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The ubiquitous commercial Wi-Fi has brought unlimited possibilities to the smart city and the Internet of Things. Wi-Fi device-free sensing technology has received more and more attention in recent years. Counting the people in queuing is an uneasy task due to labile information. Most current counting schemes have existed in an ideal environment with idealistic people's behavior. In this article, we propose a more realistic counting scheme called Que-Fi, a queue number identification system based on Wi-Fi channel state information and a deep learning network. In the proposed Que-Fi scheme, the nonnegligible interference of human motion and the surrounding environment is first analyzed based on the Fresnel zone. Then, we proposed a static model based on the convolutional long short-term memory fully connected deep neural network in order to overcome the interference. A dynamic Que-Fi model is proposed to identify the entering/leaving people's behavior and update the counting number. In this article, different preprocessing methods are analyzed and compared to test and evaluate the proposed Que-Fi. Experiments have shown that the proposed Que-Fi outperforms the traditional support vector machine and provide accuracy up to 95% and 96.67% for static and dynamic models, respectively.

Interleukin-11 (IL-11) is a profibrotic cytokine essential for the differentiation of fibroblasts into collagen-secreting, actin alpha 2, smooth muscle–positive (ACTA2+) myofibroblasts, driving processes underlying the pathogenesis of idiopathic pulmonary fibrosis (IPF). Here, we developed an inhalable and mucus-penetrative nanoparticle (NP) system incorporating siRNA againstIL11(siIL11@PPGC NPs) and investigated therapeutic potential for the treatment of IPF. NPs are formulated through self-assembly of a biodegradable PLGA-PEG diblock copolymer and a self-created cationic lipid-like molecule G0-C14 to enable efficient transmucosal delivery of siIL11. Noninvasive aerosol inhalation hindered fibroblast differentiation and reduced ECM deposition via inhibition of ERK and SMAD2. Furthermore, siIL11@PPGC NPs significantly diminished fibrosis development and improved pulmonary function in a mouse model of bleomycin-induced pulmonary fibrosis without inducing systemic toxicity. This work presents a versatile NP platform for the locally inhaled delivery of siRNA therapeutics and exhibits promising clinical potential in the treatment of numerous respiratory diseases, including IPF.

Highly efficient microwave absorption materials with tunable electromagnetic properties have been attracting extensive attention. However, it still remains a challenge to fabricate the chiral materials decorated with core-shell structured magnetic-particles for excellent microwave absorption performance. Herein, a novel composite of helical carbon nanocoils (CNCs) and Fe3O4@C core-shell structures are synthesized, for the first time, via sequential processes of chemical vapor deposition (CVD) technique and hydrothermal reactions. By controlling the reaction temperature and time in CVD process, the composites with different morphologies and multilevel heterostructural interfaces are obtained. The minimum reflection loss of the CNC/Fe3O4@C composite reaches −47.5 dB at 13.4 GHz with a thickness of only 1.7 mm. Meanwhile, the composite also exhibits an effective frequency range (≤−10 dB) of as wide as 5.03 GHz at a thickness of only 1.5 mm. Our designs not only provide a scalable way for preparing a kind of novel and robust absorber but also offer inspirations for construction of a kind of composite consisting of chiral and core-shell structured materials.

Two coupled resonance modes can lead to exotic transmission spectra due to internal interference processes. Examples include electromagnetically induced transparency (EIT) in atoms and mode splitting in optics. The ability to control individual modes plays a crucial role in controlling such transmission spectra for practical applications. Here we experimentally demonstrate a controllable EIT-like mode splitting in a single microcavity using a double-port excitation. The mode splitting caused by internal coupling between two counter-propagating resonances can be effectively controlled by varying the power of the two inputs, as well as their relative phase. Moreover, the presence of asymmetric scattering in the microcavity leads to chiral behaviors in the mode splitting in the two propagating directions, manifesting itself in terms of a Fano-like resonance mode. These results may offer a compact platform for a tunable device in all-optical information processing.

Relativistic electrons moving over a periodic metal grating can lead to an intriguing emission of light, known as Smith-Purcell radiation (SPR), the precursor of the free-electron laser. During the radiation process, the speed of light plays a critical role in determining the emitted angle and frequency spectrum. Inspired by the photonic SPR, here we experimentally demonstrate a photoacoustic version of the Smith-Purcell effect using laser-induced surface shock waves generation. We observe similar acoustic radiation pattern and their associated frequency spectrum in the far-field, perfectly predicted by a universal theory working for both the photonic and acoustic SPR. Moreover, our numerical studies reveal non-constant frequency components due to the supersonic traveling of the shock waves in the near field, greatly contrasting its photonic counterpart. This scheme extends the SPR into the acoustic domain by levitating the wave’s speed limit, paves the way towards coherent acoustic wave generation and microstructure metrology.

