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15. Dehydroepiandrosterone attenuates preadipocyte growth in primary cultures of stromal-vascular cells

Author

McIntosh, M., Hausman, D., Martin, R., and Hausman, G.

Subjects
Swine -- Physiological aspects, Rats -- Physiological aspects, Dehydroepiandrosterone -- Research, Adipose tissues -- Research, Biological sciences
Abstract

A study show that the dehydroepiandrosterone (DHEA) decreases adipogenesis through the attenuation of preadipocyte growth and differentiation in primary cultures of stromal-vascular (SV) cells. The finding is based on experiments performed on pig and rat SV cells. For the proliferation assays, pig SV cells were isolated from dorsal subcutaneous adipose tissue of seven-day-old pigs and the rat SV cells were isolated from inguinal fat pads of five-week-old male rats. For the differentiation assays, pig and rat SV cells were laboratory grown in media containing DHEA.

Published
1998

20. Abstract P6-17-13: ZW49, a HER2 targeted biparatopic antibody drug conjugate for the treatment of HER2 expressing cancers

Author

Hamblett, KJ, primary, Barnscher, SD, additional, Davies, RH, additional, Hammond, PW, additional, Hernandez, A, additional, Wickman, GR, additional, Fung, VK, additional, Ding, T, additional, Garnett, G, additional, Galey, AS, additional, Zwierzchowski, P, additional, Clavette, BC, additional, Winters, GC, additional, Rich, JR, additional, Rowse, GJ, additional, Babcook, JS, additional, and Hausman, D, additional

Published
2019
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21. Global Health and the Changing Contours of Human Life

Author

Aikins, A., Wikler, D., Allotey, P., Beisel, U., Cooper, M., Eyal, N., Hausman, D., Lutz, W., Norheim, O.F., Roberts, E., Vågerö, D., Jebari, K., Aikins, A., Wikler, D., Allotey, P., Beisel, U., Cooper, M., Eyal, N., Hausman, D., Lutz, W., Norheim, O.F., Roberts, E., Vågerö, D., and Jebari, K.

Published
2018

22. Motives and markets in health care

Author

Hausman, D

Subjects
Health and health policy, Economics, Ethics (Moral philosophy), Ethics and communication in health care, Practical ethics
Abstract

The truth about health care policy lies between two exaggerated views: a market view in which individuals purchase their own health care from profit maximizing health-care firms and a control view in which costs are controlled by regulations limiting which treatments health insurance will pay for. This essay suggests a way to avoid on the one hand the suffering, unfairness, and abandonment of solidarity entailed by the market view and, on the other hand, to diminish the inflexibility and inefficiency of the control view. It suggests that the way to mitigate these problems is to recognize the malleability of motivation and the range of factors, in addition to financial incentives, that may influence the behavior of patients and especially physicians.

Published
2016

24. Phase 1 dose-escalation study of single-agent ZW25, a HER2-targeted bispecific antibody, in patients (pts) with HER2-expressing cancers

Author

Beeram, M., primary, Hamilton, E., additional, Blum Murphy, M., additional, Hausman, D., additional, Infante, J.R., additional, Korn, R., additional, Patnaik, A., additional, Piha-Paul, S.A., additional, Rasco, D., additional, Rowse, G., additional, Thimmarayappa, J., additional, Tolcher, A., additional, and Meric-Bernstam, F., additional

Published
2017
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25. Somatotropin and adipose tissue metabolism: Substrate and temporal effects

Author

Lee, K. C., Azain, M. J., Hausman, D. B., and Ramsay, T. G.

Subjects
Adipose tissues -- Research, Lipid metabolism -- Research, Swine -- Research, Somatotropin -- Research, Zoology and wildlife conservation
Abstract

The purpose of these studies was to determine the time course for changes in feed intake, blood metabolites, and lipogenic activity in adipose tissue in response to the initiation of porcine somatotropin (pST) treatment and following withdrawal from treatment in barrows. An initial study was conducted to determine the impact of chronic pST treatment (4 wk of daily injection; 0 vs 4 mg/d) on adipose tissue lipid metabolism in barrows (initial weight 67 kg). Feed efficiency was improved 27%, backfat thickness was decreased 43%, and glucose and lactate oxidation and incorporation into lipid in adipose tissue was reduced 70 to 86% in pST-treated pigs. Palmitate esterification was decreased 44%, whereas palmitate oxidation was unaffected. In vitro metabolism of lactate, glucose, and palmitate in liver slices was not affected by pST treatment. The time-course for changes in intake and adipose tissue metabolism in response to 7 d of pST (0 vs 4 mg/d) treatment and 7 d of withdrawal was examined in subsequent studies in barrows (initial weight 75 kg). Feed intake during pST treatment was significantly (P [is less than] .05) less than in control pigs within 24 h of the initiation of treatment and remained low through 3 d after withdrawal. Adipose tissue biopsies were obtained on d 0, 1, 2, 4, and 7 of the treatment phase and on d 2, 4, and 7 after withdrawal from 7 d of treatment. Maximal inhibition of lipogenesis by pST treatment in adipose tissue in vitro was observed on d 4 (-68%) and d 7 (-69%). Similarly, fatty acid synthase activity declined during the treatment period, with the greatest change noted on d 7 (-26%). After withdrawal from treatment, lipogenesis gradually increased, returning to control values 7 d after withdrawal. Levels of IGF-I began to increase from d 1 to d 7 of treatment, continually decreased during withdrawal, and were normalized by the end of the withdrawal period. Plasma urea nitrogen concentrations decreased during treatment, increased during the withdrawal phase, and were normalized 4 d after the last pST treatment. Overall results indicate that most of the metabolic changes in response to pST occur within 1 wk of treatment and return to pretreatment values after 7 d of withdrawal from treatment. Key Words: Adipose Tissue, Lipid Metabolism, Pigs, Somatotropin

