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1. Anniversary of Academician of the Russian Academy of Sciences Vladimir Mikhaylovich Alpatov

Author

Strugova Ye. V., Korchagina T. I., Nechayeva L. T., and Gurevich T. M.

Subjects
japanese language, grammar, japanese studies, anniversary, linguistics, History of Asia, DS1-937, Political science
Abstract

The article was written on the occasion of the 75th anniversary of Academician V. M. Alpatov. The authors have known the hero of the day since he was a student and made his first steps in the Japanese studies. From the standpoint of their own professional interest in the Japanese studies, each of them tried to reflect the multifaceted talent of Vladimir M. Alpatov — academician, researcher, chronicler, teacher, and mentor of the people who linked their fate with the study of the Japanese language and Japan.

Published
2021
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3. Continuous subcutaneous levodopa/carbidopa infusion (ND0612) for patients with Parkinson’s disease and motor fluctuations: A Phase 3, active-controlled study (BouNDless)

Author

Stocchi, F., primary, Espay, A., additional, Albanese, A., additional, Ellenbogen, A., additional, Ferreira, J.J., additional, Giladi, N., additional, Gurevich, T., additional, Hassin-Baer, S., additional, Hernandez-Vara, J., additional, Isaacson, S., additional, Kieburtz, K., additional, LeWitt, P., additional, Lopez-Manzanares, L., additional, Olanow, C.W., additional, Pahwa, R., additional, Poewe, W., additional, Sarva, H., additional, Yardeni, T., additional, Adar, L., additional, Lopes, N., additional, Sasson, N., additional, Case, R., additional, and Rascol, O., additional

Published
2024
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21. Clinical characteristics of long-term survivors in multiple system atrophy: An analysis of the EMSA-SG registry: 299

Author

Krismer, F., Duerr, S., Seppi, K., Scherfler, C., Boesch, S., Ostergaard, K., Dupont, E., Tolosa, E., Cardozo, A., Klockgether, T., Abele, M., Tison, F., Yekhlef, F., Deuschl, G., Daniels, C., Sampaio, C., Coelho, M., Quinn, N., Bozi, M., Schrag, A., Mathias, C. J., Fowler, C., Widner, H., Nilsson, C. F., Oertel, W., Schimke, N., Albanese, A., del Sorbo, F., Barone, P., Pellecchia, M. T., Djaldetti, R., Colosimo, C., Meco, G., Gonzalez-Mandly, A., Berciano, J., Gurevich, T., Giladi, N., Rascol, O., Galitzky, M., Gasser, T., Kamm, C., Poewe, W., and Wenning, G. K.

Published
2014

24. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease

Author

Sidransky, E., Nalls, M.A., Aasly, J.O., Aharon-Peretz, J., Annesi, G., Barbosa, E.R., Bar-Shira, A., Berg, D., Bras, J., Brice, A., C.-M. Chen, Clark, L.N., Condroyer, C., De Marco, E.V., Eblan, M.J., Fahn, S., Farrer, M.J., Durr, A., H.-C. Fung, Gan-Or, Z., Gasser, T., Gershoni-Baruch R., Giladi, N., Griffith, A., Gurevich, T., Januario, C., Kropp, P., Lang, A.E., C.-J. Lee Chen, Lesage, S., Marder, K., Mata, I.F., Mirelman, A., Mutsui, J., Mizuta, I., Nicoletti, G., Oliveira, C., Ottman, R., Orr-Urteger, A., Pereira, L.V., Quattron, A., Spitz, M., E.-K. Tan, Tayebi, N., Toda, T., Troiano, S., Tsuji, S., Wittstock, M., Wolfsberg, T.G., Y.-R. Wu, Zabetian, C.P., Y. Zhao, and Ziegler, S.G.

