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9 results on '"Haley L. Faust"'

1. Acceptability, Feasibility, and Quality of Telehealth for Adolescent Health Care Delivery During the COVID-19 Pandemic: Cross-sectional Study of Patient and Family Experiences

Author

Sarah M Wood, Julia Pickel, Alexis W Phillips, Kari Baber, John Chuo, Pegah Maleki, Haley L Faust, Danielle Petsis, Danielle E Apple, Nadia Dowshen, and Lisa A Schwartz

Subjects
Pediatrics, RJ1-570
Abstract

BackgroundData regarding the acceptability, feasibility, and quality of telehealth among adolescents and young adults (AYA) and their parents and caregivers (caregivers) are lacking. ObjectiveThe aim of this study was to assess the noninferiority of telehealth versus in-person visits by comparing acceptability with respect to efficiency, effectiveness, equity, patient-centeredness, and confidentiality. MethodsCross-sectional web-based surveys were sent to caregivers and AYA following video visits within an Adolescent Medicine subspecialty clinic in May-July 2020. Proportions of AYA and caregivers who rated telehealth as noninferior were compared using chi-squared tests. Feasibility was assessed via items measuring technical difficulties. Deductive thematic analysis using the Institute of Medicine dimensions of health care quality was used to code open-ended question responses. ResultsSurvey response rates were 20.5% (55/268) for AYA and 21.8% (123/563) for caregivers. The majority of the respondents were White cisgender females. Most AYA and caregivers rated telehealth as noninferior to in-person visits with respect to confidentiality, communication, medication management, and mental health care. A higher proportion of AYA compared to caregivers found telehealth inferior with respect to confidentiality (11/51, 22% vs 3/118, 2.5%, P

Published
2021
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2. Acceptability of Telehealth for Gender-Affirming Care in Transgender and Gender Diverse Youth and Their Caregivers

Author

Sarah M. Wood, Lisa A. Schwartz, Haley L Faust, Kari Freeman Baber, Danielle E. Apple, Danielle Petsis, Elle Lett, John Chuo, and Nadia Dowshen

Subjects
Gender Studies, Gerontology, Short Reports, Coronavirus disease 2019 (COVID-19), Transgender, Medicine (miscellaneous), Telehealth, Psychology
Abstract

Gender-affirming care (GAC) is critical to the well-being of transgender and gender diverse youth and was limited by COVID-19 stay-at-home orders. Telehealth created opportunities for youth to continue receiving lifesaving care. We examined the attitudes of patients (n=21) and caregivers (n=38) receiving telehealth-delivered GAC (TGAC) from May to July 2020. Participants completed surveys after telehealth visits. Descriptive statistics compared telehealth with in-person visits across key domains. Overall, 86.5% of patients and 95.4% of caregivers were satisfied with medical TGAC and 94.3% and 93.3% were satisfied with behavioral health TGAC. Future research should determine the effectiveness of TGAC and identify areas for improvement.

Published
2022
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3. Figure S1 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Kimberly Stegmaier, Mignon L. Loh, Marian H. Harris, Jeffrey W. Tyner, Lewis B. Silverman, Katherine A. Janeway, Lia Gore, Neal I. Lindeman, Annette S. Kim, Stephen P. Hunger, Alexandre Puissant, Andrew E. Place, Elliot Stieglitz, Katherine Tarlock, Amy Saur Conway, Amanda L. Robichaud, Angela Su, Neekesh V. Dharia, Matthew P. Jacobson, Diego Garrido Ruiz, Wilian A. Cortopassi, Anjali Cremer, Cristina F. Contreras, Haley L. Faust, Tasleema Patel, Cristina E. Tognon, Alma Imamovic, Shan Lin, Yuting Li, Giacomo Gotti, Nicole Ocasio-Martinez, Catherine M. Clinton, Asmani A. Adhav, Lisa Gennarini, Jeffrey A. Magee, Matthew J. Barth, Jing Chen, Justine M. Kahn, Peter D. Cole, Neerav N. Shukla, Jennifer L. McNeer, Nathan Gossai, Patrick A. Brown, Michael J. Burke, Kelly W. Maloney, Melinda Pauly, Todd M. Cooper, Beth Apsel Winger, Traci M. Blonquist, Kristen Stevenson, Maria Luisa Sulis, Sarah K. Tasian, and Yana Pikman

