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431 results on '"Hauser, Alan R."'

1. Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence

Author

Kochan, Travis J., Nozick, Sophia H., Valdes, Aliki, Mitra, Sumitra D., Cheung, Bettina H., Lebrun-Corbin, Marine, Medernach, Rachel L., Vessely, Madeleine B., Mills, Jori O., Axline, Christopher M. R., Nelson, Julia A., VanGosen, Ethan M., Ward, Timothy J., Ozer, Egon A., van Duin, David, Chen, Liang, Kreiswirth, Barry N., Long, S. Wesley, Musser, James M., Bulman, Zackery P., Wunderink, Richard G., and Hauser, Alan R.

Published
2023
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3. Correction

Author

Allen, Jonathan P., Ozer, Egon A., Minasov, George, Shuvalova, Ludmilla, Kiryukhina, Olga, Satchell, Karla J. F., and Hauser, Alan R.

Published
2020

6. Individual meropenem epithelial lining fluid and plasma PK/PD target attainment

Author

Rohani, Roxane, primary, Yarnold, Paul R., additional, Scheetz, Marc H., additional, Neely, Michael N., additional, Kang, Mengjia, additional, Donnelly, Helen K., additional, Dedicatoria, Kay, additional, Nozick, Sophie H., additional, Medernach, Rachel L., additional, Hauser, Alan R., additional, Ozer, Egon A., additional, Diaz, Estefani, additional, Misharin, Alexander V., additional, Wunderink, Richard G., additional, and Rhodes, Nathaniel J., additional

Published
2023
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9. 2560. Individual Meropenem Epithelial Lining Fluid and Plasma PK/PD Target Attainment in Patients with Pneumonia

Author

Rohani, Roxane, primary, Yarnold, Paul R, additional, Scheetz, Marc H, additional, Neely, Michael N, additional, Kang, Mengjia, additional, Donnelly, Helen K, additional, Dedicatoria, Kay, additional, Nozick, Sophia, additional, Medernach, Rachel, additional, Hauser, Alan R, additional, Ozer, Egon A, additional, Diaz, Estefani, additional, Misharin, Alexander V, additional, Wunderink, Richard G, additional, and Rhodes, Nathaniel J, additional

Published
2023
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10. Taxonomic characterization of Pseudomonas hygromyciniae sp. nov., a novel species discovered from a commercially purchased antibiotic

Author

Turner, Timothy L., primary, Mitra, Sumitra D., additional, Kochan, Travis J., additional, Pincus, Nathan B., additional, Lebrun-Corbin, Marine, additional, Cheung, Bettina H., additional, Gatesy, Samuel W., additional, Afzal, Tania, additional, Nozick, Sophie H., additional, Ozer, Egon A., additional, and Hauser, Alan R., additional

Published
2023
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16. Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia

Author

Rohani, Roxane, Scheetz, Marc H, Donnelly, Helen K, Donayre, Alvaro, Kang, Mengjia, Diaz, Estefani, Dedicatoria, Kay, Hauser, Alan R, Ozer, Egon A, Nozick, Sophia, Qi, Chao, Pawlowski, Anna E, Neely, Michael N, Misharin, Alexander V, Wunderink, Richard G, and Rhodes, Nathaniel J

Subjects
Pharmacology, Microbiology (medical), Critical Illness, Meropenem, Microbial Sensitivity Tests, Pneumonia, Hospitals, Anti-Bacterial Agents, Intensive Care Units, Infectious Diseases, Humans, Pharmacology (medical), Prospective Studies, Original Research
Abstract

Objectives Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD) attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired pneumonia. Methods Meropenem plasma PK data (n = 70 patients) were modelled, PK/PD attainment rates were calculated for empirical and definitive targets, and between-patient variability was quantified [as a coefficient of variation (CV%)]. Results Attainment of 100% T>4×MIC was variable for both empirical (CV% = 92) and directed (CV% = 33%) treatment. Conclusions Individualization is required to achieve suggested PK/PD targets in critically ill patients.

