7 results on '"Hao-Jun Lei"'
Search Results
2. Dietary Seleno-l-Methionine Causes Alterations in Neurotransmitters, Ultrastructure of the Brain, and Behaviors in Zebrafish (
- Author
-
Jingli Mu, Dan Li, Hao-Jun Lei, Daniel Schlenk, Xinrong Wei, Hongxing Chen, Bo Yan, Hongsong Liu, Lingtian Xie, and Xiao Li
- Subjects
medicine.medical_specialty ,Danio ,Respiratory chain ,Antioxidants ,chemistry.chemical_compound ,Dopamine ,Internal medicine ,medicine ,Environmental Chemistry ,Animals ,Selenomethionine ,Zebrafish ,Neurotransmitter Agents ,biology ,Brain ,General Chemistry ,biology.organism_classification ,Malondialdehyde ,Endocrinology ,chemistry ,Serotonin ,Acetylcholine ,Histamine ,Water Pollutants, Chemical ,medicine.drug - Abstract
Elevated concentrations of dietary selenium (Se) cause abnormalities and extirpation of fish inhabiting in Se-contaminated environments. However, its effect on fish behavior and the underlying mechanisms remain largely unknown. In this study, two-month-old zebrafish (Danio rerio) was fed seleno-l-methionine (Se-Met) at environmentally relevant concentrations (i.e., control (2.61), low (5.43), medium (12.16), and high (34.61) μg Se/g dry weight (dw), respectively, corresponding to the C, L, M, and H treatments) for 60 days. Targeted metabolomics, histopathological, and targeted transcriptional endpoints were compared to behavioral metrics to evaluate the effects of dietary exposure to Se-Met . The results showed that the levels of total Se and malondialdehyde in fish brains were increased in a dose-dependent pattern. Meanwhile, mitochondrial damages and decreased activities of the mitochondria respiratory chain complexes were observed in the neurons at the M and H treatments. In addition, dietary Se-Met affected neurotransmitters, metabolites, and transcripts of the genes associated with the dopamine, serotonin, gamma-aminobutyric acid, acetylcholine, and histamine signaling pathways in zebrafish brains at the H treatments. The total swimming distance and duration in the Novel Arm were lowered in fish from the H treatment. This study has demonstrated that dietary Se-Met affects the ultrastructure of the zebrafish brain, neurotransmitters, and associated fish behaviors and may help enhance adverse outcome pathways for neurotransmitter-behavior key events in zebrafish.
- Published
- 2021
3. The effects of the chemotherapy drug cyclophosphamide on the structure and functioning of freshwater communities under sub-tropical conditions: A mesocosm study
- Author
-
Dan Li, Guang-Guo Ying, Dimitri Van de Perre, Hao Jun Lei, Kai Sheng Yao, and Paul J. Van den Brink
- Subjects
Environmental Risk Assessment ,Aquatic Ecology and Water Quality Management ,Environmental Engineering ,Fresh Water ,Biology ,Zooplankton ,Freshwater ecosystem ,Mesocosm ,Animal science ,Phytoplankton ,Dissolved organic carbon ,Environmental Chemistry ,Animals ,Ecosystem ,Waste Management and Disposal ,Cyclophosphamide ,Freshwater communities ,WIMEK ,Plankton ,Aquatic ecotoxicology ,Aquatische Ecologie en Waterkwaliteitsbeheer ,Pollution ,Mesocosms ,Pharmaceutical Preparations ,Chemotherapy drug ,Microbial loop ,Water Pollutants, Chemical - Abstract
Cyclophosphamide (CP) is a chemotherapy drug which is widely used in the treatment of neoplastic diseases and have often been detected in urban and hospital wastewater, and surface waters. However, at present the effects of CP on aquatic organisms and ecosystems are poorly understood. The main objective of the present study was to assess the effect of CP on the structure and functioning of a sub-tropical freshwater ecosystem (macroinvertebrates, zooplankton and phytoplankton) at environmental relevant concentrations. CP (0, 0.5, 5 and 50 μg/L) was applied weekly to 13,600 L mesocosms over a period of four weeks followed by a one month post exposure period. CP was found to dissipate much faster than previous reported in literature and the half-dissipation times were treatment dependent, being 2.2, 21.3 and 23.6 days in the lowest, middle and highest treatments respectively. Only treatment related effects were observed on the community structure at individual samplings with zooplankton (NOECcommunity = 0.5 μg/L) responding at lower concentrations than phytoplankton (NOECcommunity = 5 μg/L) and macroinvertebrates (NOECcommunity ≥ 50 μg/L). The dissolved organic carbon concentration was consistently higher in the 2 highest treatments, indicating a potential effect on food web interactions and/or the microbial loop. At the population level, consistent adverse effects were observed for the plankton taxa Pleuroxus laevis, Dissotrocha sp. and Oscillatoria sp. at all CP concentrations (NOEC
