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1. Software development and integration of an adaptive-optics testbed using the Giant Magellan Telescope software frameworks

Author

Ibsen, Jorge, Chiozzi, Gianluca, Molgó, J., Schoenell, W., Filgueira, J. M., Quirós-Pacheco, F., Puglisi, A., Rossi, F., Lapucci, T., Bouchez, A., Xin, B., Schurter, P., Demers, R., Close, L., Haffert, S., Kautz, M., Males, J., Cox, M., Soto, J., Peng, C., Swett, H., Contaxis, C., Barrios, J., El-Halabi, G., and Silva, P. H.

Published
2024
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3. Dialyse péritonéale : ce que doit savoir le médecin généraliste [Peritoneal dialysis : what the general practitioner should know about peritoneal dialysis]

Author

Schneider, M., Pruijm, M., and Halabi, G.

Subjects
General Practitioners/education, Humans, Kidney Failure, Chronic/economics, Kidney Failure, Chronic/therapy, Peritoneal Dialysis/economics, Switzerland
Abstract

Peritoneal dialysis (PD) has often been considered as a renal replacement method that is not feasible for the elderly population. Numerous recent studies have shown that this method is in fact very well, if not better tolerated by elderly patients. In Switzerland and abroad, its economic advantages have also been underlined during the past ten years. As a consequence, the use of PD is increasing, and primary care physicians are more often confronted to PD patients. Therefore, they have to be aware of some basic treatment principles, which are reviewed in this article.

Published
2020

4. Multimodal imaging of retinal pigment epithelial detachments in patients with C3 glomerulopathy: case report and review of the literature

Author

Kheir, V., Dirani, A., Halfon, M., Venetz, J.P., Halabi, G., and Guex-Crosier, Y.

Subjects
Alternative pathway, Choroidal neovascularization, Complement 3 glomerulopathy, Drusenoid pigment epithelial detachments, Multimodal imaging, Optic coherence tomography angiography, genetic structures, sense organs, eye diseases
Abstract

To describe the optical coherence tomography angiograhy (OCTA) of drusenoid pigment epithelial detachments (PEDs) in a woman affected by Complement 3 (C3) glomerulopathy, which represents a spectrum of glomerular diseases characterized on fluorescent microscopy by C3 accumulation with absent, or scanty, immunoglobulin deposits. It is due to acquired or genetically defective alternative pathway control and is generally associated with drusen-like deposits in Bruch's membrane, as well as choriocapillaris. These retinal lesions can be associated with choroidal neovascularization and central serous chorioretinopathy (CSCR). OCTA is useful to detect neovascularization without injecting a contrast product, particularly in these patients who may have renal insufficiency. A 28-year-old woman affected by C3 glomerulpathy was diagnosed with asymptomatic multiple bilateral PEDs during a routine ophthalmologic consultation. To better characterize the lesions, multimodal imaging was performed and included: optic coherence tomography (OCT), en-face OCT, OCTA, fluorescence and indocyanine angiography. The OCTA clearly identified vascular network rarefaction with decreased choriocapillary vascularization. It confirmed that PEDs associated with C3 glomerulonephritis are not vascularized, but rather of serous type. Patients affected by C3 glomerulopathy can develop neovascular membranes as retinal complications of pigment epithelial detachments. Optical coherence angiography may be indicated to identify this complication, without injecting any contrast product that could produce further kidney damage.

Published
2017

9. CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation

Author

Arabi, A., primary, Khoueiry-Zgheib, N ., additional, Awada, Z., additional, Mahfouz, R., additional, Al-Shaar, L., additional, Hoteit, M., additional, Rahme, M., additional, Baddoura, R., additional, Halabi, G., additional, Singh, R., additional, and El Hajj Fuleihan, G., additional

Published
2016
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11. Usefulness of Telemetric Blood Pressure Monitoring in Hypertensive Patients with Chronic Kidney Diseases

Author

Burnier, M., Bock, A., Halabi, G., Gasser, U.E., Pechère Bertschi, A., Ambühl, P., Forster, C., Gabutti, L., Giovannini, M., Hess, B., Höfliger, N., Meier, P., Mohaupt, M., Pfammatter, R., Schönholzer, C., Schwarz, A., Steiger, J., Wagner, G., and Würzner, G.

Subjects
Creatinine, medicine.medical_specialty, business.industry, medicine.drug_class, Lercanidipine, Diastole, Renal function, law.invention, chemistry.chemical_compound, Blood pressure, chemistry, Randomized controlled trial, law, Internal medicine, Heart rate, Cardiology, Medicine, business, Antihypertensive drug, medicine.drug
Abstract

Introduction: The quality of Blood Pressure (BP) control remains poor among patients with Chronic Kidney Diseases (CKD). It is therefore crucial to develop therapeutic strategies enabling improvement in BP control in order to retard the progression of the underlying renal diseases. The cornerstones of therapy include the use of effective and well tolerated drugs and a good drug adherence. In this pilot study conducted in ambulant routine care we evaluated the potential clinical benefits of implementing a Telemonitoring System (TMS) in parallel to an anticipated change of treatment in hypertensive CKD patients with uncontrolled hypertension and/or adverse reactions due to the current antihypertensive treatment. Methods: This is an observational study conducted by 13 Swiss nephrologists in patients with CKD stage III-IV and a BP >130/80 mmHg under treatment with an antihypertensive drug. A validated, automated TMS for home BP and Heart Rate (HR) monitoring and an electronic scale to measure Body Weight (BW) and a modem to transfer the measured parameters to a central database were provided to each patient. The protocol included a run-in phase and a drug titration phase of 1 month each and a 2 month maintenance phase. During the titration phase, the calcium antagonist lercanidipine could be introduced and up titrated in case of uncontrolled BP. Results: The use of a TMS in conjunction with the introduction of lercanidipine resulted in a significant reduction of office systolic and diastolic BP of respectively -10 ± 21 mmHg (p=0.028) and -5.0 ± 11 mmHg (p=0.049). Home BP revealed a parallel significant reduction of -3 ± 1.4 mmHg systolic (p=0.043) and -3 ± 1.2 mmHg (p=0.021) diastolic, respectively. The fall in BP was associated with a slight but significant increase in serum creatinine and decrease in Estimated Glomerular Filtration Rate (eGFR). Conclusion: The results of this observational pilot study suggest that a telemonitoring system enabling to follow home BP may be useful to improve BP control in hypertensive patients with CKD. However, a prospective randomized control study would be needed to assess the real added benefits of this strategy. Administration of lercanidipine in CKD patients was effective and well tolerated.

