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1. Evolution of the autoresonant plasma wave excitation in two-dimensional particle-in-cell simulations

Author

Luo, Mufei., Riconda, Caterina., Grassi, Anna., Wang, Ning., Wurtele, Jonathan S., Fülöp, Tünde, and Pusztai, István

Subjects
Physics - Plasma Physics
Abstract

The generation of an autoresonantly phase-locked high amplitude plasma waves to the chirped beat frequency of two driving lasers is studied in two dimensions using particle-in-cell simulations. The two-dimensional plasma and laser parameters correspond to those that optimized the plasma wave amplitude in one-dimensional simulations. Near the start of autoresonant locking, the two-dimensional simulations appear similar to one-dimensional particle-in-cell results [Luo et al., Phys. Rev. Res. 6, 013338 (2024)] with plasma wave amplitudes above the Rosenbluth-Liu limit. Later, just below wave-breaking, the two-dimensional simulation exhibits a Weibel-like instability and eventually laser beam filamentation. These limit the coherence of the plasma oscillation after the peak plasma wave field is obtained. In spite of the reduction of spatial coherence of the accelerating density structure, the acceleration of self-injected electrons in the case studied remains at $70\%$ to $80\%$ of that observed in one dimension. Other effects such as plasma wave bowing are discussed., Comment: 23 pages, 13 figures

Published
2024

2. Safety and efficacy of narsoplimab in pediatric and adult patients with transplant-associated thrombotic microangiopathy: a real-world experience

Author

Castelli, Marta, Micò, Maria Caterina, Grassi, Anna, Algarotti, Alessandra, Lussana, Federico, Finazzi, Maria Chiara, Rambaldi, Benedetta, Pavoni, Chiara, Rizzuto, Giuliana, Tebaldi, Paola, Vendemini, Francesca, Verna, Marta, Bonanomi, Sonia, Biondi, Andrea, Balduzzi, Adriana, Rambaldi, Alessandro, and Gotti, Giacomo

Published
2024
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4. Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Author

Cavallaro, Gianluca, Grassi, Anna, Pavoni, Chiara, Micò, Maria Caterina, Busca, Alessandro, Cavattoni, Irene Maria, Santarone, Stella, Borghero, Carlo, Olivieri, Attilio, Milone, Giuseppe, Chiusolo, Patrizia, Musto, Pellegrino, Saccardi, Riccardo, Patriarca, Francesca, Pane, Fabrizio, Saporiti, Giorgia, Rivela, Paolo, Terruzzi, Elisabetta, Cerretti, Raffaella, Marotta, Giuseppe, Carella, Angelo Michele, Nagler, Arnon, Russo, Domenico, Corradini, Paolo, Bernasconi, Paolo, Iori, Anna Paola, Castagna, Luca, Mordini, Nicola, Oldani, Elena, Di Grazia, Carmen, Bacigalupo, Andrea, and Rambaldi, Alessandro

Published
2024
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5. On the control of electron heating for optimal laser radiation pressure ion acceleration

Author

Chou, H. -G. Jason, Grassi, Anna, Glenzer, Siegfried H., and Fiuza, Frederico

Subjects
Physics - Plasma Physics
Abstract

We study the onset of electron heating in intense laser-solid interactions and its impact on the spectral quality of radiation pressure accelerated ions in both hole boring and light sail regimes. Two- and three-dimensional particle-in-cell (PIC) simulations are performed over a wide range of laser and target parameters and reveal how the pulse duration, profile, polarization, and target surface stability control the electron heating, the dominant ion acceleration mechanisms, and the ion spectra. We find that the onset of strong electron heating is associated with the growth of the Rayleigh-Taylor-like instability at the front surface and must be controlled to produce high-quality ion beams, even when circularly polarized lasers are employed. We define a threshold condition for the maximum duration of the laser pulse that allows mitigation of electron heating and radiation pressure acceleration of narrow energy spread ion beams. The model is validated by three-dimensional PIC simulations, and the few experimental studies that reported low energy spread radiation pressure accelerated ion beams appear to meet the derived criteria. The understanding provided by our work will be important in guiding future experimental developments, for example for the ultrashort laser pulses becoming available at state-of-the-art laser facilities, for which we predict that proton beams with ~150 - 250 MeV, ~30% energy spread, and a total laser-to-proton conversion efficiency of ~20% can be produced., Comment: 20 (25) pages, 10 figures

