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30 results on '"Gurto, R."'

7. Hepatoprotective Effects of Immobilized Granulocyte Colony-Stimulating Factor and Hyaluronidase Preparation and Their Mechanisms

Author

Dygai, A. M., Zhdanov, V. V., Zyuzkov, G. N., Stavrova, L. A., Miroshnichenko, L. A., Udut, E. V., Khrichkova, T. Yu., Simanina, E. V., Artamonov, A. V., Bekarev, A. A., Madonov, P. G., Kinsht, D. N., Gurto, R. V., Chaikovskiy, A. V., Markova, T. S., Fomina, T. I., Ermolaeva, L. A., Vetoshkina, T. V., and Dubskaya, T. Yu.

Published
2012
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20. Development of a method for preparing octreotide derivative for diagnosis of neuroendocrine tumors

Author

Larkina, M. S., primary, Podrezova, E. V., additional, Bragina, O. D., additional, Tagirova, E. A., additional, Chernov, V. I., additional, Yusubov, M. S., additional, Nesterov, E. A., additional, Skuridin, V. S., additional, Krivoshchekov, S. V., additional, Yanovskaya, E. A., additional, Gurto, R. V., additional, and Belousov, M. V., additional

Published
2019
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21. Role of JAK/STAT3 Signaling in Functional Stimulation of Mesenchymal Progenitor Cells by Fibroblast Growth Factor.

Author

Zyuz'kov, G. N., Udut, E. V., Miroshnichenko, L. A., Polyakova, T. Yu., Simanina, E. V., Stavrova, L. A., Prosekin, G. A., Minakova, M. Yu., Borodulina, E. V., Mareev, I. V., Gurto, R. V., Zhdanov, V. V., and Udut, V. V.

Subjects
MESENCHYMAL stem cells, CELL proliferation, CYTOKINES, FIBROBLAST growth factors, CYTOLOGY
Abstract

JAK/STAT signaling pathway was examined during functional stimulation of mesenchymal progenitor cells with fibroblast growth factor. The differences were observed in the realizations of the proliferation-differentiation potential of CFU-fibroblasts under blockade of JAKs or during selective inactivation of STAT3. The study revealed stimulating influences of JAKs and STAT3 on mitotic activity of progenitor cells and individual roles of these proteins in the control of their maturation. Blockade of JAKs diminished the level of fibroblast colony formation and the score of actively proliferating CFU-fibroblasts at the background increase of the differentiation rate of progenitor cells. In contrast, STAT3 inhibitor resulted in a coordinated decrease of all examined parameters. [ABSTRACT FROM AUTHOR]

Published
2018
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22. Pharmacological Correction of the Negative Effects of Acetylsalicylic Acid on the Energy Production System.

Author

Bryushinina, O., Gurto, R., Slepichev, V., Stykon, G., Zyuz'kova, Yu., Yanovskaya, E., and Udut, V.

Subjects
*ASPIRIN, *PHARMACOKINETICS, *RATS, *MITOCHONDRIA, *SUCCINIC acid
Abstract

Experiments of outbred rats with modeled xenobiotic load with acetylsalicylic acid (250 mg/kg for 7 days) revealed inhibition of mitochondrial respiration rate in states of rest and active phosphorylation, inhibition of succinate-dependent oxidation pathway, and a decrease in energization of organelles in the heart. For correction of the observed changes in energy production, succinic acid was preventively administered in a dose of 50 mg/kg for 7 days, which abolished the negative metabolic shifts in myocardial mitochondria. Comparison of pharmacokinetics of acetylsalicylic acid and acetylsalicylic acid against the background of succinate treatment performed on rabbits revealed complete coincidence of the studied parameters, which attests to the possibility of prevention of mitochondrial dysregulations with this Krebs cycle intermediate. [ABSTRACT FROM AUTHOR]

Published
2010
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27. [Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration].

