Additional file 8 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Additional file 8: Figure S8. Core genome phylogenetic tree of hypervirulent K. pneumoniae isolates. A maximum likelihood phylogenetic tree was generated from core genome SNP loci in hvKP isolates from United States hospitals and selected global reference isolates. Isolates labeled in red text are NMH bloodstream isolates from this study. Clonal group 23 sublineage 1 (CG23-1) isolates are indicated in a red box. Sequence types (ST) and capsule types (KL) are indicated. The presence of virulence genes is indicated next to each isolate: ybt = yersiniabactin biosynthesis loci, clb = colibactin biosynthesis loci, rmpADC = mucoid regulator operon, rmpA2 = regulator of mucoid phenotype 2, iuc = aerobactin biosynthesis genes, iro = salmochelin biosynthesis genes. KPPR1, KP52.145, SB5881, K180005, NCTC9494, NTUH-K2044, RJF999, and ED2 are isolates used as references (accession numbers are listed in Table S7).