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161 results on '"Hagège, Agnès"'

1. AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Author

Carmès, Léna, Bort, Guillaume, Lux, François, Seban, Léa, Rocchi, Paul, Muradova, Zeinaf, Hagège, Agnès, Heinrich-Balard, Laurence, Delolme, Frédéric, Gueguen-Chaignon, Virginie, Truillet, Charles, Crowley, Stephanie, Bello, Elisa, Doussineau, Tristan, Dougan, Michael, Tillement, Olivier, Schoenfeld, Jonathan, Brown, Needa, and Berbeco, Ross

Subjects
Physics - Biological Physics
Abstract

Comparison of click chemistry and sortagging grafting strategies for functionalizing AGuIX nanoparticles with nanobodies to develop a tri-functional technology combining MRI imaging, radiotherapy, and immunotherapy by inhibiting immune checkpoints., Comment: Nanoscale, 2024

Published
2024
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2. Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification

Author

Brown, Needa, Rocchi, Paul, Carmès, Léna, Guthier, Romy, Iyer, Meghna, Seban, Léa, Morris, Toby, Bennett, Stephanie, Lavelle, Michael, Penailillo, Johany, Carrasco, Ruben, Williams, Chris, Huynh, Elizabeth, Han, Zhaohui, Kaza, Evangelia, Doussineau, Tristan, Toprani, Sneh M, Qin, Xingping, Nagel, Zachary D, Sarosiek, Kristopher A, Hagège, Agnès, Dufort, Sandrine, Bort, Guillaume, Lux, François, Tillement, Olivier, and Berbeco, Ross

Subjects
Condensed Matter - Materials Science
Abstract

Background: The introduction of magnetic resonance (MR)-guided radiation treatment planning has opened a new space for theranostic nanoparticles to reduce acute toxicity while improving local control. In this work, second-generation AGuIX nanoparticles (AGuIX-Bi) are synthesized and validated. AGuIX-Bi are shown to maintain MR positive contrast while further amplifying the radiation dose by the replacement of some Gd$^{3+}$ cations with higher Z Bi$^{3+}$. These next-generation nanoparticles are based on the AGuIX platform, which is currently being evaluated in multiple Phase II clinical trials in combination with radiotherapy. Methods: In this clinically scalable methodology, AGuIX is used as an initial chelation platform to exchange Gd$^{3+}$ for Bi$^{3+}$. AGuIX-Bi nanoparticles are synthesized with three ratios of Gd/Bi, each maintaining MR contrast while further amplifying radiation dose relative to Bi$^{3+}$. Safety, efficacy, and theranostic potential of the nanoparticles were evaluated in vitro and in vivo in a human non-small cell lung cancer model. Results: We demonstrated that increasing Bi$^{3+}$ in the nanoparticles is associated with more DNA damage and improves in vivo efficacy with a statistically significant delay in tumor growth and 33% complete regression for the largest Bi/Gd ratio tested. The addition of Bi$^{3+}$ by our synthetic method leads to nanoparticles that present slightly altered pharmacokinetics and lengthening of the period of high tumor accumulation with no observed evidence of toxicity. Conclusions: We confirmed the safety and enhanced efficacy of AGuIX-Bi with radiation therapy at the selected ratio of 30Gd/70Bi. These results provide crucial evidence towards patient translation.

Published
2023
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5. Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation.

Author

Balzergue, Coline, Dartevelle, Thibault, Godon, Christian, Laugier, Edith, Meisrimler, Claudia, Teulon, Jean-Marie, Creff, Audrey, Bissler, Marie, Brouchoud, Corinne, Hagège, Agnès, Müller, Jens, Chiarenza, Serge, Javot, Hélène, Becuwe-Linka, Noëlle, David, Pascale, Péret, Benjamin, Delannoy, Etienne, Thibaud, Marie-Christine, Armengaud, Jean, Abel, Steffen, Pellequer, Jean-Luc, Nussaume, Laurent, and Desnos, Thierry

Subjects
Arabidopsis, Arabidopsis Proteins, Cell Enlargement, Cell Wall, Gene Expression Regulation, Plant, Iron, Malates, Meristem, Organic Anion Transporters, Oxidoreductases, Peroxidase, Phosphates, Plant Roots, Plants, Genetically Modified, Signal Transduction, Transcription Factors
Abstract

