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16 results on '"Hamalainen, Eija"'

1. The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Author

Nehme, Ralda, Pietiläinen, Olli, Artomov, Mykyta, Tegtmeyer, Matthew, Valakh, Vera, Lehtonen, Leevi, Bell, Christina, Singh, Tarjinder, Trehan, Aditi, Sherwood, John, Manning, Danielle, Peirent, Emily, Malik, Rhea, Guss, Ellen J., Hawes, Derek, Beccard, Amanda, Bara, Anne M., Hazelbaker, Dane Z., Zuccaro, Emanuela, Genovese, Giulio, Loboda, Alexander A., Neumann, Anna, Lilliehook, Christina, Kuismin, Outi, Hamalainen, Eija, Kurki, Mitja, Hultman, Christina M., Kähler, Anna K., Paulo, Joao A., Ganna, Andrea, Madison, Jon, Cohen, Bruce, McPhie, Donna, Adolfsson, Rolf, Perlis, Roy, Dolmetsch, Ricardo, Farhi, Samouil, McCarroll, Steven, Hyman, Steven, Neale, Ben, Barrett, Lindy E., Harper, Wade, Palotie, Aarno, Daly, Mark, and Eggan, Kevin

Published
2022
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3. The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Author

Nehme, Ralda, primary, Pietiläinen, Olli, additional, Artomov, Mykyta, additional, Tegtmeyer, Matthew, additional, Bell, Christina, additional, Ganna, Andrea, additional, Singh, Tarjinder, additional, Trehan, Aditi, additional, Valakh, Vera, additional, Sherwood, John, additional, Manning, Danielle, additional, Peirent, Emily, additional, Malik, Rhea, additional, Guss, Ellen J., additional, Hawes, Derek, additional, Beccard, Amanda, additional, Bara, Anne M., additional, Hazelbaker, Dane Z., additional, Zuccaro, Emanuela, additional, Genovese, Giulio, additional, Loboda, Alexander A, additional, Neumann, Anna, additional, Lilliehook, Christina, additional, Kuismin, Outi, additional, Hamalainen, Eija, additional, Kurki, Mitja, additional, Hultman, Christina M., additional, Kähler, Anna K., additional, Paulo, Joao A., additional, Madison, Jon, additional, Cohen, Bruce, additional, McPhie, Donna, additional, Adolfsson, Rolf, additional, Perlis, Roy, additional, Dolmetsch, Ricardo, additional, Farhi, Samouil, additional, McCarroll, Steven, additional, Hyman, Steven, additional, Neale, Ben, additional, Barrett, Lindy E., additional, Harper, Wade, additional, Palotie, Aarno, additional, Daly, Mark, additional, and Eggan, Kevin, additional

Published
2021
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4. Consistently replicating locus linked to migraine on 10q22-q23

Author

Anttila, Verneri, Nyholt, Dale R., Kallela, Mikko, Artto, Ville, Vepsalainen, Salli, Jakkula, Eveliina, Wennerstrom, Annika, Tikka-Kleemola, Paivi, Kaunisto, Mari A., Hamalainen, Eija, Widen, Elisabeth, Terwilliger, Joseph, Merikangas, Kathleen, Montgomery, Grant W., Martin, Nicholas G., Daly, Mark, Kapiro, Jaakko, Peltonen, Leena, Farkkila, Markus, Wessman, Maija, and Palotie, Aarno

Subjects
DNA replication -- Analysis, Human genome -- Research, Migraine -- Genetic aspects, Biological sciences
Abstract

The article discusses the results obtained from two genome-wide studies, where in several migraine-phenotyping methods detect and replicate a locus on 10q22-q23. The 10q22-q23 locus is shown to contain one or more of the migraine susceptibility variants.

