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In order to obtain the microwave absorption (MA) materials with light weight, high efficiency and tunable properties, the carbonized mesophase pitch (CMP) with the variation in carbonization temperatures and particle sizes were prepared and characterized. The carbonization temperature mainly controlled the graphitization degree of the CMP to affect their conductive loss. The carbon residues were generated on the CMP surface when the temperature was higher than 700 °C, which contributed significantly to the polarization loss of the CMP. For scale regulation, the segregation between the particles in the paraffin ring caused by the reduction particles of CMP carbonization at 750 °C (750 CMP) resulted in a significant reduction in conductive losses while improving their impedance matching. The 750 CMP over 300 mesh sieved had the strongest MA properties of −53 dB at 3.49 GHz within 5.5 mm. Moreover, the prepared CMPs were multi-layer compounded and optimized by CST microwave studio. The synergistic effect derived from the improved impedance matching and the enhanced interfacial polarization resulted in significant reflection loss in multi-layer CMP. Overall, these findings lead to the systematically regulation of carbon-based materials for MA, showing an attractive application prospect for the preparation of high-performance MA materials.

IntroductionThis study examines how negation is processed in a nonverbal context (e.g., when assessing ▲ ≠ ▲) by speakers of a truth-based system like Mandarin and a polarity-based system like English. In a truth-based system, negation may take longer to process because it is typically attached to the negation as a whole (it is not true that triangle does not equal triangle), whereas in polarity-based systems, negation is processed relatively faster because it is attached to just the equation symbol (triangle does not equal triangle), which is processed relatively faster. Our hypothesis was that negation processing routines previously observed for verbal contexts, namely that speakers of Mandarin get slowed down more when processing negative stimuli than positive stimuli compared to speakers of English, also extend to contexts when language use is not obligatory.MethodsTo test this, we asked participants to agree/disagree with equations comprising simple shapes and positive ‘=’ or negative ‘≠’ equation symbols. English speakers showed a response-time advantage over Mandarin speakers in negation conditions. In a separate experiment, we also tested the contribution of equation symbols ‘≠’/‘=’ to the cognitive demands by asking participants to judge shape sameness in symbol-free trials, such as ▲ ■. This comparison allowed us to test whether crosslinguistic differences arise not because of shape congruence judgement but arguably due to negation attachment.Results and discussionThe effect of the ‘≠’ symbol on shape congruence was language-specific, speeding up English speakers but slowing down Mandarin speakers when the two shapes differed. These findings suggest language-specific processing of negation in negative equations, interpreted as novel support for linguistic relativity.

Abstract Aim This study aimed to determine whether family‐centred care (FCC) intervention reduces the ICU delirium prevalence. Design A systematic review and meta‐analysis. Methods The databases, including PubMed, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL Complete, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), WANFANG Data and VIP Information, were systematically searched up to 30 November 2021. The search term includes keywords related to intensive care units, delirium and family‐centred care. Meta‐analyses were performed and presented by risk ratio (RR), mean difference (MD) and corresponding 95% confidence intervals (CIs). Results The meta‐analysis results showed that compared with the usual care, FCC intervention has positive effects on reducing ICU delirium prevalence [RR = 0.54, 95% CIs (0.36, 0.81), p

BackgroundPostoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, which is associated with age and massive bleeding. However, whether thyroid hormone (TH) level can affect POAF remains controversial.AimTo investigate the occurrence and risk factors of POAF, in particular, the preoperative TH level of patients was introduced into this study as a variable for analysis, and a column graph prediction model of POAF was constructed.MethodsPatients who underwent valve surgery in Fujian Cardiac Medical Center from January 2019 to May 2022 were retrospectively analyzed and divided into POAF group and NO-POAF group. Baseline characteristics and relevant clinical data were collected from the two groups of patients. Independent risk factors for POAF were screened using univariate analysis and binary logistic regression analysis, and a column line graph prediction model was established based on the regression analysis results, and the diagnostic efficacy and calibration of the model were evaluated using the Receiver Operating Characteristic Curve (ROC) and calibration curve.ResultsA total of 2,340 patients underwent valve surgery, excluding 1,751 patients, a total of 589 patients were included, including 89 patients in POAF group and 500 patients in NO-POAF group. The total incidence of POAF was 15.1%. The results of the Logistics regression analysis showed that gender, age, leukocytes and TSH were risk factors of POAF. The area under the ROC curve of the nomogram prediction model for POAF was 0.747 (95% CI: 0.688–0.806, P 0.05, the calibration curve was well fitted.ConclusionThe results of this study show that gender, age, leukocyte and TSH are risk factors of POAF, and the nomogram prediction model has a good prediction effect. Due to the limited sample size and included population, more studies are needed to validate this result.

