100 results on '"Hafize Otcu"'
Search Results
2. The Possible Role of IVIG in the Treatment of Atrial Fibrillation Accompanied by Fulminant Myocarditis in a 12-Year-Old Pediatric Patient
- Author
-
Can Yilmaz Yozgat, Osman Yesilbas, Selcuk Uzuner, Nigar Bayramova, Gokce Ergun, Lala Nurmammadova, Eser Tekin, Hafize Otcu Temur, and Yilmaz Yozgat
- Subjects
Pediatrics ,RJ1-570 - Abstract
Background. Fulminant myocarditis (FM) is a potentially lethal condition in children due to rapid progressive hemodynamic instability and cardiogenic shock. Patients with FM might show different clinical manifestations on emergency department admission. Case. Herein, we describe the case of a 12-year-old girl who was admitted to our institution’s emergency department due to complaints of abdominal pain and incessant vomiting. However, we detected an early onset of atrial fibrillation (AF) accompanied by FM. The patient’s condition of AF and severe hemodynamic disorder was successfully treated in our institution’s pediatric intensive care unit. Conclusion. To the best of our knowledge, this is the first report of the co-occurrence of FM and AF successfully treated in childhood. This case report will serve as a guide for the treatment of cases with FM accompanied by AF.
- Published
- 2021
- Full Text
- View/download PDF
3. A Rare Cause of Pulmonary Hypertension in a 4-Year-Old Toddler: Association of Cor Triatriatum Sinister and Pulmonary Arteriovenous Malformation
- Author
-
Can Yilmaz Yozgat, Erkan Cakir, Hakan Yazan, Hafize Otcu Temur, Kahraman Yakut, and Yilmaz Yozgat
- Subjects
Pediatrics ,RJ1-570 - Abstract
Cor triatriatum sinister is a rare congenital cardiac anomaly. The anomaly is caused by a fibromuscular membrane that divides the left atrium into two cavities. This membrane can lead to the obstruction of left atrial flow and also create pulmonary venous hypertension. Pulmonary arteriovenous malformation (PAVM) is notorious for its aberrant blood flow between the pulmonary arteries and veins. Herein, we report a case of a 4-year-old toddler who had a unique form of pulmonary hypertension presenting with cor triatriatum sinister and diffuse PAVM. After the surgical treatment of cor triatriatum sinister, both pulmonary arteriovenous malformation and pulmonary hypertension disappeared.
- Published
- 2020
- Full Text
- View/download PDF
4. Co-occurrence of interrupted aortic arch and Apert syndrome: A case report
- Author
-
Serap Nur Ergor, Mehmet Serdar Kutuk, Nilgun Duman, Can Yilmaz Yozgat, Hafize Otcu Temur, Murat Ugurlucan, and Yilmaz Yozgat
- Subjects
Pediatrics ,RJ1-570 - Published
- 2021
- Full Text
- View/download PDF
5. Localization Features of Loose Bodies in Secondary Synovial Chondromatosis of the Knee Joint
- Author
-
Çiğdem Özkara Bilgili, Tuba Selçuk, Fuat Bilgili, Hafize Otcu, Ferhat Çengel, and Nurdan Göçgün
- Subjects
Synovial chondromatosis ,magnetic resonance imaging ,secondary ,knee joint ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim: To investigate the relationship of cartilage loss in tibiofemoral and patellofemoral joints with the number, size and location of loose bodies in secondary synovial chondromatosis (SC). Methods: Eighty-eight patients with secondary SC were evaluated retrospectively. The size and location of loose bodies were evaluated by both X-ray and magnetic resonance imaging. The relationship between cartilage lesions and the number, location and size of loose bodies were assessed by Chi-square test and Fisher’s exact test. Results: When the relationship between the presence of loose body and cartilage damage was evaluated, it was observed that 83% of subjects (n=74) had cartilage loss at the tibiofemoral joint, 75% (n=66) on the medial and 9% (n=8) of patients had on the lateral side. It was determined that when the number of loose bodies was ≤5, the mean diameter was 7.3 mm (2-21 mm). It was 12.7 mm (2-30 mm) when the number was >5. The most frequently affected locations were the posterior compartment of the posterior cruciate ligament and the superior compartment of the popliteal fossa, regardless of the degree of cartilage loss. Conclusion: We concluded that the higher the cartilage damage, the higher the number and size of loose bodies. We assume that our study provides insight into further investigations to study new classification system for secondary SC in the knee joint.
- Published
- 2015
- Full Text
- View/download PDF
6. Focal nodular hyperplasia vs. hemangioma: Computed tomography and magnetic resonance imaging findings
- Author
-
Ridvan Karahasanoglu, Hafize Otcu, Tuba Selcuk, Adem Ucar, and Adem Kiris
- Subjects
Focal nodular hyperplasia ,Hemangioma ,Hepatic metastasis ,Specialties of internal medicine ,RC581-951 - Abstract
Focal nodular hyperplasia (FNH) and hemangioma are benign and generally asymptomatic hepatic tumors. With distinctive imaging findings on dynamic computed tomography (CT) and magnetic resonance imaging (MRI), differentiation of these benign hepatic tumors from metastases can be made. We described imaging findings of these hepatic lesions in a 57-year-old man who presented with rectal adenocarcinoma for staging.
- Published
- 2011
- Full Text
- View/download PDF
7. Short-term efficacy of ORS formulation and propranolol regimen in children with POTS
- Author
-
Yozgat, Yilmaz, Temur, Hafize Otcu, Coban, Senay, Oner, Taliha, Karaarslan, Utku, Yozgat, Can Yilmaz, Karadeniz, Cem, Ergor, Serap Nur, and Erenberk, Ufuk
- Published
- 2020
- Full Text
- View/download PDF
8. MRI evaluation of right heart functions in children with mild cystic fibrosis
- Author
-
Hafize Otcu Temur, Alpay Alkan, Can Yilmaz Yozgat, Erkan Cakir, Hakan Yazan, Fatma Celik Yabul, Dilek Hacer Cesme, Yilmaz Yozgat, and ALKAN, ALPAY
- Subjects
Pediatrics, Perinatology and Child Health ,General Medicine ,Cardiology and Cardiovascular Medicine ,Temur H. O. , Alkan A., Yozgat C. Y. , Cakir E., Yazan H., Yabul F. C. , Cesme D. H. , Yozgat Y., -MRI evaluation of right heart functions in children with mild cystic fibrosis.-, Cardiology in the young, ss.1-6, 2022 - Abstract
Background: This study aimed to assess the ventricular anatomy, function of the right ventricle, and the haemodynamic findings of pulmonary artery in children with cystic fibrosis using cardiac MRI. Patients: This prospective study consisted of 32 children with mild cystic fibrosis and 30 age-matched healthy control participants. Methods: Cardiac MRI was used to assess right ventricular volumes, anatomy, and function and to assessment of haemodynamic findings of pulmonary artery in the control and study groups. Haemodynamic findings of pulmonary arteries were determined using pulmonary arteries peak velocity (cm/s), and pulmonary arteries time-to-peak velocity (ms) and pulmonary artery systolic pressure. All data of children with mild cystic fibrosis were compared with those of 30 age-matched healthy control group participants. Results: Our patients and their age-matched controls were aged from 6 to 17 years and from 7 to 15 years, respectively. We found that ejection fraction (%), cardiac output (L/ml), cardiac output (L/ml/m2), and systolic volume (ml/m2) were significantly lower in children with cystic fibrosis (p < 0.01). Right ventricular anterior wall thickness (mm) was significantly higher in children with cystic fibrosis (p = 0.01). No significant difference was observed between the haemodynamic parameters of pulmonary artery in the patient group. Conclusion: In our study, cardiac MRI was used to investigate whether the right ventricle was affected functionally and anatomically in children with mild cystic fibrosis. We detected a significant decrease in right ventricular systolic functions and notable alterations in the right ventricular geometry of children with mild cystic fibrosis. These alterations usually manifest themselves as hypertrophy of the right ventricle. Our study’s results demonstrate no relationship between the development of pulmonary hypertension in mild cystic fibrosis children.