Published
2008

5. A susceptibility locus for migraine with aura, on chromosome 4q24

Author

Wessman, Maija, Kallela, Mikko, Kaunisto, Mari A., Marttila, Pia, Sobel, Eric, Hartiala, Jaana, Oswell, Greg, Leal, Suzanne M., Papp, Jeanette C., Hamalainen, Eija, Broas, Petra, Joslyn, Geoffrey, Hovatta, Iiris, Hiekkalinna, Tero, Kaprio, Jaakko, Ott, Jurg, Cantor, Rita M., Zwart, John-Anker, Ilmavirta, Matti, Havanka, Hannele, Farkkila, Markus, Peltonen, Leena, and Palotie, Aarno

Subjects
Migraine -- Genetic aspects, Headache -- Genetic aspects, Heredity, Human -- Research, Linkage (Genetics) -- Analysis, Biological sciences
Published
2002

6. Migraine polygenic risk score associates with efficacy of migraine-specific drugs

Author

Kogelman, Lisette JA, Esserlind, Ann-Louise, Christensen, Anne Francke, Awasthi, Swapnil, Ripke, Stephan, Ingason, Andres, Davidsson, Olafur B, Erikstrup, Christian, Hjalgrim, Henrik, Ullum, Henrik, Olesen, Jes, Hansen, Thomas Folkmann, Gudbjartsson, Daniel, Gastafsson, Omar, Stefansson, Kari, Stefansson, Hreinn, Porsteinsdottir, Unnur, Andersen, Steffen, Banasik, Karina, Brunak, Soren, Buil, Alfonso, Burgdorf, Kristoffer, Gregor, Jemec, Jennum, Poul, Nielsen, Kasper Rene, Nyegaard, Mette, Paarup, Helene Mariana, Pedersen, Ole Birger, Sorensen, Erik, Werge, Thomas, Anttila, Verneri, Artto, Ville, Belin, Andrea Carmine, de Boer, Irene, Boomsma, Dorret I, Borte, Sigrid, Chasman, Daniel I, Cherkas, Lynn, Cormand, Bru, Cuenca-Leon, Ester, Davey-Smith, George, Dichgans, Martin, van Duijn, Cornelia, Esko, Tonu, Ferrari, Michel, Frants, Rune R, Freilinger, Tobias, Furlotte, Nick, Gormley, Padhraig, Griffiths, Lyn, Hamalainen, Eija, Hiekkala, Marjo, Ikram, M Arfan, Jarvelin, Marjo-Riitta, Kajanne, Risto, Kallela, Mikko, Kaprio, Jaakko, Kaunisto, Mari, Kubisch, Christian, Kurki, Mitja, Kurth, Tobias, Launer, Lenore, Lehtimaki, Terho, Lessel, Davor, Ligthart, Lannie, Litterman, Nadia, van den Maagdenberg, Arn, Macaya, Alfons, Malik, Rainer, Mangino, Massimo, McMahon, George, Muller-Myhsok, Bertram, Neale, Benjamin M, Northover, Carrie, Nyholt, Dale R, Palotie, Aarno, Palta, Priit, Pedersen, Linda, Pedersen, Nancy, Posthuma, Danielle, Pozo-Rosich, Patricia, Pressman, Alice, Raitakari, Olli, Schurks, Markus, Sintas, Celia, Steinberg, Stacy, Strachan, David, Terwindt, Gisela, Vila-Pueyo, Marta, Wessman, Maija, Winsvold, Bendik S, Zhao, Huiying, Zwart, John-Anker, Consortium, DBDS Genomic, Consortium, Int Headache Genetics, Neurologian yksikkö, HUS Helsinki and Uusimaa Hospital District, HUS Neurocenter, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, University of Helsinki, Centre of Excellence in Complex Disease Genetics, Research Programs Unit, and Aarno Palotie / Principal Investigator

Subjects
0301 basic medicine, medicine.medical_specialty, SUSCEPTIBILITY LOCI, PHARMACOGENOMICS, Triptans, Logistic regression, Article, 3124 Neurology and psychiatry, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, SCHIZOPHRENIA, Medicine, Migraine treatment, METAANALYSIS, Genetics (clinical), business.industry, 1184 Genetics, developmental biology, physiology, 3112 Neurosciences, Area under the curve, Odds ratio, medicine.disease, Confidence interval, 3. Good health, 030104 developmental biology, Migraine, Cohort, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug
Abstract

