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27 results on '"Groth-Pedersen, Line"'

5. Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

Author

Petersen, Nikolaj H.T., Olsen, Ole D., Groth-Pedersen, Line, Ellegaard, Anne-Marie, Bilgin, Mesut, Redmer, Susanne, Ostenfeld, Marie S., Ulanet, Danielle, Dovmark, Tobias H., Lønborg, Andreas, Vindeløv, Signe D., Hanahan, Douglas, Arenz, Christoph, Ejsing, Christer S., Kirkegaard, Thomas, Rohde, Mikkel, Nylandsted, Jesper, and Jäättelä, Marja

Published
2013
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7. High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

Author

Mollerup, Sarah, Asplund, Maria, Friis-Nielsen, Jens, Kjartansdóttir, Kristín Rós, Fridholm, Helena, Hansen, Thomas Arn, Herrera, José Alejandro Romero, Barnes, Christopher James, Jensen, Randi Holm, Richter, Stine Raith, Nielsen, Ida Broman, Pietroni, Carlotta, Alquezar-Planas, David E, Rey-Iglesia, Alba, Olsen, Pernille V S, Rajpert-De Meyts, Ewa, Groth-Pedersen, Line, von Buchwald, Christian, Jensen, David H, Gniadecki, Robert, Høgdall, Estrid, Langhoff, Jill Levin, Pete, Imre, Vereczkey, Ildikó, Baranyai, Zsolt, Dybkaer, Karen, Johnsen, Hans Erik, Steiniche, Torben, Hokland, Peter, Rosenberg, Jacob, Baandrup, Ulrik, Sicheritz-Pontén, Thomas, Willerslev, Eske, Brunak, Søren, Lund, Ole, Mourier, Tobias, Vinner, Lasse, Izarzugaza, Jose M G, Nielsen, Lars Peter, Hansen, Anders Johannes, Mollerup, Sarah, Asplund, Maria, Friis-Nielsen, Jens, Kjartansdóttir, Kristín Rós, Fridholm, Helena, Hansen, Thomas Arn, Herrera, José Alejandro Romero, Barnes, Christopher James, Jensen, Randi Holm, Richter, Stine Raith, Nielsen, Ida Broman, Pietroni, Carlotta, Alquezar-Planas, David E, Rey-Iglesia, Alba, Olsen, Pernille V S, Rajpert-De Meyts, Ewa, Groth-Pedersen, Line, von Buchwald, Christian, Jensen, David H, Gniadecki, Robert, Høgdall, Estrid, Langhoff, Jill Levin, Pete, Imre, Vereczkey, Ildikó, Baranyai, Zsolt, Dybkaer, Karen, Johnsen, Hans Erik, Steiniche, Torben, Hokland, Peter, Rosenberg, Jacob, Baandrup, Ulrik, Sicheritz-Pontén, Thomas, Willerslev, Eske, Brunak, Søren, Lund, Ole, Mourier, Tobias, Vinner, Lasse, Izarzugaza, Jose M G, Nielsen, Lars Peter, and Hansen, Anders Johannes

Abstract

BACKGROUND: Viruses and other infectious agents cause more than 15% of human cancer cases. High-throughput sequencing-based studies of virus-cancer associations have mainly focused on cancer transcriptome data.METHODS: In this study, we applied a diverse selection of presequencing enrichment methods targeting all major viral groups, to characterize the viruses present in 197 samples from 18 sample types of cancerous origin. Using high-throughput sequencing, we generated 710 datasets constituting 57 billion sequencing reads.RESULTS: Detailed in silico investigation of the viral content, including exclusion of viral artefacts, from de novo assembled contigs and individual sequencing reads yielded a map of the viruses detected. Our data reveal a virome dominated by papillomaviruses, anelloviruses, herpesviruses, and parvoviruses. More than half of the included samples contained 1 or more viruses; however, no link between specific viruses and cancer types were found.CONCLUSIONS: Our study sheds light on viral presence in cancers and provides highly relevant virome data for future reference.