Objective To evaluate plasma phosphorylated neurofilament heavy chain (pNF‐H) as a biomarker in spinal muscular atrophy (SMA). Methods Levels of pNF‐H were measured using the ProteinSimple® platform in plasma samples from infants with SMA enrolled in ENDEAR (NCT02193074) and infants/children without neurological disease. Results Median pNF‐H plasma level was 167.0 pg/mL (7.46–7,030; n = 34) in children without SMA (aged 7 weeks–18 years) and was higher in those aged

In this study, we report a combined meso–microscale computational study of Pickering emulsions stabilized by sulfonated polystyrene-grafted silica nanoparticles for the glycerol/dodecanol system using dissipative particle dynamics. Different glycerol/dodecanol emulsification regimes could be ascertained as a function of the length of polystyrene brushes as well as the surface density, sulfonation degree, and distribution of sulfonic acid groups in the brushes, matching experimental results. Local nanomixing effects between glycerol and dodecanol could be clearly identified in the vicinity of the catalytic sulfonic acid groups, unraveling potential reactivity zones for etherification.

8-methoxypsoralen (8-MOP) with ultraviolet A radiation therapy (PUVA) is the standard therapy for patients with psoriasis, despite the reported potential risks of 8-MOP-induced cholestatic liver injury in both humans and animals. Usually, patients with chronic cholestasis exhibit lower serum 25-hydroxy vitamin D (25(OH)D) levels. But those patients receiving PUVA for psoriasis showed an increase in serum 25(OH)D levels, probably highlighting that the vitamin D-vitamin D nuclear receptor (VD-VDR) axis play a protective role in 8-MOP-induced hepatotoxicity. The present study confirmed 8-MOP could increase serum 25(OH)D levels in conventional lighting and diet (CLD) and vitamin D deficient (VDD) Sprague-Dawley rats. Potential liver risks were also found in CLD and VDD rats after 8-MOP treatment. We proved that 8-MOP could be a potent ligand for VDR using molecular docking and luciferase report assay. Effect of 8-MOP on VDR subcellular distribution was determined using human liver cell line L02. We found 8-MOP could increase VDR protein expression in the nuclear and cytosol extracts and also total cell extracts in L02. siRNAs for VDR were used to determine the role of VDR in protecting 8-MOP-induced cholestasis and potential cellular mechanisms. The results showed 8-MOP could affect the CYP7A1, SHP and MRP3 expression via VDR, and such effects could be reversed by knockdown of VDR expression, suggesting a vital role of VDR involved in 8-MOP-regulated bile acid synthesis and transportation. In conclusion, these results revealed activation of VD-VDR axis may play a beneficial role in 8-MOP-mediated regulation of bile acid synthesis and transportation.

With the continuous application of high technology in command and operation, the era of big data in military field has come. Traditional data processing can't satisfy the deep analysis of massive heterogeneous data. Cloud computing provides necessary storage, management and computing solutions for big data analysis. Based on the characteristics of big data, using cloud computing and data mining technology, this paper proposes a command and decision system model based on Hadoop to provide efficient and reliable ad hoc analysis, and finally establishes a big data analysis ecosystem for battle command and decision-making.

Pickering Interfacial Catalysts (PIC) has emerged as a powerful concept for designing multiphasic reactions between immiscible reagents using heterogeneous catalysts. Nonetheless, systematic studies addressing the influence of the particle self-assembly on the catalytic properties are scarce. To fill this gap, here we studied the effect of the particle size and surface roughness of catalytic nanoparticles on the reactivity of non-aqueous immiscible systems in the presence of Pickering emulsions. To this aim, we prepared a library of amphiphilic silica nanoparticles with the same surface properties and bearing catalytically active acid centers, but showing variable particle sizes in the range 90-460 nm and surface roughness. The nanoparticles were characterized in detail using different techniques, including acid-base titration, TGA, TEM and DLS. The silicas were tested in the biphasic acetalization reaction of dodecanal and ethylene glycol. The catalyst productivity was enhanced for smaller sized nanoparticles (

