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Serum Irisin Levels in Central Precocious Puberty and Its Variants
- Source :
- The Journal of clinical endocrinology and metabolism. 106(1)
- Publication Year :
- 2020
-
Abstract
- Aim The exact mechanisms that trigger the onset of puberty are not well known. Adipomyokines are postulated to stimulate the central neural network. In the present study, we investigated irisin levels in girls with central precocious puberty (CPP), slowly progressing precocious puberty (SPPP), or premature thelarche (PT); we also studied prepubertal girls and to determine if this adipomyokine could be used as a marker in this context. Methods A total of 94 girls including 33 with CPP, 31 with precocious puberty (PP) variants (SPPP or PT), and 30 healthy controls were enrolled to the study. The mean irisin levels were compared between groups. The bivariate correlations of irisin levels with clinical and laboratory parameters were assessed. Multivariate linear regression analysis was performed to determine independent predictive factors of irisin levels. Results Irisin levels were higher in the CPP group compared with the other groups (CPP group: 723.25 ± 62.35 ng/mL; PP variants group: 529.60 ± 39.66 ng/mL; and control group: 325.03 ± 27.53 ng/mL) (P Conclusions The mean irisin levels were higher in patients with CPP compared with other groups. The results of this study imply that increased irisin levels may be used as a marker of CPP provided that these findings are confirmed in larger prospective studies.
- Subjects :
- Irisin
medicine.medical_specialty
Turkey
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Central precocious puberty
Uterus
Puberty, Precocious
Context (language use)
Biochemistry
Body Mass Index
Gonadotropin-Releasing Hormone
Precocious puberty
Endocrinology
Bayesian multivariate linear regression
Internal medicine
Age Determination by Skeleton
medicine
Humans
Prospective cohort study
Child
business.industry
Biochemistry (medical)
Bone age
Luteinizing Hormone
medicine.disease
Fibronectins
Premature thelarche
medicine.anatomical_structure
Slowly progressing precocious puberty
Case-Control Studies
Adipomyokine
Female
Follicle Stimulating Hormone
business
Body mass index
Biomarkers
Subjects
Details
- ISSN :
- 19457197
- Volume :
- 106
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....4babc70a1ee7cfc3453730a4fc18b038