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Common brain disorders are associated with heritable patterns of apparent aging of the brain
Authors :
Kaufmann, Tobias van der Meer, Dennis Doan, Nhat Trung Schwarz, Emanuel Lund, Martina J. Agartz, Ingrid Alnaes, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Bettella, Francesco Beyer, Mona K. Boen, Erlend Borgwardt, Stefan Brandt, Christine L. Buitelaar, Jan Celius, Elisabeth G. Cervenka, Simon Conzelmann, Annette Cordova-Palomera, Aldo Dale, Anders M. de Quervain, Dominique J. F. Carlo, PasqualeDi Djurovic, Srdjan Dorum, Erlend S. Eisenacher, Sarah Elvsashagen, Torbjorn Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Haatveit, Beathe Haberg, Asta K. Harbo, Hanne F. Hartman, Catharina A. Heslenfeld, Dirk Hoekstra, Pieter J. Hogestol, Einar A. Jernigan, Terry L. Jonassen, Rune Jonsson, Erik G. Kirsch, Peter Ktoszewska, Iwona Kolskar, Knut K. Landro, Nils Inge Hellard, StephanieLe Lesch, Klaus-Peter Lovestone, Simon Lundervold, Arvid Lundervold, Astri J. Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Norbom, Linn B. Nordvik, Jan Egil Nyberg, Lars Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin Richard, Genevieve Rokicki, Jaroslav Sanders, Anne-Marthe Selbaek, Geir Shadrin, Alexey A. Smeland, Olav B. Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Ulrichsen, Kristine M. Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Farde, Lars Flyckts, Lena Engberg, Goran Erhardt, Sophie Fatouros-Bergmann, Helena Schwieler, Lilly Piehl, Fredrik Collste, Karin Victorsson, Pauliina Malmqvist, Anna Hedberg, Mikael Orhan, Funda Kaufmann, Tobias van der Meer, Dennis Doan, Nhat Trung Schwarz, Emanuel Lund, Martina J. Agartz, Ingrid Alnaes, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Bettella, Francesco Beyer, Mona K. Boen, Erlend Borgwardt, Stefan Brandt, Christine L. Buitelaar, Jan Celius, Elisabeth G. Cervenka, Simon Conzelmann, Annette Cordova-Palomera, Aldo Dale, Anders M. de Quervain, Dominique J. F. Carlo, PasqualeDi Djurovic, Srdjan Dorum, Erlend S. Eisenacher, Sarah Elvsashagen, Torbjorn Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Haatveit, Beathe Haberg, Asta K. Harbo, Hanne F. Hartman, Catharina A. Heslenfeld, Dirk Hoekstra, Pieter J. Hogestol, Einar A. Jernigan, Terry L. Jonassen, Rune Jonsson, Erik G. Kirsch, Peter Ktoszewska, Iwona Kolskar, Knut K. Landro, Nils Inge Hellard, StephanieLe Lesch, Klaus-Peter Lovestone, Simon Lundervold, Arvid Lundervold, Astri J. Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Norbom, Linn B. Nordvik, Jan Egil Nyberg, Lars Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin Richard, Genevieve Rokicki, Jaroslav Sanders, Anne-Marthe Selbaek, Geir Shadrin, Alexey A. Smeland, Olav B. Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Ulrichsen, Kristine M. Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Farde, Lars Flyckts, Lena Engberg, Goran Erhardt, Sophie Fatouros-Bergmann, Helena Schwieler, Lilly Piehl, Fredrik Collste, Karin Victorsson, Pauliina Malmqvist, Anna Hedberg, Mikael Orhan, Funda
Publication Year :
2019
Abstract
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1234641678
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41593-019-0471-7