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473 results on '"Harms, G."'

2. OC 49.4 Targeting Myeloid Cell Coagulation Signaling Blocks Map Kinase/TGF-β1 Driven Fibrotic Remodeling, Improves Cardiac Function and Improves Survival in Ischemic Heart Failure

Author

Garlapati, V., primary, Molitor, M., additional, Michna, T., additional, Finger, S., additional, Harms, G., additional, Daiber, A., additional, Brandt, M., additional, Tenzer, S., additional, Gori, T., additional, Milting, H., additional, Ruf, W., additional, and Wenzel, P., additional

Published
2023
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9. High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma

Author

Rust, R, Harms, G, Blokzijl, T, Boot, M, Diepstra, A, Kluiver, J, Visser, J, Peh, S-C, Lim, M, Kamps, W A, Poppema, S, and van der Berg, A

Subjects
Tumors in children -- Diagnosis, Tumors in children -- Care and treatment, Tumors in children -- Research, Lymphomas -- Diagnosis, Lymphomas -- Care and treatment, Lymphomas -- Research, Gene expression -- Research, Gene expression -- Comparative analysis, Health
Published
2005

11. Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop. (Major Article)

Author

Jelinek, T., Muhlberger, N., Harms, G., Corachan, M., Grobusch, M.P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjorup, I., Chalupa, P., Hatz, C., Matteelli, A., Schmid, M., Nielsen, L.N., Cunha, S. da, Atouguia, J., Myrvang, B., and Fleischer, K.

Subjects
Dengue -- Care and treatment, Dengue -- Diagnosis, Dengue -- Demographic aspects, Travelers -- Health aspects, Health, Health care industry
Published
2002

12. Imported falciparum malaria in Europe: Sentinel surveillance data from the European network on surveillance of imported infectious diseases. (Major Article)

Author

Jelinek, T., Schulte, C., Behrens, R., Grobusch, M.P., Coulaud, J.P., Bisoffi, Z., Matteelli, A., Clerinx, J., Corachan, M., Puente, S., Gjorup, I., Harms, G., Kollaritsch, H., Kotlowski, A., Bjorkmann, A., Delmont, J.P., Knobloch, J., Nielsen, L.N., Cuadros, J., Hatz, C., Doolittle, Hilda, Schmid, M.L., Schulze, M., Lopez-Velez, R., Fleischer, K., Kapaun, A., McWhinney, P., Kern, P., Atougia, J., Fry, G., Cunha, S. da, and Boecken, G.

Subjects
Europe -- Health aspects, Malaria -- Demographic aspects, Health, Health care industry
Published
2002

13. Optimization of high-temperature superconducting power transformers

Author

Sissitamos, E., Harms, G., and Oswald, B.R.

Subjects
Electric transformers -- Research, Industrial design -- Product information, Structural optimization -- Research, Superconductivity -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Research is presented describing how high-temperature superconducting power transformers are designed to optimize performance. The most effective design in terms of low load and non-load losses must take into account the transformer volume and the voltage of the impedance.

Published
2001

31. Animal-Associated Exposure to Rabies Virus among Travelers, 1997–2012

Author

Gautret, P., Harvey, K., Pandey, P., Lim, P. L., Leder, K., Piyaphanee, W., Shaw, M., Mcdonald, S. C., Schwartz, E., Esposito, D. H., Parola, P., Delmont, J., Torresi, J., Brown, G., Yoshimura, Y., Tachikawa, N., Kurai, H., Sagara, H., Von Sonnenburg, F., Kanagawa, S., Kato, Y., Mizunno, Y., Hern, A., Chappuis, F., Loutan, L., Keystone, J. S., Kain, K., Grobusch, M., De Vries, P., Gadroen, K., Using, J., Froberg, G., Libman, M. D., Ward, B., Dick Maclean, J., Rapp, C., Aoun, O., Valdez, L. M., Siu, H., Cramer, J., Burchard, G. -D., Phu, P. T. H., Anderson, N., Batchelor, T., Meisch, D., Jensenius, M., Lalloo, D. G., Beeching, N. J., Stauffer, W., Walker, P., Kass, R., Jean Haulman, N., Roesel, D., Jong, E. C., Wang, A., Eason, J., Kendall, B., Hale, D. C., Anand, R., Gelman, S. S., Chen, L. H., Wilson, M. E., Silachamroon, U., Borwein, S., Van Genderen, P. J., Vincelette, J., Gurtman, A., Kozarsky, P. E., Wu, H., Fairley, J., Franco-Paredes, C., Schlagenhauf, P., Weber, R., Steffen, R., Yates, J., Ansdell, V., Mendelson, M., Vincent, P., Mockenhaupt, F., Harms, G., Perret, C., Valdivieso, F., Doyle, P., Ghesquiere, W., Cahill, J. D., Mckinley, G., Mccarthy, A., Caumes, E., Perignon, A., Anderson, S., Hynes, N. A., Bradley Sack, R., Mckenzie, R., Field, V., Connor, B. A., Muller, R., Freedman, D. O., Hagmann, S., Miller, A. O., Gkrania-Klotsas, E., Tenenboim, S., Jenks, N. P., Kerr, C., Licitra, C., Crespo, A., Castelli, F., Carosi, G., Holtom, P., Goad, J., and Anglim, A.