ObjectiveTo assess whether the polygenic risk score (PRS) for migraine is associated with acute and/or prophylactic migraine treatment response.MethodsWe interviewed 2,219 unrelated patients at the Danish Headache Center using a semistructured interview to diagnose migraine and assess acute and prophylactic drug response. All patients were genotyped. A PRS was calculated with the linkage disequilibrium pred algorithm using summary statistics from the most recent migraine genome-wide association study comprising ∼375,000 cases and controls. The PRS was scaled to a unit corresponding to a twofold increase in migraine risk, using 929 unrelated Danish controls as reference. The association of the PRS with treatment response was assessed by logistic regression, and the predictive power of the model by area under the curve using a case-control design with treatment response as outcome.ResultsA twofold increase in migraine risk associates with positive response to migraine-specific acute treatment (odds ratio [OR] = 1.25 [95% confidence interval (CI) = 1.05–1.49]). The association between migraine risk and migraine-specific acute treatment was replicated in an independent cohort consisting of 5,616 triptan users with prescription history (OR = 3.20 [95% CI = 1.26–8.14]). No association was found for acute treatment with non–migraine-specific weak analgesics and prophylactic treatment response.ConclusionsThe migraine PRS can significantly identify subgroups of patients with a higher-than-average likelihood of a positive response to triptans, which provides a first step toward genetics-based precision medicine in migraine.

Published
2019

7. Shared genetic risk between migraine and coronary artery disease:A genome-wide analysis of common variants

Author

Winsvold, Bendik S., Bettella, Francesco, Witoelar, Aree, Anttila, Verneri, Gormley, Padhraig, Kurth, Tobias, Terwindt, Gisela M., Freilinger, Tobias, Frei, Oleksander, Shadrin, Alexey, Wang, Yunpeng, Dale, Anders M., van den Maagdenberg, Arn M.J.M., Nyholt, Dale R., Palotie, Aarno, Andreassen, Ole A., Zwart, John Anker, Artto, Ville, Belin, Andrea Carmine, Boomsma, Dorret I., Børte, Sigrid, Chasman, Daniel I., Cherkas, Lynn, Christensen, Anne Francke, Cormand, Bru, Cuenca-Leon, Ester, Davey-Smith, George, Dichgans, Martin, van Duijn, Cornelia, Eising, Else, Esko, Tonu, Esserlind, Ann Louise, Ferrari, Michel, Frants, Rune R., Furlotte, Nick, Griffiths, Lyn, Hamalainen, Eija, Hansen, Thomas Folkmann, Hiekkala, Marjo, Arfan Ikram, M., Ingason, Andres, Järvelin, Marjo Riitta, Kajanne, Risto, Kallela, Mikko, Kaprio, Jaakko, Kaunisto, Mari, Kubisch, Christian, Kurki, Mitja, Olesen, Jes, and Yao, Yong-Gang

Subjects
0301 basic medicine, Male, Epidemiology, Genome-wide association study, Disease, Coronary Artery Disease, Pathology and Laboratory Medicine, Bioinformatics, Cardiovascular, Vascular Medicine, Migraines, Medicine and Health Sciences, Coronary Heart Disease, 2.1 Biological and endogenous factors, Aetiology, Genetics, Multidisciplinary, Headaches, Pain Research, International Headache Genetics Consortium, Genomics, Single Nucleotide, Phenotype, Heart Disease, Genetic Epidemiology, Medicine, Medical genetics, Female, Pathogens, Chronic Pain, Research Article, Biotechnology, medicine.medical_specialty, General Science & Technology, Science, Migraine Disorders, Cardiology, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Molecular Genetics, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Clinical Research, Genome-Wide Association Studies, medicine, SNP, Humans, Genetic Predisposition to Disease, Polymorphism, Molecular Biology, Migraine, Heart Disease - Coronary Heart Disease, Genetic association, Clinical Genetics, Prevention, Human Genome, Biology and Life Sciences, Computational Biology, Human Genetics, Genome Analysis, medicine.disease, Atherosclerosis, Brain Disorders, 030104 developmental biology, Genetic epidemiology, Genetic Loci, Genome-Wide Association Study
Abstract

Migraine is a recurrent pain condition traditionally viewed as a neurovascular disorder, but little is known of its vascular basis. In epidemiological studies migraine is associated with an increased risk of cardiovascular disease, including coronary artery disease (CAD), suggesting shared pathogenic mechanisms. This study aimed to determine the genetic overlap between migraine and CAD, and to identify shared genetic risk loci, utilizing a conditional false discovery rate approach and data from two large-scale genome-wide association studies (GWAS) of CAD (C4D, 15,420 cases, 15,062 controls; CARDIoGRAM, 22,233 cases, 64,762 controls) and one of migraine (22,120 cases, 91,284 controls). We found significant enrichment of genetic variants associated with CAD as a function of their association with migraine, which was replicated across two independent CAD GWAS studies. One shared risk locus in the PHACTR1 gene (conjunctional false discovery rate for index SNP rs9349379 < 3.90 x 10−5), which was also identified in previous studies, explained much of the enrichment. Two further loci (in KCNK5 and AS3MT) showed evidence for shared risk (conjunctional false discovery rate < 0.05). The index SNPs at two of the three loci had opposite effect directions in migraine and CAD. Our results confirm previous reports that migraine and CAD share genetic risk loci in excess of what would be expected by chance, and highlight one shared risk locus in PHACTR1. Understanding the biological mechanisms underpinning this shared risk is likely to improve our understanding of both disorders. © 2017 Winsvold et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published
2017

8. Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

Author

Gormley, Padhraig, primary, Kurki, Mitja I., additional, Hiekkala, Marjo Eveliina, additional, Veerapen, Kumar, additional, Häppölä, Paavo, additional, Mitchell, Adele A., additional, Lal, Dennis, additional, Palta, Priit, additional, Surakka, Ida, additional, Kaunisto, Mari Anneli, additional, Hämäläinen, Eija, additional, Vepsäläinen, Salli, additional, Havanka, Hannele, additional, Harno, Hanna, additional, Ilmavirta, Matti, additional, Nissilä, Markku, additional, Säkö, Erkki, additional, Sumelahti, Marja-Liisa, additional, Liukkonen, Jarmo, additional, Sillanpää, Matti, additional, Metsähonkala, Liisa, additional, Koskinen, Seppo, additional, Lehtimäki, Terho, additional, Raitakari, Olli, additional, Männikkö, Minna, additional, Ran, Caroline, additional, Belin, Andrea Carmine, additional, Jousilahti, Pekka, additional, Anttila, Verneri, additional, Salomaa, Veikko, additional, Artto, Ville, additional, Färkkilä, Markus, additional, Runz, Heiko, additional, Daly, Mark J., additional, Neale, Benjamin M., additional, Ripatti, Samuli, additional, Kallela, Mikko, additional, Wessman, Maija, additional, Palotie, Aarno, additional, Agee, Michelle, additional, Alipanahi, Babak, additional, Auton, Adam, additional, Bell, Robert K., additional, Bryc, Katarzyna, additional, Elson, Sarah L., additional, Fontanillas, Pierre, additional, Furlotte, Nicholas A., additional, Huber, Karen E., additional, Kleinman, Aaron, additional, Litterman, Nadia K., additional, McCreight, Jennifer C., additional, McIntyre, Matthew H., additional, Mountain, Joanna L., additional, Northover, Carrie A.M., additional, Pitts, Steven J., additional, Sathirapongsasuti, J. Fah, additional, Sazonova, Olga V., additional, Shelton, Janie F., additional, Shringarpure, Suyash, additional, Tian, Chao, additional, Tung, Joyce Y., additional, Vacic, Vladimir, additional, Wilson, Catherine H., additional, Boomsma, Dorret I., additional, Børte, Sigrid, additional, Chasman, Daniel I., additional, Cherkas, Lynn, additional, Christensen, Anne Francke, additional, Cormand, Bru, additional, Cuenca-Leon, Ester, additional, Davey-Smith, George, additional, Dichgans, Martin, additional, van Duijn, Cornelia, additional, Esko, Tonu, additional, Esserlind, Ann-Louise, additional, Ferrari, Michel D., additional, Frants, Rune R., additional, Freilinger, Tobias, additional, Furlotte, Nick, additional, Gormley, Padhraig, additional, Griffiths, Lyn, additional, Hamalainen, Eija, additional, Hansen, Thomas Folkmann, additional, Hiekkala, Marjo, additional, Ikram, M Arfan, additional, Ingason, Andres, additional, Järvelin, Marjo-Riitta, additional, Kajanne, Risto, additional, Kaprio, Jaakko, additional, Kaunisto, Mari, additional, Kubisch, Christian, additional, Kurki, Mitja, additional, Kurth, Tobias, additional, Launer, Lenore, additional, Lehtimaki, Terho, additional, Lessel, Davor, additional, Ligthart, Lannie, additional, Litterman, Nadia, additional, van den Maagdenberg, Arn, additional, Macaya, Alfons, additional, Malik, Rainer, additional, Mangino, Massimo, additional, McMahon, George, additional, Muller-Myhsok, Bertram, additional, Northover, Carrie, additional, Nyholt, Dale R., additional, Olesen, Jes, additional, Pedersen, Linda, additional, Pedersen, Nancy, additional, Posthuma, Danielle, additional, Pozo-Rosich, Patricia, additional, Pressman, Alice, additional, Quaye, Lydia, additional, Schürks, Markus, additional, Sintas, Celia, additional, Stefansson, Kari, additional, Stefansson, Hreinn, additional, Steinberg, Stacy, additional, Strachan, David, additional, Terwindt, Gisela, additional, Vila-Pueyo, Marta, additional, Winsvold, Bendik S., additional, Wrenthal, William, additional, Zhao, Huiying, additional, and Zwart, John-Anker, additional

