article initially published, spaces were missing in the names of Stephanie Le Hellard and Pasquale Di Carlo. The errors have been corrected in the HTML and PDF versions of the article.

Published
2020
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6. Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Author

Farde, Lars, Flyckt, Lena, Fatouros-Bergman, Helena, Cervenka, Simon, Agartz, Ingrid, Collste, Karin, Victorsson, Pauliina, Engberg, Göran, Erhardt, Sophie, Schwieler, Lilly, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Piehl, Fredrik, van Erp, Theo G.M., Walton, Esther, Hibar, Derrek P., Schmaal, Lianne, Jiang, Wenhao, Glahn, David C., Pearlson, Godfrey D., Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Yamamori, Hidenaga, Clark, Vincent P., Mueller, Bryon A., de Zwarte, Sonja M.C., Ophoff, Roel A., van Haren, Neeltje E.M., Andreassen, Ole A., Gurholt, Tiril P., Gruber, Oliver, Kraemer, Bernd, Richter, Anja, Calhoun, Vince D., Crespo-Facorro, Benedicto, Roiz-Santiañez, Roberto, Tordesillas-Gutiérrez, Diana, Loughland, Carmel, Catts, Stanley, Fullerton, Janice M., Green, Melissa J., Henskens, Frans, Jablensky, Assen, Mowry, Bryan J., Pantelis, Christos, Quidé, Yann, Schall, Ulrich, Scott, Rodney J., Cairns, Murray J., Seal, Marc, Tooney, Paul A., Rasser, Paul E., Cooper, Gavin, Shannon Weickert, Cynthia, Weickert, Thomas W., Hong, Elliot, Kochunov, Peter, Gur, Raquel E., Gur, Ruben C., Ford, Judith M., Macciardi, Fabio, Mathalon, Daniel H., Potkin, Steven G., Preda, Adrian, Fan, Fengmei, Ehrlich, Stefan, King, Margaret D., De Haan, Lieuwe, Veltman, Dick J., Assogna, Francesca, Banaj, Nerisa, de Rossi, Pietro, Iorio, Mariangela, Piras, Fabrizio, Spalletta, Gianfranco, Pomarol-Clotet, Edith, Kelly, Sinead, Ciufolini, Simone, Radua, Joaquim, Murray, Robin, Marques, Tiago Reis, Simmons, Andrew, Borgwardt, Stefan, Schönborn-Harrisberger, Fabienne, Riecher-Rössler, Anita, Smieskova, Renata, Alpert, Kathryn I., Bertolino, Alessandro, Bonvino, Aurora, Di Giorgio, Annabella, Neilson, Emma, Mayer, Andrew R., Yun, Je-Yeon, Cannon, Dara M., Lebedeva, Irina, Tomyshev, Alexander S., Akhadov, Tolibjohn, Kaleda, Vasily, Rosa, Pedro G.P., Serpa, Mauricio H., Zanetti, Marcus V., Hoschl, Cyril, Skoch, Antonin, Spaniel, Filip, Tomecek, David, McIntosh, Andrew M., Whalley, Heather C., Knöchel, Christian, Oertel-Knöchel, Viola, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Uhlmann, Anne, Lopez-Jaramillo, Carlos, Dima, Danai, Faskowitz, Joshua I., Gutman, Boris A., Jahanshad, Neda, Thompson, Paul M., and Turner, Jessica A.

Published
2019
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8. Common brain disorders are associated with heritable patterns of apparent aging of the brain

