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657 results on '"Hansch, Corwin"'

10. Classical and Three-Dimensional QSAR in Agrochemistry

Author

CORWIN HANSCH, Corwin Hansch, Toshio Fujita, Toshio Fujita, Chisako Yamagami, Toshio Fujita, Toshiyuki Katagi, Masakazu Miyakado, Chiyozo Takayama, Shizuya Tanaka, Albert J. Leo, Marvin Charton, D. A. Kleier, Shizuya Tanaka, Masahiro Takahashi, Yuji Funaki, Kazuo Izumi, Hirotaka Takano, Masakazu Miy

Published
1995

13. Comparative QSAR and the radical toxicity of various functional groups

Author

Selassie, Cynthia D., Garg, Rajni, Kapur, Sanjay, Kurup, Alka, Verma, Rajeshwar P., Mekapati, Suresh Babu, and Hansch, Corwin

Subjects
Chemical research -- Analysis, Radicals (Chemistry) -- Physiological aspects, Toxins -- Physiological aspects, Olefins -- Physiological aspects, Amines -- Physiological aspects, Reactivity (Chemistry) -- Research, Carbon compounds -- Physiological aspects, Aldehydes -- Physiological aspects, Chemistry
Abstract

The authors review the publications on the chemical reactivity and biological activity of various functional groups. The topics of interest include the chemical reactivity of nitro, amino, olefinic, hydroxy and carboxaldehyde functional groups.

Published
2002

14. Chem-bioinformatics: comparative QSAR at the interface between chemistry and biology

Author

Hansch, Corwin, Hoekman, David, Leo, A., Weininger, David, and Selassie, Cynthia D.

Subjects
Chemical research -- Analysis, Computational biology -- Research, Information storage and retrieval -- Analysis, Databases -- Usage, Chemistry
Abstract

The authors discuss the approach to organize chemical and biological reaction data in numerical mechanistic terms for easy information retrieval. The topics of interest include the best ways to search databases for specific information and to make comparisons of quantitative structure-activity relationship between chemical reactions and the reactions from the biological systems.

Published
2002

15. Comparative QSAR: angiotensin II antagonists

Author

Kupur, Alka, Garg, Rajni, Carini, D. J., and Hansch, Corwin

Subjects
Chemistry, Organic -- Research, Angiotensin -- Physiological aspects, Renin -- Physiological aspects, Hormones -- Physiological aspects, Peptides -- Analysis, Chemistry
Abstract

Research has been conducted on the nonpeptide angiotensin antagonists. The role of the vasoactive hormone angiotensin II produced by the renin-angiotensin system has been reviewed and discussed.

Published
2001

16. Comparative QSAR study of tyrosine kinase inhibitors

Author

Kurup, Alka, Garg, Rajni, and Hansch, Corwin

Subjects
Biochemistry -- Research, Tyrosine -- Physiological aspects, Chemistry
Abstract

Research has been conducted on the tyrosine kinase inhibitors. The use of QSAR in investigating the inhibitory activity of a number of compounds against these protein tyrosine kinases is described.

Published
2001

17. Chem-bioinformatics and QSAR: a review of QSAR lacking positive hydrophobic terms

Author

Hansch, Corwin, Kurup, Alka, Garg, Rajni, and Gao, Hua

Subjects
Computational biology -- Research, Structure-activity relationships (Biochemistry) -- Analysis, Biological control systems -- Analysis, Membranes (Biology) -- Research, Chemistry
Abstract

This review examines the necessity of establishing a database for quantitative structure-activity relationships (QSAR) of chemical-biological interactions for applying bioinformatics to the biological systems. Data indicate that lack of hydrophobic terminology hinders interpretation of biological activities occurring at the cell surface and membrane systems from mechanistic organic chemistry point of view.

Published
2001

27. Comparative QSAR: radical reactions of benzene derivatives in chemistry and biology

Author

Hansch, Corwin and Gao, Hua

Subjects
Chemistry, Analytic -- Quantitative, Structure-activity relationships (Biochemistry) -- Analysis, Benzene -- Analysis, Chemistry
Abstract

Analysis of quantitative structure-activity relationships (QSAR) can describe the effects of organic compounds in biological systems. The comparison of QSARs in organic chemistry and those based on biological experiments can provide important predictive data for use in the development of pharmaceuticals, pesticides, and other agents. QSAR analysis of reactants in benzene and other solvents can identify toxic potentials.

Published
1997

28. Comparative QSAR: toward a deeper understanding of chemicobiological interactions

Author

Hansch, Corwin, Hoekman, David, and Hua Gao

Subjects
Structure-activity relationships (Biochemistry) -- Research, Chemistry, Analytic -- Quantitative, Biological systems -- Analysis, Chemistry
Abstract

The biological quantitative structure-activity relationships (QSARs) containing terms in sigma or sigma-bar are useful in the comparative analysis of electronic effects for heterogenous and homogeneous biological systems. Comparative QSAR are done in mustards, insecticides, and carbonic anhydrase inhibitors. The electronic effects from QSAR in animals to QSAR in cells and then to QSAR from physical organic chemistry can be correlated in aniline mustards.

Published
1996

33. Quantitative structure-activity relationships of the benzodiazepines. A review and reevaluation

Author

Hadjipavlou-Litina, Dimitra and Hansch, Corwin

Subjects
Benzodiazepines -- Structure-activity relationships, Chemistry
Abstract

Hydrophobic interaction beyond the 7-position is vital to derive quantitative structure-activity relationships (QSAR) for benzodiazepines (BDZs). Use of global hydrophobic parameter logP demonstrates the presence of optimum hydrophobicity in three cases. Substituents in the 7- and 2'-positions experience more steric influence than electronic effect. A comparative study supports the use of log P values calculated by CLOGP program version 3.7.0 to derive QSAR for BDZs.

Published
1994

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