Published
2022
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6. Radiation pressure acceleration of high-quality ion beams using ultrashort laser pulses

Author

Chou, H. -G. Jason, Grassi, Anna, Glenzer, Siegfried H., and Fiuza, Frederico

Subjects
Physics - Plasma Physics, Physics - Accelerator Physics
Abstract

The generation of compact, high-energy ion beams is one of the most promising applications of intense laser-matter interactions, but the control of the beam spectral quality remains an outstanding challenge. We show that in radiation pressure acceleration of a thin solid target the onset of electron heating is determined by the growth of the Rayleigh-Taylor-like instability at the front surface and must be controlled to produce ion beams with high spectral quality in the light sail regime. The growth rate of the instability imposes an upper limit on the laser pulse duration and intensity to achieve high spectral beam quality and we demonstrate that under this optimal regime, the maximum peak ion beam energy per nucleon is independent of target density, composition, and laser energy (transverse spot size). Our predictions are validated by two- and three-dimensional particle-in-cell simulations, which indicate that for recent and upcoming experimental facilities using ultrashort ($\lesssim 25$ fs) laser pulses it is possible to produce $100 - 300$ MeV proton beams with $\sim 30\%$ energy spread and high laser-to-proton energy conversion efficiency., Comment: 6 pages, 6 figures

Published
2022
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8. Efficient generation of turbulent collisionless shocks in laser-ablated counter-streaming plasmas

Author

Grassi, Anna and Fiuza, Frederico

Subjects
Physics - Plasma Physics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Laser-ablated high-energy-density (HED) plasmas offer a promising route to study astrophysically relevant processes underlying collisionless shock formation, magnetic field amplification, and particle acceleration in the laboratory. Using large-scale, multi-dimensional particle-in-cell simulations, we explore the interpenetration of laser-ablated counter-streaming plasmas for realistic experimental flow profiles. We find that the shock formation and its structure are substantially different from those of more idealized and commonly considered uniform flows: shock formation can be up to 10 times faster due to the transition from small-angle scattering to magnetic reflection and the shock front develops strong corrugations at the ion gyroradius scale. These findings have important consequences for current experimental programs and open exciting prospects for studying the microphysics of turbulent collisionless shocks with currently available high-energy laser systems., Comment: 9 pages, 9 figures

Published
2021
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9. Momentum Absorption and Magnetic Field Generation by Obliquely Incident Light

Author

Macchi, Andrea, Grassi, Anna, Amiranoff, François, and Riconda, Caterina

Subjects
Physics - Optics, Physics - Plasma Physics
Abstract

The partial reflection of an electromagnetic (EM) wave from a medium leads to absorption of momentum in the direction perpendicular to the surface (the standard radiation pressure) {and, for oblique incidence on a partially reflecting medium}, also in the parallel direction. This latter component drives a transverse current and a slowly growing, quasi-static magnetic field in the evanescence ``skin'' layer. Through a simple model we illustrate how EM momentum is transfered to ions and estimate the value of the magnetic field which may be of the order of the driving EM wave field, i.e. up to several hundreds of megagauss for high intensity laser-solid interactions., Comment: 7 pages, 2 figures

Published
2019

10. Neurological complications in adult allogeneic hematopoietic stem cell transplant patients: Incidence, characteristics and long-term follow-up in a multicenter series

Author

Wieczorek, Michele, Mariotto, Sara, Ferrari, Sergio, Mosna, Federico, Micò, Maria Caterina, Borghero, Carlo, Dubbini, Maria Vittoria, Malagola, Michele, Skert, Cristina, Andreini, Angelo, De Marco, Beatrice, Polo, Diana, Tfaily, Ahmad, Krampera, Mauro, Grassi, Anna, Candoni, Anna, Ranzato, Federica, Volonghi, Irene, Quatrale, Rocco, Benedetti, Fabio, and Tecchio, Cristina

Published
2022
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11. Myeloablative conditioning with thiotepa-busulfan-fludarabine does not improve the outcome of patients transplanted with active leukemia: final results of the GITMO prospective trial GANDALF-01