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J., Agartz, Ingrid, Alnaes, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K., Boen, Erlend, Borgwardt, Stefan, Brandt, Christine L., Buitelaar, Jan, Celius, Elisabeth G., Cervenka, Simon, Conzelmann, Annette, Cordova-Palomera, Aldo, Dale, Anders M., de Quervain, Dominique J. F., Carlo, PasqualeDi, Djurovic, Srdjan, Dorum, Erlend S., Eisenacher, Sarah, Elvsashagen, Torbjorn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Haberg, Asta K., Harbo, Hanne F., Hartman, Catharina A., Heslenfeld, Dirk, Hoekstra, Pieter J., Hogestol, Einar A., Jernigan, Terry L., Jonassen, Rune, Jonsson, Erik G., Kirsch, Peter, Ktoszewska, Iwona, Kolskar, Knut K., Landro, Nils Inge, Hellard, StephanieLe, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J., Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B., Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Genevieve, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbaek, Geir, Shadrin, Alexey A., Smeland, Olav B., Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Ulrichsen, Kristine M., Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., Westlye, Lars T., Farde, Lars, Flyckts, Lena, Engberg, Goran, Erhardt, Sophie, Fatouros-Bergmann, Helena, Schwieler, Lilly, Piehl, Fredrik, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J., Agartz, Ingrid, Alnaes, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K., Boen, Erlend, Borgwardt, Stefan, Brandt, Christine L., Buitelaar, Jan, Celius, Elisabeth G., Cervenka, Simon, Conzelmann, Annette, Cordova-Palomera, Aldo, Dale, Anders M., de Quervain, Dominique J. F., Carlo, PasqualeDi, Djurovic, Srdjan, Dorum, Erlend S., Eisenacher, Sarah, Elvsashagen, Torbjorn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Haberg, Asta K., Harbo, Hanne F., Hartman, Catharina A., Heslenfeld, Dirk, Hoekstra, Pieter J., Hogestol, Einar A., Jernigan, Terry L., Jonassen, Rune, Jonsson, Erik G., Kirsch, Peter, Ktoszewska, Iwona, Kolskar, Knut K., Landro, Nils Inge, Hellard, StephanieLe, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J., Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B., Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Genevieve, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbaek, Geir, Shadrin, Alexey A., Smeland, Olav B., Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Ulrichsen, Kristine M., Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., Westlye, Lars T., Farde, Lars, Flyckts, Lena, Engberg, Goran, Erhardt, Sophie, Fatouros-Bergmann, Helena, Schwieler, Lilly, Piehl, Fredrik, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, and Orhan, Funda

Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Published
2019
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9. Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk

Author

Alnaes, Dag, Kaufmann, Tobias, van der Meer, Dennis, Cordova-Palomera, Aldo, Rokicki, Jaroslav, Moberget, Torgeir, Bettella, Francesco, Agartz, Ingrid, Barch, Deanna M., Bertolino, Alessandro, Brandt, Christine L., Cervenka, Simon, Djurovic, Srdjan, Doan, Nhat Trung, Eisenacher, Sarah, Fatouros-Bergman, Helena, Flyckt, Lena, Di Giorgio, Annabella, Haatveit, Beathe, Jonsson, Erik G., Kirsch, Peter, Lund, Martina J., Meyer-Lindenberg, Andreas, Pergola, Giulio, Schwarz, Emanuel, Smeland, Olav B., Quarto, Tiziana, Zink, Mathias, Andreassen, Ole A., Westlye, Lars T., Farde, Lars, Collste, Karin, Victorsson, Pauliina, Engberg, Goran, Erhardt, Sophie, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl M., Schwieler, Lilly, Piehl, Fredrik, Alnaes, Dag, Kaufmann, Tobias, van der Meer, Dennis, Cordova-Palomera, Aldo, Rokicki, Jaroslav, Moberget, Torgeir, Bettella, Francesco, Agartz, Ingrid, Barch, Deanna M., Bertolino, Alessandro, Brandt, Christine L., Cervenka, Simon, Djurovic, Srdjan, Doan, Nhat Trung, Eisenacher, Sarah, Fatouros-Bergman, Helena, Flyckt, Lena, Di Giorgio, Annabella, Haatveit, Beathe, Jonsson, Erik G., Kirsch, Peter, Lund, Martina J., Meyer-Lindenberg, Andreas, Pergola, Giulio, Schwarz, Emanuel, Smeland, Olav B., Quarto, Tiziana, Zink, Mathias, Andreassen, Ole A., Westlye, Lars T., Farde, Lars, Collste, Karin, Victorsson, Pauliina, Engberg, Goran, Erhardt, Sophie, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl M., Schwieler, Lilly, and Piehl, Fredrik

