Search

Your search keyword '"Gross-Paju, Katrin"' showing total 109 results
Start Over Author "Gross-Paju, Katrin"
109 results on '"Gross-Paju, Katrin"'

1. A multi-centre longitudinal study analysing multiple sclerosis disease-modifying therapy prescribing patterns during the COVID-19 pandemic

Author

Lal, Anoushka P., Foong, Yi Chao, Sanfilippo, Paul G., Spelman, Tim, Rath, Louise, Levitz, David, Fabis-Pedrini, Marzena, Foschi, Matteo, Habek, Mario, Kalincik, Tomas, Roos, Izanne, Lechner-Scott, Jeannette, John, Nevin, Soysal, Aysun, D’Amico, Emanuele, Gouider, Riadh, Mrabet, Saloua, Gross-Paju, Katrin, Cárdenas-Robledo, Simón, Moghadasi, Abdorreza Naser, Sa, Maria Jose, Gray, Orla, Oh, Jiwon, Reddel, Stephen, Ramanathan, Sudarshini, Al-Harbi, Talal, Altintas, Ayse, Hardy, Todd A., Ozakbas, Serkan, Alroughani, Raed, Kermode, Allan G., Surcinelli, Andrea, Laureys, Guy, Eichau, Sara, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Hodgkinson, Suzanne, Ramo-Tello, Cristina, Maimone, Davide, McCombe, Pamela, Spitaleri, Daniele, Sanchez-Menoyo, Jose Luis, Yetkin, Mehmet Fatih, Baghbanian, Seyed Mohammad, Karabudak, Rana, Al-Asmi, Abdullah, Jakob, Gregor Brecl, Khoury, Samia J., Etemadifar, Masoud, van Pesch, Vincent, Buzzard, Katherine, Taylor, Bruce, Butzkueven, Helmut, and Van der Walt, Anneke

Published
2024
Full Text
View/download PDF

2. Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment

Author

Kerkhoff, Henk, Wermer, Marieke JH., Jellema, Korné, Kwa, Vincent IH., Jansen, Ben P., Schreuder, Tobien AHCML., Zinkstok, Sanne M., Moudrous, Walid, Antsov, Katrin, Gross-Paju, Katrin, Kalju, Inga, Hamann, Gerhard F., Rosenkranz, Michael, Gumbinger, Christoph, Royl, Georg, Müller, Susanne, Vassilopoulou, Sophie, Protogerou, Athanasios D., Manios, Efstathios, Bereczki, Dániel, Jakab, Gábor, Nagy, Ferenc, Folyovich, András, Szapáry, László, Gilberti, Nicola, Righetti, Enrico, Bassi, Pietro, Marcheselli, Simona, Giossi, Alessia, Holtan, Anne G., Maini, Sameer, Fryze, Waldemar, Brola, Waldemar, Sobolewski, Piotr, Bilik, Marta, Davies, Ruth, Nair, Anand, Dutta, Dipankar, Cooper, Martin, Rashed, Khalid, Shaw, Louise, Selvarajah, Johann R., Redgrave, Jessica, MacLeod, Mary Joan, Clatworthy, Philip, Papavasileiou, Vasileios, Cvoro, Vera, Halse, Omid, Ghani, Usman, de Jonge, Jeroen C., Sluis, Wouter M., Reinink, Hendrik, Bath, Philip M., Woodhouse, Lisa J., Zweedijk, Berber, van de Beek, Diederik, Aamodt, Anne Hege, Alpers, Iris, Ciccone, Alfonso, Csiba, Laszlo, Demotes, Jacques, Kõrv, Janika, Kurkowska-Jastrzebska, Iwona, Dawson, Jesse, Macleod, Malcolm R., Ntaios, George, Poli, Sven, Milionis, Haralampos, Ricci, Stefano, Cenciarelli, Silvia, Candelaresi, Paolo, de Bruijn, Sebastiaan FTM., Pathansali, Rohan, Krishnan, Kailash, Clarke, Brian, Thomalla, Götz, and van der Worp, H Bart

Published
2024
Full Text
View/download PDF

3. Stroke in COVID-19

Author

Gross-Paju, Katrin, Kõrv, Janika, Viigimaa, Margus, Toth, Peter P., Series Editor, and Banach, Maciej, editor

Published
2022
Full Text
View/download PDF

4. Safety and efficacy of teriflunomide in paediatric multiple sclerosis (TERIKIDS): a multicentre, double-blind, phase 3, randomised, placebo-controlled trial

Author

Dubois, Benedicte, Verhelst, Helene, Bojinova-Tchamova, Veneta, Mah, Jean, Cui, Li-Ying, Fang, Fang, Hao, Yunpeng, Jiang, Li, Li, Ling, Mao, Ding'An, Qiu, Wei, Tan, Guojun, Wu, Ye, Zhang, Meini, Zhou, Hongyu, Zhou, Shuizhen, Gross-Paju, Katrin, Cheuret, Emmanuel, Deiva, Kumaran, Edan, Giles, Vukusic, Sandra, Chrousos, George, Zafeiriou, Dimitrios, Achiron, Anat, Vaknin-Dembinsky, Adi, Yamout, Bassem, Laurynaitiene, Jurate, Vaiciene-Magistris, Nerija, Bojkovski, Vladimir, Trajkova, Vesna, Chaouki, Sana, Kissani, Najib, Neuteboom, Rinze, Palavra, Filipe, Belova, Anna, Boyko, Alexey, Evdoshenko, Evgeny, Kairbekova, Ekaterina, Malkova, Nadezhda, Shumilina, Maria, Skripchenko, Natalya, Nikolic, Dimitrije, Meca-Lallana, Jose, Triki, Chahnez Charfi, Chokri, Mhiri, Gouider, Riadh, Anlar, Banu, Gücüyener, Kivilcim, Hiz, Ayse Semra, Idiman, Egemen, Turkoglu, Recai, Yapici, Zuhal, Yilmaz, Unsal, Tantsura, Lyudmyla, Voloshyna, Nataliia, Lim, Ming, Wassmer, Evangeline, Cascione, Mark, Chitnis, Tanuja, LaGanke, Christopher, Rathke, Kevin, Scagnelli, John, Banwell, Brenda, Kappos, Ludwig, Arnold, Douglas L, Skripchenko, Natalia, Saubadu, Stephane, Hu, Wenruo, Benamor, Myriam, Le-Halpere, Annaig, Truffinet, Philippe, and Tardieu, Marc

Published
2021
Full Text
View/download PDF

5. Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial

Author

Grand'Maison, Francois, Jacques, Francois, Traboulsee, Anthony, Tyblova, Michaela, Meluzinova, Eva, Ampapa, Radek, Valis, Martin, Hradilke, Pavel, Mareš, Miroslav, Stourac, Pavel, Gross-Paju, Katrin, Laplaud, David, Mathey, Guillaume, Uitdehaag, Bernard, Evdoshenkoo, Evgeny, Popova, Ekaterina, Zakharova, Maria, Totolyan, Natalia, Litvinenko, Igor, Khabirov, Farit, Sivertseva, Stella, Hancinova, Viera, Kantorova, Ema, Gines, Maria Luisa Martinez, Montalban, Xavier, Maduano, Sara Eichau, Meca-Lallana, Jose, Ramió-Torrentà, Lluís, Nehrych, Tetyanna, Pashkovskyy, Valeriy, Moskovko, Sergii, Kalbus, Oleksandr, Khavunka, Marta, Pryshchepa, Volodymyr, Goloborodko, Alla, Wynn, Daniel, Honeycutt, William, Wray, Sibyl, Steingo, Brian, LaGanke, Christopher, Huang, Deren, Hemphill, John Michael, Goldstick, Lawrence, Robertson, Derrick, Reich, Daniel S, Arnold, Douglas L, Vermersch, Patrick, Bar-Or, Amit, Fox, Robert J, Matta, Andre, Turner, Timothy, Wallström, Erik, Zhang, Xinyan, and Khabirov, Farit A

Published
2021
Full Text
View/download PDF

7. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Author

Achiron, Anat, Achtnichts, Lutz, Agan, Kadriye, Akman-Demir, Gulsen, Allen, Alison B, Antel, Jack P, Antiguedad, Alfredo Rodriguez, Apperson, Michelle, Applebee, Angela M, Ayuso, Guillermo Izquierdo, Baba, Masayuki, Bajenaru, Ovidiu, Balasa, Rodica, Balci, Belgin Petek, Barnett, Michael, Bass, Ann, Becker, Veit U, Bejinariu, Mihaela, Bergh, Florian Then, Bergmann, Arnfin, Bernitsas, Evanthia, Berthele, Achim, Bhan, Virender, Bischof, Felix, Bjork, Randall John, Blevins, Gregg, Boehringer, Matthias, Boerner, Thomas, Bonek, Robert, Bowen, James D, Bowling, Allen, Boyko, Alexey N, Boz, Cavit, Bracknies, Vera, Braune, Stefan, Brescia Morra, Vincenzo, Brochet, Bruno, Brola, Waldemar, Brownstone, Paul Kenneth, Brozman, Miroslav, Brunet, Donald, Buraga, Ioan, Burnett, Margaret, Buttmann, Mathias, Butzkueven, Helmut, Cahill, Jonathan, Calkwood, Jonathan C, Camu, William, Cascione, Mark, Castelnovo, Giovani, Centonze, Diego, Cerqueira, Joao, Chan, Andrew, Cimprichova, Andrea, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cooper, Joanna A, Corboy, John, Correale, Jorge, Costell, Brian, Cottrell, David A, Coyle, Patricia K, Craner, Matthew, Cui, Liying, Cunha, Luis, Czlonkowska, Anna, da Silva, Ana Martins, de Sa, Joao, de Seze, Jérôme, Debouverie, Marc, Debruyne, Jan, Decoo, Danny, Defer, Gilles, Derfuss, Tobias, Deri, Norma H, Dihenia, Bhupesh, Dioszeghy, Peter, Donath, Vladimir, Dubois, Benedicte, Duddy, Martin, Duquette, Pierre, Edan, Gilles, Efendi, Husnu, Elias, Stanton, Emrich, Peter J, Estruch, Bonaventura Casanova, Evdoshenko, Evgeniy P, Faiss, Juergen, Fedyanin, Alexander S, Feneberg, Wolfgang, Fermont, Jiske, Fernandez, Oscar Fernandez, Ferrer, Francisco Coret, Fink, Katharina, Ford, Helen, Ford, Corey, Francia, Ada, Freedman, Mark, Frishberg, Benjamin, Galgani, Simonetta, Garmany, George P, Gehring, Klaus, Gitt, Jeffrey, Gobbi, Claudio, Goldstick, Lawrence P, Gonzalez, Rafael Arroyo, Grandmaison, Francois, Grigoriadis, Nikolaos, Grigorova, Olga, Grimaldi, Luigi Maria Edoardo, Gross, Jeffrey, Gross-Paju, Katrin, Gudesblatt, Mark, Guillaume, Daniel, Haas, Judith, Hancinova, Viera, Hancu, Anca, Hardiman, Orla, Harmjanz, Arndt, Heidenreich, Fedor R, Hengstman, G J D, Herbert, Joseph, Herring, Mark, Hodgkinson, Suzanne, Hoffmann, Olaf M, Hofmann, Werner E, Honeycutt, William D, Hua, Le Hanh, Huang, Dehui, Huang, Yining, Huang, DeRen, Hupperts, Raymond, Imre, Piroska, Jacobs, Alan Keith, Jakab, Gabor, Jasinska, Elzbieta, Kaida, Kenichi, Kalnina, Jolanta, Kaprelyan, Ara, Karelis, Guntis, Karussis, Dimitrios, Katz, Amos, Khabirov, Farit A, Khatri, Bhupendra, Kimura, Takashi, Kister, Ilya, Kizlaitiene, Rasa, Klimova, Eleonora, Koehler, Juergen, Komatineni, Aparna, Kornhuber, Anselm, Kovacs, Krisztina, Koves, Agnes, Kozubski, Wojciech, Krastev, Georgi, Krupp, Lauren B, Kurca, Egon, Lassek, Christoph, Laureys, Guy, Lee, Liesly, Lensch, Eckart, Leutmezer, Fritz, Li, Hongzeng, Linker, Ralf A, Linnebank, Michael, Liskova, Petra, Llanera, Cristina, Lu, Jiahong, Lutterotti, Andreas, Lycke, Jan, Macdonell, Richard, Maciejowski, Maciej, Maeurer, Mathias, Magzhanov, Rim V, Maida, Eva-Maria, Malciene, Lina, Mao-Draayer, Yang, Marfia, Girolama Alessandra, Markowitz, Clyde, Mastorodimos, Vasileios, Matyas, Klotild, Meca-Lallana, Jose, Merino, Juan Antonio Garcia, Mihetiu, Ioan Gheorghe, Milanov, Ivan, Miller, Aaron E, Millers, Andrejs, Mirabella, Massimiliano, Mizuno, Masanori, Montalban, Xavier, Montoya, Lilina, Mori, Masahiro, Mueller, Stefanie, Nakahara, Jin, Nakatsuji, Yuji, Newsome, Scott, Nicholas, Richard, Nielsen, A Scott, Nikfekr, Esmaeil, Nocentini, Ugo, Nohara, Chiyoko, Nomura, Kyoichi, Odinak, Miroslav M, Olsson, Tomas, van Oosten, B W, Oreja-Guevara, Celia, Oschmann, Patrick, Overell, James, Pachner, Andrew, Panczel, Gyula, Pandolfo, Massimo, Papeix, Caroline, Patrucco, Liliana, Pelletier, Jean, Piedrabuena, Raul, Pless, Misha, Polzer, Udo, Pozsegovits, Krisztian, Rastenyte, Daiva, Rauer, Sebastian, Reifschneider, Gerd, Rey, Roberto, Rizvi, Syed A, Robertson, Derrick, Rodriguez, Jose Martinez, Rog, David, Roshanisefat, Homayoun, Rowe, Vernon, Rozsa, Csilla, Rubin, Susan, Rusek, Stanislaw, Saccà, Francesco, Saida, Takahiko, Salgado, Antonio Vasco, Sanchez, Victoria Eugenia Fernandez, Sanders, Kalina, Satori, Maria, Sazonov, Denis V, Scarpini, Elio Angelo, Schlegel, Eugen, Schluep, Myriam, Schmidt, Stephan, Scholz, Erich, Schrijver, H M, Schwab, Matthias, Schwartz, Raymond, Scott, James, Selmaj, Krzysztof, Shafer, Stuart, Sharrack, Basil, Shchukin, Ivan A, Shimizu, Yuko, Shotekov, Penko, Siever, Arno, Sigel, Karl-Otto, Silliman, Scott, Simo, Magdolna, Simu, Mihaela, Sinay, Vladimiro, Siquier, Antonio Escartin, Siva, Aksel, Skoda, Ondrej, Solomon, Andrew, Stangel, Martin, Stefoski, Dusan, Steingo, Brian, Stolyarov, Igor D, Stourac, Pavel, Strassburger-Krogias, Katrin, Strauss, Erik, Stuve, Olaf, Tarnev, Ivaylo, Tavernarakis, Antonios, Tello, Cristina Ramo, Terzi, Murat, Ticha, Veronika, Ticmeanu, Marina, Tiel-Wilck, Klaus, Toomsoo, Toomas, Tubridy, Niall, Tullman, Mark J, Tumani, Hayrettin, Turcani, Peter, Turner, Ben, Uccelli, Antonio, Urtaza, Francisco Javier Olascoaga, Vachova, Marta, Valikovics, Attila, Walter, Silke, Van Wijmeersch, Bart, Vanopdenbosch, Ludo, Weber, Joerg R, Weiss, Sara, Weissert, Robert, Vermersch, Patrick, West, Timothy, Wiendl, Heinz, Wiertlewski, Sandrine, Wildemann, Brigitte, Willekens, Barbara, Visser, L H, Vorobeychik, Galina, Xu, Xianhao, Yamamura, Takashi, Yang, Yi N, Yelamos, Sergio Martinez, Yeung, Michael, Zacharias, Alan, Zelkowitz, Marvin, Zettl, Uwe, Zhang, Meini, Zhou, Hongyu, Zieman, Ulf, Ziemssen, Tjalf, Kappos, Ludwig, Bar-Or, Amit, Cree, Bruce A C, Fox, Robert J, Giovannoni, Gavin, Gold, Ralf, Arnold, Douglas L, Arnould, Sophie, Scherz, Tatiana, Wolf, Christian, Wallström, Erik, and Dahlke, Frank