Author

Bonifazi, Francesca, Pavoni, Chiara, Peccatori, Jacopo, Giglio, Fabio, Arpinati, Mario, Busca, Alessandro, Bernasconi, Paolo, Grassi, Anna, Iori, Anna Paola, Patriarca, Francesca, Brunello, Lucia, Di Grazia, Carmen, Carella, Angelo Michele, Cilloni, Daniela, Picardi, Alessandra, Proia, Anna, Santarone, Stella, Sorasio, Roberto, Carluccio, Paola, Chiusolo, Patrizia, Cupri, Alessandra, Luppi, Mario, Nozzoli, Chiara, Baronciani, Donatella, Casini, Marco, Grillo, Giovanni, Musso, Maurizio, Onida, Francesco, Palazzo, Giulia, Parma, Matteo, Tringali, Stefania, Vacca, Adriana, Vallisa, Daniele, Sacchi, Nicoletta, Oldani, Elena, Masciulli, Arianna, Gheorghiu, Angela, Girmenia, Corrado, Martino, Massimo, Bruno, Benedetto, Rambaldi, Alessandro, and Ciceri, Fabio

Published
2022
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12. Perpendicular relativistic shocks in magnetized pair plasma

Author

Plotnikov, Illya, Grassi, Anna, and Grech, Mickael

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Physics - Computational Physics, Physics - Plasma Physics
Abstract

Perpendicular relativistic ($\gamma_0=10$) shocks in magnetized pair plasmas are investigated using two dimensional Particle-in-Cell simulations. A systematic survey, from unmagnetized to strongly magnetized shocks, is presented accurately capturing the transition from Weibel-mediated to magnetic-reflection-shaped shocks. This transition is found to occur for upstream flow magnetizations $10^{-3}<\sigma<10^{-2}$ at which a strong perpendicular net current is observed in the precursor, driving the so-called current-filamentation instability. The global structure of the shock and shock formation time are discussed. The MHD shock jump conditions are found in good agreement with the numerical results, except for $10^{-4} < \sigma < 10^{-2}$ where a deviation up to 10\% is observed. The particle precursor length converges toward the Larmor radius of particles injected in the upstream magnetic field at intermediate magnetizations. For $\sigma>10^{-2}$, it leaves place to a purely electromagnetic precursor following from the strong emission of electromagnetic waves at the shock front. Particle acceleration is found to be efficient in weakly magnetized perpendicular shocks in agreement with previous works, and is fully suppressed for $\sigma > 10^{-2}$. Diffusive Shock Acceleration is observed only in weakly magnetized shocks, while a dominant contribution of Shock Drift Acceleration is evidenced at intermediate magnetizations. The spatial diffusion coefficients are extracted from the simulations allowing for a deeper insight into the self-consistent particle kinematics and scale with the square of the particle energy in weakly magnetized shocks. These results have implications for particle acceleration in the internal shocks of AGN jets and in the termination shocks of Pulsar Wind Nebulae., Comment: 23 pages, 18 figures, 2 appendices, to appear in MNRAS

Published
2017
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15. Radiation Pressure Driven Ion Weibel Instability and Collisionless Shocks

Author

Grassi, Anna, Grech, Mickael, Amiranoff, Francois, Macchi, Andrea, and Riconda, Caterina

Subjects
Physics - Plasma Physics
Abstract

The Weibel instability from counterstreaming plasma flows is a basic process highly relevant for collisionless shock formation in astrophysics. In this Letter we investigate, via two- and three- dimensional simulations, suitable configurations for laboratory investigations of the ion Weibel instability (IWI) driven by a fast quasi-neutral plasma flow launched into the target via the radiation pressure of an ultra-high-intensity (UHI) laser pulse ('Hole-Boring' process). The use of S-polarized light at oblique incidence is found to be an optimal configuration for driving IWI, as it prevents the development of surface rippling observed at normal incidence, that would lead to strong electron heating and favors competing instabilities. Conditions for the evolution of IWI into a collisionless shock are also investigated., Comment: 5 pages, 4 figures

Published
2017
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16. In situ occurrence and conservation of Beta vulgaris subsp. maritima ((L.) Arcangeli) in Italy.

Author

Zucchini, Cecilia, Raggi, Lorenzo, Grassi, Anna, Spataro, Giorgia, Gigante, Daniela, Negri, Valeria, Smykal, Petr, and Hauser, Samantha S.