Author

Smol'iakova VI, Chernysheva GA, Ianovskaia EA, Gurto RV, Kuchin AV, Chukicheva IIu, Udut VV, and Plotnikov MB

Subjects
Animals, Antioxidants administration & dosage, Antioxidants metabolism, Area Under Curve, Camphanes administration & dosage, Camphanes blood, Cresols administration & dosage, Cresols blood, Drug Administration Schedule, Intestinal Absorption physiology, Male, Rats, Rats, Wistar, Stomach, Antioxidants pharmacokinetics, Camphanes pharmacokinetics, Cresols pharmacokinetics, Intestinal Mucosa metabolism
Abstract

The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.

Published
2014

28. [Distribution of 4-methyl-2,6-diisobornylphenol in rat tissues].

Author

Smol'iakova VI, Chernysheva GA, Ianovskaia EA, Gurto RV, Kuchin AV, Chukicheva IIu, Udut VV, and Plotnikov MB

Subjects
Adipose Tissue metabolism, Administration, Oral, Animals, Brain metabolism, Camphanes blood, Cresols blood, Female, Fibrinolytic Agents blood, Kidney metabolism, Liver metabolism, Male, Muscles metabolism, Myocardium metabolism, Rats, Rats, Wistar, Tissue Distribution, Camphanes pharmacokinetics, Cresols pharmacokinetics, Fibrinolytic Agents pharmacokinetics
Abstract

We have studied the distribution of the new compound 4-methyl-2,6-diisobornylphenol in rats after a single oral administration in a dose of 20 mg/kg. The pharmacokinetic parameters have been estimated by the noncompartmental method. It is established that the drug is nonuniformly distributed in the body and has a high affinity for liver and heart. A low penetration of 4-methyl-2,6-diisobornilphenol has been found in brain tissue. The accumulation of 4-methyl-2,6-diisobornilphenol in adipose tissues has not been found. It been showed that the drug is slowly eliminated from the body, especially from the heart tissues for which the mean retention time is MRT = 45 h.

Published
2014

29. [Pharmacokinetics of phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intravenous injection].

Author

Chernyshova GA, Smol'iakova VI, Plotnikov MB, Ianovskaia EA, Gurto RV, Udut VV, Kuchin AV, and Chukicheva IIu

Subjects
Animals, Antioxidants administration & dosage, Antioxidants chemistry, Camphanes administration & dosage, Camphanes blood, Camphanes chemistry, Cresols administration & dosage, Cresols blood, Cresols chemistry, Injections, Intravenous, Male, Organ Specificity, Rats, Rats, Wistar, Tissue Distribution, Antioxidants pharmacokinetics, Camphanes pharmacokinetics, Cresols pharmacokinetics, Models, Biological
Abstract

The pharmacokinetics of 4-methyl-2,6-diisobornylphenol (MDIBP) in rat blood plasma has been studied after intravenous injection. The drug concentration in the plasma was determined using a reverse-phase HPLC procedure. It is shown that MDIBP rapidly penetrates into intensively perfused organs, but is slowly eliminated from the organism (MRT value amounting to 9 h).

Published
2011

30. [Dependence of the pharmacokinetics of captopril on the type of adaptation reactions in the organism].

Author

Udut VV, Khazanov VA, Gurto RV, Borodulina EV, and Postnikova IuE

Subjects
Adult, Biological Availability, Female, Humans, Male, Middle Aged, Adaptation, Physiological, Angiotensin-Converting Enzyme Inhibitors pharmacokinetics, Antihypertensive Agents pharmacokinetics, Captopril pharmacokinetics, General Adaptation Syndrome metabolism
Abstract

The dependence of the pharmacokinetic profiles (PhP) of captopril in the phase of adaptation reactions in the organism has been studied within the framework of randomized, comparative, double cross research of bioeqivalency of captopril (Aspharma Co, Anzhero-Sudzhensk) and capoten (Bristol Myers Squibb Co.; official Russian producer, Akrikhin KhimFarmKombinat). It is established that the maximum bioaccessibility and high concentration of captopril in the blood plasma is determined on the background of physiologically optimum reactions of training and in the zone of quiet activation. These characteristics decrease during the reactions of general adaptation syndrome according to the type of increased activation and reactivation.

Published
2007

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