1. Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd0-CalB CLEA as a Biohybrid Catalyst
- Author
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Universidad de Sevilla. Departamento de Química orgánica, Swedish Research Council, Knut and Alice Wallenberg Foundation, Gustafson, Karl P.J., Görbe, Tamás, Gonzalo Calvo, Gonzalo de, Yuan, Ning, Schreiber, Cynthia L., Shchukarev, Andrey, Tai, Cheuk Wai, Persson, Ingmar, Zou, Xiaodong, Bäckvall, Jan E., Universidad de Sevilla. Departamento de Química orgánica, Swedish Research Council, Knut and Alice Wallenberg Foundation, Gustafson, Karl P.J., Görbe, Tamás, Gonzalo Calvo, Gonzalo de, Yuan, Ning, Schreiber, Cynthia L., Shchukarev, Andrey, Tai, Cheuk Wai, Persson, Ingmar, Zou, Xiaodong, and Bäckvall, Jan E.
- Abstract
Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.
- Published
- 2019