Abstract

VAF concordance

Published
2023
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4. Supplementary Methods from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Kimberly Stegmaier, Mignon L. Loh, Marian H. Harris, Jeffrey W. Tyner, Lewis B. Silverman, Katherine A. Janeway, Lia Gore, Neal I. Lindeman, Annette S. Kim, Stephen P. Hunger, Alexandre Puissant, Andrew E. Place, Elliot Stieglitz, Katherine Tarlock, Amy Saur Conway, Amanda L. Robichaud, Angela Su, Neekesh V. Dharia, Matthew P. Jacobson, Diego Garrido Ruiz, Wilian A. Cortopassi, Anjali Cremer, Cristina F. Contreras, Haley L. Faust, Tasleema Patel, Cristina E. Tognon, Alma Imamovic, Shan Lin, Yuting Li, Giacomo Gotti, Nicole Ocasio-Martinez, Catherine M. Clinton, Asmani A. Adhav, Lisa Gennarini, Jeffrey A. Magee, Matthew J. Barth, Jing Chen, Justine M. Kahn, Peter D. Cole, Neerav N. Shukla, Jennifer L. McNeer, Nathan Gossai, Patrick A. Brown, Michael J. Burke, Kelly W. Maloney, Melinda Pauly, Todd M. Cooper, Beth Apsel Winger, Traci M. Blonquist, Kristen Stevenson, Maria Luisa Sulis, Sarah K. Tasian, and Yana Pikman

Abstract

Supplementary Data file including supplementary methods and clinical case vignettes.

Published
2023
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5. Table S3 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Kimberly Stegmaier, Mignon L. Loh, Marian H. Harris, Jeffrey W. Tyner, Lewis B. Silverman, Katherine A. Janeway, Lia Gore, Neal I. Lindeman, Annette S. Kim, Stephen P. Hunger, Alexandre Puissant, Andrew E. Place, Elliot Stieglitz, Katherine Tarlock, Amy Saur Conway, Amanda L. Robichaud, Angela Su, Neekesh V. Dharia, Matthew P. Jacobson, Diego Garrido Ruiz, Wilian A. Cortopassi, Anjali Cremer, Cristina F. Contreras, Haley L. Faust, Tasleema Patel, Cristina E. Tognon, Alma Imamovic, Shan Lin, Yuting Li, Giacomo Gotti, Nicole Ocasio-Martinez, Catherine M. Clinton, Asmani A. Adhav, Lisa Gennarini, Jeffrey A. Magee, Matthew J. Barth, Jing Chen, Justine M. Kahn, Peter D. Cole, Neerav N. Shukla, Jennifer L. McNeer, Nathan Gossai, Patrick A. Brown, Michael J. Burke, Kelly W. Maloney, Melinda Pauly, Todd M. Cooper, Beth Apsel Winger, Traci M. Blonquist, Kristen Stevenson, Maria Luisa Sulis, Sarah K. Tasian, and Yana Pikman

Abstract

Reasons for not using recommended targeted therapy.

Published
2023
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6. Supplementary Data from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Kimberly Stegmaier, Mignon L. Loh, Marian H. Harris, Jeffrey W. Tyner, Lewis B. Silverman, Katherine A. Janeway, Lia Gore, Neal I. Lindeman, Annette S. Kim, Stephen P. Hunger, Alexandre Puissant, Andrew E. Place, Elliot Stieglitz, Katherine Tarlock, Amy Saur Conway, Amanda L. Robichaud, Angela Su, Neekesh V. Dharia, Matthew P. Jacobson, Diego Garrido Ruiz, Wilian A. Cortopassi, Anjali Cremer, Cristina F. Contreras, Haley L. Faust, Tasleema Patel, Cristina E. Tognon, Alma Imamovic, Shan Lin, Yuting Li, Giacomo Gotti, Nicole Ocasio-Martinez, Catherine M. Clinton, Asmani A. Adhav, Lisa Gennarini, Jeffrey A. Magee, Matthew J. Barth, Jing Chen, Justine M. Kahn, Peter D. Cole, Neerav N. Shukla, Jennifer L. McNeer, Nathan Gossai, Patrick A. Brown, Michael J. Burke, Kelly W. Maloney, Melinda Pauly, Todd M. Cooper, Beth Apsel Winger, Traci M. Blonquist, Kristen Stevenson, Maria Luisa Sulis, Sarah K. Tasian, and Yana Pikman

Abstract

Patient sequencing data, by patient number and diagnosis.