Environmental cues profoundly modulate cell proliferation and cell elongation to inform and direct plant growth and development. External phosphate (Pi) limitation inhibits primary root growth in many plant species. However, the underlying Pi sensory mechanisms are unknown. Here we genetically uncouple two Pi sensing pathways in the root apex of Arabidopsis thaliana. First, the rapid inhibition of cell elongation in the transition zone is controlled by transcription factor STOP1, by its direct target, ALMT1, encoding a malate channel, and by ferroxidase LPR1, which together mediate Fe and peroxidase-dependent cell wall stiffening. Second, during the subsequent slow inhibition of cell proliferation in the apical meristem, which is mediated by LPR1-dependent, but largely STOP1-ALMT1-independent, Fe and callose accumulate in the stem cell niche, leading to meristem reduction. Our work uncovers STOP1 and ALMT1 as a signalling pathway of low Pi availability and exuded malate as an unexpected apoplastic inhibitor of root cell wall expansion.

Published
2017

7. AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Author

Carmès, Léna, primary, Bort, Guillaume, additional, Lux, François, additional, Seban, Léa, additional, Rocchi, Paul, additional, Muradova, Zeinaf, additional, Hagège, Agnès, additional, Heinrich-Balard, Laurence, additional, Delolme, Frédéric, additional, Gueguen-Chaignon, Virginie, additional, Truillet, Charles, additional, Crowley, Stephanie, additional, Bello, Elisa, additional, Doussineau, Tristan, additional, Dougan, Michael, additional, Tillement, Olivier, additional, Schoenfeld, Jonathan D., additional, Brown, Needa, additional, and Berbeco, Ross, additional

Published
2024
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8. Energy Transfer between AGuIX Nanoparticles and Photofrin under Light or X-ray Excitation for PDT Applications.

Author

Dhaini, Batoul, Arnoux, Philippe, Daouk, Joël, Lux, François, Tillement, Olivier, Hagège, Agnès, Hamieh, Tayssir, Shafirstein, Gal, and Frochot, Céline

Subjects
REACTIVE oxygen species, ENERGY transfer, PHOTODYNAMIC therapy, LUNG cancer, METASTASIS
Abstract

Photodynamic therapy is an accepted therapy cancer treatment. Its advantages encourage researchers to delve deeper. The use of nanoparticles in PDT has several advantages including the passive targeting of cancer cells. The aim of this article is to evaluate the effectiveness of AGuIX nanoparticles (activation and guiding of irradiation by X-ray) in the presence or absence of a photosensitizer, Photofrin, under illumination of 630 nm or under X-ray irradiation. The goal is to improve local tumor control by combining PDT with low-dose-X-ray-activated NPs in the treatment of locally advanced metastatic lung cancer. The study of the energy transfer, which occurs after excitation of Gd/Tb chelated in AGuIX in the presence of Photofrin, was carried out. We could observe the formation of singlet oxygen after the light or X-ray excitation of Gd and Tb that was not observed for AGuIX or Photofrin alone, proving that it is possible to realize energy transfer between both compounds. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification

Author

Brown, Needa, primary, Rocchi, Paul, additional, Carmès, Léna, additional, Guthier, Romy, additional, Iyer, Meghna, additional, Seban, Léa, additional, Morris, Toby, additional, Bennett, Stephanie, additional, Lavelle, Michael, additional, Penailillo, Johany, additional, Carrasco, Ruben, additional, Williams, Chris, additional, Huynh, Elizabeth, additional, Han, Zhaohui, additional, Kaza, Evangelia, additional, Doussineau, Tristan, additional, Toprani, Sneh M., additional, Qin, Xingping, additional, Nagel, Zachary D., additional, Sarosiek, Kristopher A., additional, Hagège, Agnès, additional, Dufort, Sandrine, additional, Bort, Guillaume, additional, Lux, François, additional, Tillement, Olivier, additional, and Berbeco, Ross, additional

Published
2023
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14. Effect of natural uranium on bone cells

Author

Gritsaenko Tatiana, Hurault Lucile, Pierrefite-Carle Valérie, Santucci-Darmanin Sabine, Pagnotta Sophie, Vidaud Claude, Hagège Agnès, Solari Pier Lorenzo, Creff Gaëlle, Den Auwer Christophe, and Carle Georges F.