- Published
- 2022
9. MRI evaluation of right heart functions in children with mild cystic fibrosis.
- Author
-
Temur, Hafize Otcu, Alkan, Alpay, Yozgat, Can Yilmaz, Cakir, Erkan, Yazan, Hakan, Yabul, Fatma Celik, Cesme, Dilek Hacer, and Yozgat, Yilmaz
- Published
- 2023
- Full Text
- View/download PDF
10. MRI evaluation of right heart functions in children with mild cystic fibrosis
- Author
-
Temur, Hafize Otcu, primary, Alkan, Alpay, additional, Yozgat, Can Yilmaz, additional, Cakir, Erkan, additional, Yazan, Hakan, additional, Yabul, Fatma Celik, additional, Cesme, Dilek Hacer, additional, and Yozgat, Yilmaz, additional
- Published
- 2022
- Full Text
- View/download PDF
11. Impaired integrity of commissural and association fibers in essential tremor patients: Evidence from a diffusion tensor imaging study
- Author
-
Aygül Tantik Pak, Alpay Alkan, Yildizhan Sengul, and Hafize Otcu Temur
- Subjects
0303 health sciences ,medicine.medical_specialty ,Essential tremor ,030306 microbiology ,business.industry ,Superior longitudinal fasciculus ,Splenium ,General Medicine ,030204 cardiovascular system & hematology ,Corpus callosum ,medicine.disease ,White matter ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Internal medicine ,Fractional anisotropy ,medicine ,Cardiology ,Inferior longitudinal fasciculus ,business ,Diffusion MRI - Abstract
Background/aim The evolving understanding of essential tremors (ET) has led to a new definition of neurodegenerative disease, pointing to diffuse brain network involvement with a wide spectrum of associated motor and nonmotor symptoms. Considering the fact that white matter should also be affected by the nature of the disease, our study aimed to evaluate the integrity of white matter and its clinical correlations in ET patients. Materials and methods Approximately 40 patients diagnosed with ET and 40 age-and sex-matched control subjects (ranging between 18–80 years old) were included in the study. The sociodemographic characteristics and clinical features of the patients were recorded. Tremors were assessed using the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS). Diffusion Tensor Imaging (DTI) was performed to evaluate the integrity of white matter. The selected white matter regions used for DTI assessment were the corpus callosum (CC) (i.e., the largest commissural tract in the human brain), the superior longitudinal fasciculus (SLF), and the inferior longitudinal fasciculus (ILF) (i.e., the largest association fiber bundles). Results The mean age of the ET patients and control subjects was 44.23 ± 18.91 and 37.45 ± 10.95 years old (P = 0.542). The fractional anisotropy (FA) values of the CC body (P = 0.003), ILF (p = 0.016), average diffusion coefficient (ADC) values of the CC body (p = 0.001), genu (P = 0.049), SLF (V < 0.001), and ILF (P < 0.001) differed between groups. After controlling for age and sex, there was no correlation between tremor severity and DTI parameters, but impaired integrity in the genu of CC FA (P = 0.035, r = 0.442) and the splenium of CC ADC (P = 0.007, r = 0.543) were related with a longer duration of tremor. Finally, positive family history was correlated with the splenium of CC FA and ADC (P = 0.008, r = 0.536; P = 0.027, r = 0.461) and ILF ADC (P = 0.011, r = –0.519). Conclusion In our study, major white matter structure changes were found in the ET patients. The results suggest that possible neurodegeneration also affects white matter structures in ET patients and that the duration of the tremor and family history are related with impaired integrity of white matter.
- Published
- 2021
12. Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli
- Author
-
Yilmaz Yozgat, Hafize Otcu Temur, Can Yilmaz Yozgat, Nurver Akinci, Sirin Sonmez, Osman Yeşilbaş, Uzeyir Jafarov, Faraz Talebazadeh, Eser Tekin, and SÖNMEZ, ŞİRİN
- Subjects
medicine.medical_specialty ,Myocarditis ,business.industry ,030232 urology & nephrology ,Cardiomyopathy ,030204 cardiovascular system & hematology ,Eculizumab ,Critical Care and Intensive Care Medicine ,medicine.disease ,Gastroenterology ,YEŞİLBAŞ O., Yozgat C. Y. , AKINCI N., SÖNMEZ Ş., TEKİN E., TALEBAZADEH F., JAFAROV U., OTÇU TEMUR H., YOZGAT Y., -Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli-, JOURNAL OF PEDIATRIC INTENSIVE CARE, cilt.10, sa.3, ss.216-220, 2021 ,03 medical and health sciences ,0302 clinical medicine ,Acute myocarditis ,Cholestasis ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Medicine ,Therapeutic plasma exchange ,Toddler ,business ,Shiga toxin-producing Escherichia coli ,medicine.drug - Abstract
Cardiovascular involvement is uncommon in pediatric patients with hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC-HUS). In this case report we presented a case of 17-month-old toddler who had a sporadic type of STEC-HUS complicated by acute myocarditis. The patient was successfully treated by a single dose of eculizumab after six doses of therapeutic plasma exchange (TPE) were inefficient to prevent the cardiac complication. Hepatotoxicity was observed after a single dose of eculizumab. Hepatic and cholestatic enzyme levels slowly returned to normal within 6 months. To the best of our knowledge, this is the first case of myocarditis/cardiomyopathy treated with eculizumab in STEC-HUS. This case illustrates the need for vigilance regarding myocardial involvement and eculizumab-induced hepatotoxicity in STEC-HUS.
- Published
- 2020
13. A Case Series of Malign Hyperechoic Breast Lesions
- Author
-
Hafize Otcu Temur, Temel Fatih Yilmaz, Huseyin Toprak, Seyma Yildiz, Lutfullah Sari, and SARI, LÜTFULLAH
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Ductal carcinoma ,Malignancy ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Toprak H., -A Case Series of Malign Hyperechoic Breast Lesions-, Current Medical Imaging Reviews, cilt.16, no.16, ss.766-773, 2020 ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Invasive lobular carcinoma ,Biopsy ,medicine ,Carcinoma ,Radiology, Nuclear Medicine and imaging ,Elastography ,Radiology ,Microcalcification ,medicine.symptom ,skin and connective tissue diseases ,business ,Breast ultrasound - Abstract
Background:: Hyperechoic breast lesions are a rare group of breast masses in routine practice. Most of these lesions are benign. However, they rarely may be malignant. Hyperechoic lesions can be evaluated using the same criteria for malignant lesions. Clinical history, mammographic appearance, and certain sonographic features (non-circumscribed margins, irregular shape, presence of hypoechoic areas, nonparallel orientation, and association with microcalcifications can be suggestive of malignancy). In this article, hyperechoic breast lesions with malignant pathology have been presented. Methods: : Seven cases during breast ultrasound examination were detected. Results:: Four patients had invasive ductal carcinoma, 1 patient had invasive lobular carcinoma, 1 patient had high-grade ductal carcinoma in situ (DCIS), and 1 patient had lymphoma. Ultrasonography of the breast showed a heterogeneous appearance in all the patients, microcalcification in two patients, and an ambiguous contour in one patient. Conclusion:: Hyperechoic breast lesions should be evaluated using specific sonographic criteria to prevent misdiagnosis and identify patients who require biopsy and further examination.
- Published
- 2020
14. Development of Myocardial Infarction in a 12-Year-Old Female after the Use of Inhaled Salbutamol
- Author
-
Hafize Otcu Temur, Selcuk Uzuner, Serap Nur Ergor, Yilmaz Yozgat, Senay Coban, Irmak Tahaoglu, Can Yilmaz Yozgat, Aynur Guliyeva, and YOZGAT, YILMAZ
- Subjects
medicine.medical_specialty ,Myocardial Infarction ,Salbutamol ,Infarction ,Critical Care and Intensive Care Medicine ,Chest pain ,Sudden death ,03 medical and health sciences ,0302 clinical medicine ,Left coronary artery ,ALCAPA ,030225 pediatrics ,medicine.artery ,Internal medicine ,Medicine ,Myocardial infarction ,Yozgat C. Y. , UZUNER S., OTÇU TEMUR H., ERGÖR S. N. , GULİYEVA A., Tahaoglu I., Coban S., YOZGAT Y., -Development of Myocardial Infarction in a 12-Year-Old Female after the Use of Inhaled Salbutamol-, JOURNAL OF PEDIATRIC INTENSIVE CARE, cilt.9, ss.295-298, 2020 ,Asthma ,business.industry ,030208 emergency & critical care medicine ,medicine.disease ,Pediatrics, Perinatology and Child Health ,Pulmonary artery ,Cardiology ,medicine.symptom ,business ,medicine.drug - Abstract
Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) accounts for 0.023% of all cases reported in pediatric patients. According to literature, only a handful of ALCAPA patients are able to reach adulthood. Clinical manifestations of ALCAPA range from fatigue during exercise to sudden death in adulthood. Herein, we described a 12-year-old symptomatic patient with ALCAPA who had severe chest pain after using salbutamol treatment for presumed asthma. ALCAPA is one of the curable versions of myocardial ischemia and infarction in childhood. Due to clinical findings in conjunction with electrocardiogram and echocardiography, a computed tomography scan with coronary angiography was performed and the diagnosis of ALCAPA was confirmed. We presented this case because ALCAPA-related myocardial ischemia and infarction in children are rare with only sporadic cases reported. This case illustrated the need for close monitoring and surgery as the best treatment for ALCAPA associated with myocardial infarction.