Published
2022

18. A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae

Author

Inniss, Nicole L., primary, Kochan, Travis J., additional, Minasov, George, additional, Wawrzak, Zdzislaw, additional, Chang, Changsoo, additional, Tan, Kemin, additional, Shuvalova, Ludmilla, additional, Kiryukhina, Olga, additional, Pshenychnyi, Sergii, additional, Wu, Ruiying, additional, Dubrovska, Ivegeniia, additional, Babnigg, Gyorgy, additional, Endres, Michael, additional, Anderson, Wayne F., additional, Hauser, Alan R., additional, Joachimiak, Andrzej, additional, and Satchell, Karla J. F., additional

Published
2023
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24. Functional and Structural Characterization of OXA-935, a Novel OXA-10-Family β-Lactamase from Pseudomonas aeruginosa

Author

Pincus, Nathan B., primary, Rosas-Lemus, Monica, additional, Gatesy, Samuel W. M., additional, Bertucci, Hanna K., additional, Brunzelle, Joseph S., additional, Minasov, George, additional, Shuvalova, Ludmilla A., additional, Lebrun-Corbin, Marine, additional, Satchell, Karla J. F., additional, Ozer, Egon A., additional, Hauser, Alan R., additional, and Bachta, Kelly E. R., additional

Published
2022
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25. Urinary Metabolomics From a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury

Author

Locci, Emanuela, primary, Liu, Jiajun, additional, Pais, Gwendolyn M., additional, Chighine, Alberto, additional, Kahnamoei, Dariusc Andrea, additional, Xanthos, Theodoros, additional, Chalkias, Athanasios, additional, Lee, Andrew, additional, Hauser, Alan R., additional, Chang, Jack, additional, Rhodes, Nathaniel J., additional, d'Aloja, Ernesto, additional, and Scheetz, Marc H., additional

Published
2022
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26. Association Between Clostridium innocuum and Antibiotic-Associated Diarrhea in Adults and Children: A Cross-sectional Study and Comparative Genomics Analysis

Author

Cherny, Kathryn E, primary, Muscat, Emily B, additional, Balaji, Aakash, additional, Mukherjee, Jayabrata, additional, Ozer, Egon A, additional, Angarone, Michael P, additional, Hauser, Alan R, additional, Sichel, Joseph S, additional, Amponsah, Emmanuel, additional, and Kociolek, Larry K, additional

Published
2022
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30. Additional file 9 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Abstract

Additional file 9: Figure S9. Siderophore activity and virulence of NMH bloodstream isolates. Siderophore activity and virulence is plotted for each isolate (A) and against each other (B): left y-axis (A, purple triangles) or x-axis (B). In (B), aerobactin-positive (iuc+) strains are labeled in purple (B). Virulence was measured by LD50 values in a mouse model of pneumonia. Siderophore activity was measured by dipyridyl equivalents (mM) detected in cell free supernatants of bacterial cultures. Number of mice and doses used to determine LD50 values are listed in Table S8.

Published
2022
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31. Additional file 1 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Abstract

Additional file 1: Figure S1. A variety of Klebsiella spp. were identified among NMH bloodstream isolates. Maximum likelihood phylogenetic tree generated from core genome SNP loci in 140 Klebsiella spp. bloodstream isolates. The tree has a truncated outlier branch for Klebsiella oxytoca (yellow). The scale bar represents genetic distance (number of substitutions per site).

Published
2022
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32. Additional file 5 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Abstract

Additional file 5: Figure S5. Predicted plasmids containing virulence genes among NMH bloodstream isolates. Putative plasmids predicted to contain iuc or ybt loci were inferred and clustered using MOB-suite. Individual nodes represent a plasmid, and different colors represent a different plasmid group. Two plasmids are connected by an edge if their Jaccard index is ≥ 0.95. Networks were graphed using Cytoscape.

Published
2022
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33. Additional file 7 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Subjects
bacteria
Abstract

Additional file 7: Figure S7. The bloodstream isolate KPN23 harbors a plasmid containing aerobactin biosynthesis genes. The indicated plasmids were aligned to a plasmid identified in strain KPCTRSRTH01_p2 (A) or to pKPN23_1 (B) using BRIG. A sequence identity threshold of 85% was used. Aerobactin biosynthesis genes are indicated with green arrows. Plasmid accession numbers for previously published plasmids are listed in Table S7.