Published
2012

12. Peritoneal dialysis II

Author

Yayar, O., primary, Buyukbakkal, M., additional, Eser, B., additional, Yildirim, T., additional, Ercan, Z., additional, Erdogan, B., additional, Kali, A., additional, Merhametsiz, O., additional, Haspulat, A., additional, Akdag, I., additional, Ayli, M. D., additional, Quach, T., additional, Tregaskis, P., additional, Menahem, S., additional, Koukounaras, J., additional, Mott, N., additional, Walker, R., additional, Zeiler, M., additional, Santarelli, S., additional, Degano, G., additional, Monteburini, T., additional, Agostinelli, R. M., additional, Marinelli, R., additional, Ceraudo, E., additional, Grzelak, T., additional, Kramkowska, M., additional, Walczak, M., additional, Czyzewska, K., additional, Guney, I., additional, Turkmen, K., additional, Yazici, R., additional, Arslan, S., additional, Altintepe, L., additional, Yeksan, M., additional, Vaduva, C., additional, Popa, S., additional, Mota, M., additional, Mota, E., additional, Wan Md Adnan, W. A. H., additional, Zaharan, N. L., additional, Moreiras-Plaza, M., additional, Blanco-Garcia, R., additional, Beato-Coo, L., additional, Cossio-Aranibar, C., additional, Martin-Baez, I., additional, Santos, M. T., additional, Fonseca, I., additional, Santos, O., additional, Aguiar, P., additional, Rocha, M. J., additional, Carvalho, M. J., additional, Cabrita, A., additional, Rodrigues, A., additional, Guo, Z., additional, Lai, X., additional, Theodoridis, M., additional, Panagoutsos, S., additional, Thodis, E., additional, Karanikas, M., additional, Mitrakas, A., additional, Kriki, P., additional, Kantartzi, K., additional, Passadakis, P., additional, Vargemezis, V., additional, Vakilzadeh, N., additional, Pruijm, M., additional, Burnier, M., additional, Halabi, G., additional, Azevedo, P., additional, Carvalho, M., additional, Laplante, S., additional, Rutherford, P., additional, Shutov, E., additional, Isachkina, A., additional, Gorelova, E., additional, Troya, M.-I., additional, Teixido, J., additional, Pedreira, G., additional, Del Rio, M., additional, Romero, R., additional, Bonet, J., additional, Zhang, X., additional, Ma, J., additional, Kim, Y., additional, Kim, J.-K., additional, Song, Y. R., additional, Kim, S. G., additional, Kim, H. J., additional, Eloot, S., additional, Vanholder, R., additional, Van Biesen, W., additional, Heaf, J., additional, Pedersen, C., additional, Elgborn, A., additional, Arabaci, T., additional, Emrem, G., additional, Keles, M., additional, Kizildag, A., additional, Martino, F., additional, Amici, G., additional, Rodighiero, M. P., additional, Crepaldi, C., additional, Ronco, C., additional, Tanaka, H., additional, Tsuneyoshi, S., additional, Yamasaki, K., additional, Daijo, Y., additional, Tatsumoto, N., additional, Al-Hilali, N., additional, Hussain, N., additional, Fathy, V., additional, Negm, H., additional, Alhilali, M., additional, Grzegorzewska, A., additional, Cieszynski, K., additional, Kaczmarek, A., additional, Sowinska, A., additional, Soleymanian, T., additional, Najafi, I., additional, Ganji, M. R., additional, Ahmadi, F., additional, Saddadi, F., additional, Hakemi, M., additional, Amini, M., additional, Tong, L. N. M. N., additional, Yongcheng, H. N. M. N., additional, Qijun, W. N. M. N., additional, Shaodong, L. N. M. N., additional, Velioglu, A., additional, Albaz, M., additional, Arikan, H., additional, Tuglular, S., additional, Ozener, C., additional, Bakirdogen, S., additional, Eren, N., additional, Mehtap, O., additional, Bek, S. G., additional, Cekmen, M. B., additional, Yilmaz, A., additional, Cabana Carcasi, M. L. L., additional, Fernandez Ferreiro, A., additional, Fidalgo Diaz, M., additional, Becerra Mosquera, V., additional, Alonso Valente, R., additional, Buttigieg, J., additional, Borg Cauchi, A., additional, Rogers, M., additional, Buhagiar, L., additional, Farrugia Agius, J., additional, Vella, M. P., additional, Farrugia, E., additional, Han, J. H., additional, Kim, H. R., additional, Ko, K. I., additional, Kim, C. H., additional, Koo, H. M., additional, Doh, F. M., additional, Lee, M. J., additional, Oh, H. J., additional, Han, S. H., additional, Yoo, T.-H., additional, Kang, S.-W., additional, Choi, K. H., additional, Sikorska, D., additional, Frankiewicz, D., additional, Klysz, P., additional, Schwermer, K., additional, Hoppe, K., additional, Nealis, J., additional, Kaczmarek, J., additional, Baum, E., additional, Wanic-Kossowska, M., additional, Pawlaczyk, K., additional, Oko, A., additional, Hiss, M., additional, Gerstein, F., additional, Haller, H., additional, Gueler, F., additional, Fukasawa, M., additional, Manabe, T., additional, Wan, Q., additional, He, Y., additional, Zhu, D., additional, Li, J., additional, Xu, H., additional, Yayar, O., additional, Oztemel, A., additional, Pilcevic, D., additional, Kovacevic, Z., additional, Maksic, D., additional, Paunic, Z., additional, Tadic-Pilcevic, J., additional, Mijuskovic, M., additional, Petrovic, M., additional, Obrencevic, K., additional, Rabrenovic, V., additional, Ignjatovic, L., additional, Terzic, B., additional, Jovanovic, D., additional, Chang, C.-H., additional, Chang, Y.-S., additional, Busuioc, M., additional, Guerraoui, A., additional, Caillette-Beaudoin, A., additional, Bahte, S. K., additional, Kielstein, J. T., additional, Polinder-Bos, H., additional, Emmelot-Vonk, M., additional, and Gaillard, C., additional

Published
2013
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13. Mineral and bone disease - CKD 5D