- Published
- 2020
15. Double Aortic Arch Mimics the Clinical Characteristics of Severe Reactive Airway Disease in a Pediatric Patient
- Author
-
Bahar Temur, Agop Çıtak, Güntülü Şık, Osman Yeşilbaş, Hazar Dogus Kus, Yilmaz Yozgat, Can Yilmaz Yozgat, Erkan Cakir, Hafize Otcu Temur, KUŞ, HAZAR DOĞUŞ, ÇAKIR, Erkan, and Acibadem University Dspace
- Subjects
medicine.medical_specialty ,Double aortic arch ,Yeşilbaş O., Kuş H. D. , Şık G., Çıtak A., Temur B., Yozgat C. Y. , Temur H., Çakır E., Yozgat Y., -Double Aortic Arch Mimics the Clinical Characteristics of Severe Reactive Airway Disease in a Pediatric Patient.-, journal of pediatric intensive care, cilt.9, ss.141-144, 2020 ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,Wheeze ,respiratory insufficiency ,medicine ,YEŞİLBAŞ O., KUŞ H. D. , ŞIK S. G. , ÇITAK A., TEMUR B., yozgat c. y. , otçu temur h., ÇAKIR E., YOZGAT Y., -Double Aortic Arch Mimics the Clinical Characteristics of Severe Reactive Airway Disease in a Pediatric Patient-, JOURNAL OF PEDIATRIC INTENSIVE CARE, 2020 ,childhood ,Computed tomography angiography ,Asthma ,Pediatric intensive care unit ,Reactive airway disease ,reactive airway disease ,medicine.diagnostic_test ,business.industry ,Vascular ring ,double aortic arch ,030208 emergency & critical care medicine ,medicine.disease ,respiratory tract diseases ,Congenital Cardiovascular Abnormality ,Pediatrics, Perinatology and Child Health ,Cardiology ,medicine.symptom ,business - Abstract
Reactive airway disease is a prevalent condition that can be detected in the early infancy period. The condition might also deteriorate into asthma in some cases. If infants do not respond to the treatment of persistent wheeze and coughing, other rare causes should be investigated. The complete form of vascular ring is an extremely uncommon congenital cardiovascular abnormality. Double aortic arch constitutes the most significant portion of the complete vascular ring anomalies. Clinical manifestations of the anomaly are mainly respiratory due to the tracheal compression and mimicking the conditions of asthma. There have not been many reports about the clinical presentations of double aortic arch being remarkably similar to the same clinical manifestations of asthma in the literature. As far as we can be sure, there have not been any reported cases about severe reactive airway disease that caused a patient to have a life-threatening condition in the pediatric intensive care unit. Herein, we present a 5-month-old girl who had double aortic arch. Her anatomical aberration was diagnosed by three-dimensional computed tomography angiography of thorax, and the anomaly mimicked the clinical characteristics of life-threatening severe reactive airway disease.
- Published
- 2020
16. Cognitive and brain micro-structural correlates of alexithymia in essential tremor patients
- Author
-
Hakan Serdar Sengul, Aygul Tantik Pak, Hafize Otcu, Alpay Alkan, Zeynep Corakci, Yıldızhan Şengül, and ÇORAKÇI, Zeynep
- Subjects
Adult ,medicine.medical_specialty ,Essential tremor ,Essential Tremor ,Brain ,Cognition ,Middle Aged ,medicine.disease ,Clinical neurology ,Neuropsychology and Physiological Psychology ,Physical medicine and rehabilitation ,Diffusion Tensor Imaging ,Alexithymia ,Tantik P., Otcu H., Sengul H., Corakci Z., Sengul Y., Alkan A., -Cognitive and brain micro-structural correlates of alexithymia in essential tremor patients.-, Applied neuropsychology. Adult, ss.1-10, 2020 ,Developmental and Educational Psychology ,medicine ,Humans ,Affective Symptoms ,Psychology ,Diffusion MRI ,Aged - Abstract
Essential tremor (ET) is the most common movement disorder which has both motor and non-motor findings such as neuropsychiatic symptoms. Alexithymia is defined as inability to identify and describe emotions experienced by one's self or others. In our study, we aimed to evaluate the neurocognitive and brain micro-structural correlates of alexithymia in ET. 40 ET patients (mean age = 53.05 ± 19.74 years), were included. Fahn-Tolosa-Marin Tremor Rating Scale, Toronto Alexithymia Scale (TAS), Beck Depression Inventory, Beck Anxiety Inventory and detailed neurocognitive evaluation were applied to all patients. The patients were divided into three groups based on their TAS scores: no alexithymia, probable alexithymia, definite alexithymia. Diffusion Tensor Imaging (DTI) was performed in all patients. The mean TAS score was 50.05 ± 10.06. Depressive symptoms and anxiety levels were higher in definite alexithymia (p < 0.001, p < 0.01). Partial correlation controlling for age, gender and educational level between alexithymia scores and each cognitive test showed significant association between similarities (p < 0.001) and phonemic verbal fluency (p = 0.04). Left orbitofrontal cortex average diffusion coefficient (ADC) value (p = 0.05), left anterior cingulate cortex fractional anisotropy (FA) value (p = 0.04), right cuneus FA value (p = 0.04), left amygdala ADC value (p = 0.01) and left insula ADC value (p = 0.02) were differed between groups. TAS and DTImetrics were not found to be independently associated with the level of anxiety (p < 0.001) and depressive symptoms (p < 0.01). As a conclusion, impairments in executive function and complex attention were correlated with higher levels of alexithymia in ET. Many micro-structural alterations were determined to be correlated with alexithymia levels.
- Published
- 2022
- Full Text
- View/download PDF
17. Comparison of MRI Features of Invasive Pleomorphic and Classical Lobular Carcinoma: Differentiation Is Possible?
- Author
-
Temel Fatih Yilmaz, Hafize Otcu, Lutfullah Sari, Zuhal Gucin, Mehmet Ali Gultekin, Fatma Celik Yabul, Huseyin Toprak, Seyma Yildiz, ÇELİK YABUL, FATMA, GÜLTEKİN, MEHMET ALİ, GÜCİN, ZÜHAL, SARI, LÜTFULLAH, OTÇU TEMUR, HAFİZE, TOPRAK, HÜSEYİN, YILMAZ, TEMEL FATİH, and YILDIZ, ŞEYMA
- Subjects
body regions ,Differentiation Is Possible?-, INDIAN JOURNAL OF SURGERY, 2022 [YILMAZ T. F. , OTÇU TEMUR H., SARI L., GÜCİN Z., GÜLTEKİN M. A. , ÇELİK YABUL F., TOPRAK H., YILDIZ Ş., -Comparison of MRI Features of Invasive Pleomorphic and Classical Lobular Carcinoma] ,Surgery ,skin and connective tissue diseases - Abstract
To evaluate breast MRI and DWI and demographic features of pleomorphic invasive lobular carcinoma (pILC) and classic invasive lobular carcinoma (cILC). Invasive lobular (ILC) is the second most common breast malignancy after invasive ductal carcinoma (IDC) and constitutes the 8-14% of all invasive breast cancers. ILC morphologically can be classified into the classic, alveolar, solid, tubulolobular, and pleomorphic subtypes according to WHO. This study was performed retrospectively. The MRI and demographic features of 18 patients with 23 pILC were compared with those 22 consecutive patients with 27 cILC. There was no significant difference in demographic features of patients, MR appearance, kinetics, and ADC values between two groups. pILC, an aggressive subtype of ILC, cannot be differentiated from cILC with breast MRI.
- Published
- 2022
18. Pulmonary Edema in the Acute Stage of Rheumatic Fever Treated with Double-Valve Replacement in a Pediatric Patient
- Author
-
Hafize Otcu Temur, Selcuk Uzuner, Mustafa Ogur, Yilmaz Yozgat, Can Yilmaz Yozgat, Kahraman Yakut, Osman Yeşilbaş, Yasin Ay, and YAKUT, KAHRAMAN
- Subjects
medicine.medical_specialty ,business.industry ,030208 emergency & critical care medicine ,Acute rheumatic fever ,Critical Care and Intensive Care Medicine ,medicine.disease ,Pulmonary edema ,Yozgat Y., Uzuner S., YEŞİLBAŞ O., Ogur M., YAKUT K., Yozgat C. Y. , Temur H. O. , AY Y., -Pulmonary Edema in the Acute Stage of Rheumatic Fever Treated with Double-Valve Replacement in a Pediatric Patient-, JOURNAL OF PEDIATRIC INTENSIVE CARE, cilt.9, ss.77-80, 2020 ,Acute stage ,Surgery ,03 medical and health sciences ,Pediatric patient ,0302 clinical medicine ,Cardiogenic pulmonary edema ,030225 pediatrics ,Pediatrics, Perinatology and Child Health ,medicine ,Rheumatic fever ,Stage (cooking) ,business ,Double valve replacement - Abstract
Cardiogenic pulmonary edema (CPE) is a rare clinical condition of acute rheumatic fever (ARF) in the early stage. Generally, CPE can be convalesced by steroid and anticongestive treatment. Herein, we describe a case of a 14-year-old boy with ARF presenting with bilateral pulmonary edema secondary to acute mitral and aortic insufficiency. In this case, the pulmonary edema of ARF was successfully managed by combined surgical replacements of both valves.
- Published
- 2019
19. Lifesaving Treatment of Aortic Valve Staphylococcus aureus Endocarditis: Daptomycin and Early Surgical Therapy
- Author
-
Muhittin Calim, Hafize Otcu Temur, Selcuk Uzuner, Burcu Bursal Duramaz, Yilmaz Yozgat, Nur Buyukpinarbasili, Yasin Ay, Can Yilmaz Yozgat, Ozden Turel, BURSAL DURAMAZ, BURCU, {{contributorinst}}, AY, YASİN, UZUNER, SELÇUK, and TÜREL, Özden
- Subjects
Aortic valve ,open cardiac surgery ,medicine.medical_specialty ,Staphylococcus aureus ,daptomycin ,Critical Care and Intensive Care Medicine ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,polycyclic compounds ,Endocarditis ,Nafcillin ,Antistaphylococcal penicillins ,Native Valve Endocarditis ,business.industry ,infective endocarditis ,030208 emergency & critical care medicine ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Infective endocarditis ,Pediatrics, Perinatology and Child Health ,Daptomycin ,business ,pediatric intensive care unit ,medicine.drug - Abstract
Infective endocarditis (IE) is an uncommon infection in children. The recommended treatment for native valve endocarditis secondary to methicillin-susceptible Staphylococcus aureus infection is antistaphylococcal penicillins such as nafcillin or oxacillin. If the initial therapy fails in IE, it can lead to catastrophic results. Nowadays, daptomycin is the best alternative antimicrobial agent to treat children with severe infections, when standard antimicrobial therapy does not yield a result. Herein, in this article, we described a case of a 16-year-old boy who had aortic valve S. aureus endocarditis with septic embolization and stroke. The patient was successfully treated only with daptomycin as well as surgical therapy in the early phase of the infection.