Abstract The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐MSCs) may be responsible for the poor clinical outcomes and poor reproducibility of treatments based on WJ‐MSCs. Exploration of WJ‐MSC heterogeneity with multimodal single‐cell technologies will aid in establishing accurate MSC subtyping and developing screening protocols for dominant functional subpopulations. Here, the characteristics of WJ‐MSCs are systematically analyzed by single cell and spatial transcriptome sequencing. Single‐cell transcriptomics analysis identifies four WJ‐MSC subpopulations, namely proliferative_MSCs, niche‐supporting_MSCs, metabolism‐related_MSCs and biofunctional‐type_MSCs. Furthermore, the transcriptome, cellular heterogeneity, and cell‐state trajectories of these subpopulations are characterized. Intriguingly, the biofunctional‐type MSCs (marked by S100A9, CD29, and CD142) selected in this study exhibit promising wound repair properties in vitro and in vivo. Finally, by integrating omics data, it has been found that the S100A9+CD29+CD142+ subpopulation is more enriched in the fetal segment of the umbilical cord, suggesting that this subpopulation deriving from the fetal segment may have potential for developing into an ideal therapeutic agent for wound healing. Overall, the presented study comprehensively maps the heterogeneity of WJ‐MSCs and provides an essential resource for future development of WJ‐MSC‐based drugs.

Résumé Contexte en tant que nouvelle méthode chirurgicale pour le traitement de l’insuffisance cardiaque chez les personnes âgées, la chirurgie par pince de la valve mitral aiguë nécessite la collaboration de médecins multidisciplinaires pour assurer un traitement et des soins appropriés. Objectifs étudier l’application du modèle de soins en équipe multidisciplinaire dans le traitement clinique et les soins aux patients atteints de la valve mitral par pince. Méthode sur 10 patients, 4 hommes (40%) et 6 femmes (60%) ont un âge moyen de 71.4 à 5.2 ans. L’équipe multidisciplinaire est. composée d’infirmiers spécialisés dans les maladies graves, la santé cardiaque, la réadaptation, la psychologie, la nutrition et la douleur. L’équipe a mené une discussion approfondie sur les problèmes spécifiques des patients soumis à une opération de la valve mitral transspiroptérale, a élaboré des mesures de soins personnalisées et a mis en œuvre des politiques précises. Résultats aucune complication postoperatoire grave n’a été observée chez les 10 patients de ce groupe, et les défaillances cardiaques ont été nettement améliorées chez tous les patients. Une double échographie en couleur a montré que le degré de regurgitation mitral était inférieur ou égal à 2+ dans 10 patients sortant de cette étude; Les scores sur l’échelle des activités de la vie quotidienne à la sortie de l’hôpital étaient nettement plus élevés dans 10 cas que dans le cas préopératoire (69.0 ± 4.6 contre 55.0 ± 5.8). En outre, les résultats d’un essai de marche de 6 min à la sortie de l’hôpital étaient nettement supérieurs à ceux observés avant l’opération (318.0 ± 21.7 m contre 295.2 ± 18.4 m). Conclusion le recours à des équipes multidisciplinaires permet aux infirmiers/infirmières spécialisés de fournir des soins plus complets et systématiques aux patients soumis à la chirurgie par compression de la valve mitral, ce qui facilite leur réadaptation.

Abstract Background Small extracellular vesicles (sEVs) with genetic information secreted by cells play a crucial role in the cellular microenvironment. In this study, our purpose is to explore the characteristics of the small extracellular vesicles of human adipose-derived mesenchymal stromal cells (hADMSC-sEVs) and studied the role of hADMSC-sEVs in improving the survival rate of grafted fat. Methods In the present study, we used the transmission electron microscopy, nano-tracking analysis, nanoflow surface protein analysis, and zeta potential value to identify sEVs. SEVs’ trajectory was traced dynamically to verify whether hADMSC-sEVs can be internalized into human umbilical vein endothelial cells (HUVECs) in vitro at different times. The angiogenic property of hADMSC-sEVs was observed by measuring the volume, weight, and histological analysis of the grafted fats in nude mouse models. Results Our research showed that the hADMSC-sEVs were sEVs with double-layer membrane structure and the diameter of which is within 30–150 nm. hADMSC-sEVs exert biological influence mainly through internalization into cells. Compared with the control group, the hADMSC-sEVs group had a significantly higher survival rate of grafted fat, morphological integrity, and a lower degree of inflammation and fibrosis. And immunohistochemistry showed that hADMSC-sEVs significantly increased the neovascularisation and the expression of CD34, VEGFR2, and Ki-67 in the graft tissue. Conclusions As a potential nanomaterial, hADMSC-sEVs have been explored in the field of cell-free application of stem cell technology. hADMSC-sEVs promoted the survival of grafted fats by promoting the formation of new blood vessels, which is another promising progress in the field of regenerative medicine. We believe that hADMSC-sEVs will have a broad application prospect in the field of regenerative medicine in the future.