Published
2018
Full Text
View/download PDF

11. Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study

Author

Bar-Or, Amit, Wiendl, Heinz, Montalban, Xavier, Alvarez, Enrique, Davydovskaya, Maria, Delgado, Silvia R., Evdoshenko, Evgeniy P., Giedraitiene, Natasa, Gross-Paju, Katrin, Haldre, Sulev, Herrman, Craig E., Izquierdo, Guillermo, Karelis, Guntis, Leutmezer, Fritz, Mares, Miroslav, Meca-Lallana, Jose Eustasio, Mickeviciene, Dalia, Nicholas, Jacqueline, Robertson, Derrick S., Sazonov, Denis V., Sharlin, Kenneth, Sundaram, Bharathy, Totolyan, Natalia, Vachova, Marta, Valis, Martin, Bagger, Morten, Häring, Dieter A., Ludwig, Inga, Willi, Roman, Zalesak, Martin, Su, Wendy, Merschhemke, Martin, Fox, Edward J., Universitat Autònoma de Barcelona, Institut Català de la Salut, [Bar-Or A] Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [Wiendl H] Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Alvarez E] Department of Neurology, Rocky Mountain MS Center, University of Colorado, Aurora, CO, USA. [Davydovskaya M] Pirogov Russian National Research Medical University, Moscow, Russian Federation. [Delgado SR] MS Center and Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Multiple Sclerosis, medicine.drug_class, Injections, Subcutaneous, Otros calificadores::Otros calificadores::/inducido químicamente [Otros calificadores], Phases of clinical research, Esclerosi múltiple, Pharmacology, Bioequivalence, Ofatumumab, Monoclonal antibody, Antibodies, Monoclonal, Humanized, Multiple sclerosis, chemistry.chemical_compound, Pharmacokinetics, autoinjector pen, bioequivalence, multiple sclerosis, pharmacokinetics, pre-filled syringe, medicine, Humans, business.industry, Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES], Antibodies, Monoclonal, Injeccions hipodèrmiques, medicine.disease, Autoinjector pen, B cell depletion, Neurology, chemistry, Pre-filled syringe, Other subheadings::Other subheadings::/chemically induced [Other subheadings], enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES], Neurology (clinical), business, Anticossos monoclonals
Abstract

Ofatumumab; Multiple sclerosis; Pharmacokinetics Ofatumumab; Esclerosis múltiple; Farmacocinética Ofatumumab; Esclerosi múltiple; Farmacocinètica Background: Ofatumumab, the first fully human anti-CD20 monoclonal antibody, is approved in several countries for relapsing multiple sclerosis (RMS). Objective: To demonstrate the bioequivalence of ofatumumab administered by an autoinjector versus a pre-filled syringe (PFS) and to explore the effect of ofatumumab on B-cell depletion. Methods: APLIOS (NCT03560739) is a 12-week, open-label, parallel-group, phase-2 study in patients with RMS receiving subcutaneous ofatumumab 20 mg every 4 weeks (q4w) (from Week 4, after initial doses on Days 1, 7, and 14). Patients were randomized 10:10:1:1 to autoinjector or PFS in the abdomen, or autoinjector or PFS in the thigh, respectively. Bioequivalence was determined by area under the curve (AUCτ) and maximum plasma concentration (Cmax) for Weeks 8–12. B-cell depletion and safety/tolerability were assessed. Results: A total of 256 patients contributed to the bioequivalence analyses (autoinjector-abdomen, n = 128; PFS-abdomen, n = 128). Abdominal ofatumumab pharmacokinetic exposure was bioequivalent for autoinjector and PFS (geometric mean AUCτ, 487.7 vs 474.1 h × µg/mL (ratio 1.03); Cmax, 1.409 vs 1.409 µg/mL (ratio 1.00)). B-cell counts (median cells/µL) depleted rapidly in all groups from 214.0 (baseline) to 2.0 (Day 14). Ofatumumab was well tolerated. Conclusion: Ofatumumab 20 mg q4w self-administered subcutaneously via autoinjector is bioequivalent to PFS administration and provides rapid B-cell depletion. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the APLIOS trial was funded by Novartis Pharmaceuticals. Novartis Pharmaceuticals supported the development of this manuscript, provided data analyses according to the direction of the authors, and paid for medical writing support.

Published
2021

13. The Birth Prevalence of Spinal Muscular Atrophy: A Population Specific Approach in Estonia

Author

Sarv, Siiri, primary, Kahre, Tiina, additional, Vaidla, Eve, additional, Pajusalu, Sander, additional, Muru, Kai, additional, Põder, Haide, additional, Gross-Paju, Katrin, additional, Ütt, Sandra, additional, Žordania, Riina, additional, Talvik, Inga, additional, Õiglane-Shlik, Eve, additional, Muhu, Kristina, additional, and Õunap, Katrin, additional

Published
2021
Full Text
View/download PDF

14. Safety and efficacy of teriflunomide in paediatric multiple sclerosis (TERIKIDS): a multicentre, double-blind, phase 3, randomised, placebo-controlled trial

Author

Chitnis, Tanuja, primary, Banwell, Brenda, additional, Kappos, Ludwig, additional, Arnold, Douglas L, additional, Gücüyener, Kivilcim, additional, Deiva, Kumaran, additional, Skripchenko, Natalia, additional, Cui, Li-Ying, additional, Saubadu, Stephane, additional, Hu, Wenruo, additional, Benamor, Myriam, additional, Le-Halpere, Annaig, additional, Truffinet, Philippe, additional, Tardieu, Marc, additional, Dubois, Benedicte, additional, Verhelst, Helene, additional, Bojinova-Tchamova, Veneta, additional, Mah, Jean, additional, Fang, Fang, additional, Hao, Yunpeng, additional, Jiang, Li, additional, Li, Ling, additional, Mao, Ding'An, additional, Qiu, Wei, additional, Tan, Guojun, additional, Wu, Ye, additional, Zhang, Meini, additional, Zhou, Hongyu, additional, Zhou, Shuizhen, additional, Gross-Paju, Katrin, additional, Cheuret, Emmanuel, additional, Edan, Giles, additional, Vukusic, Sandra, additional, Chrousos, George, additional, Zafeiriou, Dimitrios, additional, Achiron, Anat, additional, Vaknin-Dembinsky, Adi, additional, Yamout, Bassem, additional, Laurynaitiene, Jurate, additional, Vaiciene-Magistris, Nerija, additional, Bojkovski, Vladimir, additional, Trajkova, Vesna, additional, Chaouki, Sana, additional, Kissani, Najib, additional, Neuteboom, Rinze, additional, Palavra, Filipe, additional, Belova, Anna, additional, Boyko, Alexey, additional, Evdoshenko, Evgeny, additional, Kairbekova, Ekaterina, additional, Malkova, Nadezhda, additional, Shumilina, Maria, additional, Skripchenko, Natalya, additional, Nikolic, Dimitrije, additional, Meca-Lallana, Jose, additional, Triki, Chahnez Charfi, additional, Chokri, Mhiri, additional, Gouider, Riadh, additional, Anlar, Banu, additional, Hiz, Ayse Semra, additional, Idiman, Egemen, additional, Turkoglu, Recai, additional, Yapici, Zuhal, additional, Yilmaz, Unsal, additional, Tantsura, Lyudmyla, additional, Voloshyna, Nataliia, additional, Lim, Ming, additional, Wassmer, Evangeline, additional, Cascione, Mark, additional, Chitnis, Tanuja, additional, LaGanke, Christopher, additional, Rathke, Kevin, additional, and Scagnelli, John, additional

Published
2021
Full Text
View/download PDF

17. Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

Author

Nogueira, Raul, Qureshi, Muhammad, Abdalkader, Mohamad, Martins, Sheila Ouriques, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama Yassin, Sathya, Anvitha, Czlonkowska, Anna, Tsivgoulis, Georgios, Aguiar de Sousa, Diana, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Kõrv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine Anne, Turan, Tanya, Ntaios, George, Malhotra, Konark, Tayal, Ashis, Loochtan, Aaron, Ranta, Annamarei, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Mohammaden, Mahmoud, Frankel, Michael, Bila Lamou, Eric Guemekane, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Menecie, Tarek, Mustafa, Wessam, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred, Alabi, Tolulope Oyetunde, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole, Yaria, Joseph, Mohammed, Haytham Hussein, Adebayo, Philip, Riahi, Anis, Sassi, Samia Ben, Gwaunza, Lenon, Ngwende, Gift Wilson, Sahakyan, David, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj Durai, Sylaja, Pn, Usman, Fritz Sumantri, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Horev, Anat, Reznik, Anna, Sivan Hoffmann, Rotem, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Kondybayeva, Aida, Faizullina, Kamila, Kamenova, Saltanat, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Jin Soo, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Sohn, Sung Il, Young, Chang Jun, Ahdab, Rechdi, Wan Zaidi, Wan Asyraf, Aziz, Zariah Abdul, Basri, Hamidon Bin, Chung, Law Wan, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yahia Zakaria, Akhtar, Naveed, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Venketasubramanian, Narayanaswamy, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Akil, Esref, Aykaç, Özlem, Ozdemir, Atilla Ozcan, Giray, Semih, Hussain, Syed Irteza, John, Seby, Le Vu, Huynh, Tran, Anh Duc, Nguyen, Huy Hoang, Nhu Pham, Thong, Nguyen, Thang Huy, Nguyen, Trung Quoc, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, de Blauwe, Sofie, Vanhooren, Geert, de Raedt, Sylvie, Dusart, Anne, Lemmens, Robin, Ligot, Noemie, Pierre Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedeković, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, František, Karpowic, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Daniel, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henryk, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurák, Lubomír, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Krarup Christensen, Hanne, Drenck, Nicolas, Klingenberg Iversen, Helle, Simonsen, Claus, Truelsen, Thomas Clement, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emilie, Ondze, Basile, Peres, Roxane, Pico, Fernando, Piotin, Michel, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nino, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Götz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Klivenyi, Peter, Szapary, Laszlo, Tarkanyi, Gabor, Adami, Alessandro, Bandini, Fabio, Calabresi, Paolo, Frisullo, Giovanni, Renieri, Leonardo, Sangalli, Davide, Pirson, Anne, Uyttenboogaart, Maarten, van den Wijngaard, Ido, Kristoffersen, Espen Saxhaug, Brola, Waldemar, Fudala, Małgorzata, Horoch-Lyszczarek, Ewa, Karlinski, Michal, Kazmierski, Radoslaw, Kram, Pawel, Rogoziewicz, Marcin, Kaczorowski, Rafal, Luchowski, Piotr, Sienkiewicz-Jarosz, Halina, Sobolewski, Piotr, Fryze, Waldemar, Wisniewska, Anna, Wiszniewska, Malgorzata, Ferreira, Patricia, Ferreira, Paulo, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Nunes, Ana Paiva, Rodrigues, Miguel, Tedim Cruz, Vítor, Falup-Pecurariu, Cristian, Krastev, Georgi, Mako, Miroslav, de Leciñana, María Alonso, Arenillas, Juan, Ayo-Martin, Oscar, Cruz Culebras, Antonio, Tejedor, Exuperio Diez, Montaner, Joan, Pérez-Sánchez, Soledad, Tola Arribas, Miguel Angel, Rodriguez Vasquez, Alejandro, Mayza, Michael, Bernava, Gianmarco, Brehm, Alex, Machi, Paolo, Fischer, Urs, Gralla, Jan, Michel, Patrik, Psychogios, Marios-Nikos, Strambo, Davide, Banerjee, Soma, Krishnan, Kailash, Kwan, Joseph, Butt, Asif, Catanese, Luciana, Demchuk, Andrew, Field, Thalia, Haynes, Jennifer, Hill, Michael, Khosravani, Houman, Mackey, Ariane, Pikula, Aleksandra, Saposnik, Gustavo, Scott, Courtney Anne, Shoamanesh, Ashkan, Shuaib, Ashfaq, Yip, Samuel, Barboza, Miguel, Barrientos, Jose Domingo, Portillo Rivera, Ligia Ibeth, Gongora-Rivera, Fernando, Novarro-Escudero, Nelson, Blanco, Anmylene, Abraham, Michael, Alsbrook, Diana, Altschul, Dorothea, Alvarado-Ortiz, Anthony, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Brereton, Charmaine, Castonguay, Alicia, Chaturvedi, Seemant, Chaudry, Saqib, Choe, Hana, Choi, Jae, Dharmadhikari, Sushrut, Desai, Kinjal, Devlin, Thomas, Doss, Vinodh, Edgell, Randall, Etherton, Mark, Farooqui, Mudassir, Frei, Don, Gandhi, Dheeraj, Grigoryan, Mikayel, Gupta, Rishi, Hassan, Ameer, Helenius, Johanna, Kaliaev, Artem, Kaushal, Ritesh, Khandelwal, Priyank, Khawaja, Ayaz, Khoury, Naim, Kim, Benny, Kleindorfer, Dawn, Koyfman, Feliks, Lee, Vivien, Leung, Lester, Linares, Guillermo, Linfante, Italo, Lutsep, Helmi, Macdougall, Lisa, Male, Shailesh, Malik, Amer, Masoud, Hesham, Mcdermott, Molly, Mehta, Brijesh, Min, Jiangyong, Mittal, Manoj, Morris, Jane, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Nguyen, Claude, Novakovic-White, Roberta, Ortega-Gutierrez, Santiago, Rahangdale, Rahul, Ramakrishnan, Pankajavalli, Romero, Jose Rafael, Rost, Natalia, Rothstein, Aaron, Ruland, Sean, Shah, Ruchir, Sharma, Malveeka, Silver, Brian, Simmons, Marc, Singh, Abhishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Voetsch, Barbara, Balaguera, Oscar, Pujol Lereis, Virginia, Luraschi, Adriana, Almeida, Marcele Schettini, Cardoso, Fabricio Buchdid, Conforto, Adriana, de Deus Silva, Leonardo, Varrone Giacomini, Luidia, Oliveira Lima, Fabricio, Longo, Alexandre, Magalhães, Pedro, Martins, Rodrigo Targa, Mont'Alverne, Francisco, Mora Cuervo, Daissy Liliana, Costa Rebello, Leticia, Valler, Lenise, Zetola, Viviane Flumignan, Lavados, Pablo, Navia, Victor, Olavarría, Verónica, Almeida Toro, Juan Manuel, Amaya, Pablo Felipe Ricardo, Bayona, Hernan, Corredor, Angel, Rivera Ordonez, Carlos Eduardo, Mantilla Barbosa, Diana Katherine, Lara, Osvaldo, Patiño, Mauricio, Diaz Escobar, Luis Fernando, Dejesus Melgarejo Fariña, Donoband Edson, Cardozo Villamayor, Analia, Zelaya Zarza, Adolfo Javier, Barrientos Iman, Danny Moises, Rodriguez Kadota, Liliana, Campbell, Bruce, Hankey, Graeme, Hair, Casey, Kleinig, Timothy, Ma, Alice, Tomazini Martins, Rodrigo, Sahathevan, Ramesh, Thijs, Vincent, Salazar, Daniel, Yuan-Hao Wu, Teddy, Haussen, Diogo, Liebeskind, David, Yavagal, Dileep, Jovin, Tudor, Zaidat, Osama, Nguyen, Thanh, Magalhães, Pedro S.C., Emory University School of Medicine, Emory University [Atlanta, GA], Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Max Super Speciality Hospital -Saket [New Delhi, Inde] (Max Saket), Dupuis, Christine, Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, MESH: Pandemics, HSJ NEU, Cross-sectional study, medicine.medical_treatment, [SDV]Life Sciences [q-bio], SVIN COVID-19 Global Stroke Registry, MESH: Hospitalization, 030204 cardiovascular system & hematology, Article, MESH: Stroke, COVID-19, cross-sectional studies, hospitalization, humans, pandemics, retrospective studies, SARS-CoV-2, stroke, 03 medical and health sciences, 0302 clinical medicine, MESH: Cross-Sectional Studies, Pandemic, Medicine, Humans, MESH: COVID-19, Thrombolytic Therapy, MESH: SARS-CoV-2, Stroke, Pandemics, Retrospective Studies, MESH: Thrombolytic Therapy, Rehabilitation, MESH: Humans, business.industry, Retrospective cohort study, MESH: Retrospective Studies, medicine.disease, Thrombolysis, Confidence interval, 3. Good health, Hospitalization, [SDV] Life Sciences [q-bio], Clinical research, Cross-Sectional Studies, Emergency medicine, Observational study, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