Subjects
Microbiology, QR1-502, Physiology, QP1-981, Zoology, QL1-991
Published
2019
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17. CE-ICP-MS : un couplage de choix pour étudier l’implication du cuivre dans la maladie d’Alzheimer

Author

Duroux, Coraline, Hagège, Agnès, Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AFSEP, and Bussy, Agnès

Subjects
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

18. Etude du devenir de nanoparticules en milieu biologique par TDA-ICP-MS

Author

Lucie, Labied, Hagège, Agnès, Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AFSEP, and Bussy, Agnès

Subjects
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

22. Taylor dispersion analysis coupled to ICP-MS for ultrasmall nano-particle size measurement: from drug product to biological media studies

Author

Labied, Lucie, Rocchi, Paul, Doussineau, Tristan, Randon, Jérôme, Tillement, Olivier, Lux, François, Hagège, Agnès, Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Formation, élaboration de nanomatériaux et cristaux (FENNEC), Institut Lumière Matière [Villeurbanne] (ILM), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, NH TherAguix SA [Meylan], Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), This work has been supported by a French Government Grant managed by the French National Research Agency (ANR-18-CE17-0025-02)., and ANR-18-CE17-0025,ANALYTAGUIX,Caractérisation analytique de nanoparticules hybrides en vue d'essais cliniques(2018)

Subjects
[CHIM]Chemical Sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Abstract

The authors would like to thank Mexbrain for providing the cerebrospinal fluid.; International audience; During last decade, special focus has been laid on ultrasmall nanoparticles for nanomedicine and eventual clinical translation. To achieve such translation, a lot of challenges have to be solved. Among them, size determination is a particularly tricky one. In this aim, we have developed a simple hyphenation between Taylor dispersion analysis and ICP-MS. This method was proven to allow the determination of the hydrodynamic radius of metal-containing nanoparticles, even for sizes under 5 nm, with a relative standard deviation below 10% (with a 95% confidence interval) and at low concentrations. Moreover, its specificity provides the opportunity to perform measurements in complex biological media. This was applied to the characterization of an ultrasmall gadolinium-containing nanoparticle, used as theranostic agent in cancer diseases. Hydrodynamic radii measured in urine, cerebrospinal fluid and undiluted serum demonstrated the absence of interaction between the particle and biological compounds such as proteins.

Published
2021
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25. CE-ICP/MS and TDA/ICP-MS for the characterization of a therapeutic gadolinium-based nanoparticle

Author

Lucie, Labied, Lux, François, Hagège, Agnès, Bussy, Agnès, Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut Universitaire de France (IUF), and Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)

Subjects
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [CHIM] Chemical Sciences, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [CHIM]Chemical Sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

26. Toxicological Assessment of ITER-Like Tungsten Nanoparticles Using an In Vitro 3D Human Airway Epithelium Model

Author

George, Isabelle, Uboldi, Chiara, Bernard, Elodie, Sobrido, Marcos Sanles, Dine, Sarah, Hagège, Agnès, Vrel, Dominique, Herlin, Nathalie, Rose, Jérôme, Orsiere, Thierry, Grisolia, Christian, Rousseau, Bernard, Malard, Veronique, Service de Chimie Bio-Organique et de Marquage (SCBM), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Laboratoire des Sciences des Procédés et des Matériaux (LSPM), Université Paris 13 (UP13)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire Edifices Nanométriques (LEDNA), Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M) (NIMBE UMR 3685), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Interactions Protéine Métal (IPM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), 'Programme transverse de toxicologie du Commissariat à l’Energie Atomique et aux Energies Alternatives' through the TWEET project, ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Cité (USPC)-Institut Galilée-Université Paris 13 (UP13), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), ANR-11-IDEX-0001-02/11-IDEX-0001,AMIDEX,AMIDEX(2011), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Separative Methods - Techniques séparatives (TechSep), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
inorganic chemicals, nanoparticles, tungsten, lung, MucilAir (TM), acute toxicity, TOXICITY, GENOTOXICITY, METAL, education, technology, industry, and agriculture, [CHIM.MATE]Chemical Sciences/Material chemistry, equipment and supplies, Article, lcsh:Chemistry, lcsh:QD1-999, MucilAir™, [SDV.TOX]Life Sciences [q-bio]/Toxicology, health care economics and organizations
Abstract

The International Thermonuclear Experimental Reactor (ITER) is an international project aimed at the production of carbon-free energy through the use of thermonuclear fusion. During ITER operation, in case of a loss-of-vacuum-accident, tungsten nanoparticles (W-NPs) could potentially be released into the environment and induce occupational exposure via inhalation. W-NPs toxicity was evaluated on MucilAir&trade, a 3D in vitro cell model of the human airway epithelium. MucilAir&trade, was exposed for 24 h to metallic ITER-like milled W-NPs, tungstate (WO42&minus, ) and tungsten carbide cobalt particles alloy (WC-Co). Cytotoxicity and its reversibility were assessed using a kinetic mode up to 28 days after exposure. Epithelial tightness, metabolic activity and interleukin-8 release were also evaluated. Electron microscopy was performed to determine any morphological modification, while mass spectrometry allowed the quantification of W-NPs internalization and of W transfer through the MucilAir&trade, Our results underlined a decrease in barrier integrity, no effect on metabolic activity or cell viability and a transient increase in IL-8 secretion after exposure to ITER-like milled W-NPs. These effects were associated with W-transfer through the epithelium, but not with intracellular accumulation. We have shown that, under our experimental conditions, ITER-like milled W-NPs have a minor impact on the MucilAir&trade, in vitro model.