- Published
- 2021
20. A Rare Cause of Pulmonary Hypertension in a 4-Year-Old Toddler: Association of Cor Triatriatum Sinister and Pulmonary Arteriovenous Malformation
- Author
-
Yilmaz Yozgat, Kahraman Yakut, Hafize Otcu Temur, Can Yilmaz Yozgat, Hakan Yazan, Erkan Cakir, and OTÇU TEMUR, HAFİZE
- Subjects
medicine.medical_specialty ,Case Report ,CONGENITAL CARDIAC ANOMALY ,Pediatrics ,RJ1-570 ,03 medical and health sciences ,0302 clinical medicine ,Left atrial ,030225 pediatrics ,Internal medicine ,Medicine ,cardiovascular diseases ,Toddler ,Surgical treatment ,Pulmonary arteriovenous malformation ,Pulmonary Hypertension ,business.industry ,food and beverages ,General Medicine ,medicine.disease ,Pulmonary hypertension ,Pulmonary Arteriovenous Malformation ,Cor triatriatum sinister ,cardiovascular system ,Cardiology ,Pulmonary venous hypertension ,business ,030217 neurology & neurosurgery - Abstract
Cor triatriatum sinister is a rare congenital cardiac anomaly. The anomaly is caused by a fibromuscular membrane that divides the left atrium into two cavities. This membrane can lead to the obstruction of left atrial flow and also create pulmonary venous hypertension. Pulmonary arteriovenous malformation (PAVM) is notorious for its aberrant blood flow between the pulmonary arteries and veins. Herein, we report a case of a 4-year-old toddler who had a unique form of pulmonary hypertension presenting with cor triatriatum sinister and diffuse PAVM. After the surgical treatment of cor triatriatum sinister, both pulmonary arteriovenous malformation and pulmonary hypertension disappeared.
- Published
- 2020
21. Sleep disturbances in essential tremor: an investigation of associated brain microstructural changes using diffusion tensor imaging
- Author
-
Alpay Alkan, Ismet Ustun, Keith H. Radler, Elan D. Louis, Hafize Otcu Temur, Yıldızhan Şengül, Hakan Serdar Sengul, and ALKAN, ALPAY
- Subjects
medicine.medical_specialty ,Neurology ,Essential tremor ,Physiology ,business.industry ,Fornix ,medicine.disease ,Dorsolateral prefrontal cortex ,Neuropsychology and Physiological Psychology ,Superior cerebellar peduncle ,medicine.anatomical_structure ,Physiology (medical) ,Internal medicine ,Fractional anisotropy ,medicine ,Cardiology ,Effective diffusion coefficient ,an investigation of associated brain microstructural changes using diffusion tensor imaging-, SLEEP AND BIOLOGICAL RHYTHMS, 2021 [Sengul Y., Temur H. O. , Sengul H. S. , Ustun I., Radler K., ALKAN A., Louis E. D. , -Sleep disturbances in essential tremor] ,business ,Diffusion MRI - Abstract
Essential tremor (ET) is a complex, neurodegenerative disorder that includes motor and non-motor symptoms. There is growing interest in its non-motor features, including sleep disturbances (SD). There are no studies evaluating the brain structural correlates of SD in ET. We aimed to identify brain microstructural changes related to SD in ET. SD was evaluated using the Pittsburg sleep quality index (PSQI). Diffusion tensor imaging (DTI), with reported measures being fractional anisotropy (FA) and apparent diffusion coefficient (ADC), was used to evaluate microstructural brain changes. DTI data were compared in ET patients with vs. without SD. The mean age of 40 ET patients was 49.20 +/- 21.06 years. The mean PSQI score was 6.13 +/- 3.99, and 18 (45.0%) patients had SD. The mean PSQI score of patients with vs. without SD was 9.78 +/- 2.98 vs. 3.14 +/- 1.28 (p < 0.001). Patients with vs. without SD differed significantly with respect to several DTI findings: right (R) superior cerebellar peduncle ADC (p = 0.04), left (L) dorsolateral prefrontal cortex FA (p < 0.01), L frontooccipital fasciculus FA (p = 0.02), R posterior corona radiata (RPCR) FA (p = 0.01), L posterior corona radiata FA (p = 0.04), R posterior thalamic radiation (RPTR) FA (p = 0.02), and fornix FA (p = 0.03) Significant correlations between PSQI scores and RPCR FA (r = - 0.50, p = 0.02) and RPTR FA (r = - 0.67, p = 0.001) were also observed. Our findings suggest that certain brain changes may be associated with the clinical expression of SD in ET. These changes are discussed in terms of their possible neuroanatomical and physiological significance.
- Published
- 2021
22. Epicardial adipose tissue volume predicts long term major adverse cardiovascular events in patients with Type 2 diabetes
- Author
-
Hafize Otcu Temur, Begum Uygur, Ali Rıza Demir, Deniz Alis, Cagdas Arslan, Mehmet Erturk, Ceren Yildirim, Ömer Çelik, Muammer Karakayalı, Büşra Çörekçioğlu, and OTÇU TEMUR, HAFİZE
- Subjects
Male ,medicine.medical_specialty ,Computed Tomography Angiography ,medicine.medical_treatment ,Myocardial Infarction ,Type 2 diabetes ,Coronary Angiography ,Sensitivity and Specificity ,Coronary artery disease ,Risk Factors ,Internal medicine ,Epicardial adipose tissue ,Type 2 diabetes mellitus ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,cardiovascular diseases ,Myocardial infarction ,Angina, Unstable ,Coronary atherosclerosis ,Retrospective Studies ,Analysis of Variance ,Unstable angina ,business.industry ,Age Factors ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,RC31-1245 ,Long-term major adverse cardiovascular events ,Adipose Tissue ,Diabetes Mellitus, Type 2 ,ROC Curve ,Heart failure ,RC666-701 ,Cardiology ,Medicine ,Female ,Cardiology and Cardiovascular Medicine ,business ,Pericardium ,Mace ,Diabetic Angiopathies - Abstract
Objective Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot that plays an important role in coronary atherosclerosis. In this study, our aim was to investigate the relationship between long-term major adverse cardiovascular events (MACEs) and EAT volume detected by coronary computed tomography angiography (CCTA) in patients with Type 2 diabetes mellitus (T2-DM) without previous coronary events. Methods A total of 127 patients with diabetes who underwent CCTA between 2012 and 2014 were enrolled retrospectively. The study population was divided into 2 groups according to whether they experienced or did not experience MACE, which was defined as cardiac death, non-fatal myocardial infarction or unstable angina requiring hospitalization, coronary revascularizations (percutaneous coronary intervention or coronary artery bypass grafting surgery), heart failure, peripheral arterial disease, or ischemic stroke. In both groups, EAT volumes were measured by CCTA. Results During 60±7 months follow-up period, 22 participants experienced MACEs. Data were evaluated with univariate and multivariate analyses and receiver operating characteristic (ROC) analysis. Age, male sex, coronary artery disease, hemoglobin A1c, glucose, creatinine, C- reactive protein, and cholesterol levels were found to be associated with MACE. EAT volume (odds ratio [OR]: 1.027; 95% confidence interval [CI]: 1.010‒1.044, p=0.002) and low-density lipoprotein (OR: 1.015; 95% CI: 1.000‒1.030, p=0.050) were found to be independent predictors for MACE. ROC analysis indicated that EAT volumes >123.2 mL had a 72.7% sensitivity and a 77.1% specificity for predicting long-term MACE in patients with T2-DM (area under the curve: 0.820; 95% CI: 0.733-0.908). Conclusion EAT volume is an independent predictor of long-term MACE in patients with T2-DM without previous coronary events. EAT volume may be used additionally in risk stratification for MACE besides the well-known vascular risk factors in patients with T2-DM.