© 2021 American Academy of Neurology, Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, p < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI -13.8 to -12.7, p < 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI -13.7 to -10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2-9.8, p < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. Conclusions: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.

Published
2021
Full Text
View/download PDF

18. Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial

Author

Reich, Daniel S, primary, Arnold, Douglas L, additional, Vermersch, Patrick, additional, Bar-Or, Amit, additional, Fox, Robert J, additional, Matta, Andre, additional, Turner, Timothy, additional, Wallström, Erik, additional, Zhang, Xinyan, additional, Mareš, Miroslav, additional, Khabirov, Farit A, additional, Traboulsee, Anthony, additional, Grand'Maison, Francois, additional, Jacques, Francois, additional, Tyblova, Michaela, additional, Meluzinova, Eva, additional, Ampapa, Radek, additional, Valis, Martin, additional, Hradilke, Pavel, additional, Stourac, Pavel, additional, Gross-Paju, Katrin, additional, Laplaud, David, additional, Mathey, Guillaume, additional, Uitdehaag, Bernard, additional, Evdoshenkoo, Evgeny, additional, Popova, Ekaterina, additional, Zakharova, Maria, additional, Totolyan, Natalia, additional, Litvinenko, Igor, additional, Khabirov, Farit, additional, Sivertseva, Stella, additional, Hancinova, Viera, additional, Kantorova, Ema, additional, Gines, Maria Luisa Martinez, additional, Montalban, Xavier, additional, Maduano, Sara Eichau, additional, Meca-Lallana, Jose, additional, Ramió-Torrentà, Lluís, additional, Nehrych, Tetyanna, additional, Pashkovskyy, Valeriy, additional, Moskovko, Sergii, additional, Kalbus, Oleksandr, additional, Khavunka, Marta, additional, Pryshchepa, Volodymyr, additional, Goloborodko, Alla, additional, Wynn, Daniel, additional, Honeycutt, William, additional, Wray, Sibyl, additional, Steingo, Brian, additional, LaGanke, Christopher, additional, Huang, Deren, additional, Hemphill, John Michael, additional, Goldstick, Lawrence, additional, and Robertson, Derrick, additional

Published
2021
Full Text
View/download PDF

19. sj-docx-1-msj-10.1177_13524585211044479 – Supplemental material for Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study

Author

Bar-Or, Amit, Wiendl, Heinz, Montalban, Xavier, Alvarez, Enrique, Davydovskaya, Maria, Delgado, Silvia R, Evdoshenko, Evgeniy P, Giedraitiene, Natasa, Gross-Paju, Katrin, Haldre, Sulev, Herrman, Craig E, Izquierdo, Guillermo, Karelis, Guntis, Leutmezer, Fritz, Mares, Miroslav, Meca-Lallana, Jose E, Mickeviciene, Dalia, Nicholas, Jacqueline, Robertson, Derrick S, Sazonov, Denis V, Sharlin, Kenneth, Sundaram, Bharathy, Totolyan, Natalia, Vachova, Marta, Valis, Martin, Bagger, Morten, Häring, Dieter A, Ludwig, Inga, Willi, Roman, Zalesak, Martin, Su, Wendy, Merschhemke, Martin, and Fox, Edward J

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585211044479 for Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study by Amit Bar-Or, Heinz Wiendl, Xavier Montalban, Enrique Alvarez, Maria Davydovskaya, Silvia R Delgado, Evgeniy P Evdoshenko, Natasa Giedraitiene, Katrin Gross-Paju, Sulev Haldre, Craig E Herrman, Guillermo Izquierdo, Guntis Karelis, Fritz Leutmezer, Miroslav Mares, Jose E Meca-Lallana, Dalia Mickeviciene, Jacqueline Nicholas, Derrick S Robertson, Denis V Sazonov, Kenneth Sharlin, Bharathy Sundaram, Natalia Totolyan, Marta Vachova, Martin Valis, Morten Bagger, Dieter A Häring, Inga Ludwig, Roman Willi, Martin Zalesak, Wendy Su, Martin Merschhemke and Edward J Fox in Multiple Sclerosis Journal

Published
2021
Full Text
View/download PDF

20. Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis

Author

Nogueira, Raul G, Qureshi, Muhammed M, Abdalkader, Mohamad, Martins, Sheila Ouriques, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama Yassin, Sathya, Anvitha, Czlonkowska, Anna, Tsivgoulis, Georgios, Aguiar de Sousa, Diana, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James E, Kõrv, Janika, Biller, Jose, Liang, Conrad W, Sangha, Navdeep S, Zha, Alicia M, Czap, Alexandra L, Holmstedt, Christine Anne, Turan, Tanya N, Ntaios, George, Malhotra, Konark, Tayal, Ashis, Loochtan, Aaron, Ranta, Annamarei, Mistry, Eva A, Alexandrov, Anne W, Huang, David Y, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil A, Mohammaden, Mahmoud H, Frankel, Michael, Bila Lamou, Eric Guemekane, Aref, Hany M, Elbassiouny, Ahmed, Hassan, Farouk, Menecie, Tarek, Mustafa, Wessam, Shokri, Hossam M, Roushdy, Tamer, Sarfo, Fred S, Alabi, Tolulope Oyetunde, Arabambi, Babawale, Nwazor, Ernest O, Sunmonu, Taofiki Ajao, Wahab, Kolawole, Yaria, Joseph, Mohammed, Haytham Hussein, Adebayo, Philip B, Riahi, Anis D, Ben Sassi, Samia, Gwaunza, Lenon, Ngwende, Gift Wilson, Sahakyan, David, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas W, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj Durai, Sylaja, P N, Usman, Fritz Sumantri, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Horev, Anat, Reznik, Anna, Hoffmann, Rotem Sivan, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Kondybayeva, Aida, Faizullina, Kamila, Kamenova, Saltanat, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Jin Soo, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Sohn, Sung Il, Young, Chang Jun, Ahdab, Rechdi, Wan Zaidi, Wan Asyraf, Aziz, Zariah Abdul, Basri, Hamidon Bin, Chung, Law Wan, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal M, Imam, Yahia Zakaria, Akhtar, Naveed, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Venketasubramanian, Narayanaswamy, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Akil, Esref, Aykaç, Ozlem, Ozdemir, Atilla Ozcan, Giray, Semih, Hussain, Syed Irteza, John, Seby, Le Vu, Huynh, Tran, Anh Duc, Nguyen, Huy Hoang, Pham, Thong Nhu, Nguyen, Thang Huy, Nguyen, Trung Quoc, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Vanhooren, Geert, De Raedt, Sylvie, Dusart, Anne, Lemmens, Robin, Ligot, Noemie, Rutgers, Matthieu Pierre, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedeković, Marina Roje, Budincevic, Hrvoje, Cindrić, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantiek, Karpowic, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Daniel, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henryk, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurák, Lubomír, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle Klingenberg, Simonsen, Claus Z, Truelsen, Thomas Clement, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emilie, Ondze, Basile, Peres, Roxane, Pico, Fernando, Piotin, Michel, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nino, Tsikaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Götz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Klivenyi, Peter, Szapary, Laszlo, Tarkanyi, Gabor, Adami, Alessandro, Bandini, Fabio, Calabresi, Paolo, Frisullo, Giovanni, Renieri, Leonardo, Sangalli, Davide, Pirson, Anne V, Uyttenboogaart, Maarten, van den Wijngaard, Ido, Kristoffersen, Espen Saxhaug, Brola, Waldemar, Fudala, Małgorzata, Horoch-Lyszczarek, Ewa, Karlinski, Michal, Kazmierski, Radoslaw, Kram, Pawel, Rogoziewicz, Marcin, Kaczorowski, Rafal, Luchowski, Piotr, Sienkiewicz-Jarosz, Halina, Sobolewski, Piotr, Fryze, Waldemar, Wisniewska, Anna, Wiszniewska, Malgorzata, Ferreira, Patricia, Ferreira, Paulo, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Nunes, Ana Paiva, Rodrigues, Miguel, Cruz, Vítor Tedim, Falup-Pecurariu, Cristian, Krastev, Georgi, Mako, Miroslav, Alonso de Leciñana, María, Arenillas, Juan F, Ayo-Martin, Oscar, Culebras, Antonio Cruz, Tejedor, Exuperio Diez, Montaner, Joan, Pérez-Sánchez, Soledad, Tola Arribas, Miguel Angel, Vasquez, Alejandro Rodriguez, Mazya, Michael, Bernava, Gianmarco, Brehm, Alex, Machi, Paolo, Fischer, Urs, Gralla, Jan, Michel, Patrik L, Psychogios, Marios-Nikos, Strambo, Davide, Banerjee, Soma, Krishnan, Kailash, Kwan, Joseph, Butt, Asif, Catanese, Luciana, Demchuk, Andrew, Field, Thalia, Haynes, Jennifer, Hill, Michael D, Khosravani, Houman, Mackey, Ariane, Pikula, Aleksandra, Saposnik, Gustavo, Scott, Courtney Anne, Shoamanesh, Ashkan, Shuaib, Ashfaq, Yip, Samuel, Barboza, Miguel A, Barrientos, Jose Domingo, Portillo Rivera, Ligia Ibeth, Gongora-Rivera, Fernando, Novarro-Escudero, Nelson, Blanco, Anmylene, Abraham, Michael, Alsbrook, Diana, Altschul, Dorothea, Alvarado-Ortiz, Anthony J, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Brereton, Charmaine, Castonguay, Alicia, Chaturvedi, Seemant, Chaudhry, Saqib A, Choe, Hana, Choi, Jae H, Dharmadhikari, Sushrut, Desai, Kinjal, Devlin, Thomas G, Doss, Vinodh T, Edgell, Randall, Etherton, Mark, Farooqui, Mudassir, Frei, Don, Gandhi, Dheeraj, Grigoryan, Mikayel, Gupta, Rishi, Hassan, Ameer E, Helenius, Johanna, Kaliaev, Artem, Kaushal, Ritesh, Khandelwal, Priyank, Khawaja, Ayaz M, Khoury, Naim N, Kim, Benny S, Kleindorfer, Dawn O, Koyfman, Feliks, Lee, Vivien H, Leung, Lester Y, Linares, Guillermo, Linfante, Italo, Lutsep, Helmi L, Macdougall, Lisa, Male, Shailesh, Malik, Amer, Masoud, Hesham, McDermott, Molly, Mehta, Brijesh P, Min, Jiangyong, Mittal, Manoj, Morris, Jane G, Multani, Sumeet S, Nahab, Fadi, Nalleballe, Krishna, Nguyen, Claude B, Novakovic-White, Roberta, Ortega-Gutierrez, Santiago, Rahangdale, Rahul H, Ramakrishnan, Pankajavalli, Romero, Jose Rafael, Rost, Natalia, Rothstein, Aaron, Ruland, Sean, Shah, Ruchir, Sharma, Malveeka, Silver, Brian, Simmons, Marc, Singh, Abhishek, Starosciak, Amy K, Strasser, Sheryl L, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny P, Voetsch, Barbara, Balaguera, Oscar, Pujol Lereis, Virginia A, Luraschi, Adriana, Almeida, Marcele Schettini, Cardoso, Fabricio Buchdid, Conforto, Adriana, De Deus Silva, Leonardo, Giacomini, Luidia Varrone, Lima, Fabricio Oliveira, Longo, Alexandre L, Magalhães, Pedro Sc, Martins, Rodrigo Targa, Mont'alverne, Francisco, Mora Cuervo, Daissy Liliana, Rebello, Leticia Costa, Valler, Lenise, Zetola, Viviane Flumignan, Lavados, Pablo M, Navia, Victor, Olavarría, Verónica V, Almeida Toro, Juan Manuel, Ricardo Amaya, Pablo Felipe, Bayona, Hernan, Corredor-Quintero, Angel Basilio, Rivera Ordonez, Carlos Eduardo, Mantilla Barbosa, Diana Katherine, Lara, Osvaldo, Patiño, Mauricio R, Diaz Escobar, Luis Fernando, Dejesus Melgarejo Farina, Donoband Edson, Villamayor, Analia Cardozo, Zelaya Zarza, Adolfo Javier, Barrientos Iman, Danny Moises, Kadota, Liliana Rodriguez, Campbell, Bruce, Hankey, Graeme J, Hair, Casey, Kleinig, Timothy, Ma, Alice, Martins, Rodrigo Tomazini, Sahathevan, Ramesh, Thijs, Vincent, Salazar, Daniel, Yuan-Hao Wu, Teddy, Haussen, Diogo C, Liebeskind, David, Yavagal, Dileep, Jovin, Tudor G, Zaidat, Osama O, and Nguyen, Thanh N

Subjects
610 Medicine & health
Abstract

OBJECTIVE The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. METHODS We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases. RESULTS There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p