Published
2019
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27. Metallomics: emerging role of hyphenated techniques using ICP/MS

Author

Hagège, Agnès, Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Bussy, Agnès

Subjects
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences
Abstract

https://893bbb69-1c89-44e0-b481-d40c1024f133.filesusr.com/ugd/cefdf1_3c2010489a83417f8d35fcfd862ca60b.pdf; International audience

Published
2019

30. Uranium Effect on Osteocytic Cells In Vitro

Author

Hurault, Lucile, primary, Creff, Gaelle, additional, Hagège, Agnès, additional, Santucci-Darmanin, Sabine, additional, Pagnotta, Sophie, additional, Farlay, Delphine, additional, Den Auwer, Christophe, additional, Pierrefite-Carle, Valérie, additional, and Carle, Georges F, additional

Published
2019
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31. Hyphenated CE-ICP/MS : a promising technique to boost the metallomics toolbox

Author

Huynh, T.N.S, Vidaud, Claude, Hagège, Agnès, Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Separative Methods - Techniques séparatives (TechSep), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Bussy, Agnès

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

34. Hyphenated capillary electrophoresis ICP/MS: a promising technique to boost the metallomics toolbox

Author

Hagège, Agnès, Bussy, Agnès, Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

35. Interactions protéine/métal : les potentialités du couplage CE-ICP/M

Author

Huynh, T.N.S, Vidaud, Claude, Hagège, Agnès, Bussy, Agnès, Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Separative Methods - Techniques séparatives (TechSep), Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), AFSEP - Club Ile de France, Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Separative Methods - Techniques séparatives, Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2016

36. Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation

Author

Balzergue, Coline, primary, Dartevelle, Thibault, additional, Godon, Christian, additional, Laugier, Edith, additional, Meisrimler, Claudia, additional, Teulon, Jean-Marie, additional, Creff, Audrey, additional, Bissler, Marie, additional, Brouchoud, Corinne, additional, Hagège, Agnès, additional, Müller, Jens, additional, Chiarenza, Serge, additional, Javot, Hélène, additional, Becuwe-Linka, Noëlle, additional, David, Pascale, additional, Péret, Benjamin, additional, Delannoy, Etienne, additional, Thibaud, Marie-Christine, additional, Armengaud, Jean, additional, Abel, Steffen, additional, Pellequer, Jean-Luc, additional, Nussaume, Laurent, additional, and Desnos, Thierry, additional

Published
2017
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39. Structure–Activity Optimization of Luminescent Tb-doped LaF3Nanoparticles

Author

Rahali, Mohammed A., Heinritz, Charlotte L., Hagège, Agnès, Ronot, Pascale, Boos, Anne, Charbonnière, Loïc J., and Cheignon, Clémence

Abstract

A series of Tb-doped LaF3nanoparticles (NPs) was prepared by systematically varying the Tb doping rate from 0 to 100%. The elemental composition was confirmed by inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis, and the size, morphology, and crystal structure were determined in the solid state by transmission electron microscopy and X-ray diffractometry, while the size and ζ-potential of the NPs in solution were studied by dynamic light scattering, Taylor dispersion analysis, and laser Doppler electrophoresis. While the crystal structure appears to be hexagonal for a doping rate of up to 70%, an admixture of hexagonal and orthorhombic phases is observed for 80 and 90% Tb contents with a pure orthorhombic phase being obtained for TbF3. The spectroscopic properties of the NPs were studied for bare NPs and in the presence of dipicolinic acid as a surface-capping antenna ligand in solution. The coverage of the NPs by the ligand resulted in an increase in the luminescence lifetime of the emitting Tb centers, as a consequence of a better protection toward luminescence quenching from water molecules, as well as a large improvement in the brightness of the NPs. Taking into account the various parameters, a doping rate of 40% Tb was shown to be the best compromise for the development of such NPs for bioanalytical applications.

Published
2024
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