- Published
- 2021
23. Bewertung der Funktionen des rechten Herzens bei Kindern mit leichter Mukoviszidose
- Author
-
Guliyeva, Aynur, Cakir, Erkan, Yazan, Hakan, AlShadfan, Lina, Sharifov, Rasul, Temur, Hafize Otcu, Karaarslan, Utku, Yozgat, Can Yilmaz, Erenberk, Ufuk, Yakut, Kahraman, Yozgat, YILMAZ, and YOZGAT, YILMAZ
- Subjects
Guliyeva A., Cakir E., Yazan H., AlShadfan L., Sharifov R., Temur H. O. , Karaarslan U., Yozgat C. Y. , Erenberk U., Yakut K., et al., -Bewertung der Funktionen des rechten Herzens bei Kindern mit leichter Mukoviszidose.-, Klinische Padiatrie, 2021 - Published
- 2021
24. The Possible Role of IVIG in the Treatment of Atrial Fibrillation Accompanied by Fulminant Myocarditis in a 12-Year-Old Pediatric Patient
- Author
-
Yozgat, Can Yilmaz, primary, Yesilbas, Osman, additional, Uzuner, Selcuk, additional, Bayramova, Nigar, additional, Ergun, Gokce, additional, Nurmammadova, Lala, additional, Tekin, Eser, additional, Temur, Hafize Otcu, additional, and Yozgat, Yilmaz, additional
- Published
- 2021
- Full Text
- View/download PDF
25. Evaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma
- Author
-
H.D. Kus, Yilmaz Yozgat, Turkay Saritas, Ufuk Erenberk, C.K. Firat, Can Yilmaz Yozgat, Serap Nur Ergor, Kahraman Yakut, Mine Yuksel, Akin Iscan, A. Toprak, S.S. Sahin, Hafize Otcu Temur, Feyza Ustabas Kahraman, and YAKUT, KAHRAMAN
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Rhabdomyoma ,Yozgat Y., Kus H. D. , Kahraman F. U. , Yuksel M., Firat C. K. , Toprak A., Yozgat C. Y. , Yakut K., Sahin S. S. , Iscan A., et al., -Evaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma-, ARCHIVES DE PEDIATRIE, cilt.28, sa.3, ss.204-208, 2021 ,Heart Neoplasms ,Electrocardiography ,03 medical and health sciences ,Tuberous sclerosis ,0302 clinical medicine ,Tuberous Sclerosis ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,In patient ,Prospective Studies ,cardiovascular diseases ,Child ,Prospective cohort study ,Qtc dispersion ,Tp-e Interval Dispersion ,P wave dispersion ,business.industry ,P Wave Dispersion ,Cardiac rhabdomyoma ,Infant ,Cardiac arrhythmia ,Arrhythmias, Cardiac ,medicine.disease ,Case-Control Studies ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cardiology ,cardiovascular system ,Cardiac Rhabdomyoma ,Female ,business ,QTc Dispersion - Abstract
Background: Tuberous sclerosis (TS) is an autosomal dominant and hereditary disorder. Cardiac rhabdomyoma and arrhythmias are the most deleterious risk factors linked to TS. Although arrhythmias in pediatric patients with TS who have cardiac rhabdomyoma have been frequently reported, arrhythmia in patients who have TS without rhabdomyoma is rarely reported in the literature. The study aimed to assess the susceptibility of pediatric patients who have TS without cardiac rhabdomyoma to cardiac arrhythmia using electrocardiographic (ECG) markers. Methods: This prospective study included 10 patients who had TS without cardiac rhabdomyoma. The control group was made up of 30 healthy children of the same age and sex as the patient group. P wave, P wave dispersion, QT dispersion, QTc dispersion, TP-e interval, and TP-e interval dispersion were calculated on 12-lead surface ECGs for each patient in both groups and compared. Results: P wave, P wave dispersion, QT dispersion, and QTc dispersion were found to be significantly higher in the patient group (P
- Published
- 2021
26. The Possible Role of IVIG in the Treatment of Atrial Fibrillation Accompanied by Fulminant Myocarditis in a 12-Year-Old Pediatric Patient
- Author
-
Selcuk Uzuner, Can Yilmaz Yozgat, Gokce Ergun, Osman Yeşilbaş, Eser Tekin, Lala Nurmammadova, Hafize Otcu Temur, Yilmaz Yozgat, and Nigar Bayramova
- Subjects
Abdominal pain ,Pediatrics ,medicine.medical_specialty ,Myocarditis ,Fulminant ,Case Report ,030204 cardiovascular system & hematology ,RJ1-570 ,03 medical and health sciences ,0302 clinical medicine ,Treatment of Atrial Fibrillation ,medicine ,030212 general & internal medicine ,The Possible Role of IVIG ,Pediatric intensive care unit ,business.industry ,Cardiogenic shock ,Atrial fibrillation ,General Medicine ,Emergency department ,medicine.disease ,Vomiting ,Pediatric Patient ,medicine.symptom ,business - Abstract
Background. Fulminant myocarditis (FM) is a potentially lethal condition in children due to rapid progressive hemodynamic instability and cardiogenic shock. Patients with FM might show different clinical manifestations on emergency department admission. Case. Herein, we describe the case of a 12-year-old girl who was admitted to our institution’s emergency department due to complaints of abdominal pain and incessant vomiting. However, we detected an early onset of atrial fibrillation (AF) accompanied by FM. The patient’s condition of AF and severe hemodynamic disorder was successfully treated in our institution’s pediatric intensive care unit. Conclusion. To the best of our knowledge, this is the first report of the co-occurrence of FM and AF successfully treated in childhood. This case report will serve as a guide for the treatment of cases with FM accompanied by AF.
- Published
- 2021
27. Co-occurrence of interrupted aortic arch and Apert syndrome: A case report
- Author
-
Nilgun Duman, Can Yilmaz Yozgat, Serap Nur Ergor, Mehmet Serdar Kutuk, Murat Ugurlucan, Yilmaz Yozgat, Hafize Otcu Temur, and ERGÖR, SERAP NUR
- Subjects
medicine.medical_specialty ,Aortic Arch ,business.industry ,Interrupted aortic arch ,lcsh:RJ1-570 ,lcsh:Pediatrics ,Apert syndrome ,medicine.disease ,Surgery ,Apert Syndrome ,Pediatrics, Perinatology and Child Health ,Co-occurrence ,medicine ,business - Published
- 2021
28. Importance of pre-treatment Fractional Anisotropy value in predicting volumetric response in patients with meningioma treated with Gamma Knife Radiosurgery
- Author
-
Dilek Hacer Cesme, Mehmet Hakan Seyithanoglu, Alpay Alkan, Lutfullah Sari, Fatma Yabul, Mahmut Esat Aykan, Mustafa Aziz Hatiboglu, Hafize Otcu Temur, HATİBOĞLU, MUSTAFA AZİZ, and ÇEŞME, DİLEK HACER
- Subjects
Gamma knife radiosurgery ,Pre treatment ,medicine.medical_treatment ,Radiosurgery ,Meningioma ,Çeşme D. H. , Alkan A., Sarı L., Çelik Yabul F., Otçu Temur H., Aykan M. E. , Seyithanaoglu M. H. , Hatiboğlu M. A. , -Importance of pre-treatment Fractional Anisotropy value in predicting volumetric response in patients with meningioma treated with Gamma Knife Radiosurgery -, Current Medical Imaging Reviews, cilt.17, ss.1-6, 2021 ,Mean diffusivity ,Fractional anisotropy ,Meningeal Neoplasms ,medicine ,Tumor volume ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,business.industry ,medicine.disease ,Diffusion tensor imaging ,Diffusion Tensor Imaging ,Anisotropy ,Negative correlation ,Nuclear medicine ,business ,Diffusion MRI - Abstract
Background: The importance of pre-treatment Diffusion Tensor Imaging (DTI) parameters in determining the response to treatment after radiosurgery in patients with meningioma has not yet been clearly revealed. Objective: This study was conducted to determine tumor volume changes in terms of radiological response in patients with meningioma treated with Gamma Knife Radiosurgery (GKR) and to analyze the relationship between Total Tumor Volume (TTV) and Diffusion Tensor Imaging (DTI) parameters. In addition, we investigated whether the response to treatment can be predicted by pre-radiosurgery DTI findings. Methods: Fifty-four patients were assessed using MRI and DTI before and after GKR. Mean Diffusivity (MD), Fractional Anisotropy (FA), Radial Diffusivity (RD), and TTV of tumour were determined. Patients with 10% or more decrease in TTV after GKR were classified as group 1 and those with less than 10% decrease in volume or increase in volume were considered group 2. The relationships between MD, RD, and FA values and TTV were investigated. Results: A decrease of 46.34% in TTV was detected in group 1 after GKR, while TTV increased by 42.91% in group 2. The lowest pre-treatment FA value was detected in group 1. In addition, after GKR, FA values showed a significant increase in group 1. MD and RD values increased in both groups after radiosurgery. There was a negative correlation between pre-treatment FA, RD, and MD values after radiosurgery. Conclusions: Detection of low FA values due to the poor fiber content in meningioma before radiosurgery may be a guide in predicting the response to treatment. Further studies are required to have a better understanding of the relationship between pre- and post-treatment follow-up FA values and tumor volume in determining the efficacy of GKR in patients with meningioma.