Published
2019

8. High-throughput sequencing-based investigation of viruses in human cancers by multi-enrichment approach

Author

Mollerup, Sarah, Asplund, Maria, Friis-Nielsen, Jens, Kjartansdóttir, Kristín Rós, Fridholm, Helena, Hansen, Thomas Arn, Herrera, José Alejandro Romero, Barnes, Christopher James, Jensen, Randi Holm, Richter, Stine Raith, Nielsen, Ida Broman, Pietroni, Carlotta, Alquezar-Planas, David E., Rey-Iglesia, Alba, Olsen, Pernille V. S., Rajpert-De Meyts, Ewa, Groth-Pedersen, Line, von Buchwald, Christian, Jensen, David H., Gniadecki, Robert, Høgdall, Estrid, Langhoff, Jill Levin, Pete, Imre, Vereczkey, Ildikó, Baranyai, Zsolt, Dybkaer, Karen, Johnsen, Hans Erik, Steiniche, Torben, Hokland, Peter, Rosenberg, Jacob, Baandrup, Ulrik, Sicheritz-Pontén, Thomas, Willerslev, Eske, Brunak, Søren, Lund, Ole, Mourier, Tobias, Vinner, Lasse, Izarzugaza, Jose M. G., Nielsen, Lars Peter, Hansen, Anders Johannes, Mollerup, Sarah, Asplund, Maria, Friis-Nielsen, Jens, Kjartansdóttir, Kristín Rós, Fridholm, Helena, Hansen, Thomas Arn, Herrera, José Alejandro Romero, Barnes, Christopher James, Jensen, Randi Holm, Richter, Stine Raith, Nielsen, Ida Broman, Pietroni, Carlotta, Alquezar-Planas, David E., Rey-Iglesia, Alba, Olsen, Pernille V. S., Rajpert-De Meyts, Ewa, Groth-Pedersen, Line, von Buchwald, Christian, Jensen, David H., Gniadecki, Robert, Høgdall, Estrid, Langhoff, Jill Levin, Pete, Imre, Vereczkey, Ildikó, Baranyai, Zsolt, Dybkaer, Karen, Johnsen, Hans Erik, Steiniche, Torben, Hokland, Peter, Rosenberg, Jacob, Baandrup, Ulrik, Sicheritz-Pontén, Thomas, Willerslev, Eske, Brunak, Søren, Lund, Ole, Mourier, Tobias, Vinner, Lasse, Izarzugaza, Jose M. G., Nielsen, Lars Peter, and Hansen, Anders Johannes

Abstract

Viruses and other infectious agents cause more than 15% of human cancer cases. High-throughput sequencing-based studies of virus-cancer associations have mainly focused on cancer transcriptome data. Here we applied a diverse selection of pre-sequencing enrichment methods targeting all major viral groups, to characterise the viruses present in 197 samples from 18 sample types of cancerous origin. Using high-throughput sequencing we generated 710 datasets constituting 57 billion sequencing reads. Detailed in silico investigation of the viral content, including exclusion of viral artefacts, from de novo assembled contigs and individual sequencing reads yielded a map of the viruses detected. Our data reveals a virome dominated by papillomaviruses, anelloviruses, herpesviruses, and parvoviruses. More than half of the included samples contained one or more viruses, however, no link between specific viruses and cancer types were found. Our study sheds light on viral presence in cancers and provides highly relevant virome data for future reference.

Published
2019

9. High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

Author

Mollerup, Sarah, primary, Asplund, Maria, additional, Friis-Nielsen, Jens, additional, Kjartansdóttir, Kristín Rós, additional, Fridholm, Helena, additional, Hansen, Thomas Arn, additional, Herrera, José Alejandro Romero, additional, Barnes, Christopher James, additional, Jensen, Randi Holm, additional, Richter, Stine Raith, additional, Nielsen, Ida Broman, additional, Pietroni, Carlotta, additional, Alquezar-Planas, David E, additional, Rey-Iglesia, Alba, additional, Olsen, Pernille V S, additional, Rajpert-De Meyts, Ewa, additional, Groth-Pedersen, Line, additional, von Buchwald, Christian, additional, Jensen, David H, additional, Gniadecki, Robert, additional, Høgdall, Estrid, additional, Langhoff, Jill Levin, additional, Pete, Imre, additional, Vereczkey, Ildikó, additional, Baranyai, Zsolt, additional, Dybkaer, Karen, additional, Johnsen, Hans Erik, additional, Steiniche, Torben, additional, Hokland, Peter, additional, Rosenberg, Jacob, additional, Baandrup, Ulrik, additional, Sicheritz-Pontén, Thomas, additional, Willerslev, Eske, additional, Brunak, Søren, additional, Lund, Ole, additional, Mourier, Tobias, additional, Vinner, Lasse, additional, Izarzugaza, Jose M G, additional, Nielsen, Lars Peter, additional, and Hansen, Anders Johannes, additional