Abstract Background Mesenchymal stem cell-based acellular therapies have been widely exploited in managing hypertrophic scars. However, low maintenance dose and transitory therapeutic effects during topical medication remain a thorny issue. Herein, this study aimed to optimize the curative effect of adipose-derived stem cell conditioned medium (ADSC-CM) in the prevention of hypertrophic scarring. Methods In the present study, ADSC-CM was concentrated via the freeze-drying procedure. The efficacy of different dose groups (CM, CM5, CM10) was conducted on the proliferation, apoptosis, and α-smooth muscle actin (α-SMA) expression of human keloid fibroblasts (HKFs) in vitro. Incorporation of adipose-derived stem cell concentrated conditioned medium (ADSCC-CM) into polysaccharide hydrogel was investigated in rabbit ear, in vivo. Haematoxylin-eosin (H&E) and Masson’s trichrome staining were performed for the evaluation of scar hyperplasia. Results We noted that ADSCC-CM could downregulate the α-SMA expression of HKFs in a dose-dependent manner. In the rabbit ear model, the scar hyperplasia in the medium-dose group (CM5) and high-dose group (CM10) was inhibited with reduced scar elevation index (SEI) under 4 months of observation. It is noteworthy that the union of CM5 and polysaccharide hydrogel (CM5+H) yielded the best preventive effect on scar hyperplasia. Briefly, melanin, height, vascularity, and pliability in the CM5+H group were better than those of the control group. Collagen was evenly distributed, and skin appendages could be regenerated. Conclusions Altogether, ADSCC-CM can downregulate the expression of α-SMA due to its anti-fibrosis effect and promote the rearrangement of collagen fibres, which is integral to scar precaution. The in situ cross bonding of ADSCC-CM and polysaccharide hydrogel could remarkably enhance the therapeutic outcomes in inhibiting scar proliferation. Hence, the alliance of ADSCC-CM and hydrogel may become a potential alternative in hypertrophic scar prophylaxis.

Abstract Background Neurological complications is a common complication following novel triple-branched stent graft implantation in patients with Stanford type A aortic dissection (AAD). But the incidence and risk factors of postoperative delirium (POD) are not completely clear. The aim of this study was to investigate the incidence and risk factors of POD after novel triple-branched stent graft implantation. Methods An observational study of AAD patients who underwent novel triple-branched stent graft implantation between January 2017 and July 2019 were followed up after surgery. Patients’ delirium was screened by the Richmond Agitation-Sedation Scale and the Confusion Assessment Method for the intensive care unit from the first day after the operation, lasted 5 days. The risk factors of POD were analyzed by the Cox proportional hazard models. Results A total of 280 AAD patients were enrolled in this research, the incidence of POD was 37.86%. Adjusting for age, body mass index, and mechanical ventilation duration, multivariate Cox regression analysis model revealed that non-manual work (adjusted hazard ratio [AHR] = .554; 95% CI: 0.335–0.915; P = .021), Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores > 20 (AHR = 3.359, 95% CI: 1.707–6.609, P 20, hypoxemia, and more types of analgesics and sedatives, and non-manual work was the protective factor. Trial registration This study was retrospectively registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR1900022408 ; Date: 2019/4/10).

Event segmentation tests have shown substantial overlaps in how adults recognize starts and endpoints as events unfold. However, far less is known about what role different language systems play in the process. Variations in grammatical aspect have been shown to influence event processing. We tested how closely first language (L1) speakers of Mandarin and English versus Mandarin learners of English as a second language (L2) align event boundaries with event-internal changes. We used two event boundary marking tasks (online/offline) and a sorting task. Participants saw 60 animations; their task was to indicate starts and endpoints. For punctual events (e.g., "breaking a wall"), Mandarin L1 speakers and Mandarin learners of English L2 were significantly further from event transitions than English L1 speakers. This pattern was replicated in the untimed experiment but not in sorting transitions, jointly suggesting that Mandarin L1 and Mandarin learners of English L2 may be less attentive to segmentation of phases surrounding transitions than English L1 speakers. We argue that this variation reflects L1-specific encoding of ongoingness.

Introduction: This study examines how negation is processed in a nonverbal context (e.g., when assessing ▲ ≠ ▲) by speakers of a truth-based system like Mandarin and a polarity-based system like English. In a truth-based system, negation may take longer to process because it is typically attached to the negation as a whole (it is not true that triangle does not equal triangle), whereas in polaritybased systems, negation is processed relatively faster because it is attached to just the equation symbol (triangle does not equal triangle), which is processed relatively faster. Our hypothesis was that negation processing routines previously observed for verbal contexts, namely that speakers of Mandarin get slowed down more when processing negative stimuli than positive stimuli compared to speakers of English, also extend to contexts when language use is not obligatory. Methods: To test this, we asked participants to agree/disagree with equations comprising simple shapes and positive '=' or negative '≠' equation symbols. English speakers showed a response-time advantage over Mandarin speakers in negation conditions. In a separate experiment, we also tested the contribution of equation symbols '≠'/'=' to the cognitive demands by asking participants to judge shape sameness in symbol-free trials, such as ▲ ■. This comparison allowed us to test whether crosslinguistic differences arise not because of shape congruence judgement but arguably due to negation attachment. Results and discussion: The effect of the '≠' symbol on shape congruence was language-specific, speeding up English speakers but slowing down Mandarin speakers when the two shapes differed. These findings suggest language-specific processing of negation in negative equations, interpreted as novel support for linguistic relativity. [ABSTRACT FROM AUTHOR]