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[Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration].

Authors :
Smol'iakova VI
Chernysheva GA
Ianovskaia EA
Gurto RV
Kuchin AV
Chukicheva IIu
Udut VV
Plotnikov MB
Source :
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2014; Vol. 77 (2), pp. 31-4.
Publication Year :
2014

Abstract

The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.

Details

Language :
Russian
ISSN :
0869-2092
Volume :
77
Issue :
2
Database :
MEDLINE
Journal :
Eksperimental'naia i klinicheskaia farmakologiia
Publication Type :
Academic Journal
Accession number :
24791338