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6 results on '"Halo, Laura M."'

1. Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana

Author

Halo, Laura M., Heneghan, Mary N., Yakasai, Ahmed A., Zhongshu Song, Williams, Katherine, Bailey, Andrew M., Cox, Russell J., Lazarus, Colin M., and Simpson, Thomas J.

Subjects
Cytochrome P-450 -- Chemical properties, Gene expression -- Analysis, Hydroxylation -- Analysis, Oxidation-reduction reaction -- Analysis, Chemistry
Abstract

Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauvria bassiana are examined by a combination of gene knockout, antisense RNA and gene coexpression studies. ORF2 has encoded an unusual cytochrome P450 monooxygenase needed for the selective N-hydroxylation of the 2-pyridone that is incapable of N-hydroxylation of acyltetramic acids.

Published
2008

4. Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

Author

Halo, Laura M., primary, Marshall, James W., additional, Yakasai, Ahmed A., additional, Song, Zhongshu, additional, Butts, Craig P., additional, Crump, Matthew P., additional, Heneghan, Mary, additional, Bailey, Andrew M., additional, Simpson, Thomas J., additional, Lazarus, Colin. M., additional, and Cox, Russell J., additional

Published
2008
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