Author

Hecking, M., primary, Kainz, A., additional, Bielesz, B., additional, Plischke, M., additional, Beilhack, G., additional, Hoerl, W. H., additional, Sunder-Plassmann, G., additional, Bieglmayer, C., additional, Benchetrit, S., additional, Green, J., additional, Bernheim, J., additional, Golan, E., additional, Oyake, N., additional, Suzuki, K., additional, Itoh, S., additional, Tanabe, K., additional, Fujimori, A., additional, Okada, S., additional, Yamamoto, K., additional, Sakai, M., additional, Kamiura, N., additional, Solenne, P., additional, Guebre-Egziabher, F., additional, Bacchetta, J., additional, Drai, J., additional, Richard, M., additional, Chapurlat, R., additional, Fouque, D., additional, Nowak, Z., additional, Grzegorz, K., additional, Maria, K., additional, Zofia, W., additional, Zamboch, K., additional, Zahalkova, J., additional, Kosatikova, Z., additional, Skypalova, P., additional, Skarda, J., additional, Cunha, J., additional, Boim, M., additional, Ferreira, V., additional, Naves, M., additional, Kikuchi, H., additional, Shimada, H., additional, Takimoto, Y., additional, Karasawa, R., additional, Shimotori, M., additional, Ikarashi, K., additional, Saito, N., additional, Miyazaki, S., additional, Sakai, S., additional, Suzuki, M., additional, Ogata, H., additional, Takeshima, A., additional, Yamamoto, M., additional, Asakura, K., additional, Kato, T., additional, Shishido, K., additional, Koiwa, F., additional, Mizobuchi, M., additional, Kinugasa, E., additional, Akizawa, T., additional, Londrino, F., additional, Corbani, V., additional, Ardini, M., additional, Falqui, V., additional, Zattera, T., additional, Rombola', G., additional, Takeshige, Y., additional, Matsuzaka, K., additional, Ciceri, P., additional, Volpi, E., additional, Brenna, I., additional, Elli, F., additional, Borghi, E., additional, Brancaccio, D., additional, Cozzolino, M., additional, Farrand, K., additional, Copley, J. B., additional, Heise, J., additional, Fridman, M., additional, Keith, M., additional, Silverberg, A., additional, Wilson, R., additional, Poole, L., additional, Jean, G., additional, Bresson, E., additional, Chazot, C., additional, Maduell, F., additional, Arias, M., additional, Sentis, A., additional, Rodriguez, N., additional, Jimenez, S., additional, Alemany, B., additional, Perez, N., additional, Vera, M., additional, Fontsere, N., additional, Carrera, M., additional, Cases, A., additional, Sonikian, M., additional, Miha, T., additional, Skarakis, I., additional, Karatzas, I., additional, Karaitianou, A., additional, Tomanoski, V., additional, Petkovic, D., additional, Curic, I., additional, Hrvacevic, R., additional, Kaperonis, N., additional, Kourvelou, C., additional, Sgantzos, A., additional, Nastou, D., additional, Ntatsis, G., additional, Ziakka, S., additional, Karakasis, F., additional, Nikolopoulos, V., additional, Zoubaniotou, D., additional, Koutsovasili, A., additional, Zagorianakos, A., additional, Kolovos, V., additional, Papagalanis, N., additional, Forni, V., additional, Pruijm, M., additional, Tousset, E., additional, Zweiacker, C., additional, Menetrey, I., additional, Berwert, L., additional, Bullani, R., additional, Cherpillod, A., additional, Gabutti, L., additional, Gauthier, T., additional, Halabi, G., additional, Mathieu, C., additional, Meier, P., additional, Phan, O., additional, Pianca, S., additional, Schoenholzer, C., additional, Teta, D., additional, Von Albertini, B., additional, Vrijens, B., additional, Burnier, M., additional, Kurita, N., additional, Fukagawa, M., additional, Onishi, Y., additional, Yamaguchi, T., additional, Hasegawa, T., additional, Fukuma, S., additional, Kurokawa, K., additional, Fukuhara, S., additional, Urena, P., additional, Bridges, I., additional, Christiano, C., additional, Cournoyer, S., additional, Cooper, K., additional, Farouk, M., additional, Kopyt, N., additional, Rodriguez, M., additional, Zehnder, D., additional, Covic, A., additional, Tominaga, Y., additional, Hiramitsu, T., additional, Yamamoto, T., additional, Nanmoku, K., additional, Matsuda, Y., additional, Tsuzuki, T., additional, Lang, C.-L., additional, Lu, K.-C., additional, Wang, M.-H., additional, Liu, S.-Y., additional, Huang, J.-W., additional, Chiang, C.-K., additional, Hung, K.-Y., additional, Bantis, C., additional, Kouri, N.-M., additional, Tsandekidou, E., additional, Frangidis, S., additional, Tsiandoulas, A., additional, Liakou, E., additional, Bamichas, G., additional, Stangou, M., additional, Papagianni, A., additional, Efstratiadis, G., additional, Natse, T., additional, Memmos, D., additional, Messa, P., additional, Cannella, G., additional, Mazzaferro, S., additional, Yu, X., additional, Bieber, B., additional, Guidinger, M., additional, Yang, X., additional, Tentori, F., additional, Pisoni, R., additional, Qian, J., additional, Chen, N., additional, Yan, Y., additional, Wang, M., additional, Zuo, L., additional, Wang, H., additional, Albert, J., additional, Ramirez, S., additional, Caccetta, F., additional, Caroppo, M., additional, Musio, F., additional, Mudoni, A., additional, Accogli, A., additional, Zacheo, M. D., additional, Nuzzo, V., additional, Selim, G., additional, Stojceva-Taneva, O., additional, Tozija, L., additional, Gelev, S., additional, Pusevski, V., additional, Dzekova-Vidimliski, P., additional, Rambabova-Busletic, I., additional, Sikole, A., additional, Esposito, P., additional, Coppo, R., additional, Malberti, F., additional, Dal Canton, A., additional, Moriwaki, K., additional, Komaba, H., additional, Kakuta, T., additional, Cernaro, V., additional, Lupica, R., additional, Donato, V., additional, Lacquaniti, A., additional, Fazio, M. R., additional, Lucisano, S., additional, Buemi, M., additional, Okuno, S., additional, Ishimura, E., additional, Tsuboniwa, N., additional, Norimine, K., additional, Yamakawa, K., additional, Yamakawa, T., additional, Shoji, S., additional, Mori, K., additional, Nishizawa, Y., additional, Inaba, M., additional, Dahaba, M., additional, Seck, S., additional, Cisse, M., additional, Jotoku, Y., additional, Sato, Y., additional, Dimkovic, N., additional, Asicioglu, E., additional, Kahveci, A., additional, Arikan, H., additional, Koc, M., additional, Tuglular, S., additional, Ozener, C., additional, Kido, R., additional, Yamaguch, T., additional, Krasniak, A., additional, Drozdz, M., additional, Chmiel, G., additional, Podolec, P., additional, Pasowicz, M., additional, Kowalczyk-Michalek, M., additional, Sulowicz, W., additional, Perez-Suarez, G., additional, Baamonde, E., additional, Bosch, E., additional, Ramirez, J. I., additional, El Hayek, B., additional, Lago, M. D. M., additional, Garcia, C., additional, Checa, M. D., additional, Hiramatsu, R., additional, Ubara, Y., additional, Salas, K., additional, Vicent, E. S., additional, Gonzalez Oliva, J. C., additional, Fulquet, M., additional, Duarte, V., additional, Pou, M., additional, Saurina, A., additional, Macias, J., additional, Ramirez de Arellano, M., additional, Matias, P., additional, Jorge, C., additional, Mendes, M., additional, Amaral, T., additional, Ferreira, C., additional, Aires, I., additional, Gil, C., additional, Ferreira, A., additional, Arcal, C., additional, Campistol, J. M., additional, Seferi, S., additional, Rroji, M., additional, Likaj, E., additional, Petrela, E., additional, Barbullushi, M., additional, Zeneli, N., additional, Mumajesi, S., additional, Thereska, N., additional, Vulpio, C., additional, Bossola, M., additional, Stigliano, E., additional, Fadda, G., additional, Gueiros, A. P. S., additional, Borba Junior, J. O., additional, Lordsllen, A. B. d. M. D. S., additional, Gueiros, J. E. d. B., additional, Itami, N., additional, Tuneyama, K., additional, Uemura, S., additional, Hamada, H., additional, Takada, J., additional, Takahashi, K., additional, Adamidis, K., additional, Apostolou, T., additional, Pleros, C., additional, Oikonomaki, T., additional, Kyratzi, E., additional, Exarchos, D., additional, Metaxatos, G., additional, Dracopoulos, S., additional, Nikolopoulou, N., additional, Delanaye, P., additional, Dubois, B., additional, Krzesinski, J.-M., additional, Cavalier, E., additional, De la Fuente, V., additional, Gil, M. T., additional, Gutierrez, P., additional, Delgado, P., additional, Ribero, J., additional, Arenas, L., additional, Sezer, S., additional, Tutal, E., additional, Bal, Z., additional, Erkmen Uyar, M., additional, Ozdemir Acar, F. N., additional, Azevedo de Oliveira, R., additional, Carvalho Barreto, F., additional, Dos Reis, L., additional, Cunha Ferreira, J., additional, Maria Leme Britto, Z., additional, Maria Moyses, R., additional, Jorgetti, V., additional, Ozelsancak, R., additional, Gurlek Demirci, B., additional, Torun, D., additional, Veljancic, L., additional, Radojevic, M., additional, Paunic, Z., additional, Vavic, N., additional, Obrencevic, K., additional, Kovacevic, Z., additional, and Pejovic, J., additional

Published
2012
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14. Nutrition, inflammation and oxidative stress - CKD 5D