Subjects
Male, History, Veterinary medicine, Time Factors, Epidemiology, lcsh:Medicine, rabies, medicine.disease_cause, Global Health, Medical care, 0302 clinical medicine, Rabies vaccine, 80 and over, Global health, 030212 general & internal medicine, Child, travel, Animal Bites, Aged, 80 and over, Middle Aged, 21st Century, 3. Good health, 20th Century, Vaccination, Infectious Diseases, GeoSentinel, animal-related exposure, rabies virus, viruses, Adolescent, Adult, Aged, Animals, Female, History, 20th Century, History, 21st Century, Humans, Population Surveillance, Rabies, Seasons, Young Adult, Rabies virus, Travel, Synopsis, medicine.drug, Microbiology (medical), 030231 tropical medicine, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Environmental health, medicine, lcsh:RC109-216, Rabies transmission, business.industry, lcsh:R, medicine.disease, Animal-Associated Exposure to Rabies Virus among Travelers, 1997–2012, business, human activities
Abstract

No demographic characteristics identified who might benefit most from pretravel counseling., Among travelers, rabies cases are rare, but animal bites are relatively common. To determine which travelers are at highest risk for rabies, we studied 2,697 travelers receiving care for animal-related exposures and requiring rabies postexposure prophylaxis at GeoSentinel clinics during 1997–2012. No specific demographic characteristics differentiated these travelers from other travelers seeking medical care, making it challenging to identify travelers who might benefit from reinforced pretravel rabies prevention counseling. Median travel duration was short for these travelers: 15 days for those seeking care after completion of travel and 20 days for those seeking care during travel. This finding contradicts the view that preexposure rabies vaccine recommendations should be partly based on longer travel durations. Over half of exposures occurred in Thailand, Indonesia, Nepal, China, and India. International travelers to rabies-endemic regions, particularly Asia, should be informed about potential rabies exposure and benefits of pretravel vaccination, regardless of demographics or length of stay.

Published
2015

42. HIV and syphilis in Madagascar

Author

Harms, G., Kirsch, Th., Rahelimiarana, N., Hof, U., Rarivoharilala, E., Andriamahenina, R., Rajhonson, M., and Rasamindrakotroka, A. J.

Published
1994

44. Gas utility okays joining method for tie-ins and repairs - part 2

Author

Harms, G. Art

Subjects
Canadian Western Natural Gas -- Equipment and supplies, Gas utilities -- Equipment and supplies, Pipe lines -- Maintenance and repair, Business, Petroleum, energy and mining industries
Abstract

After extensive test evaluations, documentation demonstrated electrofusion provided economic benefits Canadian Western Natural Gas (CWNG), like most U.S. and Canadian gas distribution utilities, was slow to adopt electrofusion for joining [...]

Published
1993

48. Epidemiology and Clinical Features of Imported Dengue Fever in Europe: Sentinel Surveillance Data from TropNetEurop

Author

Jelinek, T., Mühlberger, N., Harms, G., Corachán, M., Grobusch, M. P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjørup, I., Chalupa, P., Hatz, C., Matteelli, A., Schmid, M., Nielsen, L. N., da Cunha, S., Atouguia, J., Myrvang, B., Fleischer, K., Jelinek, T., Mühlberger, N., Harms, G., Corachán, M., Grobusch, M. P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjørup, I., Chalupa, P., Hatz, C., Matteelli, A., Schmid, M., Nielsen, L. N., da Cunha, S., Atouguia, J., Myrvang, B., and Fleischer, K.

Abstract

Travelers have the potential both to acquire and to spread dengue virus infection. The incidence of dengue fever (DF) among European travelers certainly is underestimated, because few centers use standardized diagnostic procedures for febrile patients. In addition, DF is currently not reported in most European public health systems. Surveillance has commenced within the framework of a European Network on Imported Infectious Disease Surveillance (TropNetEurop) to gain information on the quantity and severity of cases of dengue imported into Europe. Descriptions of 294 patients with DF were analyzed for epidemiological information and clinical features. By far the most infections were imported from Asia, which suggests a high risk of DF for travelers to that region. Dengue hemorrhagic fever occurred in 7 patients (2.4%) all of whom recovered. Data reported by member sites of the TropNetEurop can contribute to understanding the epidemiology and clinical characteristics of imported DF

Published
2017

49. Imported Falciparum Malaria in Europe: Sentinel Surveillance Data from the European Network on Surveillance of Imported Infectious Diseases