Abstract

ImportanceBetween-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature. ObjectivesTo compare brain structural variability between individuals with schizophrenia and healthy controls and to test whether respective variability reflects the polygenic risk score (PRS) for schizophrenia in an independent sample of healthy controls. Design, Setting, and ParticipantsThis case-control and polygenic risk analysis compared MRI-derived cortical thickness and subcortical volumes between healthy controls and patients with schizophrenia across 16 cohorts and tested for associations between PRS and MRI features in a control cohort from the UK Biobank. Data were collected from October 27, 2004, through April 12, 2018, and analyzed from December 3, 2017, through August 1, 2018. Main Outcomes and MeasuresMean and dispersion parameters were estimated using double generalized linear models. Vertex-wise analysis was used to assess cortical thickness, and regions-of-interest analyses were used to assess total cortical volume, total surface area, and white matter, subcortical, and hippocampal subfield volumes. Follow-up analyses included within-sample analysis, test of robustness of the PRS threshold, population covariates, outlier removal, and control for image quality. ResultsA comparison of 1151 patients with schizophrenia (mean [SD] age,33.8[10.6] years; 68.6% male [n=790] and 31.4% female [n=361]) with 2010 healthy controls (mean [SD] age,32.6[10.4] years; 56.0% male [n=1126] and 44.0% female [n=884]) revealed higher heterogeneity in schizophrenia for cortical thickness and area (t = 3.34)

Published
2019
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10. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Author

Kong, Xiang-Zhen, Mathias, Samuel R, Francks, Clyde, Grabe, Hans, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K, Harris, Mathew A, Hartman, Catharina A, Hernández, Maria Del Carmen Valdés, Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C, Hoekstra, Pieter J, van Holst, Ruth J, Hoogman, Martine, Høvik, Marie F, Howells, Fleur M, Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Irwin, Lourdes, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L, Jönsson, Erik G, Guadalupe, Tulio, Kähler, Claas, Kaleda, Vasily, Kelly, Clare, Kerich, Michael, Keshavan, Matcheri S, Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Abé, Christoph, Krämer, Bernd, Krug, Axel, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Agartz, Ingrid, Lim, Kelvin O, Liu, Jia, Lochner, Christine, London, Edythe D, Lonning, Vera, Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J, Mackey, Scott, Akudjedu, Theophilus N, MacMaster, Frank P, Maingault, Sophie, Malpas, Charles B, Malt, Ulrik F, Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R, McCarthy, Hazel, Mitchell, Philip B, Mueller, Bryon A, Aleman, Andre, Maniega, Susana Muñoz, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L, McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M, Narayanaswamy, Janardhanan C, Moreira, José Carlos Vasques, Alhusaini, Saud, Nerland, Stener, Nestor, Liam, Newman, Erik, Nigg, Joel T, Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L, Oosterlaan, Jaap, Oranje, Bob, Allen, Nicholas B, Orr, Catherine, Overs, Bronwyn, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, von Polier, Georg G, Pomarol-Clotet, Edith, Portella, Maria J, Qiu, Jiang, Radua, Joaquim, Ames, David, Ramos-Quiroga, Josep Antoni, Reddy, Y C Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Schmaal, Lianne, Andreassen, Ole A, Schulte-Rüther, Martin, Schweren, Lizanne, Seidman, Larry, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J, Simmons, Alan N, Simulionyte, Egle, Vasquez, Alejandro Arias, Sinha, Rajita, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R, Stein, Dan J, Stein, Elliot A, Stevens, Michael, Armstrong, Nicola J, Strike, Lachlan T, Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S, Thoma, Robert J, Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Bergo, Felipe, van Erp, Theo G M, van den Heuvel, Odile A, van der Meer, Dennis, van Eijk, Liza, Vance, Alasdair, Veer, Ilya M, Veltman, Dick J, Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Bastin, Mark E, Voineskos, Aristotle N, Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M, Wen, Wei, Westlye, Lars T, Whelan, Christopher D, Batalla, Albert, White, Tonya, Wiers, Reinout W, Wright, Margaret J, Wittfeld, Katharina, Yang, Tony T, Yasuda, Clarissa L, Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Bauer, Jochen, Zhen, Zonglei, Zhu, Xing-Xing, Ziegler, Georg C, Zierhut, Kathrin, de Zubicaray, Greig I, Zwiers, Marcel, Glahn, David C, Franke, Barbara, Crivello, Fabrice, Tzourio-Mazoyer, Nathalie, Baune, Bernhard T, Fisher, Simon E, Thompson, Paul M, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Baur-Streubel, Ramona, Piehl, Fredrik, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Group, ENIGMA Laterality Working, Biederman, Joseph, Blaine, Sara K, Boedhoe, Premika, Bøen, Erlend, Bose, Anushree, Bralten, Janita, Brandeis, Daniel, Brem, Silvia, Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J, Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Canive, Jose M, Cannon, Dara M, Caparelli, Elisabeth C, Castellanos, Francisco X, Cavalleri, Gianpiero L, Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-Lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Clark, Vincent P, Coghill, David, Connolly, Colm G, Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dale, Anders, Dannlowski, Udo, Ambrosino de Bruttopilo, Sara, de Zeeuw, Patrick, Deary, Ian J, Delanty, Norman, Demeter, Damion V, Di Martino, Adriana, Dickie, Erin W, Dietsche, Bruno, Doan, N Trung, Doherty, Colin P, Doyle, Alysa, Durston, Sarah, Earl, Eric, Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N, Fair, Damien A, Faraone, Stephen V, Fernández, Guillén, Filho, Geraldo Busatto, Förster, Katharina, Fouche, Jean-Paul, Foxe, John J, Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice, Garavan, Hugh, Garcia, Danielle do Santos, Gotlib, Ian H, Goudriaan, Anna E, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Stochastics, Clinical Neuropsychology, Cognitive Psychology, IBBA, APH - Mental Health, Ontwikkelingspsychologie (Psychologie, FMG), Anatomy and neurosciences, Psychiatry, Pediatric surgery, Amsterdam Neuroscience - Brain Imaging, Child Psychiatry, Adult Psychiatry, ANS - Brain Imaging, AGEM - Endocrinology, metabolism and nutrition, Graduate School, AGEM - Inborn errors of metabolism, ARD - Amsterdam Reproduction and Development, General Paediatrics, APH - Digital Health, Radiology & Nuclear Medicine, Child and Adolescent Psychiatry / Psychology, and Universitat de Barcelona