- Published
- 2020
29. Assessment of Right Heart Functions in Children with Mild Cystic Fibrosis
- Author
-
Guliyeva, Aynur, additional, Cakir, Erkan, additional, Yazan, Hakan, additional, AlShadfan, Lina, additional, Sharifov, Rasul, additional, Temur, Hafize Otcu, additional, Karaarslan, Utku, additional, Yozgat, Can Yilmaz, additional, Erenberk, Ufuk, additional, Yakut, Kahraman, additional, and Yozgat, Yilmaz, additional
- Published
- 2021
- Full Text
- View/download PDF
30. Development of Antiarrhythmic Therapy-Resistant Ventricular Tachycardia, Ventricular Fibrillation, and Premature Ventricular Contractions in a 15-Year-Old Patient
- Author
-
Ismail Yurtsever, Gokce Ergun, Osman Yeşilbaş, Hafize Otcu Temur, Can Yilmaz Yozgat, Yilmaz Yozgat, Nur Tekin, Akin Iscan, Nigar Bayramova, and İŞCAN, AKIN
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,Amiodarone ,Cardioversion ,Ventricular tachycardia ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,030212 general & internal medicine ,Yozgat C. Y. , YEŞİLBAŞ O., İŞCAN A., YURTSEVER İ., OTÇU TEMUR H., BAYRAMOVA N., ERGÜN G., TEKİN N., YOZGAT Y., -Development of Antiarrhythmic Therapy-Resistant Ventricular Tachycardia, Ventricular Fibrillation, and Premature Ventricular Contractions in a 15-Year-Old Patient-, JOURNAL OF PEDIATRIC INTENSIVE CARE, 2020 ,Flecainide ,business.industry ,Sudden cardiac arrest ,bigeminy premature ventricular contractions ,medicine.disease ,ventricular fibrillation ,Bigeminy ,Pediatrics, Perinatology and Child Health ,Pulseless electrical activity ,Ventricular fibrillation ,lidocaine ,Cardiology ,ventricular tachycardia ,medicine.symptom ,business ,pediatric intensive care unit ,medicine.drug - Abstract
Sudden cardiac arrest (SCA) is the sudden cessation of regular cardiac activity so that the victim becomes unresponsive, with no signs of circulation and no normal breathing. Asystole, ventricular tachycardia (VT), ventricular fibrillation (VF), and pulseless electrical activity are the underlying rhythm disturbances in the pediatric age group. If appropriate interventions (cardiopulmonary resuscitation-CPR and/or defibrillation or cardioversion) are not performed rapidly, this condition progresses to sudden death. There have not been many reported cases of the approach and treatment of cardiac arrhythmias after SCA. Herein, we would like to report a case of a 15-year-old female patient with dilated cardiomyopathy (DCM) who was admitted to our clinic a year ago, and while her left ventricular systolic functions were improved, SCA suddenly occurred. Since the SCA event occurred in another city, intravenous treatment of amiodarone was done immediately and was switch to continuous infusion dose of amiodarone until the patient arrived at our institution's pediatric intensive care unit (PICU) 3 hours later. During the patient's 20-day PICU hospitalization, she developed pulseless VT and VF from time to time. The patient's pulseless VT and VF attacks were brought under control by the use of a defibrillator and added antiarrhythmic drugs (amiodarone, flecainide, esmolol, and propafenone). Intriguingly, therapy-resistance bigeminy with premature ventricular contractions (PVCs) continued despite all these treatments. The patient did not have adequate blood pressure measured by invasive arterial blood pressure monitoring while having bigeminy PVCs. The intermittent bigeminy PVCs ameliorated rapidly after intermittent boluses of lidocaine. In the end, multiple antiarrhythmic therapies and intermittent bolus lidocaine doses were enough to bring her cardiac arrhythmias after SCA under control. This case illustrates that malign PVC's should be taken very seriously, since they may predispose to the development of VT or VF. Also, this case highlights the importance of close vigilance of arterial pressure tracings of patients with bigeminy PVCs which develop after SCA and should not be accepted as normal.
- Published
- 2020
31. Balanced Double Aortic Arch Causing Persistent Respiratory Symptoms Mimicking Asthma in an Infant
- Author
-
Hakan Yazan, Can Yilmaz Yozgat, Yilmaz Yozgat, Erkan Cakir, Hafize Otcu Temur, Selcuk Uzuner, Murat Ugurlucan, and YOZGAT, YILMAZ
- Subjects
medicine.medical_specialty ,Double aortic arch ,Critical Care and Intensive Care Medicine ,Pediatric Intensive Care Unit ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,medicine ,echocardiography ,Respiratory system ,Esophagus ,childhood ,Asthma ,Balanced Double Aortic Arch ,Reactive airway disease ,reactive airway disease ,Respiratory distress ,business.industry ,Vascular ring ,030208 emergency & critical care medicine ,Airway obstruction ,medicine.disease ,Childhood ,medicine.anatomical_structure ,Echocardiography ,Reactive Airway Disease ,Pediatrics, Perinatology and Child Health ,Cardiology ,OTÇU TEMUR H., Yozgat C. Y. , UZUNER S., Ugurlucan M., YAZAN H., ÇAKIR E., YOZGAT Y., -Balanced Double Aortic Arch Causing Persistent Respiratory Symptoms Mimicking Asthma in an Infant-, JOURNAL OF PEDIATRIC INTENSIVE CARE, 2020 ,business ,balanced double aortic arch ,pediatric intensive care unit - Abstract
Double aortic arch (DAA) is a common form of complete vascular ring. The condition leads to airway obstruction and compression of the esophagus. A balanced type of DAA is an extremely rare anomaly. The anatomical aberration cannot be easily distinguished by transthoracic echocardiography when an infant has chronic respiratory distress. Herein we presented a case of an 11-month-old infant who had chronic respiratory distress and a balanced type of DAA.
- Published
- 2020
32. Impaired integrity of commissural and association fibers in essential tremor patients: Evidence from a diffusion tensor imaging study
- Author
-
Aygül, Tantik Pak, Yildizhan, Şengül, Hafize, Otcu Temur, and Alpay, Alkan
- Subjects
Adult ,Male ,Essential Tremor ,Neural Conduction ,neurodegeneration ,Neurodegenerative Diseases ,diffusion tensor imaging ,Severity of Illness Index ,White Matter ,Sociological Factors ,Article ,Corpus Callosum ,average diffusion coefficient ,Anisotropy ,Humans ,Female ,Symptom Assessment ,Medical History Taking ,fractional anisotropy ,Demography - Abstract
Background/aim The evolving understanding of essential tremors (ET) has led to a new definition of neurodegenerative disease, pointing to diffuse brain network involvement with a wide spectrum of associated motor and nonmotor symptoms. Considering the fact that white matter should also be affected by the nature of the disease, our study aimed to evaluate the integrity of white matter and its clinical correlations in ET patients. Materials and methods Approximately 40 patients diagnosed with ET and 40 age-and sex-matched control subjects (ranging between 18–80 years old) were included in the study. The sociodemographic characteristics and clinical features of the patients were recorded. Tremors were assessed using the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS). Diffusion Tensor Imaging (DTI) was performed to evaluate the integrity of white matter. The selected white matter regions used for DTI assessment were the corpus callosum (CC) (i.e., the largest commissural tract in the human brain), the superior longitudinal fasciculus (SLF), and the inferior longitudinal fasciculus (ILF) (i.e., the largest association fiber bundles). Results The mean age of the ET patients and control subjects was 44.23 ± 18.91 and 37.45 ± 10.95 years old (P = 0.542). The fractional anisotropy (FA) values of the CC body (P = 0.003), ILF (p = 0.016), average diffusion coefficient (ADC) values of the CC body (p = 0.001), genu (P = 0.049), SLF (V < 0.001), and ILF (P < 0.001) differed between groups. After controlling for age and sex, there was no correlation between tremor severity and DTI parameters, but impaired integrity in the genu of CC FA (P = 0.035, r = 0.442) and the splenium of CC ADC (P = 0.007, r = 0.543) were related with a longer duration of tremor. Finally, positive family history was correlated with the splenium of CC FA and ADC (P = 0.008, r = 0.536; P = 0.027, r = 0.461) and ILF ADC (P = 0.011, r = –0.519). Conclusion In our study, major white matter structure changes were found in the ET patients. The results suggest that possible neurodegeneration also affects white matter structures in ET patients and that the duration of the tremor and family history are related with impaired integrity of white matter.
- Published
- 2020
33. Serum Irisin Levels in Central Precocious Puberty and Its Variants
- Author
-
Hafize Otcu, Huri Bulut, Esra Kutlu, İlker Tolga Özgen, Abdurrahim Kocyigit, Yaşar Cesur, and ÖZGEN, İLKER TOLGA
- Subjects
Irisin ,medicine.medical_specialty ,Turkey ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Central precocious puberty ,Uterus ,Puberty, Precocious ,Context (language use) ,Biochemistry ,Body Mass Index ,Gonadotropin-Releasing Hormone ,Precocious puberty ,Endocrinology ,Bayesian multivariate linear regression ,Internal medicine ,Age Determination by Skeleton ,medicine ,Humans ,Prospective cohort study ,Child ,business.industry ,Biochemistry (medical) ,Bone age ,Luteinizing Hormone ,medicine.disease ,Fibronectins ,Premature thelarche ,medicine.anatomical_structure ,Slowly progressing precocious puberty ,Case-Control Studies ,Adipomyokine ,Female ,Follicle Stimulating Hormone ,business ,Body mass index ,Biomarkers - Abstract
Aim The exact mechanisms that trigger the onset of puberty are not well known. Adipomyokines are postulated to stimulate the central neural network. In the present study, we investigated irisin levels in girls with central precocious puberty (CPP), slowly progressing precocious puberty (SPPP), or premature thelarche (PT); we also studied prepubertal girls and to determine if this adipomyokine could be used as a marker in this context. Methods A total of 94 girls including 33 with CPP, 31 with precocious puberty (PP) variants (SPPP or PT), and 30 healthy controls were enrolled to the study. The mean irisin levels were compared between groups. The bivariate correlations of irisin levels with clinical and laboratory parameters were assessed. Multivariate linear regression analysis was performed to determine independent predictive factors of irisin levels. Results Irisin levels were higher in the CPP group compared with the other groups (CPP group: 723.25 ± 62.35 ng/mL; PP variants group: 529.60 ± 39.66 ng/mL; and control group: 325.03 ± 27.53 ng/mL) (P Conclusions The mean irisin levels were higher in patients with CPP compared with other groups. The results of this study imply that increased irisin levels may be used as a marker of CPP provided that these findings are confirmed in larger prospective studies.