Published
2019
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10. A novel chemosensitivity profiling platform for small acute lymphoblastic leukemia cell populations

Author

Groth-Pedersen, Line, Chen, Yen-Hsi, Faber, Marianne, Valentin, Rebecca, Albertsen, Birgitte Klug, Wehner, Peder Skov, Rosthøj, Steen, Frandsen, Thomas Leth, Marquart, Hanne Vibeke, Schmiegelow, Kjeld, Groth-Pedersen, Line, Chen, Yen-Hsi, Faber, Marianne, Valentin, Rebecca, Albertsen, Birgitte Klug, Wehner, Peder Skov, Rosthøj, Steen, Frandsen, Thomas Leth, Marquart, Hanne Vibeke, and Schmiegelow, Kjeld

Published
2015

13. Flow Cytometric Leukemic Blasts Detection in Cerebrospinal Fluid of Children with Acute Lymphoblastic Leukemia

Author

Levinsen, Mette, Marquart, Hanne Vibeke, Groth-Pedersen, Line, Frandsen, Thomas Leth, Albertsen, Birgitte Klug, Pronk, Cornelis J. H., Heldrup, Jesper, Ulvmoen, Aina, Vaitkeviciene, Goda, Wehner, Peder Skov, Frost, Britt-Marie, Abrahamsson, Jonas, Harila-Saari, Arja, Niinimaki, Riitta, Lahteenmaki, Paivi, Asberg, Ann, Lund, Bendik, Gunnes, Maria Winther, Noren-Nystrom, Ulrika, Behrendtz, Mikael, Pesola, Jouni, Taskinen, Mervi, Schmiegelow, Kjeld, Levinsen, Mette, Marquart, Hanne Vibeke, Groth-Pedersen, Line, Frandsen, Thomas Leth, Albertsen, Birgitte Klug, Pronk, Cornelis J. H., Heldrup, Jesper, Ulvmoen, Aina, Vaitkeviciene, Goda, Wehner, Peder Skov, Frost, Britt-Marie, Abrahamsson, Jonas, Harila-Saari, Arja, Niinimaki, Riitta, Lahteenmaki, Paivi, Asberg, Ann, Lund, Bendik, Gunnes, Maria Winther, Noren-Nystrom, Ulrika, Behrendtz, Mikael, Pesola, Jouni, Taskinen, Mervi, and Schmiegelow, Kjeld

Published
2014

15. Flow Cytometric Leukemic Blasts Detection in Cerebrospinal Fluid of Children with Acute Lymphoblastic Leukemia

Author

Levinsen, Mette, primary, Marquart, Hanne Vibeke, additional, Groth-Pedersen, Line, additional, Frandsen, Thomas Leth, additional, Albertsen, Birgitte Klug, additional, Pronk, Cornelis J.H., additional, Heldrup, Jesper, additional, Ulvmoen, Aina, additional, Vaitkeviciene, Goda, additional, Wehner, Peder Skov, additional, Frost, Britt-Marie, additional, Abrahamsson, Jonas, additional, Harila-Saari, Arja, additional, Niinimäki, Riitta, additional, Lähteenmäki, Päivi, additional, Åsberg, Ann, additional, Lund, Bendik, additional, Gunnes, Maria Winther, additional, Norén-Nyström, Ulrika, additional, Behrendtz, Mikael, additional, Pesola, Jouni, additional, Taskinen, Mervi, additional, and Schmiegelow, Kjeld, additional

Published
2014
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16. Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells

Author

Groth-Pedersen, Line, Aits, Sonja, Corcelle-Termeau, Elisabeth, Petersen, Nikolaj H T, Nylandsted, Jesper, Jaattela, Marja, Groth-Pedersen, Line, Aits, Sonja, Corcelle-Termeau, Elisabeth, Petersen, Nikolaj H T, Nylandsted, Jesper, and Jaattela, Marja