Subjects
Parkinson's disease -- Risk factors, Hydrolases -- Health aspects, Enzymes -- Health aspects
Abstract

The study determines the frequency of glucocerebrosidase ("GBA") mutations in an ethnically diverse group of patients with Parkinson's disease. Findings indicate a strong relation between "GBA" mutations and Parkinson's disease.

Published
2009

25. The European Multiple System Atrophy-Study Group (EMSA-SG)

Author

Geser, F., Seppi, K., Stampfer-Kountchev, M., Köllensperger, M., Diem, A., Ndayisaba, J. P., Ostergaard, K., Dupont, E., Cardozo, A., Tolosa, E., Abele, M., Dodel, R., Klockgether, T., Ghorayeb, I., Yekhlef, F., Tison, F., Daniels, C., Kopper, F., Deuschl, G., Coelho, M., Ferreira, J., Rosa, M. M., Sampaio, C., Bozi, M., Schrag, A., Hooker, J., Kim, H., Scaravilli, T., Mathias, C. J., Fowler, C., Wood, N., Quinn, N., Widner, H., Nilsson, C. F., Lindvall, O., Schimke, N., Eggert, K. M., Oertel, W., del Sorbo, F., Carella, F., Albanese, A., Pellecchia, M. T., Barone, P., Djaldetti, R., Meco, G., Colosimo, C., Gonzalez-Mandly, A., Berciano, J., Gurevich, T., Giladi, N., Galitzky, M., Ory, F., Rascol, O., Kamm, C., Buerk, K., Maaß, S., Gasser, T., Poewe, W., Wenning, G. K., and on behalf of the EMSA-SG

Published
2005
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33. Applications of the European Parkinson’s Disease Association sponsored Parkinson’s Disease Composite Scale (PDCS)

Author

Balestrino, R. Hurtado-Gonzalez, C.A. Stocchi, F. Radicati, F.G. Chaudhuri, K.R. Rodriguez-Blazquez, C. Martinez-Martin, P. Adarmes, A.D. Méndez-del-Barrio, C. Ariadne, V. Aschermann, Z. Juhász, A. Harmat, M. Bostantjopoulou, S. Corbo, M. Grassi, A. Dellaporta, D. Falup-Pecurariu, C. Diaconu, Ş. Giagkou, N. Guekht, A. Popov, G. Gurevich, T. Johansson, A. Sundgren, M. Kefalopoulou, Z. Ellul, J. Kostić, V.S. Kovacs, N. Marti, M.J. Planelles, L. Migirov-Sanderovich, A. Ezra, A. Minar, M. Mir, P. Jan Necpal Popovici, M. Simitsi, A. Stefanis, L. Simu, M. Rosca, C. Skorvanek, M. Stefani, A. Cerroni, R. Stamelou, M. Tsolaki, M. Vuletic, V. Katsarou, Z. The PDCS European Study Group

Subjects
hemic and immune systems
Abstract

This study was addressed to determine the presence of Parkinson disease (PD) manifestations, their distribution according to motor subtypes, and the relationships with health-related quality of life (QoL) using the recently validated European Parkinson’s Disease Association sponsored Parkinson’s Disease Composite Scale (PDCS). Frequency of symptoms was determined by the scores of items (present if >0). Using ROC analysis and Youden method, MDS-UPDRS motor subtypes were projected on the PDCS to achieve a comparable classification based on the PDCS scores. The same method was used to estimate severity levels from other measures in the study. The association between the PDCS and QoL (PDQ-39) was analyzed by correlation and multiple linear regression. The sample consisted of 776 PD patients. We found that the frequency of PD manifestations with PDCS and MDS-UPDRS were overlapping, the average difference between scales being 5.5% only. Using the MDS-UPDRS subtyping, 215 patients (27.7%) were assigned as Tremor Dominant (TD), 60 (7.7%) Indeterminate, and 501 (64.6%) Postural Instability and Gait Difficulty (PIGD) in this cohort. With this classification as criterion, the analogous PDCS-based ratio provided these cut-off values: TD subtype, ≥1.06; Indeterminate, 0.65; and PIGD