Published
2022
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34. Additional file 3 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Subjects
genetic structures
Abstract

Additional file 3: Figure S3. Antimicrobial resistance phenotypes of K. pneumoniae bloodstream isolates from NMH. The percentage of isolates resistant (solid bars) or intermediately susceptible (cross-hatched bars) to the indicated antibiotics are shown. Antibiotic classes are grouped by color.

Published
2022
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35. Additional file 6 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Abstract

Additional file 6: Figure S6. pKPN49_2, pKPN165_1, pTK421_2, and pKPN23_1 have little similarity to pK2044. Plasmid sequences were aligned to pK2044 using blast ring image generator (BRIG). A sequence identity threshold of 85% was used. Aerobactin biosynthesis genes are indicated with green arrows, salmochelin with orange arrows, rmpA with a blue arrow, and rmpA2 with a red arrow.

Published
2022
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36. Additional file 8 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Abstract

Additional file 8: Figure S8. Core genome phylogenetic tree of hypervirulent K. pneumoniae isolates. A maximum likelihood phylogenetic tree was generated from core genome SNP loci in hvKP isolates from United States hospitals and selected global reference isolates. Isolates labeled in red text are NMH bloodstream isolates from this study. Clonal group 23 sublineage 1 (CG23-1) isolates are indicated in a red box. Sequence types (ST) and capsule types (KL) are indicated. The presence of virulence genes is indicated next to each isolate: ybt = yersiniabactin biosynthesis loci, clb = colibactin biosynthesis loci, rmpADC = mucoid regulator operon, rmpA2 = regulator of mucoid phenotype 2, iuc = aerobactin biosynthesis genes, iro = salmochelin biosynthesis genes. KPPR1, KP52.145, SB5881, K180005, NCTC9494, NTUH-K2044, RJF999, and ED2 are isolates used as references (accession numbers are listed in Table S7).

Published
2022
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37. Additional file 2 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Abstract

Additional file 2: Figure S2. NMH K. pneumoniae bloodstream isolates are highly diverse in ST, KL, and O-antigen. Numbers of genomes with each corresponding ST (A), KL (B), or O-antigen type (C) were determined using Kleborate and Kaptive.

Published
2022
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38. Additional file 4 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Author

Kochan, Travis J., Nozick, Sophia H., Medernach, Rachel L., Cheung, Bettina H., Gatesy, Samuel W. M., Lebrun-Corbin, Marine, Mitra, Sumitra D., Khalatyan, Natalia, Krapp, Fiorella, Qi, Chao, Ozer, Egon A., and Hauser, Alan R.

Subjects
polycyclic compounds, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Additional file 4: Figure S4. Beta-lactam-resistant isolates contain a variety of extended-spectrum beta-lactamase or carbapenemase genes. Numbers of genomes containing the indicated beta-lactamase genes present in isolates resistant to ceftriaxone (A), meropenem (B), ampicillin/sulbactam (C), aztreonam (D), cefazolin (E), or cefepime (F) are plotted. “- “ indicates isolates without an extended-spectrum beta-lactamase gene.

Published
2022
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40. Association Between Clostridium innocuum and Antibiotic-Associated Diarrhea in Adults and Children: A Cross-sectional Study and Comparative Genomics Analysis.