- Published
- 2021
4. Transformation products of tetracyclines in three typical municipal wastewater treatment plants
- Author
-
Shao-Fen Zhong, Bin Yang, Hao-Jun Lei, Qian Xiong, Qian-Qian Zhang, Fang Liu, and Guang-Guo Ying
- Subjects
Environmental Engineering ,Sewage ,Oxytetracycline ,Tetracycline ,Wastewater ,Pollution ,Anti-Bacterial Agents ,Water Purification ,Tetracyclines ,Doxycycline ,Animals ,Environmental Chemistry ,Waste Management and Disposal ,Water Pollutants, Chemical ,Chlortetracycline - Abstract
Antibiotics in the environment could undergo various processes with formation of transformation products, but little has been known about their occurrence and (eco)toxicological consequences. Here we investigated the occurrence and fate of nine transformation products of four tetracyclines (tetracycline, oxytetracycline, chlortetracycline and doxycycline) in three municipal wastewater treatment plants (WWTPs) in Guangzhou, China. The results showed the detection of all the tetracyclines and their transformation products in the WWTPs, with mean concentrations ranging from 17.8 ng/L (anhydrotetracycline) to 49.1 ng/L (oxytetracycline) in influent, 3.03 ng/L (tetracycline) to 6.94 ng/L (4-epi-chlortetracycline) in effluent, and 19.8 ng/g (isochlortetracycline) to 503 ng/g (4-epi-tertracycline) in sludge, respectively. The transformation products of tetracycline, oxytetracycline, chlortetracycline and doxycycline accounted for 73%-83%, 26%-52%, 70%-73% and 69%-74% of total concentrations, respectively. The aqueous removal rates of tetracyclines and their transformation products in the three WWTPs ranged from 18.4% (demethyl-chlortetracycline) to 93.7% (oxytetracycline). Mass balance analysis based on both aqueous and solid phase showed that their removals were mainly attributed to the sludge adsorption. Residual tetracyclines and their transformation products in the effluents would pose no obvious ecological risks to three aquatic organisms (green algae, daphnia and fish). However, 43.5% of sludge samples had high risks from these tetracyclines and transformation products, especially the compounds with poor biodegradability. The results from this study suggest that transformation products should be included in future environmental monitoring and control.
- Published
- 2022
5. Occurrence, fate and mass loading of benzodiazepines and their transformation products in eleven wastewater treatment plants in Guangdong province, China
- Author
-
You-Sheng Liu, Jian-Liang Zhao, Yuan-Yuan Yang, Lingtian Xie, Guang-Guo Ying, Bin Yang, Hao-Jun Lei, and Pu Ye
- Subjects
China ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,Sewage ,010501 environmental sciences ,Wastewater ,01 natural sciences ,Mass loading ,Waste Disposal, Fluid ,Persistence (computer science) ,Water Purification ,Toxicology ,Benzodiazepines ,Environmental Chemistry ,Humans ,Waste Management and Disposal ,Effluent ,0105 earth and related environmental sciences ,business.industry ,Pollution ,Environmental science ,Sewage treatment ,business ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
Benzodiazepines (BZDs) are one of the most widely prescribed psychoactive drugs, however their persistence in the receiving environment has raised great concerns about their potential ecological risks. Here we investigated the occurrence, fate and mass loading of 17 BZDs and their 3 transformation products in 11 wastewater treatment plants (WWTPs) in Guangdong province, China. A total of 10 BZDs and 1 transformation product were found in the WWTPs influents, effluents and excess sludge, with concentrations reaching up to 44.5 ng/L (clozapine), 27.1 ng/L (oxazepam) and 62.9 ng/g (clozapine), respectively. The overall removal efficiency varied widely from negative to complete removal in these 11 WWTPs. Mass balance analysis of two representative WWTPs (WWTPA and WWTPB) with different treatment processes showed that their removals were mainly attributed to the sludge adsorption and biodegradation/biotransformation. The total usage of detected BZDs was estimated to be 185 kg/y in Guangdong province, China, while the total emission was 143 kg/y. Based on sewage epidemiology method, the total back-estimated consumption and emissions of BZDs and their transformation products in one district of Guangzhou (WWTPC service area) were 1012 mg/d/1000 people and 10.1 mg/d/1000 people, respectively. The findings from this study demonstrate the persistence of BZDs in WWTPs and also provide basis for further investigation into the potential ecological risks from this group of chemicals.