- Published
- 2020
34. Short-term efficacy of ORS formulation and propranolol regimen in children with POTS
- Author
-
Cem Karadeniz, Senay Coban, Yilmaz Yozgat, Utku Karaarslan, Ufuk Erenberk, Serap Nur Ergor, Taliha Öner, Hafize Otcu Temur, Can Yilmaz Yozgat, and ERENBERK, UFUK
- Subjects
Male ,YOZGAT Y., OTÇU TEMUR H., Coban S., Oner T., Karaarslan U., Yozgat C. Y. , Karadeniz C., ERGÖR S. N. , ERENBERK U., -Short-term efficacy of ORS formulation and propranolol regimen in children with POTS-, ARCHIVES DE PEDIATRIE, cilt.27, ss.328-332, 2020 ,medicine.medical_specialty ,Supine position ,Activities of daily living ,Adolescent ,Adrenergic beta-Antagonists ,Orthostatic intolerance ,Propranolol ,Oral Rehydration Salt ,Electrolytes ,Postural Orthostatic Tachycardia Syndrome ,Internal medicine ,Heart rate ,medicine ,Humans ,Clinical efficacy ,Prospective Studies ,Child ,business.industry ,medicine.disease ,Combined Modality Therapy ,Regimen ,Treatment Outcome ,Rehydration Solutions ,Pediatrics, Perinatology and Child Health ,Orthostatic Intolerance ,Fluid Therapy ,Female ,business ,medicine.drug ,Follow-Up Studies - Abstract
Background: To evaluate the short-term effectiveness of reduced-osmolarity oral rehydration salt formulation (ORS) and propranolol in children diagnosed with postural orthostatic tachycardia syndrome (POTS) in head-up tilt testing (HUTT).Methods: Children were admitted with symptoms of orthostatic intolerance (OI) occurring in a standing position and disappearing in the supine position. Patients with heart rate increments of >= 40 bpm and symptoms of OI constituted the pediatric POTS group in HUTT. A total of 70 pediatric patients with POTS were included in the study. POTS patients were divided into two groups based on whether they were prescribed reduced-osmolarity ORS and propranolol or not. The study group comprised patients on a regimen of reduced-osmolarity ORS and propranolol (n = 34), while the control group comprised patients who were not prescribed any medication (n = 36). The frequency of symptoms and standardized symptom scores were analyzed before and after 3 months of treatment in both groups.Results: The post-treatment frequency of syncopal attacks was significantly reduced in both groups (P < 0.01 for both groups), but the post-treatment standardized symptom scores were significantly reduced in the pediatric study group compared with the control group (P < 0.01).Conclusion: The frequency of syncopal attacks was significantly reduced and the symptom scores for OI were improved in the study group. The improvement in OI symptom scores was better in the treatment group than in the control group. The control group symptoms persisted and caused extreme difficulty in their daily activities. In view of its clinical efficacy, we strongly advocate the use of combined treatment of reduced-osmolarity ORS and low-dose propranolol in pediatric patients with POTS. (C) 2020 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
- Published
- 2020
35. A Rare Cause of Pulmonary Hypertension in a 4-Year-Old Toddler: Association of Cor Triatriatum Sinister and Pulmonary Arteriovenous Malformation
- Author
-
Yozgat, Can Yilmaz, Cakir, Erkan, Yazan, Hakan, Temur, Hafize Otcu, Yakut, Kahraman, and Yozgat, Yilmaz
- Subjects
Article Subject ,cardiovascular system ,food and beverages ,cardiovascular diseases - Abstract
Cor triatriatum sinister is a rare congenital cardiac anomaly. The anomaly is caused by a fibromuscular membrane that divides the left atrium into two cavities. This membrane can lead to the obstruction of left atrial flow and also create pulmonary venous hypertension. Pulmonary arteriovenous malformation (PAVM) is notorious for its aberrant blood flow between the pulmonary arteries and veins. Herein, we report a case of a 4-year-old toddler who had a unique form of pulmonary hypertension presenting with cor triatriatum sinister and diffuse PAVM. After the surgical treatment of cor triatriatum sinister, both pulmonary arteriovenous malformation and pulmonary hypertension disappeared.
- Published
- 2020
- Full Text
- View/download PDF
36. Brain microstructural changes and cognitive function in non-demented essential tremor patients: a diffusion tensor imaging study
- Author
-
Hakan Serdar Sengul, Yildizhan Sengul, Alpay Alkan, Zeynep Corakci, Ismet Ustun, Elan D. Louis, H. Dowd, Hafize Otcu Temur, and ÇORAKÇI, Zeynep
- Subjects
0301 basic medicine ,Adult ,Essential Tremor ,Precuneus ,Grey matter ,Neuropsychological Tests ,Corpus callosum ,White matter ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cognition ,Fractional anisotropy ,medicine ,Humans ,Aged ,A Diffusion Tensor Imaging Study.-, The International journal of neuroscience, ss.1-18, 2020 [Sengul Y., Otcu H., Corakcı Z., Sengul H., Dowd H., Ustun I., Alkan A., Louis E., -Brain Microstructural Changes and Cognitive Function in Non-Demented Essential Tremor Patients] ,business.industry ,General Neuroscience ,Neuropsychology ,Brain ,General Medicine ,Middle Aged ,White Matter ,030104 developmental biology ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,nervous system ,Posterior cingulate ,business ,Neuroscience ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
Background Essential tremor (ET) is disease with both motor and non-motor features. Notable among the non-motor features is cognitive impairment. While this impairment has been attributed to cortico-thalamo-cerebellar pathway pathology, it is likely that a more complicated involvement of brain structures underlies cognitive function in ET. Objective To evaluate the brain microstructural changes of both white matter and grey matter in ET using region of interest based diffusion tensor imaging (DTI), and to correlate these changes with cognitive function assessed during detailed neuropsychological testing. Method Thirty-five non-demented ET patients with a range of cognitive function (Clinical Dementia Rating = 0-0.5, mean age = 57.5 ± 16.7 years, age range = 23-76 years) underwent a comprehensive neuropsychological evaluation and brain magnetic resonance imaging, including DTI. DTI findings were reported as fractional anisotropy, average diffusion coefficient, these values were evaluated for 32 ROIs. Cognitive domains included attention, visuospatial functions, executive function, verbal memory, visual memory, and language. Domain Z-scores were calculated each cognitive domain and compared for each brain region. Results Microstructural changes in prefrontal cortical areas (dorsolateral, ventrolateral), paralimbic and limbic structures (posterior cingulate cortex, precuneus, hippocampus), basal ganglia (substantia nigra, putamen, caudate nucleus) and white matter bundles (corpus callosum, anterior thalamic radiation, longitudinal fasciculus, frontooccipital fasciculus, etc.) correlated with specific domains of cognitive function in ET patients. Conclusion These data suggest that not only the cerebello thalamocortical pathway, but numerous other brain structures are related to level of cognitive performance and possibly underlie cognitive dysfunction in ET.
- Published
- 2020
- Full Text
- View/download PDF
37. Co-occurrence of interrupted aortic arch and Apert syndrome: A case report
- Author
-
Ergor, Serap Nur, primary, Kutuk, Mehmet Serdar, additional, Duman, Nilgun, additional, Yozgat, Can Yilmaz, additional, Temur, Hafize Otcu, additional, Ugurlucan, Murat, additional, and Yozgat, Yilmaz, additional
- Published
- 2021
- Full Text
- View/download PDF
38. Development of Antiarrhythmic Therapy-Resistant Ventricular Tachycardia, Ventricular Fibrillation, and Premature Ventricular Contractions in a 15-Year-Old Patient
- Author
-
Yozgat, Can Yilmaz, additional, Yesilbas, Osman, additional, Iscan, Akin, additional, Yurtsever, Ismail, additional, Temur, Hafize Otcu, additional, Bayramova, Nigar, additional, Ergun, Gokce, additional, Tekin, Nur, additional, and Yozgat, Yilmaz, additional
- Published
- 2020
- Full Text
- View/download PDF
39. Balanced Double Aortic Arch Causing Persistent Respiratory Symptoms Mimicking Asthma in an Infant
- Author
-
Temur, Hafize Otcu, additional, Yozgat, Can Yilmaz, additional, Uzuner, Selcuk, additional, Ugurlucan, Murat, additional, Yazan, Hakan, additional, Cakir, Erkan, additional, and Yozgat, Yilmaz, additional
- Published
- 2020
- Full Text
- View/download PDF
40. Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli
- Author
-
Yesilbas, Osman, additional, Yozgat, Can Yilmaz, additional, Akinci, Nurver, additional, Sonmez, Sirin, additional, Tekin, Eser, additional, Talebazadeh, Faraz, additional, Jafarov, Uzeyir, additional, Temur, Hafize Otcu, additional, and Yozgat, Yilmaz, additional
- Published
- 2020
- Full Text
- View/download PDF
41. Lifesaving Treatment of Aortic Valve Staphylococcus aureus Endocarditis: Daptomycin and Early Surgical Therapy
- Author
-
Yozgat, Can Yilmaz, additional, Uzuner, Selcuk, additional, Ay, Yasin, additional, Temur, Hafize Otcu, additional, Bursal Duramaz, Burcu, additional, Turel, Ozden, additional, Calim, Muhittin, additional, Buyukpinarbasili, Nur, additional, and Yozgat, Yilmaz, additional
- Published
- 2020
- Full Text
- View/download PDF
42. Development of Myocardial Infarction in a 12-Year-Old Female after the Use of Inhaled Salbutamol
- Author
-
Yozgat, Can Yilmaz, additional, Uzuner, Selcuk, additional, Temur, Hafize Otcu, additional, Ergor, Serap Nur, additional, Guliyeva, Aynur, additional, Tahaoglu, Irmak, additional, Coban, Senay, additional, and Yozgat, Yilmaz, additional
- Published
- 2020
- Full Text
- View/download PDF
43. Sudden Cardiac Arrest and Malignant Ventricular Tachycardia in an 8-Year-Old Pediatric Patient Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli
- Author
-
Yesilbas, Osman, additional, Yozgat, Can Yilmaz, additional, Akinci, Nurver, additional, Talebazadeh, Faraz, additional, Jafarov, Uzeyir, additional, Guney, Abdurrahman Zarif, additional, Temur, Hafize Otcu, additional, and Yozgat, Yilmaz, additional
- Published
- 2020
- Full Text
- View/download PDF
44. Double Aortic Arch Mimics the Clinical Characteristics of Severe Reactive Airway Disease in a Pediatric Patient
- Author
-
Yesilbas, Osman, additional, Kus, Hazar Dogus, additional, Şik, Güntülü, additional, Citak, Agop, additional, Temur, Bahar, additional, Yozgat, Can Yilmaz, additional, Temur, Hafize Otcu, additional, Cakir, Erkan, additional, and Yozgat, Yilmaz, additional
- Published
- 2020
- Full Text
- View/download PDF
45. Pulmonary Edema in the Acute Stage of Rheumatic Fever Treated with Double-Valve Replacement in a Pediatric Patient
- Author
-
Yozgat, Yilmaz, additional, Uzuner, Selcuk, additional, Yesilbas, Osman, additional, Ogur, Mustafa, additional, Yakut, Kahraman, additional, Yozgat, Can Yilmaz, additional, Temur, Hafize Otcu, additional, and Ay, Yasin, additional
