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[Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2014; Vol. 77 (2), pp. 31-4. - Publication Year :
- 2014
-
Abstract
- The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.
- Subjects :
- Animals
Antioxidants administration & dosage
Antioxidants metabolism
Area Under Curve
Camphanes administration & dosage
Camphanes blood
Cresols administration & dosage
Cresols blood
Drug Administration Schedule
Intestinal Absorption physiology
Male
Rats
Rats, Wistar
Stomach
Antioxidants pharmacokinetics
Camphanes pharmacokinetics
Cresols pharmacokinetics
Intestinal Mucosa metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 77
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 24791338