Published
2018
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9. Pitfalls In Genetic Testing: The Story Of Missed Scn1A Mutations

Author

Djemie, Tania, Weckhuysen, Sarah, von Spiczak, Sarah, Carvill, Gemma L., Jaehn, Johanna, Anttonen, Anna-Kaisa, Brilstra, Eva, Caglayan, Hande S., de Kovel, Carolien G., Depienne, Christel, Gaily, Eija, Hamalainen, Eija, Giraldez, Beatriz G., Gormley, Padhraig, Guerrero-Lopez, Rosa, Guerrini, Renzo, Hartmann, Corinna, Hernandez-Hernandez, Laura, and Hjalgrim, Helle

Abstract

Background

Published
2016

10. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Author

Gormley, Padhraig, primary, Anttila, Verneri, additional, Winsvold, Bendik S, additional, Palta, Priit, additional, Esko, Tonu, additional, Pers, Tune H, additional, Farh, Kai-How, additional, Cuenca-Leon, Ester, additional, Muona, Mikko, additional, Furlotte, Nicholas A, additional, Kurth, Tobias, additional, Ingason, Andres, additional, McMahon, George, additional, Ligthart, Lannie, additional, Terwindt, Gisela M, additional, Kallela, Mikko, additional, Freilinger, Tobias M, additional, Ran, Caroline, additional, Gordon, Scott G, additional, Stam, Anine H, additional, Steinberg, Stacy, additional, Borck, Guntram, additional, Koiranen, Markku, additional, Quaye, Lydia, additional, Adams, Hieab HH, additional, Lehtimaki, Terho, additional, Sarin, Antti-Pekka, additional, Wedenoja, Juho, additional, Hinds, David A, additional, Buring, Julie E, additional, Schurks, Markus, additional, Ridker, Paul M, additional, Hrafnsdottir, Maria Gudlaug, additional, Stefansson, Hreinn, additional, Ring, Susan M, additional, Hottenga, Jouke-Jan, additional, Penninx, Brenda WJH, additional, Farkkila, Markus, additional, Artto, Ville, additional, Kaunisto, Mari, additional, Vepsalainen, Salli, additional, Malik, Rainer, additional, Heath, Andrew C, additional, Madden, Pamela AF, additional, Martin, Nicholas G, additional, Montgomery, Grant W, additional, Hamalainen, Eija, additional, Huang, Hailiang, additional, Byrnes, Andrea E, additional, Franke, Lude, additional, Huang, Jie, additional, Stergiakouli, Evie, additional, Lee, Phil H, additional, Sandor, Cynthia, additional, Webber, Caleb, additional, Cader, Zameel, additional, Muller-Myhsok, Bertram, additional, Schreiber, Stefan, additional, Meitinger, Thomas, additional, Eriksson, Johan G, additional, Salomaa, Veikko, additional, Heikkila, Kauko, additional, Loehrer, Elizabeth, additional, Uitterlinden, Andre G, additional, Hofman, Albert, additional, van Duijn, Cornelia M, additional, Cherkas, Lynn, additional, Pedersen, Linda M, additional, Stubhaug, Audun, additional, Nielsen, Christopher S, additional, Mannikko, Minna, additional, Mihailov, Evelin, additional, Milani, Lili, additional, Gobel, Hartmut, additional, Esserlind, Ann-Louise, additional, Christensen, Anne Francke, additional, Hansen, Thomas Folkmann, additional, Werge, Thomas, additional, Kaprio, Jaakko, additional, Aromaa, Arpo J, additional, Raitakari, Olli, additional, Ikram, M Arfan, additional, Spector, Tim, additional, Jarvelin, Marjo-Riitta, additional, Metspalu, Andres, additional, Kubisch, Christian, additional, Strachan, David P, additional, Ferrari, Michel D, additional, Belin, Andrea C, additional, Dichgans, Martin, additional, Wessman, Maija, additional, van den Maagdenberg, Arn MJM, additional, Zwart, John-Anker, additional, Boomsma, Dorret I, additional, Smith, George Davey, additional, Stefansson, Kari, additional, Eriksson, Nicholas, additional, Daly, Mark J, additional, Neale, Benjamin M, additional, Olesen, Jes, additional, Chasman, Daniel I, additional, Nyholt, Dale R, additional, and Palotie, Aarno, additional

