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Neurofilament as a potential biomarker for spinal muscular atrophy
- Source :
- Annals of Clinical and Translational Neurology, Vol 6, Iss 5, Pp 932-944 (2019), Annals of Clinical and Translational Neurology
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Objective To evaluate plasma phosphorylated neurofilament heavy chain (pNF‐H) as a biomarker in spinal muscular atrophy (SMA). Methods Levels of pNF‐H were measured using the ProteinSimple® platform in plasma samples from infants with SMA enrolled in ENDEAR (NCT02193074) and infants/children without neurological disease. Results Median pNF‐H plasma level was 167.0 pg/mL (7.46–7,030; n = 34) in children without SMA (aged 7 weeks–18 years) and was higher in those aged
- Subjects :
- Male
0301 basic medicine
Treatment response
medicine.medical_specialty
Neurofilament
Adolescent
Intermediate Filaments
Neurosciences. Biological psychiatry. Neuropsychiatry
Gastroenterology
law.invention
Muscular Atrophy, Spinal
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
law
Internal medicine
medicine
Humans
Child
RC346-429
Research Articles
business.industry
General Neuroscience
Spinal muscular atrophy
medicine.disease
SMA
030104 developmental biology
Potential biomarkers
Biomarker (medicine)
Female
Nusinersen
Neurology (clinical)
Neurology. Diseases of the nervous system
business
Biomarkers
030217 neurology & neurosurgery
Research Article
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 23289503
- Volume :
- 6
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Annals of Clinical and Translational Neurology
- Accession number :
- edsair.doi.dedup.....c3a7bdc0b04bf300bd3dd57b4ad18eea