Published
2021
Full Text
View/download PDF

21. Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis

Author

Thanh Nguyen, Phuong, Qureshi, Muhammad, Martins, Sheila, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama, Czlonkowska, Anna, Abdalkader, Mohamad, Sathya, Anvitha, de Sousa, Diana Aguiar, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Korv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine, Turan, Tanya, Grant, Cheryl, Ntaios, George, Malhotra, Konard, Tayal, Ashis, Loochtan, Aaron, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Frankel, Michael, Lamou, Eric Gueumekane Bila, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Mustafa, Wessam, Menecie, Tarek, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred Stephen, Alabi, Tolulope, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole W., Mohammed, Haythem Hussein, Adebayo, Philip B., Riahi, Anis, Ben Sassi, Samia, Gwaunza, Lenon, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas K., Sahakyan, David, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj, Sylaja, P. N., Usman, Fritz Sumantri, Farhoudi, Mehdi, Sadeghi-Hokmabadi, Elyar, Reznik, Anna, Sivan-Hoffman, Rotem, Horev, Anat, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshika, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonodda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Faizullina, Kamila, Kamenova, Saltanat, Kondybayeva, Aida, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Young, Chang Jun, Ahdab, Rechdi, Aziz, Zariah Abdul, Zaidi, Wan Asyraf Wan, Bin Basri, Hamidon, Chung, Law Wan, Husin, Mazlina, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Wan Nur Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yehai Z., Akhtar, Naveed, Oliver, Christian, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Narayanaswamy, Ram, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ozcan, Hussain, Syed Irteza, John, Seby, Huynh Le Vu, Anh Duc Tran, Huy Hoang Nguyen, Pham Nhu Thong, Nguyen, Thang, Nguyen, Trung, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Van Hooren, Geert, De Raedt, Sylvie, Dusart, Anne, Ligot, Noemie, Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedekovic, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantisek, Karpowicz, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Dan, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henry, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurak, Lubomir, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle, Simonsen, Claus, Truelsen, Thomas, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emillie, Ondze, Basile, Pico, Fernando, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nina, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Gotz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Kaliaev, Artem, Liebeskind, David, Hassan, Ameer, Ranta, Anna, Devlin, Thomas, Zaidat, Osama, Castonguay, Alicia, Jovin, Tudor, Tsivgoulis, Georgios, Malik, Amer, Ma, Alice, Campbell, Bruce, Kleinig, Timothy, Wu, Teddy, Gongora, Fernando, Lavados, Pablo, Olavarria, Veronica, Lereis, Virginia Pujol, Corredor, Angel, Barbosa, Diana Mantilla, Bayona, Hernan, Barrientos, Jose Domingo, Patino, Mauricio, Thijs, Vincent, Pirson, Anne, Kristoffersen, Espen Saxhaug, Patrik, Michel, Fischer, Urs, Bernava, Gianmarco, Renieri, Leonardo, Strambo, Davide, Ayo-Martin, Oscar, Montaner, Joan, Karlinski, Michal, Cruz-Culebras, Antonio, Luchowski, Piotr, Krastev, Georgi, Arenillas, Juan, Gralla, Jan, Mangiafico, Salvatore, Blasco, Jordi, Fonseca, Luisa, Silva, M. Luis, Kwan, Joseph, Banerjee, Soma, Sangalli, Davide, Frisullo, Giovanni, Yavagal, Dileep, Uyttenboogaart, Maarten, Bandini, Fabio, Adami, Alessandro, de Lecina, Maria Alonso, Arribas, Miguel Angel Tola, Ferreira, Paulo, Cruz, Vitor Tedim, Nunes, Ana Paiva, Marto, Joao Pedro, Rodrigues, Miguel, Melo, Teresa, Saposnik, Gustavo, Scott, Courtney Anne, Shuaib, Ashfaq, Khosravani, Houman, Fields, Thalia, Shoamanesh, Ashkan, Catanese, Luciana, Mackey, Ariane, Hill, Michael, Etherton, Mark, Rost, Natalia, Lutsep, Helmi, Lee, Vivien, Mehta, Brijesh, Pikula, Aleksandra, Simmons, Marc, Macdougall, Lisa, Silver, Brian, Khandelwal, Priyank, Morris, Jane, Novakovic-White, Roberta, Ramakrishnan, Pankajavalli, Shah, Ruchir, Altschul, Dorothea, Almufti, Fawaz, Amaya, Pablo, Ordonez, Carlos Eduardo Rivera, Lara, Osvalda, Kadota, Liliana Rodriguez, Rivera, Ligia Ibeth Portillo, Novarro, Nelson, Escobar, Luis Diaz, Melgarejo, Donoband, Cardozo, Analia, Blanco, Anmylene, Zelaya, Javier Adolfo, Luraschi, Adriana, Gonzalez, Victor Hugo Navia, Almeida, Juan, Conforto, Adriana, Almeida, Marcele Schettini, Silva, Leonardo de Deus, Cuervo, Daissy Liliana Mora, Zetola, Viviane Flumignan, Martins, Rodrigo Targa, Valler, Lenise, Giacomini, Luidia Varrone, Cardoso, Fabricio Buchdid, Sahathevan, Ramesh, Hair, Casey, Hankey, Graeme, Salazar, Daniel, Lima, Fabricio Oliveira, Mont'Alverne, Francisco, Moises, Danny, Iman, Barrientos, Magalhaes, Pedro, Longo, Alexandre, Rebello, Leticia, Falup-Pecurariu, Cristian, Mazya, Michael, Wisniewska, Anna, Fryze, Waldemar, Kazmierski, Radoslaw, Wisniewska, Malgorzata, Horoch, Ewa, Sienkiewicz-Jarosz, Halina, Fudala, Malgorzata, Rogoziewicz, Marcin, Brola, Waldemar, Sobolewski, Piotr, Kaczorowski, Rafal, Stepien, Adam, Klivenyi, Peter, Szapary, Laszlo, van den Wijngaard, Ido, Demchuk, Andrew, Abraham, Michael, Alvarado-Ortiz, Tony, Kaushal, Ritesh, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Nguyen, Claude, Brereton, Charmaine, Choi, Jae H., Dharmadhikari, Sushrut, Desai, Kinjal, Doss, Vinodh, Edgell, Randall, Linares, Guillermo, Frei, Donald, Chaturvedi, Seemant, Gandhi, Dheeraj, Chaudhry, Saqib, Choe, Hana, Grigoryan, Mikayel, Gupta, Rishi, Helenius, Johanna, Voetsch, Barbara, Khwaja, Ayaz, Khoury, Naim, Kim, Benny S., Kleindorfer, Dawn, McDermott, Molly, Koyfman, Feliks, Leung, Lester, Linfante, Italo, Male, Shailesh, Masoud, Hesham, Min, Jiangyong, Mittal, Manoj, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Rahangdale, Rahul, Rafael, Jose, Rothstein, Aaron, Ruland, Sean, Sharma, Malveeka, Singh, Abishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Mohammaden, Mahmoud, Pineda-Franks, Carissa, Asyraf, Wan, Trung Quoch Nguyen, Tarkanyi, Gabor, Haussen, Diogo, Balaguera, Oscar, Vasquez, Alejandro Rodriguez, Nogueira, Raul, Thanh Nguyen, Phuong, Qureshi, Muhammad, Martins, Sheila, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama, Czlonkowska, Anna, Abdalkader, Mohamad, Sathya, Anvitha, de Sousa, Diana Aguiar, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Korv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine, Turan, Tanya, Grant, Cheryl, Ntaios, George, Malhotra, Konard, Tayal, Ashis, Loochtan, Aaron, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Frankel, Michael, Lamou, Eric Gueumekane Bila, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Mustafa, Wessam, Menecie, Tarek, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred Stephen, Alabi, Tolulope, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole W., Mohammed, Haythem Hussein, Adebayo, Philip B., Riahi, Anis, Ben Sassi, Samia, Gwaunza, Lenon, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas K., Sahakyan, David, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj, Sylaja, P. N., Usman, Fritz Sumantri, Farhoudi, Mehdi, Sadeghi-Hokmabadi, Elyar, Reznik, Anna, Sivan-Hoffman, Rotem, Horev, Anat, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshika, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonodda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Faizullina, Kamila, Kamenova, Saltanat, Kondybayeva, Aida, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Young, Chang Jun, Ahdab, Rechdi, Aziz, Zariah Abdul, Zaidi, Wan Asyraf Wan, Bin Basri, Hamidon, Chung, Law Wan, Husin, Mazlina, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Wan Nur Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yehai Z., Akhtar, Naveed, Oliver, Christian, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Narayanaswamy, Ram, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ozcan, Hussain, Syed Irteza, John, Seby, Huynh Le Vu, Anh Duc Tran, Huy Hoang Nguyen, Pham Nhu Thong, Nguyen, Thang, Nguyen, Trung, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Van Hooren, Geert, De Raedt, Sylvie, Dusart, Anne, Ligot, Noemie, Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedekovic, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantisek, Karpowicz, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Dan, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henry, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurak, Lubomir, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle, Simonsen, Claus, Truelsen, Thomas, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emillie, Ondze, Basile, Pico, Fernando, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nina, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Gotz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Kaliaev, Artem, Liebeskind, David, Hassan, Ameer, Ranta, Anna, Devlin, Thomas, Zaidat, Osama, Castonguay, Alicia, Jovin, Tudor, Tsivgoulis, Georgios, Malik, Amer, Ma, Alice, Campbell, Bruce, Kleinig, Timothy, Wu, Teddy, Gongora, Fernando, Lavados, Pablo, Olavarria, Veronica, Lereis, Virginia Pujol, Corredor, Angel, Barbosa, Diana Mantilla, Bayona, Hernan, Barrientos, Jose Domingo, Patino, Mauricio, Thijs, Vincent, Pirson, Anne, Kristoffersen, Espen Saxhaug, Patrik, Michel, Fischer, Urs, Bernava, Gianmarco, Renieri, Leonardo, Strambo, Davide, Ayo-Martin, Oscar, Montaner, Joan, Karlinski, Michal, Cruz-Culebras, Antonio, Luchowski, Piotr, Krastev, Georgi, Arenillas, Juan, Gralla, Jan, Mangiafico, Salvatore, Blasco, Jordi, Fonseca, Luisa, Silva, M. Luis, Kwan, Joseph, Banerjee, Soma, Sangalli, Davide, Frisullo, Giovanni, Yavagal, Dileep, Uyttenboogaart, Maarten, Bandini, Fabio, Adami, Alessandro, de Lecina, Maria Alonso, Arribas, Miguel Angel Tola, Ferreira, Paulo, Cruz, Vitor Tedim, Nunes, Ana Paiva, Marto, Joao Pedro, Rodrigues, Miguel, Melo, Teresa, Saposnik, Gustavo, Scott, Courtney Anne, Shuaib, Ashfaq, Khosravani, Houman, Fields, Thalia, Shoamanesh, Ashkan, Catanese, Luciana, Mackey, Ariane, Hill, Michael, Etherton, Mark, Rost, Natalia, Lutsep, Helmi, Lee, Vivien, Mehta, Brijesh, Pikula, Aleksandra, Simmons, Marc, Macdougall, Lisa, Silver, Brian, Khandelwal, Priyank, Morris, Jane, Novakovic-White, Roberta, Ramakrishnan, Pankajavalli, Shah, Ruchir, Altschul, Dorothea, Almufti, Fawaz, Amaya, Pablo, Ordonez, Carlos Eduardo Rivera, Lara, Osvalda, Kadota, Liliana Rodriguez, Rivera, Ligia Ibeth Portillo, Novarro, Nelson, Escobar, Luis Diaz, Melgarejo, Donoband, Cardozo, Analia, Blanco, Anmylene, Zelaya, Javier Adolfo, Luraschi, Adriana, Gonzalez, Victor Hugo Navia, Almeida, Juan, Conforto, Adriana, Almeida, Marcele Schettini, Silva, Leonardo de Deus, Cuervo, Daissy Liliana Mora, Zetola, Viviane Flumignan, Martins, Rodrigo Targa, Valler, Lenise, Giacomini, Luidia Varrone, Cardoso, Fabricio Buchdid, Sahathevan, Ramesh, Hair, Casey, Hankey, Graeme, Salazar, Daniel, Lima, Fabricio Oliveira, Mont'Alverne, Francisco, Moises, Danny, Iman, Barrientos, Magalhaes, Pedro, Longo, Alexandre, Rebello, Leticia, Falup-Pecurariu, Cristian, Mazya, Michael, Wisniewska, Anna, Fryze, Waldemar, Kazmierski, Radoslaw, Wisniewska, Malgorzata, Horoch, Ewa, Sienkiewicz-Jarosz, Halina, Fudala, Malgorzata, Rogoziewicz, Marcin, Brola, Waldemar, Sobolewski, Piotr, Kaczorowski, Rafal, Stepien, Adam, Klivenyi, Peter, Szapary, Laszlo, van den Wijngaard, Ido, Demchuk, Andrew, Abraham, Michael, Alvarado-Ortiz, Tony, Kaushal, Ritesh, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Nguyen, Claude, Brereton, Charmaine, Choi, Jae H., Dharmadhikari, Sushrut, Desai, Kinjal, Doss, Vinodh, Edgell, Randall, Linares, Guillermo, Frei, Donald, Chaturvedi, Seemant, Gandhi, Dheeraj, Chaudhry, Saqib, Choe, Hana, Grigoryan, Mikayel, Gupta, Rishi, Helenius, Johanna, Voetsch, Barbara, Khwaja, Ayaz, Khoury, Naim, Kim, Benny S., Kleindorfer, Dawn, McDermott, Molly, Koyfman, Feliks, Leung, Lester, Linfante, Italo, Male, Shailesh, Masoud, Hesham, Min, Jiangyong, Mittal, Manoj, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Rahangdale, Rahul, Rafael, Jose, Rothstein, Aaron, Ruland, Sean, Sharma, Malveeka, Singh, Abishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Mohammaden, Mahmoud, Pineda-Franks, Carissa, Asyraf, Wan, Trung Quoch Nguyen, Tarkanyi, Gabor, Haussen, Diogo, Balaguera, Oscar, Vasquez, Alejandro Rodriguez, and Nogueira, Raul

Published
2021

22. Bladder dysfunction in hereditary spastic paraplegia: what to expect?

Author

Braschinsky, Mark, Zopp, Inga, Kals, Mart, Haldre, Sulev, and Gross-Paju, Katrin

Subjects
Paralysis, Spastic -- Genetic aspects, Paralysis, Spastic -- Complications and side effects, Paralysis, Spastic -- Research, Urinary incontinence -- Genetic aspects, Urinary incontinence -- Development and progression, Urinary incontinence -- Research, Health, Psychology and mental health
Published
2010

23. Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis (1462)