- Published
- 2020
6. Cyclophosphamide affects eye development and locomotion in zebrafish (Danio rerio)
- Author
-
Hao-Jun Lei, Lingtian Xie, Hongxing Chen, Yongju Luo, Guang-Guo Ying, Xiao Li, Weijun Sun, Guo-Yong Huang, Wen-Jun Shi, Hongsong Liu, and Dan Li
- Subjects
Embryo, Nonmammalian ,Environmental Engineering ,Cyclophosphamide ,biology ,Developmental toxicity ,Danio ,Pharmacology ,biology.organism_classification ,Pollution ,Anticancer drug ,Larva ,Toxicity ,Eye development ,medicine ,Animals ,Environmental Chemistry ,%22">Fish ,Waste Management and Disposal ,Zebrafish ,Locomotion ,Water Pollutants, Chemical ,medicine.drug - Abstract
Cyclophosphamide (CP) is a broad-spectrum anticancer drug and has been frequently detected in aquatic environments due to its incomplete removal by wastewater treatment facilities and slow degradation in waters. Its toxicity in fish remains largely unknown. In this study, zebrafish eggs4 h post fertilization (hpf) were exposed to CP at the concentrations from 0.5 to 50.0 μg/L until 168 hpf, and its toxicity was evaluated by biochemical, transcriptomic, and behavioral approaches. The results showed that malformation and mortality rates increased with CP concentrations. The 7-day malformation EC
- Published
- 2022
7. Imidacloprid treatments induces cyanobacteria blooms in freshwater communities under sub-tropical conditions
- Author
-
Paul J. Van den Brink, Kai-Sheng Yao, Van de Perre Dimitri, Hao-Jun Lei, Dan Li, and Guang-Guo Ying
- Subjects
Environmental Risk Assessment ,Insecticides ,Aquatic Ecology and Water Quality Management ,Health, Toxicology and Mutagenesis ,Population ,Fresh Water ,Aquatic Science ,Cyanobacteria ,Zooplankton ,tropics ,Mesocosm ,Diaptomus ,Neonicotinoids ,chemistry.chemical_compound ,Imidacloprid ,Phytoplankton ,Animals ,neonicotinoid insecticides ,education ,Ecosystem ,Tropical Climate ,education.field_of_study ,WIMEK ,biology ,Ecology ,Aquatic ecosystem ,Neonicotinoid ,Aquatische Ecologie en Waterkwaliteitsbeheer ,Nitro Compounds ,aquatic ecotoxicology ,biology.organism_classification ,chemistry ,mesocosms ,Water Pollutants, Chemical - Abstract
Imidacloprid is one of the most used neonicotinoid insecticides all over the world and is considered as a contaminant of concern due to its high toxicity potential to aquatic organisms. However, the majority of the studies that have evaluated the effects of imidacloprid on aquatic organisms were conducted under temperate conditions. In the present study, a mesocosm experiment was conducted under sub-tropical conditions to assess the effects of imidacloprid on the structure (macroinvertebrates, zooplankton and phytoplankton) and functional endpoints of an aquatic ecosystem and to compare the results with similar temperate and (sub-)tropical mesocosm studies. Imidacloprid (0, 0.03, 0.3 and 3 µg/L) was applied to 13 mesocosms weekly over a period of 4 weeks, followed by a one month recovery period. At the community level a lowest NOECcommunity of 0.03 µg/L was calculated for the zooplankton, phytoplankton and macroinvertebrate communities. The highest sensitivity to imidacloprid (NOEC < 0.03 µg/L) were observed for Gerris sp., Diaptomus sp. and Brachionus quadridentatus. Imidacloprid induced population declines of the larger zooplankton species (Diaptomus sp. and Ostracoda) resulted in increased rotifer abundances and shifted the phytoplankton community to a graze resistant gelatinous cyanobacteria dominated ecosystem. These cyanobacteria blooms occurred at all different concentrations and could pose an important public health and environmental concern. Although there are some differences in species and community sensitivity between the present and the other (sub-)topical mesocosm studies, it can be observed that all show a similar general community response to imidacloprid. Under (sub-)tropical conditions, the toxic effects of imidacloprid occur at lower concentrations than found for temperate ecosystems.
- Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.