Subjects
BEETS, NATURE reserves, SUGAR beets, LAND cover, PROTECTED areas, ABIOTIC stress
Abstract

Introduction: Crop Wild Relatives (CWR) have great socioeconomic importance for humans harbouring a broad spectrum of diversity and being important elements of different habitats. Beta vulgaris subsp. maritima ((L.) Arcangeli), also known as sea beet, is an important CWR of cultivated beets (GP-1). The high adaptability of this taxon to different environmental conditions, as well as its tolerance/resistance to different biotic and abiotic stresses, makes it a vital source for sugar beet improvement. Aim of this work was to analyse the in situ and ex situ status of sea beet population conservation in Italy, so as to guide protection activities and new collecting missions. Methods: Geographical distribution data of populations were that occur in the wild and conserved in genebanks were assembled from different databases and submitted to data quality control. Distribution, habitat characterization, land cover and use of the involved sites were then evaluated to provide insight into the current condition of areas hosting this CWR diversity. The presence of populations within vs. outside Italian protected areas was also evaluated. A density analysis of the records was performed and the adequateness of sea beet ex situ conservation, in terms of number of conserved accessions, was finally estimated. Results: A collection of 138 B. vulgaris subsp. maritima high quality georeferenced records were obtained, mainly distributed into Mediterranean Biogeographic Region. About 22% of the considered populations occurs in protected sites of the Natura 2000 Network, while about 15% in areas recorded in the Official list of protected natural areas (EUAP). Occurrences within protected areas are founded primarily in natural environments, whereas those outside are mainly located in urban and cultivated areas. The comparison of distribution and density analysis results revealed the presence of several gaps between sites hosting in situ populations and sites where ex situ conserved accessions were originally collected. Discussion: Here presented data indicates that the protection status for sea beet in Italy can be considered only partially adequate; more proactive protection measures should be foreseen to increase the role of protected areas in safeguarding in situ conservation. "Out of reserve management" for populations outside protected areas should also be developed, as well as new collecting missions carried out. [ABSTRACT FROM AUTHOR]

Published
2024
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17. COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey

Author

Ljungman, Per, de la Camara, Rafael, Mikulska, Malgorzata, Tridello, Gloria, Aguado, Beatriz, Zahrani, Mohsen Al, Apperley, Jane, Berceanu, Ana, Bofarull, Rodrigo Martino, Calbacho, Maria, Ciceri, Fabio, Lopez-Corral, Lucia, Crippa, Claudia, Fox, Maria Laura, Grassi, Anna, Jimenez, Maria-Jose, Demir, Safiye Koçulu, Kwon, Mi, Llamas, Carlos Vallejo, Lorenzo, José Luis López, Mielke, Stephan, Orchard, Kim, Porras, Rocio Parody, Vallisa, Daniele, Xhaard, Alienor, Knelange, Nina Simone, Cedillo, Angel, Kröger, Nicolaus, Piñana, José Luis, and Styczynski, Jan

Published
2021
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18. Vlasov simulation of laser-driven shock acceleration and ion turbulence

Author

Grassi, Anna, Fedeli, Luca, Sgattoni, Andrea, and Macchi, Andrea

Subjects
Physics - Plasma Physics
Abstract

We present a Vlasov, i.e. a kinetic Eulerian simulation study of nonlinear collisionless ion-acoustic shocks and solitons excited by an intense laser interacting with an overdense plasma. The use of the Vlasov code avoids problems with low particle statistics and allows a validation of particle-in-cell results. A simple original correction to the splitting method for the numerical integration of the Vlasov equation has been implemented in order to ensure the charge conservation in the relativistic regime. We show that the ion distribution is affected by the development of a turbulence driven by the relativistic "fast" electron bunches generated at the laser-plasma interaction surface. This leads to the onset of ion reflection at the shock front in an initially cold plasma where only soliton solutions without ion reflection are expected to propagate. We give a simple analytic model to describe the onset of the turbulence as a nonlinear coupling of the ion density with the fast electron currents, taking the pulsed nature of the relativistic electron bunches into account.