Subjects
Dominància cerebral, Male, Databases, Factual, Planum temporale, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], 0302 clinical medicine, Transverse temporal gyrus, 130 000 Cognitive Neurology & Memory, diagnostic imaging [Cerebral Cortex], 80 and over, Brain asymmetry, Neuroimaging/methods, Child, ENIGMA Laterality Working Group, Aged, 80 and over, Cerebral Cortex, Multidisciplinary, Laterality, 05 social sciences, Human brain, Middle Aged, Databases, Factual/statistics & numerical data, medicine.anatomical_structure, Mental Health, PNAS Plus, Lateralitat, Child, Preschool, Brain size, Neurological, Biomedical Imaging, Female, ddc:500, methods [Neuroimaging], Parahippocampal gyrus, Neuroinformatics, Adult, statistics & numerical data [Databases, Factual], Adolescent, Cerebral Cortex/diagnostic imaging, 1.1 Normal biological development and functioning, BF, Inferior frontal gyrus, Neuroimaging, and over, Biology, 050105 experimental psychology, Lateralization of brain function, 03 medical and health sciences, Databases, Young Adult, All institutes and research themes of the Radboud University Medical Center, Clinical Research, Underpinning research, Journal Article, medicine, Humans, lateralization, 0501 psychology and cognitive sciences, General, Preschool, Factual, Aged, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], [SCCO.NEUR]Cognitive science/Neuroscience, Neurosciences, Infant, surface area, cortical thickness, Brain Disorders, meta-analysis, Cerebral dominance, brain asymmetry, Neuroscience, Developmental Psychopathology, 030217 neurology & neurosurgery
Abstract

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here the ENIGMA consortium presents the largest ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and brain size (indexed by intracranial volume). Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (N = 1,443 and 1,113, respectively), we found several asymmetries showing modest but highly reliable heritability. The structural asymmetries identified, and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.Significance StatementLeft-right asymmetry is a key feature of the human brain's structure and function. It remains unclear which cortical regions are asymmetrical on average in the population, and how biological factors such as age, sex and genetic variation affect these asymmetries. Here we describe by far the largest ever study of cerebral cortical brain asymmetry, based on data from 17,141 participants. We found a global anterior-posterior 'torque' pattern in cortical thickness, together with various regional asymmetries at the population level, which have not been previously described, as well as effects of age, sex, and heritability estimates. From these data, we have created an on-line resource that will serve future studies of human brain anatomy in health and disease.