Author

Nguyen, Thanh, primary, Qureshi, Muhammad, additional, Martins, Sheila, additional, Yamagami, Hiroshi, additional, Qiu, Zhongming, additional, Mansour, Ossama, additional, Czlonkowska, Anna, additional, Abdalkader, Mohamad, additional, Sathya, Anvitha, additional, de Sousa, Diana Aguiar, additional, Demeestere, Jelle, additional, Mikulik, Robert, additional, Vanacker, Peter, additional, Siegler, James, additional, Korv, Janika, additional, Biller, Jose, additional, Liang, Conrad, additional, Sangha, Navdeep, additional, Zha, Alicia, additional, Czap, Alexandra, additional, Holmstedt, Christine, additional, Turan, Tanya, additional, Grant, Cheryl, additional, Ntaios, George, additional, Malhotra, Konard, additional, Tayal, Ashis, additional, Loochtan, Aaron, additional, Mistry, Eva, additional, Alexandrov, Anne, additional, Huang, David, additional, Yaghi, Shadi, additional, Raz, Eytan, additional, Sheth, Sunil, additional, Frankel, Michael, additional, Lamou, Eric Gueumekane Bila, additional, Aref, Hany, additional, Elbassiouny, Ahmed, additional, Hassan, Farouk, additional, Mustafa, Wessam, additional, Menecie, Tarek, additional, Shokri, Hossam, additional, Roushdy, Tamer, additional, Sarfo, Fred Stephen, additional, Alabi, Tolulope, additional, Arabambi, Babawale, additional, Nwazor, Ernest, additional, Sunmonu, Taofiki Ajao, additional, Wahab, Kolawole W., additional, Mohammed, Haythem Hussein, additional, Adebayo, Philip B., additional, Riahi, Anis, additional, Ben Sassi, Samia, additional, Gwaunza, Lenon, additional, Rahman, Aminur, additional, Ai, Zhibing, additional, Bai, Fanghui, additional, Duan, Zhenhui, additional, Hao, Yonggang, additional, Huang, Wenguo, additional, Li, Guangwen, additional, Li, Wei, additional, Liu, Ganzhe, additional, Luo, Jun, additional, Shang, Xianjin, additional, Sui, Yi, additional, Tian, Ling, additional, Wen, Hongbin, additional, Wu, Bo, additional, Yan, Yuying, additional, Yuan, Zhengzhou, additional, Zhang, Hao, additional, Zhang, Jun, additional, Zhao, Wenlong, additional, Zi, Wenjie, additional, Leung, Thomas K., additional, Sahakyan, David, additional, Chugh, Chandril, additional, Huded, Vikram, additional, Menon, Bindu, additional, Pandian, Jeyaraj, additional, Sylaja, P.N., additional, Usman, Fritz Sumantri, additional, Farhoudi, Mehdi, additional, Sadeghi-Hokmabadi, Elyar, additional, Reznik, Anna, additional, Sivan-Hoffman, Rotem, additional, Horev, Anat, additional, Ohara, Nobuyuki, additional, Sakai, Nobuyuki, additional, Watanabe, Daisuke, additional, Yamamoto, Ryoo, additional, Doijiri, Ryosuke, additional, Tokuda, Naoki, additional, Yamada, Takehiro, additional, Terasaki, Tadashi, additional, Yazawa, Yukako, additional, Uwatoko, Takeshi, additional, Dembo, Tomohisa, additional, Shimizu, Hisao, additional, Sugiura, Yuri, additional, Miyashita, Fumio, additional, Fukuda, Hiroki, additional, Miyake, Kosuke, additional, Shimbo, Junsuke, additional, Sugimura, Yusuke, additional, Yagita, Yoshika, additional, Takenobu, Yohei, additional, Matsumaru, Yuji, additional, Yamada, Satoshi, additional, Kono, Ryuhei, additional, Kanamaru, Takuya, additional, Yamazaki, Hidekazu, additional, Sakaguchi, Manabu, additional, Todo, Kenichi, additional, Yamamoto, Nobuaki, additional, Sonodda, Kazutaka, additional, Yoshida, Tomoko, additional, Hashimoto, Hiroyuki, additional, Nakahara, Ichiro, additional, Faizullina, Kamila, additional, Kamenova, Saltanat, additional, Kondybayeva, Aida, additional, Zhanuzakov, Murat, additional, Baek, Jang-Hyun, additional, Hwang, Yangha, additional, Lee, Si Baek, additional, Moon, Jusun, additional, Park, Hyungjong, additional, Seo, Jung Hwa, additional, Seo, Kwon-Duk, additional, Young, Chang Jun, additional, Ahdab, Rechdi, additional, Aziz, Zariah Abdul, additional, Zaidi, Wan Asyraf Wan, additional, Basri, Hamidon Bin, additional, Chung, Law Wan, additional, Husin, Mazlina, additional, Ibrahim, Aznita Binti, additional, Ibrahim, Khairul Azmi, additional, Looi, Irene, additional, Tan, Wee Yong, additional, Yahya, Wan Nur Nafisah Wan, additional, Groppa, Stanislav, additional, Leahu, Pavel, additional, Al Hashmi, Amal, additional, Imam, Yehai Z., additional, Akhtar, Naveed, additional, Oliver, Christian, additional, Kandyba, Dmitriy, additional, Alhazzani, Adel, additional, Al-Jehani, Hosam, additional, Tham, Carol Huilian, additional, Mamauag, Marlie Jane, additional, Narayanaswamy, Ram, additional, Chen, Chih-Hao, additional, Tang, Sung-Chun, additional, Churojana, Anchalee, additional, Aykaç, Ozlem, additional, Özdemir, Atilla Özcan, additional, Hussain, Syed Irteza, additional, John, Seby, additional, Le Vu, Huynh, additional, Tran, Anh Duc, additional, Nguyen, Huy Hoang, additional, Thong, Pham Nhu, additional, Nguyen, Thang, additional, Nguyen, Trung, additional, Gattringer, Thomas, additional, Enzinger, Christian, additional, Killer-Oberpfalzer, Monika, additional, Bellante, Flavio, additional, De Blauwe, Sofie, additional, Van Hooren, Geert, additional, De Raedt, Sylvie, additional, Dusart, Anne, additional, Ligot, Noemie, additional, Rutgers, Matthieu, additional, Yperzeele, Laetitia, additional, Alexiev, Filip, additional, Sakelarova, Teodora, additional, Bedekovic, Marina Roje, additional, Budincevic, Hrvoje, additional, Cindric, Igor, additional, Hucika, Zlatko, additional, Ozretic, David, additional, Saric, Majda Seferovic, additional, Pfeifer, František, additional, Karpowicz, Igor, additional, Cernik, David, additional, Sramek, Martin, additional, Skoda, Miroslav, additional, Hlavacova, Helena, additional, Klecka, Lukas, additional, Koutny, Martin, additional, Vaclavik, Dan, additional, Skoda, Ondrej, additional, Fiksa, Jan, additional, Hanelova, Katerina, additional, Nevsimalova, Miroslava, additional, Rezek, Robert, additional, Prochazka, Petr, additional, Krejstova, Gabriela, additional, Neumann, Jiri, additional, Vachova, Marta, additional, Brzezanski, Henry, additional, Hlinovsky, David, additional, Tenora, Dusan, additional, Jura, Rene, additional, Jurak, Lubomir, additional, Novak, Jan, additional, Novak, Ales, additional, Topinka, Zdenek, additional, Fibrich, Petr, additional, Sobolova, Helena, additional, Volny, Ondrej, additional, Christensen, Hanne Krarup, additional, Drenck, Nicolas, additional, Iversen, Helle, additional, Simonsen, Claus, additional, Truelsen, Thomas, additional, Wienecke, Troels, additional, Vibo, Riina, additional, Gross-Paju, Katrin, additional, Toomsoo, Toomas, additional, Antsov, Katrin, additional, Caparros, Francois, additional, Cordonnier, Charlotte, additional, Dan, Maria, additional, Faucheux, Jean-Marc, additional, Mechtouff, Laura, additional, Eker, Omer, additional, Lesaine, Emillie, additional, Ondze, Basile, additional, Pico, Fernando, additional, Pop, Raoul, additional, Rouanet, Francois, additional, Gubeladze, Tatuli, additional, Khinikadze, Mirza, additional, Lobjanidze, Nina, additional, Tsiskaridze, Alexander, additional, Nagel, Simon, additional, Ringleb, Peter Arthur, additional, Rosenkranz, Michael, additional, Schmidt, Holger, additional, Sedghi, Annahita, additional, Siepmann, Timo, additional, Szabo, Kristina, additional, Thomalla, Gotz, additional, Palaiodimou, Lina, additional, Sagris, Dimitrios, additional, Kargiotis, Odysseas, additional, Kaliaev, Artem, additional, Liebeskind, David, additional, Hassan, Ameer, additional, Ranta, Anna, additional, Devlin, Thomas, additional, Zaidat, Osama, additional, Castonguay, Alicia, additional, Jovin, Tudor, additional, Tsivgoulis, Georgios, additional, Malik, Amer, additional, Ma, Alice, additional, Campbell, Bruce, additional, Kleinig, Timothy, additional, Wu, Teddy, additional, Gongora, Fernando, additional, Lavados, Pablo, additional, Olavarria, Veronica, additional, Lereis, Virginia Pujol, additional, Corredor, Angel, additional, Barbosa, Diana Mantilla, additional, Bayona, Hernan, additional, Barrientos, Jose Domingo, additional, Patino, Mauricio, additional, Thijs, Vincent, additional, Pirson, Anne, additional, Kristoffersen, Espen Saxhaug, additional, Patrik, Michel, additional, Fischer, Urs, additional, Bernava, Gianmarco, additional, Renieri, Leonardo, additional, Strambo, Davide, additional, Ayo-Martin, Oscar, additional, Montaner, Joan, additional, Karlinski, Michal, additional, Cruz-Culebras, Antonio, additional, Luchowski, Piotr, additional, Krastev, Georgi, additional, Arenillas, Juan, additional, Gralla, Jan, additional, Mangiafico, Salvatore, additional, Blasco, Jordi, additional, Fonseca, Luisa, additional, Silva, M. Luis, additional, Kwan, Joseph, additional, Banerjee, Soma, additional, Sangalli, Davide, additional, Frisullo, Giovanni, additional, Yavagal, Dileep, additional, Uyttenboogaart, Maarten, additional, Bandini, Fabio, additional, Adami, Alessandro, additional, de Lecina, Maria Alonso, additional, Arribas, Miguel Angel Tola, additional, Ferreira, Paulo, additional, Cruz, Vitor Tedim, additional, Nunes, Ana Paiva, additional, Marto, Joao Pedro, additional, Rodrigues, Miguel, additional, Melo, Teresa, additional, Saposnik, Gustavo, additional, Scott, Courtney Anne, additional, Shuaib, Ashfaq, additional, Khosravani, Houman, additional, Fields, Thalia, additional, Shoamanesh, Ashkan, additional, Catanese, Luciana, additional, Mackey, Ariane, additional, Hill, Michael, additional, Etherton, Mark, additional, Rost, Natalia, additional, Lutsep, Helmi, additional, Lee, Vivien, additional, Mehta, Brijesh, additional, Pikula, Aleksandra, additional, Simmons, Marc, additional, Macdougall, Lisa, additional, Silver, Brian, additional, Khandelwal, Priyank, additional, Morris, Jane, additional, Novakovic-White, Roberta, additional, Ramakrishnan, Pankajavalli, additional, Shah, Ruchir, additional, Altschul, Dorothea, additional, Almufti, Fawaz, additional, Amaya, Pablo, additional, Ordonez, Carlos Eduardo Rivera, additional, Lara, Osvalda, additional, Kadota, Liliana Rodriguez, additional, Rivera, Ligia Ibeth Portillo, additional, Novarro, Nelson, additional, Escobar, Luis Diaz, additional, Melgarejo, Donoband, additional, Cardozo, Analia, additional, Blanco, Anmylene, additional, Zelaya, Javier Adolfo, additional, Luraschi, Adriana, additional, Gonzalez, Victor Hugo Navia, additional, Almeida, Juan, additional, Conforto, Adriana, additional, Almeida, Marcele Schettini, additional, de Deus Silva, Leonardo, additional, Cuervo, Daissy Liliana Mora, additional, Zetola, Viviane Flumignan, additional, Martins, Rodrigo Targa, additional, Valler, Lenise, additional, Giacomini, Luidia Varrone, additional, Cardoso, Fabricio Buchdid, additional, Sahathevan, Ramesh, additional, Hair, Casey, additional, Hankey, Graeme, additional, Salazar, Daniel, additional, Lima, Fabricio Oliveira, additional, Mont’Alverne, Francisco, additional, Iman, Danny Moises Barrientos, additional, Magalhaes, Pedro, additional, Longo, Alexandre, additional, Rebello, Leticia, additional, Falup-Pecurariu, Cristian, additional, Mazya, Michael, additional, Wisniewska, Anna, additional, Fryze, Waldemar, additional, Kazmierski, Radoslaw, additional, Wisniewska, Malgorzata, additional, Horoch, Ewa, additional, Sienkiewicz-Jarosz, Halina, additional, Fudala, Malgorzata, additional, Rogoziewicz, Marcin, additional, Brola, Waldemar, additional, Sobolewski, Piotr, additional, Kaczorowski, Rafal, additional, Stepien, Adam, additional, Klivenyi, Peter, additional, Szapary, Laszlo, additional, van den Wijngaard, Ido, additional, Demchuk, Andrew, additional, Abraham, Michael, additional, Alvarado-Ortiz, Tony, additional, Kaushal, Ritesh, additional, Ortega-Gutierrez, Santiago, additional, Farooqui, Mudassir, additional, Bach, Ivo, additional, Badruddin, Aamir, additional, Barazangi, Nobl, additional, Nguyen, Claude, additional, Brereton, Charmaine, additional, Choi, Jae H., additional, Dharmadhikari, Sushrut, additional, Desai, Kinjal, additional, Doss, Vinodh, additional, Edgell, Randall, additional, Linares, Guillermo, additional, Frei, Donald, additional, Chaturvedi, Seemant, additional, Gandhi, Dheeraj, additional, Chaudhry, Saqib, additional, Choe, Hana, additional, Grigoryan, Mikayel, additional, Gupta, Rishi, additional, Helenius, Johanna, additional, Voetsch, Barbara, additional, Khwaja, Ayaz, additional, Khoury, Naim, additional, Kim, Benny S., additional, Kleindorfer, Dawn, additional, McDermott, Molly, additional, Koyfman, Feliks, additional, Leung, Lester, additional, Linfante, Italo, additional, Male, Shailesh, additional, Masoud, Hesham, additional, Min, Jiangyong, additional, Mittal, Manoj, additional, Multani, Sumeet, additional, Nahab, Fadi, additional, Nalleballe, Krishna, additional, Rahangdale, Rahul, additional, Rafael, Jose, additional, Rothstein, Aaron, additional, Ruland, Sean, additional, Sharma, Malveeka, additional, Singh, Abishek, additional, Starosciak, Amy, additional, Strasser, Sheryl, additional, Szeder, Viktor, additional, Teleb, Mohamed, additional, Tsai, Jenny, additional, Mohammaden, Mahmoud, additional, Pineda-Franks, Carissa, additional, Asyraf, Wan, additional, Nguyen, Trung QuocH, additional, Tarkanyi, Gabor, additional, Haussen, Diogo, additional, Balaguera, Oscar, additional, Vasquez, Alejandro Rodriguez, additional, and Nogueira, Raul, additional

Published
2021
Full Text
View/download PDF

24. Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study.