Published
2015
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22. Allogeneic hematopoietic cell transplantation with cord blood versus mismatched unrelated donor with post-transplant cyclophosphamide in acute myeloid leukemia

Author

Dholaria, Bhagirathbhai, Labopin, Myriam, Sanz, Jaime, Ruggeri, Annalisa, Cornelissen, Jan, Labussière-Wallet, Hélène, Blaise, Didier, Forcade, Edouard, Chevallier, Patrice, Grassi, Anna, Zubarovskaya, Ludmila, Kuball, Jürgen, Ceballos, Patrice, Ciceri, Fabio, Baron, Frederic, Savani, Bipin N., Nagler, Arnon, and Mohty, Mohamad

Published
2021
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25. Posttransplant cyclophosphamide versus antithymocyte globulin in patients with acute lymphoblastic leukemia treated with allogeneic hematopoietic cell transplantation from matched unrelated donors: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Giebel, Sebastian, primary, Labopin, Myriam, additional, Salmenniemi, Urpu, additional, Socié, Gerard, additional, Bondarenko, Sergey, additional, Blaise, Didier, additional, Kröger, Nicolaus, additional, Vydra, Jan, additional, Grassi, Anna, additional, Bonifazi, Francesca, additional, Czerw, Tomasz, additional, Anagnostopoulos, Achilles, additional, Lioure, Bruno, additional, Ruggeri, Annalisa, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Sanz, Jaime, additional, Peric, Zinaida, additional, Nagler, Arnon, additional, Ciceri, Fabio, additional, and Mohty, Mohamad, additional

Published
2023
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26. Veno-occlusive Disease in HSCT Patients: Consensus-based Recommendations for Risk Assessment, Diagnosis, and Management by the GITMO Group

Author

Bonifazi, Francesca, Sica, Simona, Angeletti, Alessia, Marktel, Sarah, Prete, Arcangelo, Iori, Anna Paola, Olivari, Diletta, Rossetti, Giulia, Bertaina, Alice, Botti, Stefano, Busca, Alessandro, Carella, Angelo Michele, Cerretti, Raffaella, Gargiulo, Gianpaolo, Grassi, Anna, Gualandi, Francesca, Irrera, Giuseppe, Milone, Giuseppe, Risitano, Antonio Maria, Santarone, Stella, Vassallo, Elena, Zecca, Marco, Ciceri, Fabio, and Pomponio, Giovanni

Published
2020
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27. Phase II Study of Sequential Infusion of Donor Lymphocyte Infusion and Cytokine-Induced Killer Cells for Patients Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Introna, Martino, Lussana, Federico, Algarotti, Alessandra, Gotti, Elisa, Valgardsdottir, Rut, Micò, Caterina, Grassi, Anna, Pavoni, Chiara, Ferrari, Maria Luisa, Delaini, Federica, Todisco, Elisabetta, Cavattoni, Irene, Deola, Sara, Biagi, Ettore, Balduzzi, Adriana, Rovelli, Attilio, Parma, Matteo, Napolitano, Sara, Sgroi, Giusy, Marrocco, Emanuela, Perseghin, Paolo, Belotti, Daniela, Cabiati, Benedetta, Gaipa, Giuseppe, Golay, Josée, Biondi, Andrea, and Rambaldi, Alessandro

Published
2017
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29. Case report: biallelic DNMT3A mutations in acute myeloid leukemia

Author

Cumbo, Cosimo, primary, Orsini, Paola, additional, Anelli, Luisa, additional, Zagaria, Antonella, additional, Iannò, Maria Federica, additional, De Cecco, Loris, additional, Minervini, Crescenzio Francesco, additional, Coccaro, Nicoletta, additional, Tota, Giuseppina, additional, Parciante, Elisa, additional, Conserva, Maria Rosa, additional, Redavid, Immacolata, additional, Tarantini, Francesco, additional, Minervini, Angela, additional, Carluccio, Paola, additional, De Grassi, Anna, additional, Pierri, Ciro Leonardo, additional, Specchia, Giorgina, additional, Musto, Pellegrino, additional, and Albano, Francesco, additional

Published
2023
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30. Diagnosis by liver stiffness measurement of sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation: results from the Italian multicentric prospective study (ELASTOVOD)