Abstract

Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we screened a molecular motor siRNA library in human MCF7 breast cancer cells. SiRNAs targeting four kinesins (KIF11/Eg5, KIF20A, KIF21A, KIF25), myosin 1G (MYO1G), myosin heavy chain 1 (MYH1) and tropomyosin 2 (TPM2) were identified as effective inducers of non-apoptotic cell death. The cell death induced by KIF11, KIF21A, KIF25, MYH1 or TPM2 siRNAs was preceded by lysosomal membrane permeabilization, and all identified siRNAs induced several changes in the endo-lysosomal compartment, i.e. increased lysosomal volume (KIF11, KIF20A, KIF25, MYO1G, MYH1), increased cysteine cathepsin activity (KIF20A, KIF25), altered lysosomal localization (KIF25, MYH1, TPM2), increased dextran accumulation (KIF20A), or reduced autophagic flux (MYO1G, MYH1). Importantly, all seven siRNAs also killed human cervix cancer (HeLa) and osteosarcoma (U-2-OS) cells and sensitized cancer cells to other lysosome-destabilizing treatments, i.e. photo-oxidation, siramesine, etoposide or cisplatin. Similarly to KIF11 siRNA, the KIF11 inhibitor monastrol induced lysosomal membrane permeabilization and sensitized several cancer cell lines to siramesine. While KIF11 inhibitors are under clinical development as mitotic blockers, our data reveal a new function for KIF11 in controlling lysosomal stability and introduce six other molecular motors as putative cancer drug targets.

Published
2012

19. Leukemic blasts are present at low levels in spinal fluid in one-third of childhood acute lymphoblastic leukemia cases.

Author

Levinsen, Mette, Marquart, Hanne V., Groth‐Pedersen, Line, Abrahamsson, Jonas, Albertsen, Birgitte K., Andersen, Mette K., Frandsen, Thomas L., Harila‐Saari, Arja, Pronk, Cornelis, Ulvmoen, Aina, Vaitkevičienė, Goda, Lähteenmäki, Päivi M., Niinimäki, Riitta, Taskinen, Mervi, Jeppesen, Maria, and Schmiegelow, Kjeld

Published
2016
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22. BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells

Author

Rammer, Paul, primary, Groth-Pedersen, Line, additional, Kirkegaard, Thomas, additional, Daugaard, Mads, additional, Rytter, Anna, additional, Szyniarowski, Piotr, additional, Høyer-Hansen, Maria, additional, Povlsen, Lou Klitgaard, additional, Nylandsted, Jesper, additional, Larsen, Jakob E., additional, and Jäättelä, Marja, additional

Published
2010
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24. Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

Author

Ostenfeld, Marie Stampe, primary, Høyer-Hansen, Maria, additional, Bastholm, Lone, additional, Fehrenbacher, Nicole, additional, Olsen, Ole Dines, additional, Groth-Pedersen, Line, additional, Puustinen, Pietri, additional, Kirkegaard-Sørensen, Thomas, additional, Nylandsted, Jesper, additional, Farkas, Thomas, additional, and Jäättelä, Marja, additional

Published
2008
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27. High Expression of Legumain in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia Is Associated with Central Nervous System Involvement

Author

Jeppesen, Maria, Levinsen, Mette, Rapin, Nicolas, Groth-Pedersen, Line, Aluzaite, Kristina, Albertsen, Birgitte Klug, Borup, Rehannah, Frandsen, Thomas Leth, Madsen, Hans O, Marquart, Hanne Vibeke, Rosthøj, Steen, Scharff, Bibi F.S.S., Wehner, Peder S., Porse, Bo, and Schmiegelow, Kjeld

Abstract

Background: Central nervous system (CNS) leukemia is a negative prognostic factor in pediatric acute lymphoblastic leukemia (ALL), and up to 30-40% of relapses involve the CNS. However, little is known about the biological mechanisms that lead to dissemination and survival of leukemic blasts in the CNS. This in part reflects that previous research has employed rather crude cytospin preparation methods for classification of CNS involvement. Using a highly sensitive flow-cytometry based-approach, we previously identified leukemic blasts in the cerebrospinal fluid at diagnosis in approximately 30% of ALL patients, whereas conventional cytospin microscopy only was positive in 10% of patients (Levinsen et al 2016 Pediatr Blood Cancer).

Published
2017
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