- Published
- 2019
- Full Text
- View/download PDF
46. Recurrent Elevation of Troponin Levels in Acute Myocarditis: Is it a Sign of Ventricular Tachycardia?
- Author
-
Osman Yeşilbaş, Selcuk Uzuner, Can Yilmaz Yozgat, Hafize Otcu Temur, Serap Nur Ergor, Yilmaz Yozgat, Betul Saritas, and UZUNER, SELÇUK
- Subjects
Tachycardia ,medicine.medical_specialty ,biology ,medicine.diagnostic_test ,business.industry ,Is it a Sign of Ventricular Tachycardia?-, INDIAN JOURNAL OF PEDIATRICS, 2020 [Yozgat C. Y. , YEŞİLBAŞ O., UZUNER S., SARITAŞ B., ERGÖR S. N. , OTÇU TEMUR H., YOZGAT Y., -Recurrent Elevation of Troponin Levels in Acute Myocarditis] ,Arrhythmias, Cardiac ,Ventricular tachycardia ,medicine.disease ,Troponin ,Electrocardiography ,Myocarditis ,Acute myocarditis ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Tachycardia, Ventricular ,biology.protein ,Cardiology ,medicine ,Humans ,medicine.symptom ,business ,Sign (mathematics) - Published
- 2020
47. Isolated origin of one-branch pulmonary artery from aorta mimics transient tachypnea of the newborn
- Author
-
Yilmaz Yozgat, Can Yilmaz Yozgat, Bilge Tanyeri Bayraktar, Hafize Otcu Temur, Irmak Tahaoglu, and YOZGAT, YILMAZ
- Subjects
medicine.medical_specialty ,Computed Tomography Angiography ,Vascular Malformations ,Newborn respiratory distress ,Aorta, Thoracic ,Transient tachypnea of the newborn ,Pulmonary Artery ,OTÇU TEMUR H., Yozgat C. Y. , Tanyeri Bayraktar B., Tahaoglu I., YOZGAT Y., -Isolated origin of one-branch pulmonary artery from aorta mimics transient tachypnea of the newborn-, PEDIATRICS INTERNATIONAL, cilt.62, ss.870-871, 2020 ,Diagnosis, Differential ,Internal medicine ,medicine.artery ,Intensive Care Units, Neonatal ,medicine ,Humans ,Aorta ,business.industry ,Transient Tachypnea of the Newborn ,Infant, Newborn ,medicine.disease ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,Pulmonary artery ,Cardiology ,business ,Vascular Surgical Procedures - Published
- 2019
48. The Relationship Between Precocious Puberty and Premature Thelarche with Serum Irisin Levels
- Author
-
Özgen, İlker Tolga, Kutlu, Esra, Bulut, Huri, Temur, Hafize Otcu, Torun, Emel, Cesur, Yaşar, and ÖZGEN, İLKER TOLGA
- Subjects
Kutlu E., Özgen İ. T. , Bulut H., Temur H. O. , Torun E., Cesur Y., -The Relationship Between Precocious Puberty and Premature Thelarche with Serum Irisin Levels-, HORMONE RESEARCH IN PAEDIATRICS, cilt.91, ss.326, 2019 - Abstract
https://www.karger.com/?DOI=10.1159/000495021
- Published
- 2019
49. Localization Features of Loose Bodies in Secondary Synovial Chondromatosis of the Knee Joint
- Author
-
Fuat Bilgili, Ferhat Çengel, Hafize Otcu, Çiğdem Özkara Bilgili, Nurdan Gocgun, and Tuba Selcuk
- Subjects
Synovial chondromatosis ,lcsh:R5-920 ,medicine.medical_specialty ,business.industry ,General surgery ,lcsh:R ,University faculty ,lcsh:Medicine ,Traumatology ,General Medicine ,Knee Joint ,medicine.disease ,knee joint ,medicine ,magnetic resonance imaging ,secondary ,lcsh:Medicine (General) ,business ,State hospital - Abstract
Aim: To investigate the relationship of cartilage loss in tibiofemoral and patellofemoral joints with the number, size and location of loose bodies in secondary synovial chondromatosis (SC). Methods: Eighty-eight patients with secondary SC were evaluated retrospectively. The size and location of loose bodies were evaluated by both X-ray and magnetic resonance imaging. The relationship between cartilage lesions and the number, location and size of loose bodies were assessed by Chi-square test and Fisher’s exact test. Results: When the relationship between the presence of loose body and cartilage damage was evaluated, it was observed that 83% of subjects (n=74) had cartilage loss at the tibiofemoral joint, 75% (n=66) on the medial and 9% (n=8) of patients had on the lateral side. It was determined that when the number of loose bodies was ≤5, the mean diameter was 7.3 mm (2-21 mm). It was 12.7 mm (2-30 mm) when the number was >5. The most frequently affected locations were the posterior compartment of the posterior cruciate ligament and the superior compartment of the popliteal fossa, regardless of the degree of cartilage loss. Conclusion: We concluded that the higher the cartilage damage, the higher the number and size of loose bodies. We assume that our study provides insight into further investigations to study new classification system for secondary SC in the knee joint.
- Published
- 2015
50. Correlation Between DTI Findings and Volume of Corpus Callosum in Children with AUTISM
- Author
-
Rasul Sharifov, Fatih Temel Yilmaz, Ismail Yurtsever, Tolga Turan Dundar, Alpay Alkan, Hafize Otcu Temur, Gozde Yesil, and YILMAZ, TEMEL FATİH
- Subjects
Male ,Autism Spectrum Disorder ,Splenium ,Corpus callosum ,behavioral disciplines and activities ,Corpus Callosum ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,medicine ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,Child ,Correlation of Data ,business.industry ,05 social sciences ,Temur H. O. , YURTSEVER İ., YEŞİL G., SHARIFOV R., Yilmaz F. T. , DÜNDAR T. T. , ALKAN A., -Correlation Between DTI Findings and Volume of Corpus Callosum in Children with Autism-, CURRENT MEDICAL IMAGING, cilt.15, ss.895-899, 2019 ,Anatomy ,Organ Size ,Commissure ,medicine.disease ,Sagittal plane ,Developmental disorder ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,Autism spectrum disorder ,Child, Preschool ,Autism ,Female ,business ,030217 neurology & neurosurgery ,050104 developmental & child psychology ,Diffusion MRI - Abstract
Background: Autism Spectrum Disorder (ASD) is a complex developmental disorder in which neurological basis is largely unknown. The Corpus Callosum (CC) is the main commissure that connects the cerebral hemispheres. Previous evidence suggests the involvement of the CC in the pathophysiology of autism. Aim: The aim of our study is to assess whether there were any changes in Corpus Callosum (CC) area and volume and to reveal the relationship between Diffusion Tensor Imaging (DTI) features in genu and splenium of corpus callosum in children with ASD. Methods: Eighteen patient and 15 controls were recruited. The volumetric sagittal TI images were used to provide measurements of midsagittal corpus callosum surface area while FA, MD, RD, and ADC values were extracted from genu and splenium of corpus callosum after which the correlation in the area and volume in ASD children was examined. Results: CC area and volume in children with ASD were decreased than controls. FA values obtained from the genu and splenum of CC were significantly lower and RD values were significantly higher. A positive correlation was observed between the FA of the genu and splenium and area and volume of the CC. There was a negative correlation between ADC, MD and RD of CC and area and volume measurements. Conclusion: The conclusions in the interrelations of morphometric and DTI data may demonstrate a likelihood of damages in the axons and cortical neurons. The results showed that there existed microstructural damages from the DTI findings. Furthermore, the decrease in FA could be a representation of the reduction in the myelination in nerve pathways, impaired integrity, reduced axonal density, and organization. Indeed, the changes in volumetric and microstructural of CC could be useful in evaluating underlying pathophysiology in children with autism.
- Published
- 2018
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.