Published
2018
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11. Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Author

van Erp, Theo G.M., primary, Walton, Esther, additional, Hibar, Derrek P., additional, Schmaal, Lianne, additional, Jiang, Wenhao, additional, Glahn, David C., additional, Pearlson, Godfrey D., additional, Yao, Nailin, additional, Fukunaga, Masaki, additional, Hashimoto, Ryota, additional, Okada, Naohiro, additional, Yamamori, Hidenaga, additional, Clark, Vincent P., additional, Mueller, Bryon A., additional, de Zwarte, Sonja M.C., additional, Ophoff, Roel A., additional, van Haren, Neeltje E.M., additional, Andreassen, Ole A., additional, Gurholt, Tiril P., additional, Gruber, Oliver, additional, Kraemer, Bernd, additional, Richter, Anja, additional, Calhoun, Vince D., additional, Crespo-Facorro, Benedicto, additional, Roiz-Santiañez, Roberto, additional, Tordesillas-Gutiérrez, Diana, additional, Loughland, Carmel, additional, Catts, Stanley, additional, Fullerton, Janice M., additional, Green, Melissa J., additional, Henskens, Frans, additional, Jablensky, Assen, additional, Mowry, Bryan J., additional, Pantelis, Christos, additional, Quidé, Yann, additional, Schall, Ulrich, additional, Scott, Rodney J., additional, Cairns, Murray J., additional, Seal, Marc, additional, Tooney, Paul A., additional, Rasser, Paul E., additional, Cooper, Gavin, additional, Shannon Weickert, Cynthia, additional, Weickert, Thomas W., additional, Hong, Elliot, additional, Kochunov, Peter, additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Ford, Judith M., additional, Macciardi, Fabio, additional, Mathalon, Daniel H., additional, Potkin, Steven G., additional, Preda, Adrian, additional, Fan, Fengmei, additional, Ehrlich, Stefan, additional, King, Margaret D., additional, De Haan, Lieuwe, additional, Veltman, Dick J., additional, Assogna, Francesca, additional, Banaj, Nerisa, additional, de Rossi, Pietro, additional, Iorio, Mariangela, additional, Piras, Fabrizio, additional, Spalletta, Gianfranco, additional, Pomarol-Clotet, Edith, additional, Kelly, Sinead, additional, Ciufolini, Simone, additional, Radua, Joaquim, additional, Murray, Robin, additional, Marques, Tiago Reis, additional, Simmons, Andrew, additional, Borgwardt, Stefan, additional, Schönborn-Harrisberger, Fabienne, additional, Riecher-Rössler, Anita, additional, Smieskova, Renata, additional, Alpert, Kathryn I., additional, Bertolino, Alessandro, additional, Bonvino, Aurora, additional, Di Giorgio, Annabella, additional, Neilson, Emma, additional, Mayer, Andrew R., additional, Yun, Je-Yeon, additional, Cannon, Dara M., additional, Lebedeva, Irina, additional, Tomyshev, Alexander S., additional, Akhadov, Tolibjohn, additional, Kaleda, Vasily, additional, Fatouros-Bergman, Helena, additional, Flyckt, Lena, additional, Rosa, Pedro G.P., additional, Serpa, Mauricio H., additional, Zanetti, Marcus V., additional, Hoschl, Cyril, additional, Skoch, Antonin, additional, Spaniel, Filip, additional, Tomecek, David, additional, McIntosh, Andrew M., additional, Whalley, Heather C., additional, Knöchel, Christian, additional, Oertel-Knöchel, Viola, additional, Howells, Fleur M., additional, Stein, Dan J., additional, Temmingh, Henk S., additional, Uhlmann, Anne, additional, Lopez-Jaramillo, Carlos, additional, Dima, Danai, additional, Faskowitz, Joshua I., additional, Gutman, Boris A., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Turner, Jessica A., additional, Farde, Lars, additional, Cervenka, Simon, additional, Agartz, Ingrid, additional, Collste, Karin, additional, Victorsson, Pauliina, additional, Engberg, Göran, additional, Erhardt, Sophie, additional, Schwieler, Lilly, additional, Malmqvist, Anna, additional, Hedberg, Mikael, additional, Orhan, Funda, additional, and Piehl, Fredrik, additional

Published
2019
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12. CFD simulations of Luleälven : An examination of CFD as a tool forevaluating restoration possibilities of regulated dredgedrivers

Author

Hedberg, Mikael and Hedberg, Mikael

Abstract

Dredged rivers remain from when lumber was floated downriver for processing and shipping purposes. This has left parts of some rivers in Sweden with shallow rocky beaches and deep central furrows. Restoration efforts of dredged unregulated rivers has shown positive results for fish populations. This report compares, by use of CFD two regulated parts of Luleälven, one dredged and one natural. The report looks at habitats where the Riverine Grayling prefers to lay its eggs and evaluates whether velocity and depth conditions could give an explanation for the lower population of the Riverine Grayling in the dredged river. For the water levels tested, usable areas exist for all cases, but the dredged river has substantially smaller areas suitable as a habitat. The river geometry seems to be the large issue for Mattisudden as its shallow wide riverbanks are not conducive to habitats for the Riverine Grayling. Surprisingly the "lower" test case for the dredged river showed a larger usable area than for the "higher" water level, for the same river and higher usable area than the natural river. For this case the water level is now so low that the shallow wide riverbanks are above the water level and only the central furrow is filled with water. This shows two avenues that can be used to improve the habitats for the Riverine Grayling, lower the water level, or raise the riverbanks.