Author

Jelinek, T., Schulte, C., Behrens, R., Grobusch, M. P., Coulaud, J. P., Bisoffi, Z., Matteelli, A., Clerinx, J., Corachán, M., Puente, S., Gjørup, I., Harms, G., Kollaritsch, H., Kotlowski, A., Björkmann, A., Delmont, J. P., Knobloch, J., Nielsen, L. N., Cuadros, J., Hatz, C., Beran, J., Schmid, M. L., Schulze, M., Lopez-Velez, R., Fleischer, K., Kapaun, A., McWhinney, P., Kern, P., Atougia, J., Fry, G., da Cunha, S., Boecken, G., Jelinek, T., Schulte, C., Behrens, R., Grobusch, M. P., Coulaud, J. P., Bisoffi, Z., Matteelli, A., Clerinx, J., Corachán, M., Puente, S., Gjørup, I., Harms, G., Kollaritsch, H., Kotlowski, A., Björkmann, A., Delmont, J. P., Knobloch, J., Nielsen, L. N., Cuadros, J., Hatz, C., Beran, J., Schmid, M. L., Schulze, M., Lopez-Velez, R., Fleischer, K., Kapaun, A., McWhinney, P., Kern, P., Atougia, J., Fry, G., da Cunha, S., and Boecken, G.

Abstract

Malaria continues to have a high morbidity rate associated among European travelers. Thorough recording of epidemiological and clinical aspects of imported malaria has been helpful in the detection of new outbreaks and areas of developing drug resistance. Sentinel surveillance of data collected prospectively since 1999 has begun within TropNetEurop, a European network focusing on imported infectious diseases. TropNetEurop appears to cover ∼10% of all patients with malaria seen in Europe. Reports of 1659 immigrants and European patients with Plasmodium falciparum malaria were analyzed for epidemiological information and data on clinical features. Regional data were quite diverse, reflecting local patterns of immigration and international travel. By far, the most infections were imported from West Africa. Europeans had more clinical complications; consequently, all deaths occurred in this group. Compared with European standards, the mortality rate was low (0.6% in Europeans). Data from TropNetEurop member sites can contribute to our understanding of the epidemiological and clinical findings regarding imported falciparum malaria

Published
2017

50. Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue

Author

Mencke, R., Harms, G., Mirkovic, K., Struik, J., Ark, J. van, Loon, E. van, Verkaik, M., Borst, M.H. de, Zeebregts, C.J., Hoenderop, J.G., Vervloet, M.G., Hillebrands, J.L., NIGRAM Consortium, Nephrology, ICaR - Circulation and metabolism, Groningen Kidney Center (GKC), Lifestyle Medicine (LM), Vascular Ageing Programme (VAP), Man, Biomaterials and Microbes (MBM), and Groningen Institute for Organ Transplantation (GIOT)

Subjects
Fibroblast growth factor 23, CHRONIC KIDNEY-DISEASE, medicine.medical_specialty, RENAL-FAILURE, Physiology, SMOOTH-MUSCLE-CELLS, PROTEIN, Biology, urologic and male genital diseases, Klotho, Physiology (medical), medicine.artery, Internal medicine, Chronic kidney disease, medicine, CARDIOVASCULAR EVENTS, Kidney, Aorta, TRANSCRIPTS ENCODING MEMBRANE, medicine.disease, Cardiovascular disease, GENE, CALCIFICATION, female genital diseases and pregnancy complications, Blot, MICE, medicine.anatomical_structure, Endocrinology, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Smooth muscle cells, Immunohistochemistry, Cardiology and Cardiovascular Medicine, Kidney disease, Calcification, GROWTH-FACTOR 23
Abstract

Contains fulltext : 152471.pdf (Publisher’s version ) (Closed access) AIMS: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD), a disease state that is strongly associated with loss of renal and systemic (alpha-)Klotho. Reversely, murine Klotho deficiency causes marked medial calcification. It is therefore thought that Klotho conveys a vasculoprotective effect. Klotho expression in the vessel wall, however, is disputed. METHODS AND RESULTS: We assessed Klotho expression in healthy human renal donor arteries (n = 9), CKD (renal graft recipient) arteries (n = 10), carotid endarterectomy specimens (n = 8), other elastic arteries (three groups of n = 3), and cultured human aortic smooth muscle cells (HASMCs) (three primary cell lines), using immunohistochemistry (IHC), immunofluorescence, quantitative reverse transcriptase-polymerase chain reaction, and western blotting (WB). We have extensively validated anti-Klotho antibody KM2076 by comparing staining patterns with other anti-Klotho antibodies (SC-22220, SC-22218, and AF1819), competition assays with recombinant Klotho, IHC on Klotho-deficient kl/kl mouse kidney, and WB with recombinant Klotho. Using KM2076, we could not detect full-length Klotho in vascular tissues or HASMCs. On the mRNA level, using primers against all four exon junctions, klotho expression could not be detected either. Fibroblast growth factor 23 (FGF23) injections in mice induced FGF23 signalling in kidneys but not in the aorta, indicating the absence of Klotho-dependent FGF23 signalling in the aorta. CONCLUSION: Using several independent and validated methods, we conclude that full-length, membrane-bound Klotho is not expressed in healthy or uraemic human vascular tissue.

Published
2015
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