Author

Usvyat, L. A., primary, Raimann, J., additional, Thijssen, S., additional, van der Sande, F. M., additional, Kooman, J., additional, Levin, N. W., additional, Kotanko, P., additional, Von Gersdorff, G., additional, Schaller, M., additional, Bayh, I., additional, Etter, M., additional, Grassmann, A., additional, Guinsburg, A., additional, Lam, M., additional, Marcelli, D., additional, Marelli, C., additional, Scatizzi, L., additional, Tashman, A., additional, Toffelmire, T., additional, Usvyat, L., additional, Van der Sande, F., additional, Wang, Y., additional, Barth, C., additional, Moffitt, T., additional, Hariton, F., additional, Devlin, M., additional, Garrett, P., additional, Hannon-Fletcher, M., additional, Ekramzadeh, M., additional, Sohrabi, Z., additional, Salehi, M., additional, Fallahzadeh, M. K., additional, Ayatollahi, M., additional, Geramizadeh, B., additional, Hassanzadeh, J., additional, Sagheb, M. M., additional, Beberashvili, I., additional, Sinuani, I., additional, Azar, A., additional, Kadoshi, H., additional, Shapiro, G., additional, Feldman, L., additional, Averbukh, Z., additional, Weissgarten, J., additional, Abe, Y., additional, Watanabe, M., additional, Ito, K., additional, Sasatomi, Y., additional, Ogahara, S., additional, Nakashima, H., additional, Saito, T., additional, Witt, S., additional, Kunze, R., additional, Guth, H. J., additional, Skarabis, H., additional, Vienken, J., additional, Nowak, P., additional, Wilk, R., additional, Mamelka, B., additional, Prymont-Przyminska, A., additional, Zwolinska, A., additional, Sarniak, A., additional, Wlodarczyk, A., additional, Rysz, J., additional, Nowak, D., additional, Trajceska, L., additional, Dzekova-Vidimliski, P., additional, Gelev, S., additional, Arsov, S., additional, Sikole, A., additional, Sonikian, M., additional, Dona, A., additional, Skarakis, I., additional, Metaxaki, P., additional, Chiotis, C., additional, Papoutsis, I., additional, Karaitianou, A., additional, Spiliopoulou, C., additional, Van der Sande, F. M., additional, Usvyat, L. A., additional, Teta, D., additional, Tappy, L., additional, Theumann, N., additional, Halabi, G., additional, Gauthier, T., additional, Mathieu, C., additional, Tremblay, S., additional, Coti, P., additional, Burnier, M., additional, Zanchi, A., additional, Martinez Vea, A., additional, Cabre, C., additional, Villa, D., additional, Munoz, M., additional, Vives, J. P., additional, Arruche, M., additional, Soler, J., additional, Compte, M. T., additional, Aguilera, J., additional, Romeu, M., additional, Giralt, M., additional, Barril, G., additional, Anaya, S., additional, Vozmediano, C., additional, Celayeta, A., additional, Novillo, R., additional, Bernal, V., additional, Beiret, I., additional, Huarte, E., additional, Martin, J., additional, Santana, H., additional, Torres, G., additional, Sousa, F., additional, Sanchez, R., additional, Lopez-Montes, A., additional, Tornero, F., additional, Uson, J., additional, Pousa, M., additional, Giorgi, M., additional, Rdez Cubillo, B., additional, Malhotra, R., additional, Abbas, S. R., additional, Thjissen, S., additional, Carter, M., additional, von Gersdorff, G., additional, Levin, N., additional, Jens, R., additional, Tepel, M., additional, Katharina, E., additional, Andrea, H., additional, Simone, F., additional, Florian, S., additional, Slusanschi, O., additional, Garneata, L., additional, Moraru, R., additional, Preoteasa, E., additional, Barbulescu, C., additional, Santimbrean, C., additional, Klein, C., additional, Dragomir, D., additional, Mircescu, G., additional, Idorn, T., additional, Knop, F., additional, Holst, J. J., additional, Hornum, M., additional, Feldt-Rasmussen, B., additional, Son, Y. K., additional, An, W. S., additional, Kim, S. E., additional, Kim, K. H., additional, Borrelli, S., additional, Minutolo, R., additional, De Nicola, L., additional, Conte, G., additional, De Simone, W., additional, Zito, B., additional, Guastaferro, P., additional, Nigro, F., additional, Bassi, A., additional, Leone, L., additional, Credendino, O., additional, Genualdo, R., additional, Capuano, M., additional, Iulianiello, G., additional, Auricchio, M. R., additional, Sezer, S., additional, Bal, Z., additional, Tutal, E., additional, Erkmen Uyar, M., additional, Ozdemir Acar, F. N., additional, Ribeiro, S., additional, Faria, M. S., additional, Melo, F., additional, Sereno, J., additional, Freitas, I., additional, Mendonca, M., additional, Nascimento, H., additional, Fernandes, J., additional, Rocha-Pereira, P., additional, Miranda, V., additional, Mendonca, D., additional, Quintanilha, A., additional, Belo, L., additional, Costa, E., additional, Reis, F., additional, Santos-Silva, A., additional, Valtuille, R., additional, Casos, M. E., additional, and Fernandez, E. A., additional

Published
2012
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23. Nephrectomy by laparoscopy in the live donor: an introduction of the method and preliminary results

Author

Bettschart, V., Schneider, R., Halabi, G., Wauters, J.P., Edye, M., and Mosimann, F.

Abstract

Introduction : le recours a` des donneurs vivants est une des solutions a` la pe´nurie d'organes en transplantation re´nale. Re´cemment des techniques de pre´le`vement laparoscopique ont e´te´ de´crites, permettant de re´duire la morbidite´, la dure´e de l'hospitalisation et l'arre^t de travail du donneur. Elles sont cependant difficiles, et peuvent exposer le greffon a` des risques. Me´thode : nous avons introduit le pre´le`vement de rein par laparoscopie par e´tapes, notamment en utilisant la vide´oconfe´rence a` partir d'un centre d'excellence. Nous rapportons l'analyse prospective de nos re´sultats initiaux. Re´sultats : nous avons effectue´ dix pre´le`vements, trois a` gauche et sept a` droite ; il n'y a pas eu de conversion en laparotomie. Le temps d'ische´mie chaude a e´te´ de cinq minutes en moyenne, n'exce´dant pas trois minutes lors de nos six derniers pre´le`vements. Les patients ont quitte´ l'ho^pital 4,8 jours apre`s l'ope´ration en moyenne. Les greffons ont tous pre´sente´ une excellente fonction. Conclusion : la qualite´ de ces re´sultats initiaux, lie´s a` une introduction prudente de la me´thode, devrait permettre a` terme de renforcer la motivation des donneurs potentiels et de leur entourage, augmentant ainsi le nombre d'organes a` greffer.

Published
2001
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29. Can functional food security decrease the epidemic of obesity and metabolic syndrome? A viewpoint

Author

Shastun S., Chauhan A.K., Singh R.B., Singh M., Singh R.P., Itharat A., Chibisov S., Wilson D.W., Halabi G., De Meester F., Shastun S., Chauhan A.K., Singh R.B., Singh M., Singh R.P., Itharat A., Chibisov S., Wilson D.W., Halabi G., and De Meester F.

Abstract

The world is still ignorant about the role of functional food security characterized by diversity and adequacy of nutrients that may have been beneficial and abundant in the Paleolithic diet 40,000 years ago because of food diversity. Therefore, the increased prevalence of metabolic syndrome and the resultant type 2 diabetes, hypertension and heart disease throughout the world, are closely linked to food security via westernized dietary patterns, physical inactivity, and rapid increase in the rate of obesity. There is substantial evidence that increased intake of functional foods can bring about a significant decline in the epidemic of obesity and metabolic syndrome, resulting in health promotion. We therefore propose that functional food security can maintain the normal physiology and metabolism of our bodies, resulting in prevention of diseases and improvement of world health. © 2016 Nova Science Publishers, Inc.