Author

Bar-Or, Amit, Wiendl, Heinz, Montalban, Xavier, Alvarez, Enrique, Davydovskaya, Maria, Delgado, Silvia R, Evdoshenko, Evgeniy P, Giedraitiene, Natasa, Gross-Paju, Katrin, Haldre, Sulev, Herrman, Craig E, Izquierdo, Guillermo, Karelis, Guntis, Leutmezer, Fritz, Mares, Miroslav, Meca-Lallana, Jose E, Mickeviciene, Dalia, Nicholas, Jacqueline, Robertson, Derrick S, and Sazonov, Denis V

Subjects
MULTIPLE sclerosis, MONOCLONAL antibodies, SYRINGES
Abstract

Background: Ofatumumab, the first fully human anti-CD20 monoclonal antibody, is approved in several countries for relapsing multiple sclerosis (RMS). Objective: To demonstrate the bioequivalence of ofatumumab administered by an autoinjector versus a pre-filled syringe (PFS) and to explore the effect of ofatumumab on B-cell depletion. Methods: APLIOS (NCT03560739) is a 12-week, open-label, parallel-group, phase-2 study in patients with RMS receiving subcutaneous ofatumumab 20 mg every 4 weeks (q4w) (from Week 4, after initial doses on Days 1, 7, and 14). Patients were randomized 10:10:1:1 to autoinjector or PFS in the abdomen, or autoinjector or PFS in the thigh, respectively. Bioequivalence was determined by area under the curve (AUC τ ) and maximum plasma concentration (C max) for Weeks 8–12. B-cell depletion and safety/tolerability were assessed. Results: A total of 256 patients contributed to the bioequivalence analyses (autoinjector-abdomen, n = 128; PFS-abdomen, n = 128). Abdominal ofatumumab pharmacokinetic exposure was bioequivalent for autoinjector and PFS (geometric mean AUC τ , 487.7 vs 474.1 h × µg/mL (ratio 1.03); C max, 1.409 vs 1.409 µg/mL (ratio 1.00)). B-cell counts (median cells/µL) depleted rapidly in all groups from 214.0 (baseline) to 2.0 (Day 14). Ofatumumab was well tolerated. Conclusion: Ofatumumab 20 mg q4w self-administered subcutaneously via autoinjector is bioequivalent to PFS administration and provides rapid B-cell depletion. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

25. Posterioorne kortikaalne atroofia – nägemishäirena avalduva varajase algusega Alzheimeri tõve haigusjuhu kirjeldus

Author

Reimand, Juhan, Zopp, Mairi, Varus, Heivi, Kullamaa, Silja, Laanetu, Mari-Liis, Lõokene, Margus, Gross-Paju, Katrin, Maron, Eduard, Roose, Äli, Paris, Malle, and Nazarenko, Sergei

Abstract

Posterioorne kortikaalne atroofia on kliinilis-radioloogiline sündroom, mille puhul esineb süvenev nägemis-ruumilise taju ning ruumisuhete häirumine koos radioloogiliselt avalduva parietooktspitaalse atroofiaga. Sündroomi peamiseks põhjustajaks peetakse tänapäeval Alzheimeri tõbe, kuid võrreldes klassikalise Alzheimeri tõvega on patsiendid haigestudes nooremad ning haiguse algstaadiumis ei esine neil mäluhäireid. Artiklis on kirjeldatud posterioorse kortikaalse atroofiaga haigusjuhu interdistsiplinaarset käsitlust 54aastasel naispatsiendil. Kirjeldatud haigusjuht näitab, et teadmata etioloogiaga nägemishäirega patsiendil tuleks diferentsiaaldiagnostiliselt kahtlustada ka neurodegeneratiivset haigust., Eesti Arst, 2019: Detsember

Published
2019
Full Text
View/download PDF

26. Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements

Author

Gross-Paju Katrin, Lüüs Siiri-Merike, Raukas Elve, Sachez-Ferrero Elena, Beetz Christian, Tamm Riin, Braschinsky Mark, Boillot Catherine, Canzian Federico, Metspalu Andres, and Haldre Sulev

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder that can be an autosomal-dominant, autosomal-recessive, or X-linked disease. The most common autosomal-dominant form of the disease derives from mutations in the SPAST gene. Methods The aim of this study was to analyze 49 patients diagnosed with HSP from the Estonian population for sequence variants of the SPAST gene and to describe the associated phenotypes. Healthy control individuals (n = 100) with no family history of HSP were also analyzed. All patient samples were screened using denaturing high performance liquid chromatography (DHPLC) and multiplex ligation-dependent probe amplification (MLPA) assay. Samples with abnormal DHPLC and MLPA profiles were sequenced, with the same regions sequenced in control samples. Results Sequence variants of SPAST were identified in 19/49 HSP patients (38.8%), twelve among them had pathogenic mutations. Within the latter group there was one sporadic case. Eight patients had pure, and four - complex HSP. The twelve variants were identified: seven pathogenic (c.1174-1G>C, c.1185delA, c.1276C>T, c.1352_1356delGAGAA, c.1378C>A, c.1518_1519insTC, c.1841_1842insA) and five non-pathogenic (c.131C>T, c.484G>A, c.685A>G, c.1245+202delG, c.1245+215G>C). Only 2 of these mutations had previously been described (c.131C>T, c.1245+202delG). Three mutations, c.1174-1G>C, c.1276 C>T, c.1378C>A, showed intrafamilial segregation. Conclusion This study identified new variants of the SPAST gene which included benign missense variants and short insertions/deletions. No large rearrangements were found. Based on these data, 7 new pathogenic variants of HSP are associated with clinical phenotypes.

Published
2010
Full Text
View/download PDF

27. Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

Author

Hauser, Stephen L., Bar-Or, Amit, Comi, Giancarlo, Giovannoni, Gavin, Hartung, Hans-Peter, Hemmer, Bernhard, Lublin, Fred, Montalban, Xavier, Rammohan, Kottil W., Selmaj, Krzysztof, Traboulsee, Anthony, Wolinsky, Jerry S., Arnold, Douglas L., Klingelschmitt, Gaelle, Masterman, Donna, Fontoura, Paulo, Belachew, Shibeshih, Chin, Peter, Mairon, Nicole, Garren, Hideki, Kappos, Ludwig, And Opera Ii Clinical Investigators, Opera I., Reingold, Stephen C., Sandberg-Wollheim, Magnhild, Barkhof, Frederik, Dörmer, Thomas, Evans, Scott, Mcfarland, Henry F., Steiner, Israel, Yaldizli, Özgür, D Souza, Marcus, Andelova, Michaela, Rust, Heiko, Ballario, Carlos, Giannaula, Rolando, Reich, Edgardo Gabriel, Parratt, John, Eggers, Christian, Buyle, Maarten, Pesch, Vincent, Vanopdenbosch, Ludo, Carneiro, Denise, Friedrich, Mauricio, Longo, Alexandre Luiz, Genov, Krasimir, Ivanova, Sonya, Maslarov, Dimitar, Lilovski, Hristo, Staikov, Ivan, Cueto, German, Dufek, Michal, Havrdova, Eva, Novotna, Alena, Skoda, Ondrej, Talabova, Marika, Vachova, Marta, Gross-Paju, Katrin, Haldre, Sulev, Elovaara, Irina, Brochet, Bruno, Castelnovo, Giovanni, Clavelou, Pierre, Seze, Jerome, Debouverie, Marc, Braune, Stefan, Haas, Judith, Heidenreich, Fedor, Schwarz, Wolfgang, Siever, Arno, Urban, Peter Paul, Zettl, Uwe, Ziemann, Ulf, Ziemssen, Tjalf, Zipp, Frauke, Debreczeni, Robert, Rozsa, Csilla, Satori, Maria, Chapman, Joab, Ghezzi, Angelo, Perini, Paola, Pozzilli, Carlo, Kalnina, Jolanta, Millers, Andrejs, Budrys, Valmantas, Kizlaitiene, Rasa, Malciene, Lina, Vaitkus, Antanas, Castro Farfan, Guillermo, Gongora Rivera, Juan Fernando, Frequin, S. T. F. M., Gavidia Chucan, Jorge Martin, Perez Villegas, Julio, Pretell, Edwin Javier, Rodriguez Kadota, Liliana Elizabe, Fryze, Waldemar, Hertmanowska, Hanka, Maciejowski, Maciej, Opala, Grzegorz, Cerqueira, João, Arefieva, Elena, Maslova, Natalia, Odinak, Miroslav, Pankratov, Evgeny, Perfiliev, Semen, Poverennova, Irina, Sazonov, Denis, Shirshova, Elena, Sivertseva, Stella, Volkova, Larisa, Vorobyova, Olga, Knezevic, Zorica, Raicevic, Ranko, Vojinovic, Slobodan, Hancinova, Viera, Saffova, Patricia, Turcani, Peter, Vyletelka, Juraj, Coetzee, Christo C., Garcia-Merino, Antonio, Hernandez, Miguel A., Izquierdo Ayuso, Guillermo, Rodriguez Antigüedad, Alfredo, Gobbi, Claudio, Belal, Samir, Frih-Ayed, Mahbouba, Gouider, Riadh, Mrissa, Ridha, Sergii Moskovko, Sanotskyy, Yanosh, Sokolova, Larysa, Statinova, Olena, Voloshyna, Nataliya, Turner, Benjamin, Wilson, Martin, Applebee, Angela, Bandari, Daniel, Belkin, Martin, Birnbaum, Gary, Borresen, Thor, Boyd, James, Cascione, Mark, Cohan, Stanley, Cohen, Bruce, Conway, Jill, Cree, Bruce, Dihenia, Bhupesh, Dissin, Jonathan, Flitman, Stephen, Ford, Corey, Giancarlo, Thomas, Gold, Scott, Green, Barbara, Gwynn, Matthews, Honeycutt, David, Huddlestone, John, Klawiter, Eric, Kohrman, Bruce, Langer-Gould, Annette, Lava, Neil, Lindsey, William, Mitchell, Galen, Naismith, Robert, Nicolas, Joseph, Pardo, Gabriel, Patel, Malti, Porter, John A. H., Racke, Michael, Robertson, Derrick, Rossman, Howard, Schafer, John, Shubin, Richard, Singer, Barry, Smith, Charles, Suski, Valerie, Thrower, Ben, Wilson, Christopher, Wynn, Daniel, Zabad, Rana, Estol, Conrado J., Scarlatti, Annita, Alekseenko, Yuri, Fedulau, Aliaksandr, Kulesh, Sergey, Navumava, Halina, Willekens, Barbara, Alajbegovic, Azra, Sinanovic, Osman, Christo, Paulo, Papais Alvarenga, Regina Maria, Pereira Damasceno, Benito, Baldaranov, Dimo, Grigorova, Olga, Haralanov, Lyubomir, Milanova, Milena, Ayotte, Charles, Blevins, Gregg, Freedman, Mark, Grand Maison, François, Jacques, François, Yeung, Michael, Basic, Silvio, Hajnsek, Sanja, Janko-Labinac, Dolores, Kidjemet Piskac, Spomenka, Benesova, Yvonne, Hradilek, Pavel, Brassat, David, Edan, Gilles, Hautecoeur, Patrick, Moreau, Thibault, Papeix, Caroline, Tourbah, Ayman, Vukusic, Sandra, Aktas, Orhan, Berthele, Achim, Bodenschatz, Ralf, Foerch, Christian, Hohlfeld, Reinhard, Landefeld, Harald, Lang, Michael, Platten, Michael, Puzich, Reinhard, Schmidt, Stephan, Tubridy, Niall, Ardito, Bonaventura, Capra, Ruggero, Centonze, Diego, Crociani, Paola, Danni, Maura, Grimaldi, Luigi, Gusmaroli, Graziano, Mantegazza, Renato, Mirabella, Massimiliano, Uccelli, Antonio, Carbajal Ramirez, Angelica, Lopez Meza, Elmer Guillermo, Lopez Prieto, Juan Jose, Oropeza Alba, Jose Luis, Reyes-Morales, Sarug, San Juan Orta, Daniel, Myhr, Kjell Morten, Binek, Maciej, Czarnecki, Maciej, Klodowska-Duda, Gabriela, Stelmasiak, Zbigniew, Szczudlik, Andrzej, Tutaj, Andrzej, Belova, Anna, Dorogov, Nikolay, Fedyanin, Alexander, Khasanova, Dina, Makarov, Nikolay, Mishin, Gennadiy, Sherman, Mikhail, Skoromets, Alexander, Trushnikova, Tatiana, Donath, Vladimir, Dupejova, Beata, Gurcik, Ladislav, Arroyo, Rafael, Andres, Clara, Fernandez Fernandez, Oscar, Lainez Andrep, Jose Miguel, Martinez Gines, Maria Luisa, Martinez Rodriguez, Jose Enrique, Martinez Yelamos, Sergio, Oreja Guevara, Celia, Perez Sempere, Angel, Ramio, Luis, Ramo Tello, Cristina, Lycke, Jan, Olsson, Tomas, Roshanisefat, Homayoun, Sundström, Peter, Svenningsson, Anders, Akman Demir, Gulsen, Petek Balci, Belgin, Boz, Cavit, Efendi, Husnu, Karabudak, Rana, Siva, Aksel, Terzi, Murat, Yuceyar, Ayse Nur, Chmyr, Galyna, Goncharova, Yana, Kareta, Serhiy, Lutskiy, Igor, Harrower, Timothy, Hawkins, Clive, Pearson, Owen, Silber, Eli, Absher, John, Arnold, Thomas, Bass, Ann, Bernitsas, Evanthia, Braley, Tiffany, Calkwood, Jonathan, Carnes, Kenneth, Coyle, Patricia, Dunn, Jeffrey, Edwards, Keith, English, Jeffrey, Ferencz, Gerald, Fox, Edward, Frohman, Elliott, Gazda, Suzanne, Gitt, Jeffrey, Goodman, Andrew, Gross, Jeffrey, Hendin, Barry, Herrman, Craig, Hillen, Machteld, Huang, Deren, Hunter, Samuel, Hutton, George, Jacobs, Daniel, Keller, Bridget, Khan, Omar, Kister, Ilya, Krupp, Lauren, Lathi, Ellen, Lynch, Sharon, Miller, Tamara, Miravalle, Augusto, Omidvar, Omid, Perumal, Jai, Picone, Maryann, Rao, T. Hemanth, Repovic, Pavle, Riskind, Peter, Rowe, Vernon, Sheremata, William, Steingo, Brian, Twyman, Cary, Weisman, David, Wendt, Jeanette, Wray, Sibyl, Yapundich, Robert, Zarif, Myassar, Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, Tampere University, Hauser, S. L., Bar or, A., Comi, Giancarlo, Giovannoni, G., Hartung, H. . P., Hemmer, B., Lublin, F., Montalban, X., Rammohan, K. W., Selmaj, K., Traboulsee, A., Wolinsky, J. S., Arnold, D. L., Klingelschmitt, G., Masterman, D., Fontoura, P., Belachew, S., Chin, P., Mairon, N., Garren, H., Kappos, L., Universidade do Minho, Willekens, Barbara, and OPERA I and OPERA II Clinical Investigators

