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Your search keyword '"Greenman, Kevin L."' showing total 12 results
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12 results on '"Greenman, Kevin L."'

1. Binding of madindoline A to the extracellular domain of gp130

Author

Saleh, Abu Z.M., Greenman, Kevin L., Billings, Susan, Van Vranken, David L., and Krolewski, John J.

Subjects
Extracellular fluid -- Research, Indole -- Research, Protein research, Biological sciences, Chemistry
Abstract

The binding of madindoline A (Mad A) to gp130 is specific and noncovalent and displays a relatively low affinity. It is shown that the tricyclic 3a-hydroxytetrahydrofuro[2,3-b]indole (HFI) moiety of MadA alone is not sufficient for binding.

Published
2005

4. Iron(II)-catalyzed sulfimidation and [2,3]-sigmatropic rearrangement of propargyl sulfides with tert-butoxycarbonyl azide. Access to N-allenylsulfenimides

Author

Bacci, James P., Greenman, Kevin L., and Van Vranken, David L.

Subjects
Chemistry, Organic -- Research, Organic compounds -- Composition, Iron compounds -- Composition, Rearrangements (Chemistry) -- Analysis, Catalysts -- Composition, Sulfides -- Composition, Azo compounds -- Composition, Carbon compounds -- Composition, Biological sciences, Chemistry
Abstract

Research has been conducted on tert-butoxycarbonyl azide and allyl sulfides. The authors report that the iron(II)-catalyzed Bach reaction of these compounds has been extended in order to include propargyl sulfides and to produce N-allenylsulfenimides.

Published
2003

12. Synthesis of phakellistatin 13 and oxidation to phakellistatin 3 and isophakellistatin 3.

Author

Greenman KL, Hach DM, and Van Vranken DL

Subjects
Cyclization, Models, Molecular, Molecular Structure, Oxidation-Reduction, Peptides, Cyclic chemistry, Photochemistry, Piperazines chemistry, Protein Structure, Tertiary, Peptides, Cyclic chemical synthesis, Piperazines chemical synthesis
Abstract

The natural product phakellistatin 13 cyclo-(TrpProPheGlyProThrLeu) was synthesized. Photosensitized oxidation of phakellistatin 13 gave the natural products phakellistatin 3 and isophakellistatin 3, demonstrating for the first time that a tryptophan residue can be directly converted to the corresponding 3a-hydroxypyrrolo[2,3-b]indoline in a full length peptide. Competitive oxidation of the indoline product was identified as the cause of low mass balance and is probably the source of low mass balance in the oxidative cyclization of all tryptamine derivatives. [reaction--see text]

Published
2004
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