There are many problems in the current intelligence analysis work. Data islands and data transmission monitoring problems have severely restricted the further development of intelligence analysis work. To promote and improve the level of intelligence analysis work, this article mainly introduces how to apply big data to intelligence analysis. It enters into the analysis of the problems faced by the current intelligence analysis platform, focusing on the importance of big data technology for intelligence analysis. The structure and key technologies of big data can effectively solve various problems existing in intelligence analysis work. The structure of the intelligence analysis platform based on big data and the structure of the Hadoop+Spark+Steam platform are designed, including intelligence analysis and intelligence analysis. Functional modules such as data management and intelligence storage. This platform design of this article can effectively improve the effect and efficiency of intelligence analysis, and has very high practical value.

Delayed‐release dimethyl fumarate (DMF) is an oral therapy for relapsing multiple sclerosis with anti‐inflammatory and neuroprotective properties. This 2‐period crossover study was conducted to evaluate the potential for drug–drug interaction between DMF (240 mg twice daily) and a combined oral contraceptive (OC; norgestimate 250 μg, ethinyl estradiol 35 μg). Forty‐six healthy women were enrolled; 32 completed the study. After the lead‐in period (OC alone), 41 eligible participants were randomized 1:1 to sequence 1 (OC and DMF coadministration in period 1; OC alone in period 2) or sequence 2 (regimens reversed). Mean concentration profiles of plasma norelgestromin (primary metabolite of norgestimate) and ethinyl estradiol were superimposable following OC alone and OC coadministered with DMF, with 90% confidence intervals of geometric mean ratios for area under the plasma concentration–time curve over the dosing interval and peak plasma concentration contained within the 0.8–1.25 range. Low serum progesterone levels during combined treatment confirmed suppression of ovulation. The pharmacokinetics of DMF (measured via its primary active metabolite, monomethyl fumarate) were consistent with historical data when DMF was administered alone. No new safety concerns were identified. These results suggest that norgestimate/ethinyl estradiol–based OCs may be used with DMF without dose modification.

Psoralea corylifolia L. (Fructus Psoraleae) is widely used in Asia, but there are concerns about hepatotoxicity caused by constituents such as psoralens and bakukiol. Bakuchiol (BAK) has antiinflammatory, antipyretic, antibacterial antiviral, anticancer, and estrogenic activity but appears to be hepatotoxic in in vitro tests. This study investigated the hepatotoxicity in vivo in rats. Using intragastrically administered bakuchiol at doses of 52.5 and 262.5 mg/kg for 6 weeks. Bodyweight, relative liver weight, biochemical indicators, histopathology, mRNA expression of CYP7A1, HMG-CoA reductase, BSEP, PPARα, SREBP-2, and MRP3 were measured. Many abnormalities were observed in the bakuchiol-treated groups including suppression of weight gain and food intake, change of some parameters in serum biochemistry, and increased weight of liver. The mRNA expression of CYP7A1, HMG-CoA reductase, PPARα, and SREBP-2 decreased in bakuchiol-treated group, the expression of BSEP increased in bakuchiol-treated low dosage, and the expression of BSEP decreased in bakuchiol-treated high dosage. In conclusion, we provide evidence for the first time that bakuchiol can induce cholestatic hepatotoxicity, suggesting potential hepatotoxicity. The mechanism may be related to effects on liver lipid metabolism, but further investigation is necessary. Copyright © 2017 John Wiley & Sons, Ltd.

Fructus Psoraleae, which is commonly consumed for the treatment of osteoporosis, bone fracture, and leucoderma, induces liver injury. This study investigated the pathogenesis of the ethanol extract of Fructus Psoraleae (EEFP)-induced liver injury in rats. EEFP (1.35, 1.80, and 2.25 g·kg-1) was administrated to Sprague Dawley (SD) rats for 30 d. We measured liver chemistries, histopathology, and quantitative isobaric tags for relative and absolute quantitation (iTRAQ)-based protein profiling. EEFP demonstrated parameters suggestive of liver injury with changes in bile secretion, bile flow rate, and liver histopathology. iTRAQ analysis showed that a total of 4042 proteins were expressed in liver tissues of EEFP-treated and untreated rats. Among these proteins, 81 were upregulated and 32 were downregulated in the treatment group. KEGG pathway analysis showed that the drug metabolic pathways of cytochrome P450, glutathione metabolism, glycerolipid metabolism, and bile secretion were enriched with differentially expressed proteins. The expression of key proteins related to the farnesoid X receptor (FXR), i.e., the peroxisome proliferators-activated receptor alpha (PPAR-α), were downregulated, and multidrug resistance-associated protein 3 (MRP3) was upregulated in the EEFP-treated rats. Our results provide evidence that EEFP may induce hepatotoxicity through various pathways. Furthermore, our study demonstrates changes in protein regulation using iTRAQ quantitative proteomics analysis.