30. Mechanisms and pathogenesis of cardiovascular complications of cancers in relation to circadian rhythms

Author

Chibisov S., Dementyev M., Singh R.B., Blagonravov M., Kharlitskaya E., Halabi G., Abramova M., Meladze Z., Chibisov S., Dementyev M., Singh R.B., Blagonravov M., Kharlitskaya E., Halabi G., Abramova M., and Meladze Z.

Abstract

Background: Damage to circadian system of our body may be associated with disturbances in body rhythms which may predispose to carcinogenesis. Quantitative assessment and diagnosis of desynchronization of circadian rhythms may be performed for scientific purposes, as there are no simple methods for use in daily clinical practice. The aim of our work is to develop simple methods for the diagnosis of desynchronization in body rhythms. Subjects and Methods: This study included two groups; the first group included 51 age-and sex-matched subjects from among students and staff of the University for comparison. The second group comprised 24 patients with cancer: 7 patients had breast cancer and the rest had lung cancer. The identification of desynchronization of body rhythms was carried out using correlation-regression analysis. Results: In group 1, the regression coefficients are positive and statistically significant for all parameters, and the average value in the parameters for HR - SBP and HR - DBP significantly exceeds the average in group 2. The average value of the regression coefficient HR-SBP is 0.369 ± 0.194, P < 0.05; HR-DBP is 0.503 ± 0.22, P< 0.05, also significant. In group 2, all regression coefficients are positive in relation to DBP - SBP. However, in the pair HR - SBP, the part of negative regression coefficients is 12.5%, whereas in the pair HR - DBP it is 8%. In group 2, there is significant decrease in unidirectional characteristics of changes in relations between HR - SBP and HR - DBP. However, the appearance of negative regression coefficients indicates the coherence reduction and shows the emergence of diversity in the occurrence of combined physiological functions. The average value of the regression coefficient for HR-SBP is 0.242 ± 0.224 P < 0.05, and for HR-DBP it is 0.265 ± 0.339, P < 0.05.The substantial alterations identified in comparison of group 1 for all studied relations, apparently indicate various degrees of desynchronization in body

34. Quality of care and survival of haemodialysed patients in western Switzerland

Author

Patrick, Saudan, Michel, Kossovsky, George, Halabi, Pierre Y, Martin, Thomas V, Perneger, Z, Glueck, Western Switzerland Dialysis Study Group, Fellay, G., Descombes, E., Martin, PY., Levy, M., Freudiger, H., Brunisholz, M., Robert, D., Giovanini, M., Uldry, PY., Vogel, G., Haldimann, B., Blanc, E., Evequoz, P., Schmid, M., Scherrer, P., Burnier, M., Teta, D., Halabi, G., Guignard, JP., von Albertini, B., Hudry, MT., Gautier, T., and Glueck, Z.

Subjects
Male, medicine.medical_treatment, Kaplan-Meier Estimate, Severity of Illness Index, Switzerland/epidemiology, Cause of Death, Cause of death, Aged, 80 and over, education.field_of_study, Dialysis adequacy, Age Factors, Middle Aged, Treatment Outcome, Nephrology, Kidney Failure Chronic/diagnosis/mortality/therapy, Female, Hemodialysis, Switzerland, medicine.medical_specialty, Statistics Nonparametric, Population, Risk Assessment, Statistics, Nonparametric, Sex Factors, Renal Dialysis, Internal medicine, Severity of illness, medicine, Humans, ddc:610, Quality Indicators Health Care, education, Dialysis, Survival analysis, Kaplan-Meiers Estimate, Aged, Quality Indicators, Health Care, Quality of Health Care, Retrospective Studies, Transplantation, Analysis of Variance, business.industry, Survival Analysis, Surgery, Kidney Failure, Chronic/diagnosis, Kidney Failure, Chronic/mortality, Multivariate Analysis, Renal Dialysis/methods, Renal Dialysis/mortality, Aged 80 and over, Kidney Failure, Chronic, business, Renal Dialysis/methods/mortality
Abstract

BACKGROUND: Many factors affect survival in haemodialysis (HD) patients. Our aim was to study whether quality of clinical care may affect survival in this population, when adjusted for demographic characteristics and co-morbidities. METHODS: We studied survival in 553 patients treated by chronic HD during March 2001 in 21 dialysis facilities in western Switzerland. Indicators of quality of care were established for anaemia control, calcium and phosphate product, serum albumin, pre-dialysis blood pressure (BP), type of vascular access and dialysis adequacy (spKt/V) and their baseline values were related to 3-year survival. The modified Charlson co-morbidity index (including age) and transplantation status were also considered as a predictor of survival. RESULTS: Three-year survival was obtained for 96% of the patients; 39% (211/541) of these patients had died. The 3-year survival was 50, 62 and 69%, respectively, in patients who had 0-2, 3 and >or=4 fulfilled indicators of quality of care (test for linear trend, P < 0.001). In a Cox multivariate analysis model, the absence of transplantation, a higher modified Charlson's score, decreased fulfilment of indicators of good clinical care and low pre-dialysis systolic BP were independent predictors of death. CONCLUSION: Good clinical care improves survival in HD patients, even after adjustment for availability of transplantation and co-morbidities.

Published
2017

35. Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID-19 patient.

Author

Singh RB, Halabi G, Fatima G, Rai RH, Tarnava AT, and LeBaron TW

Abstract

Administration of molecular hydrogen dissolved in water to patient with COVID-19-like symptoms may improve oxygen levels and exercise capacity., Competing Interests: AT is involved in commercial entities with interest in the marketing of hydrogen‐rich water. TWL has received travel reimbursement, honoraria, and speaking and consultancy fees from various academic and commercial entities regarding molecular hydrogen. All other authors report no conflict of interest., (© 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)

Published
2021
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36. [Peritoneal dialysis : what the general practitioner should know about peritoneal dialysis].

Author

Schneider M, Pruijm M, and Halabi G

Subjects
Humans, Kidney Failure, Chronic economics, Switzerland, General Practitioners education, Kidney Failure, Chronic therapy, Peritoneal Dialysis economics
Abstract

Peritoneal dialysis (PD) has often been considered as a renal replacement method that is not feasible for the elderly population. Numerous recent studies have shown that this method is in fact very well, if not better tolerated by elderly patients. In Switzerland and abroad, its economic advantages have also been underlined during the past ten years. As a consequence, the use of PD is increasing, and primary care physicians are more often confronted to PD patients. Therefore, they have to be aware of some basic treatment principles, which are reviewed in this article., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2020

37. [Immune checkpoint inhibitors and renal toxicity : update about an emerging pathology].

Author

Belkoniene M, Halabi G, Rotman S, and Kissling S

Subjects
Humans, Immunologic Factors adverse effects, Immunologic Factors therapeutic use, Neoplasms drug therapy, Neoplasms immunology, Nephritis, Interstitial chemically induced
Abstract

Recently, comprehension of immune mechanisms involved in anti-tumor responses has permitted the development of new oncologic drugs called immune checkpoint inhibitors. These drugs act by restoring anti-tumor responses. With their increasing use, we note a rise in the incidence rate of immune related adverse events, which can affect many organs. Renal toxicity, more precisely tubulointerstitial nephritis, is still not well understood but an emerging complication., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2020

39. [SEASONAL VARIATION OF MICROVOLT T-WAVE ALTERNANS IN PATIENTS WITH CARDIOVASCULAR DISEASE AND HEALTHY SUBJECTS].