Published
2000

26. Faire des choix justes pour une couverture sanitaire universelle : rapport final du Groupe Consultatif de l’OMS sur la Couverture Sanitaire Universelle et Equitable

Author

UCL - SSH/ISP - Institut supérieur de philosophie, Sadana, R, Saenz, C, Tan-Torres Edejer, T, Kapiriri, L, Ord, T, Segall, S, Sen, G, Voorhoeve, A, Wikler, D, Yamin, A, Reis, A, Ottersen, T, Norheim, O, Berhane, F, Chitah, B, Cookson, R, Daniels, N, Eyal, N, Flores, W, Gosseries, Axel, Hausman, D, Hurst, S, UCL - SSH/ISP - Institut supérieur de philosophie, Sadana, R, Saenz, C, Tan-Torres Edejer, T, Kapiriri, L, Ord, T, Segall, S, Sen, G, Voorhoeve, A, Wikler, D, Yamin, A, Reis, A, Ottersen, T, Norheim, O, Berhane, F, Chitah, B, Cookson, R, Daniels, N, Eyal, N, Flores, W, Gosseries, Axel, Hausman, D, and Hurst, S

Abstract

Depuis 2010, plus de cent pays ont demandé l’appui politique et le conseil technique de l’Organisation Mondiale de la Santé (OMS) sur la façon de réaliser une couverture sanitaire universelle (CSU). En réponse, l’OMS a constitué le Groupe Consultatif sur la Couverture Sanitaire Universelle et Equitable. Le rapport final du Groupe Consultatif traite des questions essentielles de justice et d’équité qui se posent lors du processus conduisant à la réalisation de la CSU en les clarifiant et en proposant des recommandations pratiques. Pour atteindre la CSU, les pays doivent faire des progrès dans au moins trois dimensions. Les pays doivent augmenter les services prioritaires, inclure plus de personnes, et réduire les paiements directs. Toutefois, dans chacune de ces dimensions, les pays sont confrontés à des choix difficiles: quels services étendre en premier, qui inclure en premier, et comment passer des paiements directs au prépaiement? Pour faire ces choix, les pays doivent d’être guidés par un engagement pour la justice - qui rejoint la préoccupation en matière d’équité - et l’engagement pour le respect des droits des personnes aux soins de santé. Une stratégie en trois volets peut guider les pays qui cherchent à réaliser la CSU de manière progressive et néanmoins équitable. Les pays peuvent : catégoriser les services en groupes prioritaires. Les critères pertinents pour cette catégorisation incluent le rapport coût-efficacité, la priorité aux plus démunis, et la protection contre le risque financier. étendre pour commencer la couverture des services de haute priorité à tous. Cela inclut l’élimination des paiements directs et le recours accru aux prépaiements obligatoires, progressifs et mettant en commun les fonds. ce faisant, veiller à ne pas laisser à la traine les groupes désavantagés. Il s’agira le plus souvent de groupes à revenus faibles et de populations rurales. Dans le cadre d’une stratégie plus globale, les pays doivent effectuer des choix minutieux au sei

Published
2015

27. Introduction

Author

Maki, IU (Uskali), Hausman, D, Maki, I.U., Backhouse, R., Hausman, D., Salanti, A., and Erasmus School of Philosophy

Published
1998

29. Phase II study of PX-866 in recurrent glioblastoma

Author

Pitz, M. W., primary, Eisenhauer, E. A., additional, MacNeil, M. V., additional, Thiessen, B., additional, Easaw, J. C., additional, Macdonald, D. R., additional, Eisenstat, D. D., additional, Kakumanu, A. S., additional, Salim, M., additional, Chalchal, H., additional, Squire, J., additional, Tsao, M. S., additional, Kamel-Reid, S., additional, Banerji, S., additional, Tu, D., additional, Powers, J., additional, Hausman, D. F., additional, and Mason, W. P., additional

Published
2015
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34. Mechanism, models and free riders

Author

Maki, IU (Uskali), Mäki, I.U., Backhouse, R., Hausman, D., Salanti, A., and Erasmus School of Philosophy

Published
1997

45. What are subcutaneous adipocytesreallygood for…?

Author

Paus, Ralf, primary, Klein, J., additional, Permana, P. A., additional, Owecki, M., additional, Chaldakov, G. N., additional, Böhm, M., additional, Hausman, G., additional, Lapière, C. M., additional, Atanassova, P., additional, Sowiński, J., additional, Fasshauer, M., additional, Hausman, D. B., additional, Maquoi, E., additional, Tonchev, A. B., additional, Peneva, V. N., additional, Vlachanov, K. P., additional, Fiore, M., additional, Aloe, L., additional, Slominski, A., additional, Reardon, C. L., additional, Ryan, T. J., additional, Pond, C. M., additional, and Ryan, Terence J., additional

Published
2007
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46. What are subcutaneous adipocytesreallygood for…?

Author

Ralf Paus, Lübeck, primary, Klein, J., additional, Permana, P. A., additional, Owecki, M., additional, Chaldakov, G. N., additional, Böhm, M., additional, Hausman, G., additional, Lapière, C. M., additional, Atanassova, P., additional, Sowiński, J., additional, Fasshauer, M., additional, Hausman, D. B., additional, Maquoi, E., additional, Tonchev, A. B., additional, Peneva, V. N., additional, Vlachanov, K. P., additional, Fiore, M., additional, Aloe, L., additional, Slominski, A., additional, Reardon, C. L., additional, Ryan, T. J., additional, and Pond, C. M., additional

Published
2007
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