Published
2019

41. Utilization of monotherapy and combination therapies in advanced Parkinson's disease patients during levodopa-carbidopa intestinal gel treatment from the cosmos study

Author

Fasano, A., primary, Parra, J.C., additional, Gurevich, T., additional, Jech, R., additional, Kovács, N., additional, Per, S., additional, Szász, J., additional, Bergmann, L., additional, Johnson, A., additional, Sanchez-Soliño, O., additional, Tang, Z., additional, and Vela-Desojo, L., additional

Published
2019
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45. Axial motor clues to identify atypical parkinsonism: A multicentre European cohort study

Author

Borm, C.D.J.M., Krismer, F., Wenning, G.K., Seppi, K., Poewe, W., Pellecchia, M.T., Barone, P., Johnsen, E.L., Ostergaard, K, Gurevich, T., Djaldetti, R., Sambati, L., Cortelli, P., Petrovic, I., Kostic, V.S., Brozova, H., Ruzicka, E., Marti, M.J., Tolosa, E., Canesi, M., Post, B., Nonnekes, J.H., Bloem, B.R., Borm, C.D.J.M., Krismer, F., Wenning, G.K., Seppi, K., Poewe, W., Pellecchia, M.T., Barone, P., Johnsen, E.L., Ostergaard, K, Gurevich, T., Djaldetti, R., Sambati, L., Cortelli, P., Petrovic, I., Kostic, V.S., Brozova, H., Ruzicka, E., Marti, M.J., Tolosa, E., Canesi, M., Post, B., Nonnekes, J.H., and Bloem, B.R.

Abstract

Item does not contain fulltext, OBJECTIVE: Differentiating Parkinson's disease (PD) from atypical parkinsonian disorders (APD) such as Multiple System Atrophy, parkinsonian type (MSA-p) or Progressive Supranuclear Palsy (PSP-RS) can be challenging. Early signs of postural Instability and gait disability (PIGD) are considered clues that may signal presence of APD. However, it remains unknown which PIGD test - or combination of tests - can best distinguish PD from APD. We evaluated the discriminative value of several widely-used PIGD tests, and aimed to develop a short PIGD evaluation that can discriminate parkinsonian disorders. METHODS: In this multicentre cohort study patients were recruited by 11 European MSA Study sites. Patients were diagnosed using standardized criteria. Postural instability and gait disability was evaluated using interviews and several clinical tests. RESULTS: Nineteen PD, 21 MSA-p and 25PSP-RS patients were recruited. PIGD was more common in APD compared to PD. There was no significant difference in axial symptoms between PSP-RS and MSA-p, except for self-reported falls (more frequent in PSP-RS patients). The test with the greatest discriminative power to distinguish APD from PD was the ability to perform tandem gait (AUC 0.83; 95% CI 71-94; p<0.001), followed by the retropulsion test (AUC 0.8; 95% CI 0.69-0.91; p<0.001) and timed-up-and-go test (TUG) (AUC 0.77; 95% CI 0.64-0.9; p=0.001). The combination of these three tests yielded highest diagnostic accuracy (AUC 0.96; 95% CI 0.92-1.0; p<0.001). CONCLUSIONS: Our study suggests that simple "bedside" PIGD tests - particularly the combination of tandem gait performance, TUG and retropulsion test - can discriminate APD from PD.

Published
2018

46. A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

Author

Thaler, A., Artzi, M., Mirelman, A., Jacob, Y., Helmich, R.C.G., Nuenen, B.F.L. van, Gurevich, T., Orr-Urtreger, A., Marder, K., Bressman, S., Bloem, B.R., Hendler, T., Giladi, N., and Bashat, D. Ben

Subjects
Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
Abstract

Item does not contain fulltext BACKGROUND: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. METHODS: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. RESULTS: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. CONCLUSIONS: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.

Published
2014

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