Subjects
0301 basic medicine, Male, Esclerosi múltiple, Adult, Antibodies, Monoclonal, Humanized, Antigens, CD20, B-Lymphocytes, Brain, Disease Progression, Female, Humans, Immunologic Factors, Infusions, Intravenous, Interferon-beta, Magnetic Resonance Imaging, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Recurrence, Medicine (all), Relapsing-Remitting, Gastroenterology, Medicina Clínica [Ciências Médicas], law.invention, 0302 clinical medicine, Immunologic Factor, Randomized controlled trial, law, Monoclonal, Clinical endpoint, Infusions, Intravenou, Immunologia, Humanized, Hazard ratio, B-Lymphocyte, General Medicine, Settore MED/26 - Neurologia, Intravenous, Neurotieteet - Neurosciences, medicine.drug, Human, medicine.medical_specialty, Infusions, Multiple Sclerosis, Immunology, Antibodies, Multiple sclerosis, 03 medical and health sciences, Internal medicine, medicine, CD20, Antigens, Ciências Médicas::Medicina Clínica, business.industry, Interferon beta-1a, medicine.disease, Confidence interval, Ocrelizumab, Interferon Beta-1a, Relapsing Multiple Sclerosis, 030104 developmental biology, Monoclonal antibodies, Human medicine, business, Anticossos monoclonals, 030217 neurology & neurosurgery
Abstract

BACKGROUND B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized monoclonal antibody that selectively depletes CD20+ B cells. METHODS In two identical phase 3 trials, we randomly assigned 821 and 835 patients with relapsing multiple sclerosis to receive intravenous ocrelizumab at a dose of 600 mg every 24 weeks or subcutaneous interferon beta-1a at a dose of 44 mu g three times weekly for 96 weeks. The primary end point was the annualized relapse rate. RESULTS The annualized relapse rate was lower with ocrelizumab than with interferon beta-1a in trial 1 (0.16 vs. 0.29; 46% lower rate with ocrelizumab; P, info:eu-repo/semantics/publishedVersion

Published
2017

28. Intravenous versus subcutaneous immunoglobulin – Authors' reply

Author

van Schaik, Ivo N, primary, Mielke, Orell, additional, Sabet, Arman, additional, George, Koshy, additional, Roberts, Leslie, additional, Carne, Ross, additional, Blum, Stefan, additional, Henderson, Robert, additional, Van Damme, Philip, additional, Demeestere, Jelle, additional, Larue, Sandrine, additional, Pinard D'Amour, Catherine-Andree, additional, Bril, Vera, additional, Breiner, Ari, additional, Kunc, Pavel, additional, Valis, Martin, additional, Sussova, Jana, additional, Kalous, Tomas, additional, Talab, Radomir, additional, Bednar, Michal, additional, Toomsoo, Toomas, additional, Rubanovits, Inna, additional, Gross-Paju, Katrin, additional, Sorro, Ulvi, additional, Saarela, Mika, additional, Auranen, Mari, additional, Pouget, Jean, additional, Attarian, Shahram, additional, Le Masson, Gwendal, additional, Wielanek-Bachelet, Anne-Cécile, additional, Desnuelle, Claude, additional, Delmont, Emilien, additional, Clavelou, Pierre, additional, Aufauvre, Dominique, additional, Schmidt, Jens, additional, Zschuentssch, Jana, additional, Sommer, Claudia, additional, Kramer, Daniela, additional, Hoffmann, Olaf, additional, Goerlitz, Carsten, additional, Haas, Judith, additional, Chatzopoulos, Marko, additional, Yoon, Min-Suk, additional, Gold, Ralf, additional, Berlit, Peter, additional, Jaspert-Grehl, Andrea, additional, Liebetanz, David, additional, Kutschenko, Anna, additional, Stangel, Martin, additional, Trebst, Corinna, additional, Baum, Petra, additional, Then Bergh, Florian, additional, Klehmet, Juliane, additional, Meisel, Andreas, additional, Klostermann, Fabian, additional, Oechtering, Johanna, additional, Lehmann, Helmar, additional, Schroeter, Michael, additional, Hagenacker, Tim, additional, Mueller, Daniel, additional, Sperfeld, Anne-Dorte, additional, Bethke, Florian, additional, Hartung, Hans-Peter, additional, Drory, Vivian, additional, Algom, Avi, additional, Yarnitsky, David, additional, Murinson, Beth Brianna, additional, Di Muzio, Antonio, additional, Ciccocioppo, Fausta, additional, Sorbi, Sandro, additional, Mata, Sabrina, additional, Schenone, Angelo, additional, Grandis, Marina, additional, Lauria, Giuseppe, additional, Cazzato, Daniele, additional, Antonini, Giovanni, additional, Morino, Stefania, additional, Cocito, Dario, additional, Zibetti, Maurizio, additional, Yokota, Takanori, additional, Ohkubo, Takuya, additional, Kanda, Takashi, additional, Kawai, Motoharu, additional, Kaida, Kenichi, additional, Onoue, Hiroyuki, additional, Kuwabara, Satoshi, additional, Mori, Masahiro, additional, Iijima, Masahiro, additional, Ohyama, Ken, additional, Sobue, Gen, additional, Baba, Masayuki, additional, Tomiyama, Masahiko, additional, Nishiyama, Kazutoshi, additional, Akutsu, Tsugio, additional, Yokoyama, Kazumasa, additional, Kanai, Kazuaki, additional, van Schaik, Ivo N., additional, Eftimov, Filip, additional, Notermans, Nicolette. C., additional, Visser, Nora. A., additional, Faber, Catharina, additional, Hoeijmakers, Janneke. G.J., additional, Merkies, Ingemar S.J., additional, van Geloven, Nan, additional, Rejdak, Konrad, additional, Chyrchel-Paszkiewicz, Urszula, additional, Casanovas Pons, Carlos, additional, Alberti Aguiló, María Antonia, additional, Gamez, Josep, additional, Figueras, María, additional, Marquez Infante, Celedonio, additional, Benitez Rivero, Sonia, additional, Lunn, Michael, additional, Morrow, Jasper, additional, Gosal, David, additional, Lavin, Timothy Myles, additional, Melamed, Isaac, additional, Testori, Alessandro, additional, Ajroud-Driss, Senda, additional, Menichella, Daniela, additional, Simpson, Ericka, additional, Chi-Ho Lai, Eugene, additional, Dimachkie, Mazen, additional, Barohn, Richard J., additional, Beydoun, Said, additional, Johl, Harpreet, additional, Lange, Dale, additional, Shtilbans, Alexander, additional, Muley, Suraj, additional, Ladha, Shafeeq, additional, Freimer, Miriam, additional, Kissel, John, additional, Latov, Norman, additional, Chin, Russell, additional, Ubogu, Eroboghene, additional, Mumfrey, Sandi, additional, Rao, T. Hermanth P., additional, MacDonald, Paul, additional, Sharma, Khema, additional, Gonzalez, Ginna, additional, Allen, Jeffrey, additional, Walk, David, additional, Hobson-Webb, Lisa, additional, Gable, Karissa, additional, Lewis, Richard A., additional, Cornblath, David R., additional, Lawo, John-Phillip, additional, Praus, Michaela, additional, and Durn, Billie L., additional

Published
2018
Full Text
View/download PDF

29. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Author

Kappos, Ludwig, primary, Bar-Or, Amit, additional, Cree, Bruce A C, additional, Fox, Robert J, additional, Giovannoni, Gavin, additional, Gold, Ralf, additional, Vermersch, Patrick, additional, Arnold, Douglas L, additional, Arnould, Sophie, additional, Scherz, Tatiana, additional, Wolf, Christian, additional, Wallström, Erik, additional, Dahlke, Frank, additional, Achiron, Anat, additional, Achtnichts, Lutz, additional, Agan, Kadriye, additional, Akman-Demir, Gulsen, additional, Allen, Alison B, additional, Antel, Jack P, additional, Antiguedad, Alfredo Rodriguez, additional, Apperson, Michelle, additional, Applebee, Angela M, additional, Ayuso, Guillermo Izquierdo, additional, Baba, Masayuki, additional, Bajenaru, Ovidiu, additional, Balasa, Rodica, additional, Balci, Belgin Petek, additional, Barnett, Michael, additional, Bass, Ann, additional, Becker, Veit U, additional, Bejinariu, Mihaela, additional, Bergh, Florian Then, additional, Bergmann, Arnfin, additional, Bernitsas, Evanthia, additional, Berthele, Achim, additional, Bhan, Virender, additional, Bischof, Felix, additional, Bjork, Randall John, additional, Blevins, Gregg, additional, Boehringer, Matthias, additional, Boerner, Thomas, additional, Bonek, Robert, additional, Bowen, James D, additional, Bowling, Allen, additional, Boyko, Alexey N, additional, Boz, Cavit, additional, Bracknies, Vera, additional, Braune, Stefan, additional, Brescia Morra, Vincenzo, additional, Brochet, Bruno, additional, Brola, Waldemar, additional, Brownstone, Paul Kenneth, additional, Brozman, Miroslav, additional, Brunet, Donald, additional, Buraga, Ioan, additional, Burnett, Margaret, additional, Buttmann, Mathias, additional, Butzkueven, Helmut, additional, Cahill, Jonathan, additional, Calkwood, Jonathan C, additional, Camu, William, additional, Cascione, Mark, additional, Castelnovo, Giovani, additional, Centonze, Diego, additional, Cerqueira, Joao, additional, Chan, Andrew, additional, Cimprichova, Andrea, additional, Cohan, Stanley, additional, Comi, Giancarlo, additional, Conway, Jill, additional, Cooper, Joanna A, additional, Corboy, John, additional, Correale, Jorge, additional, Costell, Brian, additional, Cottrell, David A, additional, Coyle, Patricia K, additional, Craner, Matthew, additional, Cui, Liying, additional, Cunha, Luis, additional, Czlonkowska, Anna, additional, da Silva, Ana Martins, additional, de Sa, Joao, additional, de Seze, Jérôme, additional, Debouverie, Marc, additional, Debruyne, Jan, additional, Decoo, Danny, additional, Defer, Gilles, additional, Derfuss, Tobias, additional, Deri, Norma H, additional, Dihenia, Bhupesh, additional, Dioszeghy, Peter, additional, Donath, Vladimir, additional, Dubois, Benedicte, additional, Duddy, Martin, additional, Duquette, Pierre, additional, Edan, Gilles, additional, Efendi, Husnu, additional, Elias, Stanton, additional, Emrich, Peter J, additional, Estruch, Bonaventura Casanova, additional, Evdoshenko, Evgeniy P, additional, Faiss, Juergen, additional, Fedyanin, Alexander S, additional, Feneberg, Wolfgang, additional, Fermont, Jiske, additional, Fernandez, Oscar Fernandez, additional, Ferrer, Francisco Coret, additional, Fink, Katharina, additional, Ford, Helen, additional, Ford, Corey, additional, Francia, Ada, additional, Freedman, Mark, additional, Frishberg, Benjamin, additional, Galgani, Simonetta, additional, Garmany, George P, additional, Gehring, Klaus, additional, Gitt, Jeffrey, additional, Gobbi, Claudio, additional, Goldstick, Lawrence P, additional, Gonzalez, Rafael Arroyo, additional, Grandmaison, Francois, additional, Grigoriadis, Nikolaos, additional, Grigorova, Olga, additional, Grimaldi, Luigi Maria Edoardo, additional, Gross, Jeffrey, additional, Gross-Paju, Katrin, additional, Gudesblatt, Mark, additional, Guillaume, Daniel, additional, Haas, Judith, additional, Hancinova, Viera, additional, Hancu, Anca, additional, Hardiman, Orla, additional, Harmjanz, Arndt, additional, Heidenreich, Fedor R, additional, Hengstman, G J D, additional, Herbert, Joseph, additional, Herring, Mark, additional, Hodgkinson, Suzanne, additional, Hoffmann, Olaf M, additional, Hofmann, Werner E, additional, Honeycutt, William D, additional, Hua, Le Hanh, additional, Huang, Dehui, additional, Huang, Yining, additional, Huang, DeRen, additional, Hupperts, Raymond, additional, Imre, Piroska, additional, Jacobs, Alan Keith, additional, Jakab, Gabor, additional, Jasinska, Elzbieta, additional, Kaida, Kenichi, additional, Kalnina, Jolanta, additional, Kaprelyan, Ara, additional, Karelis, Guntis, additional, Karussis, Dimitrios, additional, Katz, Amos, additional, Khabirov, Farit A, additional, Khatri, Bhupendra, additional, Kimura, Takashi, additional, Kister, Ilya, additional, Kizlaitiene, Rasa, additional, Klimova, Eleonora, additional, Koehler, Juergen, additional, Komatineni, Aparna, additional, Kornhuber, Anselm, additional, Kovacs, Krisztina, additional, Koves, Agnes, additional, Kozubski, Wojciech, additional, Krastev, Georgi, additional, Krupp, Lauren B, additional, Kurca, Egon, additional, Lassek, Christoph, additional, Laureys, Guy, additional, Lee, Liesly, additional, Lensch, Eckart, additional, Leutmezer, Fritz, additional, Li, Hongzeng, additional, Linker, Ralf A, additional, Linnebank, Michael, additional, Liskova, Petra, additional, Llanera, Cristina, additional, Lu, Jiahong, additional, Lutterotti, Andreas, additional, Lycke, Jan, additional, Macdonell, Richard, additional, Maciejowski, Maciej, additional, Maeurer, Mathias, additional, Magzhanov, Rim V, additional, Maida, Eva-Maria, additional, Malciene, Lina, additional, Mao-Draayer, Yang, additional, Marfia, Girolama Alessandra, additional, Markowitz, Clyde, additional, Mastorodimos, Vasileios, additional, Matyas, Klotild, additional, Meca-Lallana, Jose, additional, Merino, Juan Antonio Garcia, additional, Mihetiu, Ioan Gheorghe, additional, Milanov, Ivan, additional, Miller, Aaron E, additional, Millers, Andrejs, additional, Mirabella, Massimiliano, additional, Mizuno, Masanori, additional, Montalban, Xavier, additional, Montoya, Lilina, additional, Mori, Masahiro, additional, Mueller, Stefanie, additional, Nakahara, Jin, additional, Nakatsuji, Yuji, additional, Newsome, Scott, additional, Nicholas, Richard, additional, Nielsen, A Scott, additional, Nikfekr, Esmaeil, additional, Nocentini, Ugo, additional, Nohara, Chiyoko, additional, Nomura, Kyoichi, additional, Odinak, Miroslav M, additional, Olsson, Tomas, additional, van Oosten, B W, additional, Oreja-Guevara, Celia, additional, Oschmann, Patrick, additional, Overell, James, additional, Pachner, Andrew, additional, Panczel, Gyula, additional, Pandolfo, Massimo, additional, Papeix, Caroline, additional, Patrucco, Liliana, additional, Pelletier, Jean, additional, Piedrabuena, Raul, additional, Pless, Misha, additional, Polzer, Udo, additional, Pozsegovits, Krisztian, additional, Rastenyte, Daiva, additional, Rauer, Sebastian, additional, Reifschneider, Gerd, additional, Rey, Roberto, additional, Rizvi, Syed A, additional, Robertson, Derrick, additional, Rodriguez, Jose Martinez, additional, Rog, David, additional, Roshanisefat, Homayoun, additional, Rowe, Vernon, additional, Rozsa, Csilla, additional, Rubin, Susan, additional, Rusek, Stanislaw, additional, Saccà, Francesco, additional, Saida, Takahiko, additional, Salgado, Antonio Vasco, additional, Sanchez, Victoria Eugenia Fernandez, additional, Sanders, Kalina, additional, Satori, Maria, additional, Sazonov, Denis V, additional, Scarpini, Elio Angelo, additional, Schlegel, Eugen, additional, Schluep, Myriam, additional, Schmidt, Stephan, additional, Scholz, Erich, additional, Schrijver, H M, additional, Schwab, Matthias, additional, Schwartz, Raymond, additional, Scott, James, additional, Selmaj, Krzysztof, additional, Shafer, Stuart, additional, Sharrack, Basil, additional, Shchukin, Ivan A, additional, Shimizu, Yuko, additional, Shotekov, Penko, additional, Siever, Arno, additional, Sigel, Karl-Otto, additional, Silliman, Scott, additional, Simo, Magdolna, additional, Simu, Mihaela, additional, Sinay, Vladimiro, additional, Siquier, Antonio Escartin, additional, Siva, Aksel, additional, Skoda, Ondrej, additional, Solomon, Andrew, additional, Stangel, Martin, additional, Stefoski, Dusan, additional, Steingo, Brian, additional, Stolyarov, Igor D, additional, Stourac, Pavel, additional, Strassburger-Krogias, Katrin, additional, Strauss, Erik, additional, Stuve, Olaf, additional, Tarnev, Ivaylo, additional, Tavernarakis, Antonios, additional, Tello, Cristina Ramo, additional, Terzi, Murat, additional, Ticha, Veronika, additional, Ticmeanu, Marina, additional, Tiel-Wilck, Klaus, additional, Toomsoo, Toomas, additional, Tubridy, Niall, additional, Tullman, Mark J, additional, Tumani, Hayrettin, additional, Turcani, Peter, additional, Turner, Ben, additional, Uccelli, Antonio, additional, Urtaza, Francisco Javier Olascoaga, additional, Vachova, Marta, additional, Valikovics, Attila, additional, Walter, Silke, additional, Van Wijmeersch, Bart, additional, Vanopdenbosch, Ludo, additional, Weber, Joerg R, additional, Weiss, Sara, additional, Weissert, Robert, additional, West, Timothy, additional, Wiendl, Heinz, additional, Wiertlewski, Sandrine, additional, Wildemann, Brigitte, additional, Willekens, Barbara, additional, Visser, L H, additional, Vorobeychik, Galina, additional, Xu, Xianhao, additional, Yamamura, Takashi, additional, Yang, Yi N, additional, Yelamos, Sergio Martinez, additional, Yeung, Michael, additional, Zacharias, Alan, additional, Zelkowitz, Marvin, additional, Zettl, Uwe, additional, Zhang, Meini, additional, Zhou, Hongyu, additional, Zieman, Ulf, additional, and Ziemssen, Tjalf, additional

