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Shared genetic risk between migraine and coronary artery disease:A genome-wide analysis of common variants
- Source :
- Winsvold, B S, Bettella, F, Witoelar, A, Anttila, V, Gormley, P, Kurth, T, Terwindt, G M, Freilinger, T, Frei, O, Shadrin, A, Wang, Y, Dale, A M, van den Maagdenberg, A M J M, Nyholt, D R, Palotie, A, Andreassen, O A, Zwart, J A, Artto, V, Belin, A C, Boomsma, D I, Børte, S, Chasman, D I, Cherkas, L, Christensen, A F, Cormand, B, Cuenca-Leon, E, Davey-Smith, G, Dichgans, M, van Duijn, C, Eising, E, Esko, T, Esserlind, A L, Ferrari, M, Frants, R R, Freilinger, T, Furlotte, N, Griffiths, L, Hamalainen, E, Hansen, T F, Hiekkala, M, Arfan Ikram, M, Ingason, A, Järvelin, M R, Kajanne, R, Kallela, M, Kaprio, J, Kaunisto, M, Kubisch, C, Kurki, M, Olesen, J & International Headache Genetics Consortium 2017, ' Shared genetic risk between migraine and coronary artery disease : A genome-wide analysis of common variants ', PLoS ONE, vol. 12, no. 9, e0185663 . https://doi.org/10.1371/journal.pone.0185663, PloS one, vol 12, iss 9, PLoS ONE, 12(9), PloS one, PLoS ONE, Vol 12, Iss 9, p e0185663 (2017), Winsvold, BS; Bettella, F; Witoelar, A; Anttila, V; Gormley, P; Kurth, T; et al.(2017). Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLOS ONE, 12(9). doi: 10.1371/journal.pone.0185663. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/04m6g4fj, PLoS ONE
- Publication Year :
- 2017
-
Abstract
- Migraine is a recurrent pain condition traditionally viewed as a neurovascular disorder, but little is known of its vascular basis. In epidemiological studies migraine is associated with an increased risk of cardiovascular disease, including coronary artery disease (CAD), suggesting shared pathogenic mechanisms. This study aimed to determine the genetic overlap between migraine and CAD, and to identify shared genetic risk loci, utilizing a conditional false discovery rate approach and data from two large-scale genome-wide association studies (GWAS) of CAD (C4D, 15,420 cases, 15,062 controls; CARDIoGRAM, 22,233 cases, 64,762 controls) and one of migraine (22,120 cases, 91,284 controls). We found significant enrichment of genetic variants associated with CAD as a function of their association with migraine, which was replicated across two independent CAD GWAS studies. One shared risk locus in the PHACTR1 gene (conjunctional false discovery rate for index SNP rs9349379 < 3.90 x 10−5), which was also identified in previous studies, explained much of the enrichment. Two further loci (in KCNK5 and AS3MT) showed evidence for shared risk (conjunctional false discovery rate < 0.05). The index SNPs at two of the three loci had opposite effect directions in migraine and CAD. Our results confirm previous reports that migraine and CAD share genetic risk loci in excess of what would be expected by chance, and highlight one shared risk locus in PHACTR1. Understanding the biological mechanisms underpinning this shared risk is likely to improve our understanding of both disorders. © 2017 Winsvold et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Subjects :
- 0301 basic medicine
Male
Epidemiology
Genome-wide association study
Disease
Coronary Artery Disease
Pathology and Laboratory Medicine
Bioinformatics
Cardiovascular
Vascular Medicine
Migraines
Medicine and Health Sciences
Coronary Heart Disease
2.1 Biological and endogenous factors
Aetiology
Genetics
Multidisciplinary
Headaches
Pain Research
International Headache Genetics Consortium
Genomics
Single Nucleotide
Phenotype
Heart Disease
Genetic Epidemiology
Medicine
Medical genetics
Female
Pathogens
Chronic Pain
Research Article
Biotechnology
medicine.medical_specialty
General Science & Technology
Science
Migraine Disorders
Cardiology
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Molecular Genetics
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Clinical Research
Genome-Wide Association Studies
medicine
SNP
Humans
Genetic Predisposition to Disease
Polymorphism
Molecular Biology
Migraine
Heart Disease - Coronary Heart Disease
Genetic association
Clinical Genetics
Prevention
Human Genome
Biology and Life Sciences
Computational Biology
Human Genetics
Genome Analysis
medicine.disease
Atherosclerosis
Brain Disorders
030104 developmental biology
Genetic epidemiology
Genetic Loci
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Winsvold, B S, Bettella, F, Witoelar, A, Anttila, V, Gormley, P, Kurth, T, Terwindt, G M, Freilinger, T, Frei, O, Shadrin, A, Wang, Y, Dale, A M, van den Maagdenberg, A M J M, Nyholt, D R, Palotie, A, Andreassen, O A, Zwart, J A, Artto, V, Belin, A C, Boomsma, D I, Børte, S, Chasman, D I, Cherkas, L, Christensen, A F, Cormand, B, Cuenca-Leon, E, Davey-Smith, G, Dichgans, M, van Duijn, C, Eising, E, Esko, T, Esserlind, A L, Ferrari, M, Frants, R R, Freilinger, T, Furlotte, N, Griffiths, L, Hamalainen, E, Hansen, T F, Hiekkala, M, Arfan Ikram, M, Ingason, A, Järvelin, M R, Kajanne, R, Kallela, M, Kaprio, J, Kaunisto, M, Kubisch, C, Kurki, M, Olesen, J & International Headache Genetics Consortium 2017, ' Shared genetic risk between migraine and coronary artery disease : A genome-wide analysis of common variants ', PLoS ONE, vol. 12, no. 9, e0185663 . https://doi.org/10.1371/journal.pone.0185663, PloS one, vol 12, iss 9, PLoS ONE, 12(9), PloS one, PLoS ONE, Vol 12, Iss 9, p e0185663 (2017), Winsvold, BS; Bettella, F; Witoelar, A; Anttila, V; Gormley, P; Kurth, T; et al.(2017). Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLOS ONE, 12(9). doi: 10.1371/journal.pone.0185663. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/04m6g4fj, PLoS ONE
- Accession number :
- edsair.doi.dedup.....4779d5ee71a012df2ca04d6cde6977f1