1. Interactions of ginsenosides with ligand-bindings of GABAA and GABAB receptors
- Author
-
Hack-Seang Kim, T. Kimura, I. K. Ho, Ki Wan Oh, P.A. Saunders, and H.M. Rheu
- Subjects
Male ,Baclofen ,Ginsenosides ,Stereochemistry ,Molecular Sequence Data ,Herb-Drug Interactions ,Saponin ,Panax ,Flunitrazepam ,GABAB receptor ,Ligands ,Sulfur Radioisotopes ,Tritium ,Rats, Sprague-Dawley ,Bridged Bicyclo Compounds ,chemistry.chemical_compound ,Animals ,Pharmacology ,chemistry.chemical_classification ,Plants, Medicinal ,Muscimol ,GABAA receptor ,Saponins ,Bridged Bicyclo Compounds, Heterocyclic ,Receptors, GABA-A ,Ligand (biochemistry) ,In vitro ,Rats ,Carbohydrate Sequence ,Receptors, GABA-B ,chemistry ,Ginsenoside - Abstract
1. 1. Total saponin fraction decreased the affinity of specific [ 3 H]muscimol binding without changes in B max . Ginsenoside Rb 1 Rb 2 , Rc, Re, Rf and Rg 1 inhibited the specific [ 3 H]muscimol binding to the high-affinity site. 2. 2. Total saponin fraction increased the affinity of specific [ 3 H]flunitrazepam binding. Ginsenoside Re and Rf enhanced specific [ 3 H]flunitrazepam binding. 3. 3. Total saponin fraction decreased the affinity of specific [ 35 S]TBPS binding without changes in B max . Ginsenosides did not affect specific or non-specific [ 35 S]TBPS binding. 4. 4. Total saponin fraction decreased the affinity of specific [ 3 H]baclofen binding without changes in B max . Ginsenoside Rc inhibited specific [ 3 H]baclofen binding.
- Published
- 1994
- Full Text
- View/download PDF