Published
2018

13. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Author

van Erp, Theo G.M., primary, Walton, Esther, additional, Hibar, Derrek P., additional, Schmaal, Lianne, additional, Jiang, Wenhao, additional, Glahn, David C., additional, Pearlson, Godfrey D., additional, Yao, Nailin, additional, Fukunaga, Masaki, additional, Hashimoto, Ryota, additional, Okada, Naohiro, additional, Yamamori, Hidenaga, additional, Bustillo, Juan R., additional, Clark, Vincent P., additional, Agartz, Ingrid, additional, Mueller, Bryon A., additional, Cahn, Wiepke, additional, de Zwarte, Sonja M.C., additional, Hulshoff Pol, Hilleke E., additional, Kahn, René S., additional, Ophoff, Roel A., additional, van Haren, Neeltje E.M., additional, Andreassen, Ole A., additional, Dale, Anders M., additional, Doan, Nhat Trung, additional, Gurholt, Tiril P., additional, Hartberg, Cecilie B., additional, Haukvik, Unn K., additional, Jørgensen, Kjetil N., additional, Lagerberg, Trine V., additional, Melle, Ingrid, additional, Westlye, Lars T., additional, Gruber, Oliver, additional, Kraemer, Bernd, additional, Richter, Anja, additional, Zilles, David, additional, Calhoun, Vince D., additional, Crespo-Facorro, Benedicto, additional, Roiz-Santiañez, Roberto, additional, Tordesillas-Gutiérrez, Diana, additional, Loughland, Carmel, additional, Carr, Vaughan J., additional, Catts, Stanley, additional, Cropley, Vanessa L., additional, Fullerton, Janice M., additional, Green, Melissa J., additional, Henskens, Frans A., additional, Jablensky, Assen, additional, Lenroot, Rhoshel K., additional, Mowry, Bryan J., additional, Michie, Patricia T., additional, Pantelis, Christos, additional, Quidé, Yann, additional, Schall, Ulrich, additional, Scott, Rodney J., additional, Cairns, Murray J., additional, Seal, Marc, additional, Tooney, Paul A., additional, Rasser, Paul E., additional, Cooper, Gavin, additional, Shannon Weickert, Cynthia, additional, Weickert, Thomas W., additional, Morris, Derek W., additional, Hong, Elliot, additional, Kochunov, Peter, additional, Beard, Lauren M., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Satterthwaite, Theodore D., additional, Wolf, Daniel H., additional, Belger, Aysenil, additional, Brown, Gregory G., additional, Ford, Judith M., additional, Macciardi, Fabio, additional, Mathalon, Daniel H., additional, O’Leary, Daniel S., additional, Potkin, Steven G., additional, Preda, Adrian, additional, Voyvodic, James, additional, Lim, Kelvin O., additional, McEwen, Sarah, additional, Yang, Fude, additional, Tan, Yunlong, additional, Tan, Shuping, additional, Wang, Zhiren, additional, Fan, Fengmei, additional, Chen, Jingxu, additional, Xiang, Hong, additional, Tang, Shiyou, additional, Guo, Hua, additional, Wan, Ping, additional, Wei, Dong, additional, Bockholt, Henry J., additional, Ehrlich, Stefan, additional, Wolthusen, Rick P.F., additional, King, Margaret D., additional, Shoemaker, Jody M., additional, Sponheim, Scott R., additional, De Haan, Lieuwe, additional, Koenders, Laura, additional, Machielsen, Marise W., additional, van Amelsvoort, Therese, additional, Veltman, Dick J., additional, Assogna, Francesca, additional, Banaj, Nerisa, additional, de Rossi, Pietro, additional, Iorio, Mariangela, additional, Piras, Fabrizio, additional, Spalletta, Gianfranco, additional, McKenna, Peter J., additional, Pomarol-Clotet, Edith, additional, Salvador, Raymond, additional, Corvin, Aiden, additional, Donohoe, Gary, additional, Kelly, Sinead, additional, Whelan, Christopher D., additional, Dickie, Erin W., additional, Rotenberg, David, additional, Voineskos, Aristotle N., additional, Ciufolini, Simone, additional, Radua, Joaquim, additional, Dazzan, Paola, additional, Murray, Robin, additional, Reis Marques, Tiago, additional, Simmons, Andrew, additional, Borgwardt, Stefan, additional, Egloff, Laura, additional, Harrisberger, Fabienne, additional, Riecher-Rössler, Anita, additional, Smieskova, Renata, additional, Alpert, Kathryn I., additional, Wang, Lei, additional, Jönsson, Erik G., additional, Koops, Sanne, additional, Sommer, Iris E.C., additional, Bertolino, Alessandro, additional, Bonvino, Aurora, additional, Di Giorgio, Annabella, additional, Neilson, Emma, additional, Mayer, Andrew R., additional, Stephen, Julia M., additional, Kwon, Jun Soo, additional, Yun, Je-Yeon, additional, Cannon, Dara M., additional, McDonald, Colm, additional, Lebedeva, Irina, additional, Tomyshev, Alexander S., additional, Akhadov, Tolibjohn, additional, Kaleda, Vasily, additional, Fatouros-Bergman, Helena, additional, Flyckt, Lena, additional, Busatto, Geraldo F., additional, Rosa, Pedro G.P., additional, Serpa, Mauricio H., additional, Zanetti, Marcus V., additional, Hoschl, Cyril, additional, Skoch, Antonin, additional, Spaniel, Filip, additional, Tomecek, David, additional, Hagenaars, Saskia P., additional, McIntosh, Andrew M., additional, Whalley, Heather C., additional, Lawrie, Stephen M., additional, Knöchel, Christian, additional, Oertel-Knöchel, Viola, additional, Stäblein, Michael, additional, Howells, Fleur M., additional, Stein, Dan J., additional, Temmingh, Henk S., additional, Uhlmann, Anne, additional, Lopez-Jaramillo, Carlos, additional, Dima, Danai, additional, McMahon, Agnes, additional, Faskowitz, Joshua I., additional, Gutman, Boris A., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Turner, Jessica A., additional, Farde, Lars, additional, Engberg, Göran, additional, Erhardt, Sophie, additional, Cervenka, Simon, additional, Schwieler, Lilly, additional, Piehl, Fredrik, additional, Collste, Karin, additional, Victorsson, Pauliina, additional, Malmqvist, Anna, additional, Hedberg, Mikael, additional, and Orhan, Funda, additional