Author

Halabi G, Bulanova N, Aleksandrova S, Ivanov G, and Aleksandrova M

Subjects
Adult, Aged, Cardiomyopathies physiopathology, Case-Control Studies, Electrocardiography, Female, Humans, Hypertension physiopathology, Lebanon, Male, Middle Aged, Myocardial Ischemia physiopathology, Russia, Seasons, Cardiomyopathies diagnosis, Hypertension diagnosis, Myocardial Ischemia diagnosis
Abstract

Objective - to access seasonal variation of microvolt T-wave alternans of ECG dispersion mapping in patients with cardiovascular disease and healthy subjects. ECG data of the three groups of healthy subjects have been compared: inhabitants of Beirut, Lebanon (n=51), inhabitants of Moscow, Russia (n=94) and ECG data of healthy subjects (n=44) from the testing ECG database of the PTB - The National Metrology Institute of Germany as well as a group of patients with cardiovascular disease (n=138), inhabitants of Beirut, Lebanon. Microvolt T-wave alternans of ECG dispersion mapping was evaluated in three points - Tbeginning, Tmaximum, Tend. In healthy subjects, the seasonal variation of ECG dispersion mapping microvolt T-wave alternans was nonexistent. Myocardial lesion is characterized by an increase in Tbeg, Tmax, Tend in relation to the healthy individuals. Tbeg values are minimal in winter and summer and increase in spring and autumn. Tend values were reversed - they were maximal in winter and summer, decreasing in spring-autumn period. Seasonal variation of Tmax - Tbeg, and Tmax -Tend was detected: Tmax - Tbeg increased in the winter-summer period and decreased in spring and autumn, Tmax-Tend - increased in the spring-autumn period in relation to the winter-summer period. In patients with cardiovascular disease, in contrast to the healthy, there is a seasonal variation in microvolt T-wave alternans of ECG dispersion mapping, with the maximum differences in the winter and spring seasons, which should be taken into account when applying the method in clinical practice.

Published
2018

40. Multimodal imaging of retinal pigment epithelial detachments in patients with C3 glomerulopathy: case report and review of the literature.

Author

Kheir V, Dirani A, Halfon M, Venetz JP, Halabi G, and Guex-Crosier Y

Subjects
Adult, Complement C3 metabolism, Female, Fluorescein Angiography, Humans, Multimodal Imaging, Retinal Detachment diagnostic imaging, Retinal Pigment Epithelium diagnostic imaging, Tomography, Optical Coherence, Glomerulonephritis, Membranoproliferative complications, Retinal Detachment pathology, Retinal Pigment Epithelium pathology
Abstract

Background: To describe the optical coherence tomography angiograhy (OCTA) of drusenoid pigment epithelial detachments (PEDs) in a woman affected by Complement 3 (C3) glomerulopathy, which represents a spectrum of glomerular diseases characterized on fluorescent microscopy by C3 accumulation with absent, or scanty, immunoglobulin deposits. It is due to acquired or genetically defective alternative pathway control and is generally associated with drusen-like deposits in Bruch's membrane, as well as choriocapillaris. These retinal lesions can be associated with choroidal neovascularization and central serous chorioretinopathy (CSCR). OCTA is useful to detect neovascularization without injecting a contrast product, particularly in these patients who may have renal insufficiency., Case Presentation: A 28-year-old woman affected by C3 glomerulpathy was diagnosed with asymptomatic multiple bilateral PEDs during a routine ophthalmologic consultation. To better characterize the lesions, multimodal imaging was performed and included: optic coherence tomography (OCT), en-face OCT, OCTA, fluorescence and indocyanine angiography. The OCTA clearly identified vascular network rarefaction with decreased choriocapillary vascularization. It confirmed that PEDs associated with C3 glomerulonephritis are not vascularized, but rather of serous type., Conclusions: Patients affected by C3 glomerulopathy can develop neovascular membranes as retinal complications of pigment epithelial detachments. Optical coherence angiography may be indicated to identify this complication, without injecting any contrast product that could produce further kidney damage.

Published
2017
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41. Changing trends in end-stage renal disease patients with diabetes.

Author

Lu Y, Stamm C, Nobre D, Pruijm M, Teta D, Cherpillod A, Halabi G, Phan O, Fumeaux Z, Bullani R, Gauthier T, Mathieu C, Burnier M, and Zanchi A

Subjects
Aged, Diabetic Nephropathies complications, Diabetic Nephropathies therapy, Female, Humans, Kidney Failure, Chronic etiology, Kidney Failure, Chronic therapy, Male, Middle Aged, Prevalence, Renal Dialysis statistics & numerical data, Switzerland epidemiology, Diabetic Nephropathies epidemiology, Kidney Failure, Chronic epidemiology
Abstract

Background: Worldwide, diabetes has become the most common cause of end-stage renal disease (ESRD), yet Swiss data are largely lacking., Methods: This observational study examined ESRD patients with diabetes mellitus (ESRD-DM) at end of 2009 and 2014. The prevalence and characteristics of ESRD-DM patients were collected in all dialysis facilities in the Canton of Vaud of Switzerland in 2009 and in 2014, and the 5-year mortality rate was assessed., Results: A total of 107 and 140 ESRD-DM patients underwent dialysis at end of 2009 and 2014, respectively. Within the 5-year period a total of 167 incidental ESRD-DM patients required dialysis, corresponding to an estimated incidental rate of 0.84/1000 person-years in the diabetic population. In 2009, all patients with ESRD-DM underwent haemodialysis, decreasing to 96.2% in 2014, with 3.8% on peritoneal dialysis. Age, sex, body mass index, type of diabetes, duration of diabetes, cause of ESRD, dialysis duration, dialysis frequency, vascular access, and glycosylated haemoglobin levels did not differ between 2009 and 2014. In 2014, macrovascular comorbidity was reported more often than in 2009, but not amputations. Haemoglobin level decreased significantly from 117.9 g/l to 112.3 g/l. Calcium-containing phosphate binder and angiotensin-converting enzyme inhibitor use significantly decreased, whereas iron therapy significantly increased with time. The 5-year mortality rate was 61.7%. Five-year survivors were significantly younger and had a higher body mass index., Conclusions: The growing prevalence of ESRD-DM emphasises that prevention of chronic kidney disease and its progression should be a public health priority in Switzerland.

Published
2017
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42. Obstructive Sleep Apnea Severity and Overnight Body Fluid Shift before and after Hemodialysis.