We propose a scheme of terahertz (THz) indirect detection via plasmonic-antenna enhanced sum frequency generation process, where the THz wave is converted to optical wave that is detected by photodetector. The gold antenna built in the structure can improve the conversion efficiency by enhancing both the optical wave and THz wave. The numerical simulations show that the field enhancement is influenced by the geometry of the antenna, so the conversion efficiency can be improved highly by optimizing the antenna. Compared with commercial detectors, our detection system has a much lower noise equivalent power (NEP) of 15.4[Formula: see text]pW/[Formula: see text] at 5[Formula: see text]THz.

The exact role of VD deficiency in the development of non-alcoholic fatty liver disease (NAFLD) remains unknown. In this study, we induced VD deficiency by feeding Female Sprague-Dawley rats a VD deficient (VDD) Diet and studied the hepatic changes associated with VD deficiency. Simultaneously, we provided the VDD rats with VD or 8-methoxy psoralen (8-MOP), a suggested vitamin D receptor agonist, to test the reversibility of the hepatic changes. VDD Rats developed borderline non-alcoholic steatohepatitis (NASH) with considerable elevation in hepatic triglycerides, total cholesterol, and malondialdehyde. Furthermore, VD deficiency induced the expression of crucial enzymes and transcription factors involved in denovo lipogenesis, which justified the hepatic lipid accumulation. Insulin receptor signaling was affected by VD deficiency, demonstrated by the elevation in insulin substrate-1 (IRS1) and reduction in insulin substrate-2 (IRS2) signaling. Treatment with VD or 8-MOP attenuated IRS1 signaling and its downstream targets, leading to a decline in de novo lipogenesis, while the elevation in IRS2 expression resulted in the nuclear exclusion of forkhead box O1 (FoxO1) and diminished gluconeogenesis, a vital source of acetyl-CoA for de novo lipogenesis. Moreover, 8-MOP and Calcipotriol modulated insulin signaling in human hepatocyte cell line L02, which highlighted the crucial role of VD in the regulation of hepatic lipid contents in rats and humans. Silencing of the vitamin D receptor expression in L02 diminished the inhibitory effect of Calcipotriol and 8-MOP on fatty acid synthase and acetyl- CoA carboxylase 1 and provided the evidence that 8-MOP actions mediated via vitamin D receptor.

Shear field is widely applied to intensify interfacial molecular transport in many chemical engineering processes, and the intensification effect is generally ascribed to the significant increase of contact area between two immiscible liquid phases. Herein, by investigating molecular transport across water-benzene interfaces under different shear fields as a representative study, we show that the interfacial molecular transport per unit area of the interface can be also enhanced by shear field when surfactants are introduced. The microscopic mechanism towards the latter effect is extensively explored by means of Dissipative Particle Dynamics simulation at various shear rates (0–0.3 ps−1) and surfactant volume fractions (0–7.1%), and we find that shear flows inhibit the accumulation of surfactants at the interface, and align the remained surfactants along the direction of mass transport, thus enhancing the molecular transfer across the interface. This work provides a microscopic insight into the regulation of interfacial transport with shear flow.

Pickering emulsions offer a promising platform for conducting interfacial reactions between immiscible reagents. Despite the significant progress in the engineering of amphiphilic catalysts for such reactions, the mechanism behind their enhanced activity is still poorly understood. Herein, using the glycerol/dodecanol system as a case study, we conducted a combined meso- and microscale study of Pickering emulsions stabilized by amphiphilic silica nanoparticles bearing acid centers by marrying dissipative particle dynamics simulations with emulsification experiments. The optimal surface properties of the silica particles in terms of length and density of alkyl chains were identified, matching the experimental results. The local distribution of glycerol and dodecanol near the acid centers was ascertained, unraveling potential reactivity zones near the catalytic acid centers due to an enhanced nanomixing between glycerol and dodecanol.

