1. A Multi-Modal Classification Method for Early Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease Using Three Paradigms With Various Task Difficulties
- Author
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Sheng Chen, Chutian Zhang, Hongjun Yang, Liang Peng, Haiqun Xie, Zeping Lv, and Zeng-Guang Hou
- Subjects
Dementia ,multi-modal ,machine learning ,domain-adversarial neural network ,Medical technology ,R855-855.5 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Alzheimer’s Disease (AD) accounts for the majority of dementia, and Mild Cognitive Impairment (MCI) is the early stage of AD. Early and accurate diagnosis of dementia plays a vital role in more targeted treatments and effectively halting disease progression. However, the clinical diagnosis of dementia requires various examinations, which are expensive and require a high level of expertise from the doctor. In this paper, we proposed a classification method based on multi-modal data including Electroencephalogram (EEG), eye tracking and behavioral data for early diagnosis of AD and MCI. Paradigms with various task difficulties were used to identify different severity of dementia: eye movement task and resting-state EEG tasks were used to detect AD, while eye movement task and delayed match-to-sample task were used to detect MCI. Besides, the effects of different features were compared and suitable EEG channels were selected for the detection. Furthermore, we proposed a data augmentation method to enlarge the dataset, designed an extra ERPNet feature extract layer to extract multi-modal features and used domain-adversarial neural network to improve the performance of MCI diagnosis. We achieved an average accuracy of 88.81% for MCI diagnosis and 100% for AD diagnosis. The results of this paper suggest that our classification method can provide a feasible and affordable way to diagnose dementia.
- Published
- 2024
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