1. Richter's transformation in patients with chronic lymphocytic leukaemia:a Nationwide Epidemiological Study
- Author
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Michael Roost Clausen, Lisbeth Enggaard, Christian Brieghel, Michael A. E. Andersen, Marie Helleberg, Robert Schou Pedersen, Christian Bjørn Poulsen, Hans Bentzen, Caspar da Cunha-Bang, Mikael Frederiksen, Henrik Frederiksen, Carsten Utoft Niemann, Ilse Christiansen, Yasmin Ben-Dali, Linda Højberg Nielsen, Erik Clasen-Linde, and Mariam Hussein Hleuhel
- Subjects
Cancer Research ,medicine.medical_specialty ,Chronic lymphocytic leukemia ,Biopsy ,PATHOGENESIS ,diffuse large B-cell lymphoma ,Aggressive lymphoma ,Richter's transformation ,CLASSIFICATION ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,MUTATIONAL STATUS ,hemic and lymphatic diseases ,Epidemiology ,HODGKIN TRANSFORMATION ,medicine ,Humans ,In patient ,Richter’s transformation ,IBRUTINIB ,neoplasms ,Lymphocytic leukaemia ,business.industry ,B-CELL LYMPHOMA ,Hematology ,CHEMOTHERAPY ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Epidemiologic Studies ,Cell Transformation, Neoplastic ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,SURVIVAL ,RISK-FACTORS ,Hodgkin lymphoma ,Lymphoma, Large B-Cell, Diffuse ,business ,prognostication ,Diffuse large B-cell lymphoma ,CLL ,030215 immunology - Abstract
Richter’s transformation (RT) refers to the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Approximately, 2–10% of patients with CLL develop RT, most often as diffuse large B-cell lymphoma. To assess the incidence of RT, we examined risk factors for RT and death among patients with RT in a nationwide CLL cohort (from 2008 to 2016). Among 3772 patients, 113 had biopsy-proven RT. With a median follow-up of 4.3 years, the 5-year cumulative incidence of RT was 2.8%. Advanced Binet stage (B/C) (p
- Published
- 2020