Welded joints of poor welding surface quality are sensitive to stress concentrations, affecting both the tensile strength of workpieces and the fluidity of liquids and gases in pressure and liquid containers. Orthogonal experiments involving the laser welding of 1-mm-thick duplex stainless steel sheets were conducted using different electric current, pulse width and frequency values in order to analyse the effect of welding properties on the surface characteristics of the welded joints. Rapid judgement regarding the welded joint properties was made based on the observed welding surface quality. The results show that an even phase proportion and grain refinement are not necessarily guaranteed to provide good welding surface quality. A satisfactory welding surface quality characterised by a smaller spot pitch or spot pitch difference, smaller weld width, reduced surface roughness and valley depth of surface waviness implies better welded joint mechanical characteristics and a more even microstructure. The specimen with the most suitable welding parameters and the greatest heat input can reach the lowest volume fraction of ferrite phase of 42.5% and the highest tensile strength of 848 MPa, and its surface quality is the best.

Pre-diabetes is characterized by impaired glucose tolerance (IGT) and/or impaired fasting glucose. Impairment of skeletal muscle function is closely associated with the progression of diabetes. However, the entire pathological characteristics and mechanisms of pre-diabetes in skeletal muscle remain fully unknown. Here, we established a mouse model of pre-diabetes, in which 6-week-old male C57BL6/J mice were fed either normal diet or high-fat diet (HFD) for 8 or 16 weeks. Both non-fasting and fasting glucose levels and the results of glucose and insulin tolerance tests showed that mice fed an 8-week HFD developed pre-diabetes with IGT; whereas mice fed a 16-week HFD presented with impaired fasting glucose and impaired glucose tolerance (IFG-IGT). Mice at both stages of pre-diabetes displayed decreased numbers of mitochondria in skeletal muscle. Moreover, IFG-IGT mice exhibited decreased mitochondrial membrane potential and ATP production in skeletal muscle and muscle degeneration characterized by a shift in muscle fibers from predominantly oxidative type I to glycolytic type II. Western blotting and histological analysis confirmed that myoblast differentiation was only inhibited in IFG-IGT mice. For primary skeletal muscle satellite cells, inhibition of differentiation was observed in palmitic acid-induced insulin resistance model. Moreover, enhanced myoblast differentiation increased glucose uptake and insulin sensitivity. These findings indicate that pre-diabetes result in mitochondrial dysfunction and inhibition of myoblast differentiation in skeletal muscle. Therefore, interventions that enhance myoblast differentiation may improve insulin resistance of diabetes at the earlier stage.

Catalpol, an iridoid glycoside, has been shown to exert hypoglycemic effect by rescuing mitochondrial function, but the detailed mechanism remains unclear yet. In this study, the effect and mechanism of catalpol on the hepatic mitochondria under diabetic conditions were further examined. Oral administration of catalpol significantly reduced the blood glucose, triglyceride, and cholesterol levels in high-fat diet- and streptozotocin-induced diabetic mice. Additionally, catalpol attenuated the decrease in liver mitochondrial ATP content resulting from diabetes. Furthermore, the number of mitochondria possessing a long size was increased in catalpol-treated mice. Interestingly, the catalpol-induced recovery of mitochondrial function was associated with decreased fission protein 1 and dynamin-related protein 1 expression as well as increased mitofusin 1 expression in the liver. In HepG2 cells, catalpol alleviated the decrease of ATP content and mitochondrial membrane potential, and the increase of reactive oxygen species formation induced by high glucose. MitoTracker Green stain shows that the tubular feature of mitochondria was maintained when cells were treated with catalpol. Catalpol also decreased fission protein 1 and dynamin-related protein 1 expression and increased mitofusin 1 expression in HepG2 cells. The present results suggest that catalpol can ameliorate hepatic mitochondrial dysfunction under a diabetic state, and this may be related to its regulation of mitochondrial fusion and fission events.

