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Richter's transformation in patients with chronic lymphocytic leukaemia:a Nationwide Epidemiological Study
- Source :
- Ben-Dali, Y, Hleuhel, M H, da Cunha-Bang, C, Brieghel, C, Poulsen, C B, Clasen-Linde, E, Bentzen, H H N, Frederiksen, H, Christiansen, I, Nielsen, L H, Enggaard, L, Helleberg, M, Clausen, M, Frederiksen, M, Pedersen, R S, Niemann, C U & Andersen, M A 2020, ' Richter's transformation in patients with chronic lymphocytic leukaemia : a Nationwide Epidemiological Study ', Leukemia and Lymphoma, vol. 61, no. 6, pp. 1435-1444 . https://doi.org/10.1080/10428194.2020.1719092, Ben-Dali, Y, Hleuhel, M H, da Cunha-Bang, C, Brieghel, C, Poulsen, C B, Clasen-Linde, E, Bentzen, H H N, Frederiksen, H, Christiansen, I, Nielsen, L H, Enggaard, L, Helleberg, M, Clausen, M, Frederiksen, M, Pedersen, R S, Niemann, C U & Andersen, M A 2020, ' Richter’s transformation in patients with chronic lymphocytic leukaemia : a Nationwide Epidemiological Study ', Leukemia and Lymphoma, vol. 61, no. 6, pp. 1435-1444 . https://doi.org/10.1080/10428194.2020.1719092
- Publication Year :
- 2020
-
Abstract
- Richter’s transformation (RT) refers to the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Approximately, 2–10% of patients with CLL develop RT, most often as diffuse large B-cell lymphoma. To assess the incidence of RT, we examined risk factors for RT and death among patients with RT in a nationwide CLL cohort (from 2008 to 2016). Among 3772 patients, 113 had biopsy-proven RT. With a median follow-up of 4.3 years, the 5-year cumulative incidence of RT was 2.8%. Advanced Binet stage (B/C) (p
- Subjects :
- Cancer Research
medicine.medical_specialty
Chronic lymphocytic leukemia
Biopsy
PATHOGENESIS
diffuse large B-cell lymphoma
Aggressive lymphoma
Richter's transformation
CLASSIFICATION
03 medical and health sciences
0302 clinical medicine
immune system diseases
MUTATIONAL STATUS
hemic and lymphatic diseases
Epidemiology
HODGKIN TRANSFORMATION
medicine
Humans
In patient
Richter’s transformation
IBRUTINIB
neoplasms
Lymphocytic leukaemia
business.industry
B-CELL LYMPHOMA
Hematology
CHEMOTHERAPY
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Epidemiologic Studies
Cell Transformation, Neoplastic
Oncology
030220 oncology & carcinogenesis
Cancer research
SURVIVAL
RISK-FACTORS
Hodgkin lymphoma
Lymphoma, Large B-Cell, Diffuse
business
prognostication
Diffuse large B-cell lymphoma
CLL
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Ben-Dali, Y, Hleuhel, M H, da Cunha-Bang, C, Brieghel, C, Poulsen, C B, Clasen-Linde, E, Bentzen, H H N, Frederiksen, H, Christiansen, I, Nielsen, L H, Enggaard, L, Helleberg, M, Clausen, M, Frederiksen, M, Pedersen, R S, Niemann, C U & Andersen, M A 2020, ' Richter's transformation in patients with chronic lymphocytic leukaemia : a Nationwide Epidemiological Study ', Leukemia and Lymphoma, vol. 61, no. 6, pp. 1435-1444 . https://doi.org/10.1080/10428194.2020.1719092, Ben-Dali, Y, Hleuhel, M H, da Cunha-Bang, C, Brieghel, C, Poulsen, C B, Clasen-Linde, E, Bentzen, H H N, Frederiksen, H, Christiansen, I, Nielsen, L H, Enggaard, L, Helleberg, M, Clausen, M, Frederiksen, M, Pedersen, R S, Niemann, C U & Andersen, M A 2020, ' Richter’s transformation in patients with chronic lymphocytic leukaemia : a Nationwide Epidemiological Study ', Leukemia and Lymphoma, vol. 61, no. 6, pp. 1435-1444 . https://doi.org/10.1080/10428194.2020.1719092
- Accession number :
- edsair.doi.dedup.....331fc0ea218fb657fa665d31d9a741b6