Published
2023
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8. Acceptability, Feasibility, and Quality of Telehealth for Adolescent Health Care Delivery During the COVID-19 Pandemic: Cross-sectional Study of Patient and Family Experiences (Preprint)

Author

Sarah M Wood, Julia Pickel, Alexis W Phillips, Kari Baber, John Chuo, Pegah Maleki, Haley L Faust, Danielle Petsis, Danielle E Apple, Nadia Dowshen, and Lisa A Schwartz

Abstract

BACKGROUND Data regarding the acceptability, feasibility, and quality of telehealth among adolescents and young adults (AYA) and their parents and caregivers (caregivers) are lacking. OBJECTIVE The aim of this study was to assess the noninferiority of telehealth versus in-person visits by comparing acceptability with respect to efficiency, effectiveness, equity, patient-centeredness, and confidentiality. METHODS Cross-sectional web-based surveys were sent to caregivers and AYA following video visits within an Adolescent Medicine subspecialty clinic in May-July 2020. Proportions of AYA and caregivers who rated telehealth as noninferior were compared using chi-squared tests. Feasibility was assessed via items measuring technical difficulties. Deductive thematic analysis using the Institute of Medicine dimensions of health care quality was used to code open-ended question responses. RESULTS Survey response rates were 20.5% (55/268) for AYA and 21.8% (123/563) for caregivers. The majority of the respondents were White cisgender females. Most AYA and caregivers rated telehealth as noninferior to in-person visits with respect to confidentiality, communication, medication management, and mental health care. A higher proportion of AYA compared to caregivers found telehealth inferior with respect to confidentiality (11/51, 22% vs 3/118, 2.5%, P CONCLUSIONS Telehealth was highly acceptable among AYA and caregivers. Future optimization should include improving privacy, ameliorating technical difficulties, and standardizing at-home methods of obtaining patient data to assure patient safety.

Published
2021
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9. Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Author

Cristina E. Tognon, Alma Imamovic, Peter D. Cole, Anjali Cremer, Todd M. Cooper, Alexandre Puissant, Catherine Clinton, Asmani A. Adhav, Patrick A. Brown, Kristen E. Stevenson, Mignon L. Loh, Justine M. Kahn, Nathan Gossai, Elliot Stieglitz, Wilian A. Cortopassi, Andrew E. Place, Stephen P. Hunger, Michael J. Burke, Lewis B. Silverman, Annette S. Kim, Nicole Ocasio-Martinez, Diego Garrido Ruiz, Jeffrey W. Tyner, Matthew J. Barth, Lisa M. Gennarini, Yana Pikman, Neal I. Lindeman, Maria Luisa Sulis, Lia Gore, Beth Apsel Winger, Neekesh V. Dharia, Traci M. Blonquist, Yuting Li, Kimberly Stegmaier, Marian H. Harris, Jeffrey A. Magee, Katherine Tarlock, Neerav Shukla, Melinda Pauly, Kelly W. Maloney, Matthew P. Jacobson, Angela Su, Tasleema Patel, Giacomo Gotti, Cristina F. Contreras, Shan Lin, Haley L. Faust, Amanda L. Robichaud, Jing Chen, Sarah K. Tasian, Katherine A. Janeway, Amy Saur Conway, and Jennifer L. McNeer

Subjects
0301 basic medicine, Oncology, Male, medicine.medical_treatment, Targeted therapy, Cohort Studies, 0302 clinical medicine, 2.1 Biological and endogenous factors, Prospective Studies, Molecular Targeted Therapy, Aetiology, Child, Cancer, Pediatric, Leukemia, Tumor, Hematology, Local, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Disease Progression, Female, Development of treatments and therapeutic interventions, Biotechnology, medicine.medical_specialty, Pediatric Cancer, Childhood Leukemia, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, MEDLINE, 03 medical and health sciences, Rare Diseases, Refractory, Clinical Research, Internal medicine, Biomarkers, Tumor, medicine, Genetics, Humans, business.industry, Human Genome, medicine.disease, Precision medicine, United States, Clinical trial, 030104 developmental biology, Neoplasm Recurrence, Orphan Drug, Good Health and Well Being, Relapsed refractory, Feasibility Studies, Neoplasm Recurrence, Local, business, Biomarkers
Abstract

Despite a remarkable increase in the genomic profiling of cancer, integration of genomic discoveries into clinical care has lagged behind. We report the feasibility of rapid identification of targetable mutations in 153 pediatric patients with relapsed/refractory or high-risk leukemias enrolled on a prospective clinical trial conducted by the LEAP Consortium. Eighteen percent of patients had a high confidence Tier 1 or 2 recommendation. We describe clinical responses in the 14% of patients with relapsed/refractory leukemia who received the matched targeted therapy. Further, in order to inform future targeted therapy for patients, we validated variants of uncertain significance, performed ex vivo drug-sensitivity testing in patient leukemia samples, and identified new combinations of targeted therapies in cell lines and patient-derived xenograft models. These data and our collaborative approach should inform the design of future precision medicine trials. Significance: Patients with relapsed/refractory leukemias face limited treatment options. Systematic integration of precision medicine efforts can inform therapy. We report the feasibility of identifying targetable mutations in children with leukemia and describe correlative biology studies validating therapeutic hypotheses and novel mutations. See related commentary by Bornhauser and Bourquin, p. 1322. This article is highlighted in the In This Issue feature, p. 1307

Published
2021

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