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The etiological effect of a new low-frequency ESR1 variant on Mild Cognitive Impairment and Alzheimer’s Disease: a population-based study
- Source :
- Aging (Albany NY)
- Publication Year :
- 2018
- Publisher :
- Impact Journals, LLC, 2018.
-
Abstract
- Latent genetic variations of cholesterol metabolism-related genes in late-onset Alzheimer’s disease, especially, as well as in mild cognitive impairment pathogenesis are still to be studied extensively. Thus, we performed the targeted-sequencing of 12 nuclear receptor genes plus APOE which were involved in cholesterol content modulation to screen susceptible genetic variants and focused on a new risk variant ESR1 rs9340803 at 6q25.1 for both late-onset Alzheimer’s disease (OR=3.30[1.84~4.22], p
- Subjects :
- Male
0301 basic medicine
Apolipoprotein E
Aging
Disease
Polymorphism, Single Nucleotide
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
Apolipoproteins E
0302 clinical medicine
Alzheimer Disease
Genetic variation
Humans
Medicine
Cognitive Dysfunction
Cognitive impairment
Aβ
Amyloid beta-Peptides
ESR1
Cholesterol
business.industry
Estrogen Receptor alpha
cholesterol
AD
Cell Biology
MCI
030104 developmental biology
chemistry
Immunology
Etiology
Female
business
Estrogen receptor alpha
030217 neurology & neurosurgery
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....c90b502c62a8d094b7c632c4e2890ccc