Published
2018
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14. Competences in Agile Development : Exploring the social, functional and cognitive requirements of a systems developer

Author

Hedberg, Mikael

Abstract

Agile methodologies are becoming increasingly more popular among developers. However, there is little known research regarding the competences of working in development projects. This led me to my research question, what competences are considered important for working in agile projects? I narrowed down my research to three categories of competence; social, functional and cognitive. In order to gather the information needed for the study, I interviewed developers with and extensive knowledge and experience from working in agile development projects. The results from the study revealed that there is a need for a broad set of competences for working in agile development projects. This study is intended to contribute to the literature on competences is systems development by exploring the competence requirements for systems developers working in agile methods.

Published
2015

15. Increased number of monocytes and plasma levels of MCP‐1 and YKL‐40 in first‐episode psychosis.

Author

Orhan, F., Schwieler, L., Fatouros‐Bergman, H., Malmqvist, A., Cervenka, S., Collste, K., Flyckt, L., Farde, L., Sellgren, C. M., Piehl, F., Engberg, G., Erhardt, S., Hedberg, Mikael, and Victorsson, Pauliina

Subjects
MONOCYTES, PSYCHOSES, SCHIZOPHRENIA, CHITINASE, ANTIPSYCHOTIC agents, NEUROIMMUNOLOGY
Abstract