Author

Ogna A, Forni Ogna V, Mihalache A, Pruijm M, Halabi G, Phan O, Cornette F, Bassi I, Haba Rubio J, Burnier M, and Heinzer R

Subjects
Aged, Body Composition, Electric Impedance, Female, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic physiopathology, Male, Middle Aged, Polysomnography, Predictive Value of Tests, Risk Factors, Severity of Illness Index, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive physiopathology, Switzerland, Treatment Outcome, Fluid Shifts, Kidney Failure, Chronic therapy, Renal Dialysis, Sleep Apnea, Obstructive diagnosis
Abstract

Background and Objectives: Obstructive sleep apnea is associated with significantly increased cardiovascular morbidity and mortality. Fluid overload may promote obstructive sleep apnea in patients with ESRD through an overnight fluid shift from the legs to the neck soft tissues. Body fluid shift and severity of obstructive sleep apnea before and after hemodialysis were compared in patients with ESRD., Design, Setting, Participants, & Measurements: Seventeen patients with hemodialysis and moderate to severe obstructive sleep apnea were included. Polysomnographies were performed the night before and after hemodialysis to assess obstructive sleep apnea, and bioimpedance was used to measure fluid overload and leg fluid volume., Results: The mean overnight rostral fluid shift was 1.27±0.41 L prehemodialysis; it correlated positively with fluid overload volume (r=0.39; P=0.02) and was significantly lower posthemodialysis (0.78±0.38 L; P<0.001). There was no significant difference in the mean obstructive apnea-hypopnea index before and after hemodialysis (46.8±22.0 versus 42.1±18.6 per hour; P=0.21), but obstructive apnea-hypopnea index was significantly lower posthemodialysis (-10.1±10.8 per hour) in the group of 12 patients, with a concomitant reduction of fluid overload compared with participants without change in fluid overload (obstructive apnea-hypopnea index +8.2±16.1 per hour; P<0.01). A lower fluid overload after hemodialysis was significantly correlated (r=0.49; P=0.04) with a lower obstructive apnea-hypopnea index. Fluid overload-assessed by bioimpedance-was the best predictor of the change in obstructive apnea-hypopnea index observed after hemodialysis (standardized r=-0.68; P=0.01) in multivariate regression analysis., Conclusions: Fluid overload influences overnight rostral fluid shift and obstructive sleep apnea severity in patients with ESRD undergoing intermittent hemodialysis. Although no benefit of hemodialysis on obstructive sleep apnea severity was observed in the whole group, the change in obstructive apnea-hypopnea index was significantly correlated with the change in fluid overload after hemodialysis. Moreover, the subgroup with lower fluid overload posthemodialysis showed a significantly lower obstructive sleep apnea severity, which provides a strong incentive to further study whether optimizing fluid status in patients with obstructive sleep apnea and ESRD will improve the obstructive apnea-hypopnea index., (Copyright © 2015 by the American Society of Nephrology.)

Published
2015
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43. Prevalence and Diagnostic Approach to Sleep Apnea in Hemodialysis Patients: A Population Study.

Author

Forni Ogna V, Ogna A, Pruijm M, Bassi I, Zuercher E, Halabi G, Phan O, Bullani R, Teta D, Gauthier T, Cherpillod A, Mathieu C, Mihalache A, Cornette F, Haba-Rubio J, Burnier M, and Heinzer R

Subjects
Aged, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Prevalence, ROC Curve, Switzerland epidemiology, Renal Dialysis, Sleep Apnea, Obstructive diagnosis, Sleep Apnea, Obstructive epidemiology
Abstract

Background: Previous observations found a high prevalence of obstructive sleep apnea (OSA) in the hemodialysis population, but the best diagnostic approach remains undefined. We assessed OSA prevalence and performance of available screening tools to propose a specific diagnostic algorithm., Methods: 104 patients from 6 Swiss hemodialysis centers underwent polygraphy and completed 3 OSA screening scores: STOP-BANG, Berlin's Questionnaire, and Adjusted Neck Circumference. The OSA predictors were identified on a derivation population and used to develop the diagnostic algorithm, which was validated on an independent population., Results: We found 56% OSA prevalence (AHI ≥ 15/h), which was largely underdiagnosed. Screening scores showed poor performance for OSA screening (ROC areas 0.538 [SE 0.093] to 0.655 [SE 0.083]). Age, neck circumference, and time on renal replacement therapy were the best predictors of OSA and were used to develop a screening algorithm, with higher discriminatory performance than classical screening tools (ROC area 0.831 [0.066])., Conclusions: Our study confirms the high OSA prevalence and highlights the low diagnosis rate of this treatable cardiovascular risk factor in the hemodialysis population. Considering the poor performance of OSA screening tools, we propose and validate a specific algorithm to identify hemodialysis patients at risk for OSA for whom further sleep investigations should be considered.

Published
2015
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44. Pioglitazone improves fat distribution, the adipokine profile and hepatic insulin sensitivity in non-diabetic end-stage renal disease subjects on maintenance dialysis: a randomized cross-over pilot study.

Author

Zanchi A, Tappy L, Lê KA, Bortolotti M, Theumann N, Halabi G, Gauthier T, Mathieu C, Tremblay S, Bertrand PC, Burnier M, and Teta D

Subjects
Adipose Tissue pathology, Adult, Body Composition drug effects, Cross-Over Studies, Double-Blind Method, Fasting blood, Female, Glucose metabolism, Homeostasis drug effects, Humans, Intra-Abdominal Fat drug effects, Intra-Abdominal Fat pathology, Kidney Failure, Chronic blood, Kidney Failure, Chronic pathology, Kidney Failure, Chronic therapy, Leptin blood, Liver metabolism, Male, Middle Aged, Pilot Projects, Pioglitazone, Subcutaneous Fat drug effects, Subcutaneous Fat pathology, Thiazolidinediones adverse effects, Adipokines blood, Adipose Tissue drug effects, Insulin Resistance, Kidney Failure, Chronic metabolism, Liver drug effects, Renal Dialysis, Thiazolidinediones pharmacology
Abstract

Background: Fat redistribution, increased inflammation and insulin resistance are prevalent in non-diabetic subjects treated with maintenance dialysis. The aim of this study was to test whether pioglitazone, a powerful insulin sensitizer, alters body fat distribution and adipokine secretion in these subjects and whether it is associated with improved insulin sensitivity., Trial Design: This was a double blind cross-over study with 16 weeks of pioglitazone 45 mg vs placebo involving 12 subjects., Methods: At the end of each phase, body composition (anthropometric measurements, dual energy X-ray absorptometry (DEXA), abdominal CT), hepatic and muscle insulin sensitivity (2-step hyperinsulinemic euglycemic clamp with 2H2-glucose) were measured and fasting blood adipokines and cardiometabolic risk markers were monitored., Results: Four months treatment with pioglitazone had no effect on total body weight or total fat but decreased the visceral/sub-cutaneous adipose tissue ratio by 16% and decreased the leptin/adiponectin (L/A) ratio from 3.63 × 10(-3) to 0.76 × 10(-3). This was associated with a 20% increase in hepatic insulin sensitivity without changes in muscle insulin sensitivity, a 12% increase in HDL cholesterol and a 50% decrease in CRP., Conclusions/limitations: Pioglitazone significantly changes the visceral-subcutaneous fat distribution and plasma L/A ratio in non diabetic subjects on maintenance dialysis. This was associated with improved hepatic insulin sensitivity and a reduction of cardio-metabolic risk markers. Whether these effects may improve the outcome of non diabetic end-stage renal disease subjects on maintenance dialysis still needs further evaluation., Trial Registration: ClinicalTrial.gov NCT01253928.

Published
2014
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45. [Infectious peritonitis in peritoneal dialysis: an over-emphasized complication].

Author

Vakilzadeh N, Burnier M, and Halabi G

Subjects
Adult, Aged, Aged, 80 and over, Catheter-Related Infections epidemiology, Catheter-Related Infections etiology, Cross Infection epidemiology, Cross Infection etiology, Female, Humans, Incidence, Male, Middle Aged, Peritoneal Dialysis statistics & numerical data, Renal Insufficiency epidemiology, Socioeconomic Factors, Young Adult, Peritoneal Dialysis adverse effects, Peritonitis epidemiology, Peritonitis microbiology, Renal Insufficiency therapy
Abstract

Peritoneal dialysis is an extrarenal epuration modality which uses physiological properties of peritoneum as a dialysis membrane. Despite the improvement of peritoneal dialysis techniques in the last ten years, peritonitis remains one of the most redoubt complications. Peritonitis may sometimes lead to technical failures, which need catheter removing, but rarely lead to death. Our retrospective study at the dialysis center of CHUV has analyzed factors which can predict this kind of complication. It calculates peritonitis rate and median peritonitis free-survival for different groups of patients. It also describes causatives organisms and their sensitivity to antibiotics.