Published
2018
Full Text
View/download PDF

33. Intravenous versus subcutaneous immunoglobulin – Authors' reply

Author

Sabet, Arman, George, Koshy, Roberts, Leslie, Carne, Ross, Blum, Stefan, Henderson, Robert, Van Damme, Philip, Demeestere, Jelle, Larue, Sandrine, Pinard D'Amour, Catherine-Andree, Bril, Vera, Breiner, Ari, Kunc, Pavel, Valis, Martin, Sussova, Jana, Kalous, Tomas, Talab, Radomir, Bednar, Michal, Toomsoo, Toomas, Rubanovits, Inna, Gross-Paju, Katrin, Sorro, Ulvi, Saarela, Mika, Auranen, Mari, Pouget, Jean, Attarian, Shahram, Le Masson, Gwendal, Wielanek-Bachelet, Anne-Cécile, Desnuelle, Claude, Delmont, Emilien, Clavelou, Pierre, Aufauvre, Dominique, Schmidt, Jens, Zschuentssch, Jana, Sommer, Claudia, Kramer, Daniela, Hoffmann, Olaf, Goerlitz, Carsten, Haas, Judith, Chatzopoulos, Marko, Yoon, Min-Suk, Gold, Ralf, Berlit, Peter, Jaspert-Grehl, Andrea, Liebetanz, David, Kutschenko, Anna, Stangel, Martin, Trebst, Corinna, Baum, Petra, Then Bergh, Florian, Klehmet, Juliane, Meisel, Andreas, Klostermann, Fabian, Oechtering, Johanna, Lehmann, Helmar, Schroeter, Michael, Hagenacker, Tim, Mueller, Daniel, Sperfeld, Anne-Dorte, Bethke, Florian, Hartung, Hans-Peter, Drory, Vivian, Algom, Avi, Yarnitsky, David, Murinson, Beth Brianna, Di Muzio, Antonio, Ciccocioppo, Fausta, Sorbi, Sandro, Mata, Sabrina, Schenone, Angelo, Grandis, Marina, Lauria, Giuseppe, Cazzato, Daniele, Antonini, Giovanni, Morino, Stefania, Cocito, Dario, Zibetti, Maurizio, Yokota, Takanori, Ohkubo, Takuya, Kanda, Takashi, Kawai, Motoharu, Kaida, Kenichi, Onoue, Hiroyuki, Kuwabara, Satoshi, Mori, Masahiro, Iijima, Masahiro, Ohyama, Ken, Sobue, Gen, Baba, Masayuki, Tomiyama, Masahiko, Nishiyama, Kazutoshi, Akutsu, Tsugio, Yokoyama, Kazumasa, Kanai, Kazuaki, van Schaik, Ivo N., Eftimov, Filip, Notermans, Nicolette. C., Visser, Nora. A., Faber, Catharina, Hoeijmakers, Janneke. G.J., Merkies, Ingemar S.J., van Geloven, Nan, Rejdak, Konrad, Chyrchel-Paszkiewicz, Urszula, Casanovas Pons, Carlos, Alberti Aguiló, María Antonia, Gamez, Josep, Figueras, María, Marquez Infante, Celedonio, Benitez Rivero, Sonia, Lunn, Michael, Morrow, Jasper, Gosal, David, Lavin, Timothy Myles, Melamed, Isaac, Testori, Alessandro, Ajroud-Driss, Senda, Menichella, Daniela, Simpson, Ericka, Chi-Ho Lai, Eugene, Dimachkie, Mazen, Barohn, Richard J., Beydoun, Said, Johl, Harpreet, Lange, Dale, Shtilbans, Alexander, Muley, Suraj, Ladha, Shafeeq, Freimer, Miriam, Kissel, John, Latov, Norman, Chin, Russell, Ubogu, Eroboghene, Mumfrey, Sandi, Rao, T. Hermanth P., MacDonald, Paul, Sharma, Khema, Gonzalez, Ginna, Allen, Jeffrey, Walk, David, Hobson-Webb, Lisa, Gable, Karissa, Lewis, Richard A., Cornblath, David R., Lawo, John-Phillip, Praus, Michaela, Durn, Billie L., Mielke, Orell, and van Schaik, Ivo N

Published
2018
Full Text
View/download PDF

34. Neuroloogia

Author

Gross-Paju, Katrin

Abstract

Eesti Arst 2013; 92(5):290, Eesti Arst, Mai 2013

Published
2013
Full Text
View/download PDF

36. Insuldi käsitlus Eestis: hetkeseis ja suundumused

Author

Kõrv, Janika, Gross-Paju, Katrin, Haldre, Sulev, Jaakmees, Helle, Kreis, Andrus, Kullamaa, Silja, Liigant, Aive, Lüüs, Siiri-Merike, Taba, Pille, and Õunapuu, Anne

Subjects
insult, kliiniline audit, ravikvaliteet
Abstract

Eesti Haigekassa tellitud insuldiauditi eesmärgiks oli analüüsida Eestis teostatud insuldiravi vastavust insuldi Eesti ravijuhendile, anda hinnang haiguslugude vormistusele ja võrrelda saadud tulemusi eelmise auditeeritud perioodiga (2002–2003). Eesti L. Puusepa nimelise Neuroloogide ja Neurokirurgide Seltsi (ENNS) eksperdid hindasid 400 insuldihaige haiguslugu 17 statsionaarsest raviasutusest ühtse protokolli alusel. Selgus, et ravijuhendit järgiti ja insuldi käsitlus oli parem haiglates, kus patsiente ravivad neuroloogid. Probleemiks oli ebaselgete või valede diagnooside suur osakaal üldvalimis, vajakajäämised tegevuse dokumenteerimisel ning diagnooside vormistamisel. Võrreldes eelmise auditiga on oluliselt paranenud diagnoosimise ja ravi võimalused, kuid esineb puudujääke haige füsioloogiliste parameetrite jälgimise ja korrigeerimise osas, varajase taastusravi korraldamisel. ENNS on veendunud riikliku insuldistrateegia vajalikkuses, artiklis on esitatud ettepanekud ravikvaliteedi parandamiseks. Eesti Arst 2010; 89(6):409−415, Eesti Arst, Juuni 2010

Published
2010
Full Text
View/download PDF

37. Hereditaarset spastilist parapleegiat süsteemselt käsitlenud uuring Eestis tõi esile uusi andmeid

Author

Braschinsky, Mark, Rannikmäe, Kristiina, Tamm, Riin, Metspalu, Andres, Gross-Paju, Katrin, and Haldre, Sulev

Subjects
hereditaarne spastiline parapleegia, Strümpelli-Lorraine’i tõbi
Abstract

Hereditaarne spastiline parapleegia (HSP) on rühm harva esinevaid neurodegeneratiivseid haigusi, millele on iseloomul ik jalgade progresseeruv spastilisus hüperrefl eksiaga. Maailmas on vähe uuringuid, mis spetsiifi liselt ja süsteemselt seda haigust käsitleks. Eestis puudusid HSP-uuringud seni üldse. Nüüd valminud uuringust selgus, et HSP levimus Eestis on 4,4 juhtu 100 000 inimese kohta. Geeniuuringu tulemusena avastati kümme uut varem kirjeldamata muutust haigust põhjustavas SPAST geenis ning kirjeldati nende haigete fenotüüpe. Esmakordne tervisega seotud elukvaliteedi uuring tõestas, et HSPga inimestel esinev elukvaliteedi halvenemine on seostatav peamiselt füüsilise toimetulekuga. Eesti Arst 2010; 89(3):165−170, Eesti Arst, Märts 2010

Published
2010
Full Text
View/download PDF

38. Sclerosis multiplex’i tänapäevane ravi

Author

Kannel, Karin, Gross-Paju, Katrin, and Sorro, Ulvi

Subjects
sclerosis multiplex,immunomoduleeriv ravi, beetainterferoonid, glatirameeratsetaat, natalizumab, mitoksantroon, tsüklofosfamiid
Abstract

Sclerosis multiplex (SM) on kõige sagedasem noortel täiskasvanutel puuet põhjustav neuroloogiline haigus. Haiguskulu järgi eristatakse ägenemiste ja remissioonidega, ägenemistega sekundaarse progresseerumisega, ägenemisteta sekundaarse progresseerumisega ja primaarse progresseerumisega SMi vormi. SMi puhul on kasutusel ägenemiste, haiguse kulgu mõjutav ja sümptomaatiline ravi. Ägenemiste raviks kasutatakse metüülprednisolooni. Haiguse kulgu mõjutavad ravimid on profülaktilised, vähendavad ägenemiste arvu ning on efektiivsed ainult ägenemistega haiguskulu korral. Ravimitest on esmavalikuna kasutusel süstitavad beetainterferoonid ja glatirameeratsetaat. Esmavaliku preparaatide ebapiisava efektiivsuse või väga agressiivse kuluga haiguse puhul on näidustatud ka tsütostaatiline ravi mitoksantrooni või tsüklofosfamiidiga. Varajane ravi on tõhusam kui hiline. Käigusolevad ravimiuuringud annavad lootust, et tulevikus võetakse kasutusele ka suu kaudu manustatavad preparaadid. Eesti Arst 2009; 88(2):117−124, Eesti Arst, Veebruar 2009

Published
2009
Full Text
View/download PDF

39. Dopamiinitundlik düstoonia: kirjanduse ülevaade ja haigusjuhu kirjeldus

Author

Kolk, Anneli, Talvik, Inga, Veri, Kadi, Gross-Paju, Katrin, and Talvik, Tiina

Subjects
düstoonia, fluktuatsioonid, L-dopa
Abstract

Dopamiinitundlik düstoonia ehk Segawa sündroom on haigus, mille haigusnähtude varieeruvus võib mõnikord viia valediagnoosini nagu nt laste tserebraalparalüüs. Paljudel patsientidel esinevad sümptomid päevaste fluktuatsioonidega. Haigus allub ravile dopamiini väikeste annustega. Artiklis on kirjeldatud 11-aastase tütarlapse haigusjuhtu, mille puhul saadi hea raviefekt L-dopaga. Eesti Arst 2006; 85 (12): 841–844, Eesti Arst, Detsember 2006

Published
2006
Full Text
View/download PDF

40. Kognitiiv-käitumisteraapia kroonilise valu ravis

Author

Gross-Paju, Katrin and Sema, Liina

Subjects
krooniline valu, kognitiiv-käitumisteraapia, ravi tõhusus
Abstract

Krooniline valu põhjustab inimese jaoks muutusi mitmes eluvaldkonnas. Valuga toimetulek ja selle ravi on pikaajaline protsess. Lisaks medikamentoossele ravile on viimasel ajal valuga toimetuleku kergendamiseks järjest enam kasutusele võetud erinevaid psühhoteraapia meetodeid. Kognitiiv-käitumusliku teraapia sihiks on aidata patsiendil õppida tundma ning muutma moonutatud mõtlemist ja ebafunktsionaalset käitumist. Selle läbi saab parandada oma igapäevast toimetulekut ja psüühilist seisundit. Teraapia efektiivsus põhineb nii subjektiivsete, käitumuslike kui ka füsioloogiliste muutujate käsitlemisel. Eesti Arst 2005; 84 (6): 433-435, Eesti Arst, Juuni 2005

Published
2005
Full Text
View/download PDF

43. Sclerosis multiplex ja rasedus

Author

Teder-Braschinsky, Anneli, Gross-Paju, Katrin, Braschinsky, Mark, and Mets, Häli

Subjects
sclerosis multiplex, rasedus
Abstract

Sclerosis multiplex on enamasti noores täiskasvanueas algav närvihaigus, mis tabab naisi kaks korda sagedamini kui mehi. Kuigi selle haiguse korral ei ole rasedus vastunäidustatud, on teada, et väljendunud liikumispuudega patsiendid rasestuvad ja sünnitavad harva. Sageli on siin probleemiks, kuidas rasedus mõjutab sclerosis multiplex’i kulgu ja millised on ohud raseduse ajal ja sünnitusejärgsel perioodil. Artiklis on analüüsitud erinevatest aspektidest sclerosis multiplex’i ja raseduse koosmõju ning toodud näitena väljendunud füüsilise puudega patsiendi haigusjuht. Eesti Arst 2002; 81 (12): 812–815, Eesti Arst, Detsember 2002

Published
2002
Full Text
View/download PDF

49. Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements

Author

Braschinsky, Mark, primary, Tamm, Riin, additional, Beetz, Christian, additional, Sachez-Ferrero, Elena, additional, Raukas, Elve, additional, Lüüs, Siiri-Merike, additional, Gross-Paju, Katrin, additional, Boillot, Catherine, additional, Canzian, Federico, additional, Metspalu, Andres, additional, and Haldre, Sulev, additional

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results