Published
2015
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11. An Immune Response Network Associated with Blood Lipid Levels

Author

Inouye, Michael, primary, Silander, Kaisa, additional, Hamalainen, Eija, additional, Salomaa, Veikko, additional, Harald, Kennet, additional, Jousilahti, Pekka, additional, Männistö, Satu, additional, Eriksson, Johan G., additional, Saarela, Janna, additional, Ripatti, Samuli, additional, Perola, Markus, additional, van Ommen, Gert-Jan B., additional, Taskinen, Marja-Riitta, additional, Palotie, Aarno, additional, Dermitzakis, Emmanouil T., additional, and Peltonen, Leena, additional

Published
2010
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15. Genome-wide meta-analysis identifies new susceptibility loci for migraine

Author

Anttila, Verneri, Winsvold, Bendik S., Gormley, Padhraig, Kurth, Tobias, Bettella, Francesco, McMahon, George, Kallela, Mikko, Malik, Rainer, de Vries, Boukje, Terwindt, Gisela, Medland, Sarah E., Todt, Unda, McArdle, Wendy L., Quaye, Lydia, Koiranen, Markku, Ikram, M. Arfan, Lehtimäki, Terho, Stam, Anine H., Ligthart, Lannie, Wedenoja, Juho, Dunham, Ian, Neale, Benjamin M., Palta, Priit, Hamalainen, Eija, Schürks, Markus, Rose, Lynda M, Buring, Julie E., Ridker, Paul M., Steinberg, Stacy, Stefansson, Hreinn, Jakobsson, Finnbogi, Lawlor, Debbie A., Evans, David M., Ring, Susan M., Färkkilä, Markus, Artto, Ville, Kaunisto, Mari A, Freilinger, Tobias, Schoenen, Jean, Frants, Rune R., Pelzer, Nadine, Weller, Claudia M., Zielman, Ronald, Heath, Andrew C., Madden, Pamela A.F., Montgomery, Grant W., Martin, Nicholas G., Borck, Guntram, Göbel, Hartmut, Heinze, Axel, Heinze-Kuhn, Katja, Williams, Frances M.K., Hartikainen, Anna-Liisa, Pouta, Anneli, van den Ende, Joyce, Uitterlinden, Andre G., Hofman, Albert, Amin, Najaf, Hottenga, Jouke-Jan, Vink, Jacqueline M., Heikkilä, Kauko, Alexander, Michael, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Wichmann, Heinz Erich, Aromaa, Arpo, Eriksson, Johan G., Traynor, Bryan, Trabzuni, Daniah, Rossin, Elizabeth, Lage, Kasper, Jacobs, Suzanne B.R., Gibbs, J. Raphael, Birney, Ewan, Kaprio, Jaakko, Penninx, Brenda W., Boomsma, Dorret I., van Duijn, Cornelia, Raitakari, Olli, Jarvelin, Marjo-Riitta, Zwart, John-Anker, Cherkas, Lynn, Strachan, David P., Kubisch, Christian, Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Dichgans, Martin, Wessman, Maija, Smith, George Davey, Stefansson, Kari, Daly, Mark J., Nyholt, Dale R., Chasman, Daniel, and Palotie, Aarno

Published
2014
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16. Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Author

Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PAF, Montgomery GW, Martin NG, Borck G, Göbel H, Heinze A, Heinze-Kuhn K, Williams FMK, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor B, Trabzuni D, Rossin E, Lage K, Jacobs SBR, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AMJM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman D, and Palotie A

Subjects
Cerebellum metabolism, Computational Biology, Frontal Lobe metabolism, Humans, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Migraine Disorders genetics
Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

Published
2013
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