Published
2013

46. Asymptomatic high flow subclavian steal in a patient with hemodialysis access.

Author

Bron C, Hirt L, Halabi G, Saucy F, Qanadli SD, and Haesler E

Subjects
Adaptation, Physiological, Aged, Angioplasty, Balloon, Cerebrovascular Circulation, Hemodynamics, Humans, Kidney Failure, Chronic physiopathology, Male, Regional Blood Flow, Subclavian Steal Syndrome diagnosis, Subclavian Steal Syndrome physiopathology, Subclavian Steal Syndrome therapy, Treatment Outcome, Ultrasonography, Doppler, Arteriovenous Shunt, Surgical adverse effects, Kidney Failure, Chronic therapy, Renal Dialysis, Subclavian Steal Syndrome etiology, Upper Extremity blood supply
Abstract

Introduction: Subclavian steal phenomenon due to proximal subclavian artery stenosis or occlusion is not un-common but often remains asymptomatic., Case Report: We describe the case of a 66-year-old man with end-stage renal disease hemodialysed through a brachio-brachial loop graft of the left forearm. Echo-Doppler precerebral examination showed a high reversed flow of 570 ml/min in the ipsilateral vertebral artery. After successful endovascular recanalization of the subclavian artery, access blood flow increased and vertebral flow decreased to 30 ml/min. Complete neurological examination was normal both before and after endovascular treatment., Discussion: This case demonstrates how high a subclavian steal can be without causing symptoms and how well precerbral and cerebral circulation can adapt to hemodynamic changes.

Published
2010
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47. Quality of care and survival of haemodialysed patients in western Switzerland.

Author

Saudan P, Kossovsky M, Halabi G, Martin PY, and Perneger TV

Subjects
Age Factors, Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Kaplan-Meier Estimate, Kidney Failure, Chronic diagnosis, Male, Middle Aged, Multivariate Analysis, Quality Indicators, Health Care, Renal Dialysis methods, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Factors, Statistics, Nonparametric, Survival Analysis, Switzerland epidemiology, Treatment Outcome, Cause of Death, Kidney Failure, Chronic mortality, Kidney Failure, Chronic therapy, Quality of Health Care, Renal Dialysis mortality
Abstract

Background: Many factors affect survival in haemodialysis (HD) patients. Our aim was to study whether quality of clinical care may affect survival in this population, when adjusted for demographic characteristics and co-morbidities., Methods: We studied survival in 553 patients treated by chronic HD during March 2001 in 21 dialysis facilities in western Switzerland. Indicators of quality of care were established for anaemia control, calcium and phosphate product, serum albumin, pre-dialysis blood pressure (BP), type of vascular access and dialysis adequacy (spKt/V) and their baseline values were related to 3-year survival. The modified Charlson co-morbidity index (including age) and transplantation status were also considered as a predictor of survival., Results: Three-year survival was obtained for 96% of the patients; 39% (211/541) of these patients had died. The 3-year survival was 50, 62 and 69%, respectively, in patients who had 0-2, 3 and >or=4 fulfilled indicators of quality of care (test for linear trend, P < 0.001). In a Cox multivariate analysis model, the absence of transplantation, a higher modified Charlson's score, decreased fulfilment of indicators of good clinical care and low pre-dialysis systolic BP were independent predictors of death., Conclusion: Good clinical care improves survival in HD patients, even after adjustment for availability of transplantation and co-morbidities.

Published
2008
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48. Satisfaction of patients on chronic haemodialysis and peritoneal dialysis.

Author

Wasserfallen JB, Moinat M, Halabi G, Saudan P, Perneger T, Feldman HI, Martin PY, and Wauters JP

Subjects
Age Factors, Ambulatory Care Facilities organization & administration, Cross-Sectional Studies, Female, Humans, Kidney Failure, Chronic epidemiology, Male, Middle Aged, Patient Education as Topic, Sex Factors, Sexuality, Surveys and Questionnaires, Switzerland, Kidney Failure, Chronic therapy, Patient Satisfaction, Peritoneal Dialysis, Renal Dialysis
Abstract

Background: In contrast to quality of life, patient satisfaction on chronic haemodialysis (HD) and peritoneal dialysis (PD) has only rarely been studied., Patients and Methods: All chronic HD and PD patients of the 19 centres located in western Switzerland were asked to complete a specific questionnaire, assessing dialysis centre characteristics, treatment modalities, and information received before and during dialysis treatment. Comparison between satisfaction with PD and HD was carried out on the patients in the nine centres offering both treatment modalities., Results: Of the 558 questionnaires distributed to chronic HD patients, 455 were returned (response rate 82%). Fifty of 64 PD patients (78%) returned the questionnaire. The two groups were similar in age, gender, and duration of dialysis treatment. Completion rates were >90% for a majority of questions, with the lowest rate for information on sexuality (49% in HD and 54% in PD respectively). The lowest scores were recorded for information received about complications and costs of dialysis, and impact of end-stage kidney disease on sexuality. Satisfaction was lower in anonymous questionnaires. Satisfaction of PD patients was significantly better in 50% of the questions, particularly session tolerance (p<0.001), information about dialysis sessions (p=0.007), and complications (p=0.006)., Conclusions: PD patients were on average more satisfied with their treatment than HD patients. Satisfaction could be improved with more information about potential adverse treatment effects.

Published
2006
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49. [Chronic renal failure: what diet?].

Author

Teta D, Phan O, Halabi G, Blancheteau A, Cheseaux M, Roulet M, and Burnier M

Subjects
Diet, Protein-Restricted, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic metabolism, Water-Electrolyte Imbalance etiology, Water-Electrolyte Imbalance metabolism, Kidney Failure, Chronic diet therapy
Abstract

A low protein diet has been traditionally advocated in patients with chronic renal failure (CRF), in order to slow its progression. However, CRF is often associated with malnutrition, aggravating its prognosis, especially in elderly patients. In severe CRF, the spontaneous reduction of appetite coupled with additional restrictions regarding sodium, potassium and phophates may further impact on nutrition status. The potential benefit of a low protein diet is therefore questionable. We only recommend a moderately restricted protein diet (0,8 g/kg/day) in selected patients with no sign of malnutrition. This strategy, if applied, must be supported by a multidisciplinary approach involving a nephrologist and a specialised dietician. Additional dietary restrictions are not justified, except in particular situations.

Published
2006

50. [Malnutrition on dialysis: the end of a fatality].

Author

Bullani R, Cheseaux M, Deléaval P, Halabi G, Blancheteau A, Roulet M, and Teta D

Subjects
Humans, Malnutrition therapy, Malnutrition etiology, Renal Dialysis adverse effects
Abstract

Protein-energy malnutrition in patients treated with haemodialysis (HD) is a complex, multifactorial and prevalent problem, starting well ahead of the dialysis program. It is associated with an increased morbidity and mortality. Uraemic patients are relatively resistant to nutrients because of metabolism abnormalities. Prevention of malnutrition is therefore more efficient than treatment per se. Classical supplementation including oral nutritional supplements, intradialytic parenteral nutrition and enteral nutrition remain efficient, if applied for a sufficient time. A global approach coupling supplementation and strategies designed to optimise metabolism abnormalities should increase treatment efficacy and improve the outcome and quality of life of these patients.

Published
2006

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