Objective: Accumulating evidence implicates immune activation in the development of schizophrenia. Here, monocyte numbers, monocyte chemoattractant protein‐1 (MCP‐1) and chitinase‐3‐like protein 1 (YKL‐40) were investigated in plasma and cerebrospinal fluid (CSF) in first‐episode psychosis (FEP) patients. Method: CSF and blood were sampled from 42 first‐episode psychosis (FEP) patients and 22 healthy controls. The levels of YKL‐40 and MCP‐1 were measured using electrochemiluminescence assay, and blood monocytes were counted using an XN‐9000‐hematology analyzer. Results: We found higher plasma levels of MCP‐1 and YKL‐40 in FEP patients compared with healthy controls, a condition that was unrelated to antipsychotic and/or anxiolytic medication. This was combined with an increased number of blood monocytes and a borderline significant increase in YKL‐40 levels in the CSF of tobacco‐free FEP patients. Plasma or CSF chemokines or blood monocytes did not correlate with the severity of symptoms or the level of functioning. Conclusion: These data demonstrate activation of monocytes in FEP and strengthens the idea of an immune dysfunction of psychotic disorders. Further studies are required to perceive a role of YKL‐40 and MCP‐1 in the initiation and progression of schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2018
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16. Handling multi-projects : An empirical study of challenges faced in management

Author

Höglander, Alexander and Hedberg, Mikael

Subjects
project management, multi-projects
Abstract

With projects being a common way of working in modern organizations, multi-projects has become a more frequent occurrence and brought new situations that organizations need to handle. Research shows that project managers don‟t have complete understanding on how to handle multi-projects and the problems that can arise. In this thesis a qualitative study was conducted with five project managers from different organizations who had experience from working in multi-projects. Interviews were performed in order to plot the challenges and to identify how they were handled. Four areas of importance were pinpointed; project phases, composing teams, absence of multi-project management systems within the organizations and finally choice of project methods. The findings are to be thought of as guiding principles for organizations and project managers that experience concerns regarding multi-projects.

Published
2013

17. IT-supporten i kommunala verksamheter: En fallstudie av Umeå kommun

Author

Jönsson, Martin and Hedberg, Mikael

Subjects
kommunal IT-användning
Abstract

The objective of this study was to examine how an IT department has been affected by the changes of increased local usage of IT, and how the usage have affected municipalities IT departments demands of IT support. In the study we explore how both the IT department and the IT support works by interviewing present and former employees at the local IT department. The current IT department have undergone a series of local changes over the last 20 years, the department has gone from only having internal users to getting the entire municipalitiy’s agencies of IT as users. It started with how the municipality began to dig down fiber optic cable in the middle of the 1990’s, and today has started to develop solutions as to how to meet the demands of future usage of IT. The goal of this study is to contribute to getting a better understanding of how IT-support has changed over time when the work assignments has increased. The main impact that we have identified is the development of IT-solutions and the increase of employees IT competence.

Published
2012

18. Effekter av Outsourcing – en litteraturstudie

Author

Karatas, Ilyas and Hedberg, Mikael

Subjects
Business studies, Företagsekonomi
Abstract

I jakten på att bli mer konkurrenskraftiga och kostnadseffektiva väljer idag fler och fler företag att flytta ut hela eller delar av sin produktion till länder där de ekonomiska förutsättningarna för att bedriva verksamhet är bättre än i hemlandet. Detta sker vanligtvis genom så kallad outsourcing, antingen till en lokal leverantör eller till en leverantör lokaliserad utomlands. Ett av de största skälen till varför företag väljer att outsourca sin tillverkning är kostnadsbesparingar. Genom att outsourca till ett lågkostnadsland kan företagen dra nytta av de lägre lönekostnader som dessa länder ofta erbjuder. Vid sidan av kostnadsmotivet finns det även en rad andra vanliga motiv som företag brukar ange vid ett outsourcingbeslut. Dessa är ökat fokus på kärnverksamheten, frigörande av resurser, spridande av risk, ökad flexibilitet och tillgång till leverantörens resurser och kompetenser. Denna uppsats utgår från motiv företag kan ha vid beslut om outsourcing. Genom en litteraturstudie där vi studerat empirisk data har vi undersökt hur väl de eftersökta effekterna har uppnåtts, samt vilka eventuella problem och risker som företag möter när de outsourcar. Resultatet av uppsatsen är att outsourcing kan innebära såväl kostnadsfördelar som tillgång till ny kunskap och innovativt tänkande. Samtidigt visar uppsatsen att företag som väljer att outsourca ofta ställs inför en rad oväntade kostnader och problem, vilket gör att förväntningar om prestationsförbättringar ibland inte uppfylls i samma grad som företagen tänkt sig.

Published
2006

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