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Cyclophosphamide affects eye development and locomotion in zebrafish (Danio rerio)
- Source :
- Science of The Total Environment. 805:150460
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Cyclophosphamide (CP) is a broad-spectrum anticancer drug and has been frequently detected in aquatic environments due to its incomplete removal by wastewater treatment facilities and slow degradation in waters. Its toxicity in fish remains largely unknown. In this study, zebrafish eggs4 h post fertilization (hpf) were exposed to CP at the concentrations from 0.5 to 50.0 μg/L until 168 hpf, and its toxicity was evaluated by biochemical, transcriptomic, and behavioral approaches. The results showed that malformation and mortality rates increased with CP concentrations. The 7-day malformation EC
- Subjects :
- Embryo, Nonmammalian
Environmental Engineering
Cyclophosphamide
biology
Developmental toxicity
Danio
Pharmacology
biology.organism_classification
Pollution
Anticancer drug
Larva
Toxicity
Eye development
medicine
Animals
Environmental Chemistry
Fish
Waste Management and Disposal
Zebrafish
Locomotion
Water Pollutants, Chemical
medicine.drug
Subjects
Details
- ISSN :
- 00489697
- Volume :
- 805
- Database :
- OpenAIRE
- Journal :
- Science of The Total Environment
- Accession number :
- edsair.doi.dedup.....d00e70ce4803f2e7334d1c60cca69d2c