Since its discovery in 1987, multidrug resistance 3 P-glycoprotein (MDR3) had recognized to play a crucial role in the translocation of phospholipids from the inner to outer leaflets of bile canalicular membranes. An increasing number of reports suggest that drug-mediated functional disruption of MDR3 is responsible for drug-induced cholestasis. 8-Methoxypsoralen (8-MOP) is used clinically to treat psoriasis, vitiligo and other skin disorders. However, psoralens safety for long-term use is a concern. In the current study, we evaluate 8-MOP's potential hepatotoxicity and effects on bile formation. Sprague Dawley (SD) rats were treated daily 200mg/kg or 400mg/kg of 8-MOP orally for 28 days. The result showed a prominent decrease in biliary phospholipids output, which associated with the down-regulation of MDR3. Elevated bile acid serum level and increased biliary bile acid outputs were observed in 8-MOP-treated groups. The disturbance of bile acid homeostasis was associated with changes in enzymes and proteins involved in bile acid synthesis, regulation and transport. Human liver cell line L02 was used to determine on the mRNA and protein levels of MDR3. Cells treated with 8-MOP reveled a decrease in fluorescent PC (phosphatidylcholine) secretion into the pseudocanaliculi (formed between adjacent cells) compared with untreated cells. Our investigation represent the first evidence that 8-MOP can induce cholestatic liver injury by disturbing MDR3-mediated phospholipids efflux and bile acid homeostasis.

α-Naphthylisothiocyanate (ANIT) is a well-characterized cholestatic agent for rats. The aim of this study was to examine whether resveratrol could attenuate ANIT-induced acute cholestasis and liver injury in rats. SD rats were treated with resveratrol (15 or 30 mg/kg, ip) or a positive control drug ursodeoxycholic acid (100 mg/kg, po) for 5 consecutive days followed by a single dose of ANIT (60 mg/kg, po). Bile flow, and serum biochemical markers and bile constituents were measured 48 h after ANIT administration. Hepatic levels of oxidative repair enzymes (glutathione peroxidase, catalase and MnSOD), myeloperoxidase activity, TNF-α, IL-6 and ATP content, as well as the expression of liver transporter genes and proteins were assayed. ANIT exposure resulted in serious cholestasis and liver injury, as shown by marked neutrophil infiltration in liver, dramatically increased serum levels of ALT, AST, GGT, ALP, TBA, TBIL, IBIL and DBIL, and significantly decreased bile excretion and biliary output of GSH and HCO3−. ANIT significantly increased TNF-α and IL-6 release and myeloperoxidase activity, decreased mitochondrial biogenesis in liver, but had little effect on hepatic oxidative repair enzymes and ATP content. Furthermore, ANIT significantly decreased the expression of Mrp2, FXR and Cyp7a1, markedly increased Mrp3 expression in liver. Pretreatment with resveratrol attenuated ANIT-induced acute cholestasis and liver injury, and other pathological changes. Pretreatment with ursodeoxycholic acid was less effective. Resveratrol effectively attenuates ANIT-induced acute cholestasis and liver injury in rats, possibly through suppression of neutrophil infiltration, as well as upregulation of expression of hepatic transporters and enzymes, thus decreasing accumulation of bile acids.

With the rapid development of network technology and the prosperity of all kinds of network application, the attacks of the Internet are very frequent. the cyberspace has become a new battlefield. The network attack became a worldwide research hot spot. The network attack evaluation caused the worldwide attention, and become the cyberspace warfare analysis basis, which provides a basis for the network attack and protection. This paper analyzes the influence the effect of cyberspace. The evaluation criteria system of network attack based on the fuzzy comprehensive evaluation method was presented to promote the study of network attack in this paper. The experiment raised in this paper can prove the method mentioned in this paper.

Accounting for gene–environment (G×E) interactions in complex trait association studies can facilitate our understanding of genetic heterogeneity under different environmental exposures, improve the ability to discover susceptible genes that exhibit little marginal effect, provide insight into the biological mechanisms of complex diseases, help to identify high-risk subgroups in the population, and uncover hidden heritability. However, significant G×E interactions can be difficult to find. The sample sizes required for sufficient power to detect association are much larger than those needed for genetic main effects, and interactions are sensitive to misspecification of the main-effects model. These issues are exacerbated when working with binary phenotypes and rare variants, which bear less information on association. In this work, we present a similarity-based regression method for evaluating G×E interactions for rare variants with binary traits. The proposed model aggregates the genetic and G×E information across markers, using genetic similarity, thus increasing the ability to detect G×E signals. The model has a random effects interpretation, which leads to robustness against main-effect misspecifications when evaluating G×E interactions. We construct score tests to examine G×E interactions and a computationally efficient EM algorithm to estimate the nuisance variance components. Using simulations and data applications, we show that the proposed method is a flexible and powerful tool to study the G×E effect in common or rare variant studies with binary traits.