Interactions of ginsenosides with ligand-bindings of GABAA and GABAB receptors

1. 1. Total saponin fraction decreased the affinity of specific [ 3 H]muscimol binding without changes in B max . Ginsenoside Rb 1 Rb 2 , Rc, Re, Rf and Rg 1 inhibited the specific [ 3 H]muscimol binding to the high-affinity site. 2. 2. Total saponin fraction increased the affinity of specific [ 3 H]flunitrazepam binding. Ginsenoside Re and Rf enhanced specific [ 3 H]flunitrazepam binding. 3. 3. Total saponin fraction decreased the affinity of specific [ 35 S]TBPS binding without changes in B max . Ginsenosides did not affect specific or non-specific [ 35 S]TBPS binding. 4. 4. Total saponin fraction decreased the affinity of specific [ 3 H]baclofen binding without changes in B max . Ginsenoside Rc inhibited specific [ 3 H]baclofen binding.