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4 results on '"H.I. Ha"'

2. The Synthesis and in vitro Study of 9-fluorenylmethoxycarbonyl Protected Non-Protein Amino Acids Antimicrobial Activity

Author

T.H. Sargsyan, L.A. Stepanyan, M.H. Israyelyan, H.I. Hakobyan, S.M. Jamgaryan, A.A. Gasparyan, and A.S. Saghyan

Subjects
protecting group, peptide synthesis, non-protein amino acid, antimicrobial activity, Chemistry, QD1-999
Abstract

Using the 9-fluorenylmethoxycarbonyl protecting group, 9-fluorenylme­thoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine protected non-protein amino acid, not described in the literature, were developed. Then 9-fluorenyl­methoxycarbonyl-(S)-α-methylphenylalanine, 9-fluorenylmethoxycarbon­yl-(S)-α-allylglycine, 9-fluorenylmethoxycarbonyl-(S)-α-propargylglycine were synthesized by the same method. It was shown, that the 9-fluorenyl­methoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine (3) inhibited the growth of Gram-negative Salmonella tуphimurium G-38 and 9-fluorenyl-methoxycar­bonyl-(S)-α-methyl-phenylalanine (4) inhibited the growth Gram-positive Bacillus subtilis 17-89 bacteria.

Published
2024
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3. Intracranial Stenting of Severe Symptomatic Intracranial Stenosis: Results of 100 Consecutive Patients

Author

M.-H. Kim, Kyung Don Hahm, Deok Hee Lee, Sang Joon Kim, Hae Wook Pyun, Dae Chul Suh, June-Sung Kim, Byung Se Choi, H.I. Ha, Jin-Soo Kim, Choong-Gon Choi, H.R. Yang, Jin Woo Choi, and Y.J. Choi

Subjects
Adult, Male, Middle Cerebral Artery, medicine.medical_specialty, medicine.medical_treatment, Constriction, Pathologic, Constriction, Restenosis, Modified Rankin Scale, Angioplasty, medicine, Humans, Radiology, Nuclear Medicine and imaging, Myocardial infarction, Adverse effect, Vertebral Artery, Aged, Aged, 80 and over, Interventional, business.industry, Middle Aged, Stepwise regression, Intracranial Arteriosclerosis, medicine.disease, Surgery, Stroke, Stenosis, Basilar Artery, Female, Stents, Neurology (clinical), business, Angioplasty, Balloon, Carotid Artery, Internal
Abstract

BACKGROUND AND PURPOSE: There are a few reports regarding the outcome evaluation of balloon-expandable intracranial stent placement (BEICS). The purpose of our study was to evaluate the outcome and factors related to the adverse events (AEs) of BEICS. MATERIALS AND METHODS: We evaluated 100 consecutive patients who underwent BEICS. We assessed the procedural success (residual stenosis 50%) at 6 months. We also analyzed 18 factors including symptom patterns related to AE rate. Symptom patterns revealed 1) stable patients (n = 73) with improving, stationary, or resolved symptoms; and 2) unstable patients (n = 27) with gradual worsening or fluctuating symptoms (National Institutes of Health Stroke Scale [NIHSS] ≥4) within 2 days before stent placement. RESULTS: The procedural success rate was 99%. Overall, there were 10 (10%) AEs within the 6 months: 4 (4%) minor strokes, 3 (3%) major strokes, and 3 (3%) deaths including a death from myocardial infarction. AE rate was 4.1% in stable and 25.9% in unstable patients. Restenosis at 6 months revealed 0% (0/59). Good outcome (modified Rankin Scale ≤2) at 6 months was 97% (71/73) in stable and 67% (18/27) in unstable patients. Stepwise logistic regression model revealed that symptom pattern (unstable versus stable) was the only significant risk factor (OR, 8.167; 95% CI, 1.933–34.500; P = .004). CONCLUSION: BEICS revealed a low AE and good outcome rate at 6 months, especially in the stable patients. Midterm outcome was also favorable in the unstable patient group.

Published
2008

4. Productive and reproductive performance of rabbits does as affected by bee pollen and/or propolis, inulin and/or mannan-oligosaccharides

Author

Y.A. Attia, F. Bovera, W.S. El-Tahawy, A.M. El-Hanoun, M.A. Al-Harthi, and H.I. Habiba

Subjects
rabbit, natural growth promoters, bee pollen, propolis, inulin, mannan-oligosaccharides, Animal culture, SF1-1100, Veterinary medicine, SF600-1100
Abstract

The aim of the paper was to compare the effect of prebiotics (inulin and/or mannan-oligosaccharides, MOS) and bee products (bee pollen and/or propolis) on productive and reproductive performance of rabbit does. Seventy nulliparous V-line female rabbits were distributed among 7 groups. The groups were fed the same diet and received no supplements (control group), natural molecules (bee pollen and/or propolis) at 200 mg/kg body weight (BW) or prebiotics (inulin and/or MOS) at 35 mg/kg BW. Productive, reproductive, biochemical and haematological traits were investigated. Bee pollen with propolis significantly increased body weight gain of does 1 wk after mating (3.53%), decreased feed intake (4.49%) and caused larger litter size (39.4%), heavier body weight of litter (17.7%), a greater number of kits born alive (48.7%), higher weight of kits (87.81%) at 28 d of age, higher milk yield (43.6%) and more favourable milk conversion ratio (31.6%). Moreover, bee pollen with propolis had significantly increased plasma total protein (43.1%), albumin (45.7%), globulin (41.0) and progesterone (60.5%), and had a significantly decreased plasma cholesterol (31.1%), aspartate aminotransferase/alanine aminotransferase ratio (20.3%) compared to the control group. Does treated with growth promoters had significantly fewer services per conception (22%) and greater fertility rate (21%) compared to the control group. Inulin with or without MOS significantly increased plasma glucose (49.9 and 50%, respectively) and feed cost (90.2%) compared to the control group. Supplementation of MOS or bee pollen with or without propolis had significantly greater relative economic efficiency (61.9, 55.1 and 27.1%, respectively) than the control group. MOS and bee pollen with or without propolis are able to improve productive and reproductive performance and economic efficiency of rabbit does in comparison to the unsupplemented group.

Published
2015
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