Author

Cherny, Kathryn E, Muscat, Emily B, Balaji, Aakash, Mukherjee, Jayabrata, Ozer, Egon A, Angarone, Michael P, Hauser, Alan R, Sichel, Joseph S, Amponsah, Emmanuel, and Kociolek, Larry K

Subjects
DIARRHEA, SEQUENCE analysis, AGE distribution, MICROBIAL genetics, CROSS-sectional method, CLOSTRIDIUM diseases, RISK assessment, COMPARATIVE studies, FECES, GENOMICS, RESEARCH funding, DISEASE prevalence, DESCRIPTIVE statistics, CLOSTRIDIUM, ANTIBIOTICS, DISEASE complications, CHILDREN, ADULTS, ADOLESCENCE
Abstract

Background A recent study from Taiwan suggested that Clostridium innocuum may be an unrecognized cause of antibiotic-associated diarrhea (AAD) and clinically indistinguishable from Clostridioides difficile infection. Our objective was to compare C. innocuum prevalence and strain between those with AAD and asymptomatic controls. Methods In this cross-sectional study, we collected stool from 200 individuals with AAD and 100 asymptomatic controls. We evaluated the association between AAD and C. innocuum in stool using anaerobic culture and quantitative polymerase chain reaction (qPCR). To identify strain-specific associations with AAD, we performed whole-genome sequencing of C. innocuum isolates using Illumina MiSeq and constructed comparative genomics analyses. Results C. innocuum was isolated from stool of 126/300 (42%) subjects and more frequently from asymptomatic controls than AAD subjects (50/100 [50%] vs 76/200 [38%], respectively; P =.047). C. innocuum isolation frequency was not associated with AAD in either the adult or pediatric subgroups. C. innocuum and C. difficile were frequently co-prevalent in individuals with and without diarrhea. There were no phylogenetic differences or accessory genome associations between C. innocuum isolates from AAD subjects and asymptomatic controls. Conclusions C. innocuum was frequently isolated and at a greater frequency in asymptomatic controls than those with AAD. We did not identify strain lineages or accessory genomic elements associated with AAD. These data highlight that differentiating C. innocuum –associated diarrhea from asymptomatic colonization, and differentiating diarrhea caused by C. difficile from C. innocuum , are clinical microbiology challenges that require additional investigation to identify host-specific factors and/or biomarkers that distinguish these conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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43. 1237. Characterization and crystallization of OXA-935, a novel class D OXA-10-like beta-lactamase, found in Pseudomonas aeruginosa

Author

Pincus, Nathan B, primary, Rosas-Lemus, Monica, additional, Gatesy, Samuel W, additional, Shuvalova, Ludmilla, additional, Minasov, George, additional, Satchell, Karla, additional, Brunzelle, Joseph S, additional, Lebrun-Corbin, Marine, additional, Ozer, Egon A, additional, Hauser, Alan R, additional, and R Bachta, Kelly E, additional

Published
2021
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46. Genomic and phenotypic characterization of Pseudomonas hygromyciniae, a novel bacterial species discovered from a commercially purchased antibiotic

Author

Turner, Timothy Lee, primary, Mitra, Sumitra Debina, additional, Kochan, Travis Joseph, additional, Pincus, Nathan B, additional, Corbin, Marine L, additional, Cheung, Bettina, additional, Gatesy, Samuel WM, additional, Afzal, Tania, additional, Ozer, Egon Anderson, additional, and Hauser, Alan R, additional

Published
2021
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47. Functional and Structural Characterization of OXA-935, a Novel OXA-10-family β-lactamase from Pseudomonas aeruginosa

Author

Pincus, Nathan B, primary, Rosas-Lemus, Monica, additional, Gatesy, Samuel WM, additional, Shuvalova, Ludmilla A., additional, Brunzelle, Joseph, additional, Minasov, George A., additional, Satchell, Karla J. F., additional, Lebrun-Corbin, Marine, additional, Ozer, Egon Anderson, additional, Hauser, Alan R, additional, and Bachta, Kelly E. R., additional

Published
2021
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50. Generating Genotype-Specific Aminoglycoside Combinations with Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae

Author

Huang, Yanqin, primary, Sokolowski, Karol, additional, Rana, Amisha, additional, Singh, Nidhi, additional, Wang, Jiping, additional, Chen, Ke, additional, Lang, Yinzhi, additional, Zhou, Jieqiang, additional, Kadiyala, Neera, additional, Krapp, Fiorella, additional, Ozer, Egon A., additional, Hauser, Alan R., additional, Li, Jian, additional, Bulitta, Jürgen B., additional, and Bulman, Zackery P., additional

Published
2021
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