Author

Ravaioli, Federico, primary, Colecchia, Antonio, additional, Barbato, Francesco, additional, Peccatori, Jacopo, additional, Grassi, Anna, additional, Sarina, Barbara, additional, Pompili, Maurizio, additional, Sica, Simona, additional, Locatelli, Franco, additional, Cesaro, Simone, additional, Nozzoli, Chiara, additional, Iori, Anna Paola, additional, Prezioso, Lucia, additional, Santarone, Stella, additional, Fagioli, Franca, additional, Olivieri, Attilio, additional, Vanni, Ester, additional, Specchia, Giorgina, additional, Benedetti, Edoardo, additional, Zallio, Francesco, additional, Pane, Fabrizio, additional, Carobolante, Francesca, additional, Menconi, Maria Cristina, additional, Benedetti, Fabio, additional, Patriarca, Francesca, additional, Malagola, Michele, additional, Varaldo, Riccardo, additional, Onida, Francesco, additional, Pavone, Vincenzo, additional, Vestito, Amanda, additional, Colecchia, Luigi, additional, Dajti, Elton, additional, Alemanni, Luigina Vanessa, additional, Marasco, Giovanni, additional, Ciceri, Fabio, additional, Prete, Arcangelo, additional, Pession, Andrea, additional, Festi, Davide, additional, and Bonifazi, Francesca, additional

Published
2023
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31. An overview of combined D-2- and L-2-hydroxyglutaric aciduria: functional analysis of CIC variants

Author

Pop, Ana, Williams, Monique, Struys, Eduard A., Monné, Magnus, Jansen, Erwin E. W., De Grassi, Anna, Kanhai, Warsha A., Scarcia, Pasquale, Ojeda, Matilde R. Fernandez, Porcelli, Vito, van Dooren, Silvy J. M., Lennertz, Pascal, Nota, Benjamin, Abdenur, Jose E., Coman, David, Das, Anibh Martin, El-Gharbawy, Areeg, Nuoffer, Jean-Marc, Polic, Branka, Santer, René, Weinhold, Natalie, Zuccarelli, Britton, Palmieri, Ferdinando, Palmieri, Luigi, and Salomons, Gajja S.

Published
2018
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32. Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry

Author

Ljungman, Per, primary, Tridello, Gloria, additional, Piñana, Jose Luis, additional, Ciceri, Fabio, additional, Sengeloev, Henrik, additional, Kulagin, Alexander, additional, Mielke, Stephan, additional, Yegin, Zeynep Arzu, additional, Collin, Matthew, additional, Einardottir, Sigrun, additional, Lepretre, Sophie Ducastelle, additional, Maertens, Johan, additional, Campos, Antonio, additional, Metafuni, Elisabetta, additional, Pichler, Herbert, additional, Folber, Frantisek, additional, Solano, Carlos, additional, Nicholson, Emma, additional, Yüksel, Meltem Kurt, additional, Carlson, Kristina, additional, Aguado, Beatriz, additional, Besley, Caroline, additional, Byrne, Jenny, additional, Heras, Immaculada, additional, Dignan, Fiona, additional, Kröger, Nicolaus, additional, Robin, Christine, additional, Khan, Anjum, additional, Lenhoff, Stig, additional, Grassi, Anna, additional, Dobsinska, Veronika, additional, Miranda, Nuno, additional, Jimenez, Maria-Jose, additional, Yonal-Hindilerden, Ipek, additional, Wilson, Keith, additional, Averbuch, Dina, additional, Cesaro, Simone, additional, Xhaard, Alienor, additional, Knelange, Nina, additional, Styczynski, Jan, additional, Mikulska, Malgorzata, additional, and de la Camara, Rafael, additional

Published
2023
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34. Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19 : An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry

Author

Ljungman, Per, Tridello, Gloria, Pinana, Jose Luis, Ciceri, Fabio, Sengeloev, Henrik, Kulagin, Alexander, Mielke, Stephan, Yegin, Zeynep Arzu, Collin, Matthew, Einardottir, Sigrun, Lepretre, Sophie Ducastelle, Maertens, Johan, Campos, Antonio, Metafuni, Elisabetta, Pichler, Herbert, Folber, Frantisek, Solano, Carlos, Nicholson, Emma, Yueksel, Meltem Kurt, Carlson, Kristina, Aguado, Beatriz, Besley, Caroline, Byrne, Jenny, Heras, Immaculada, Dignan, Fiona, Kroeger, Nicolaus, Robin, Christine, Khan, Anjum, Lenhoff, Stig, Grassi, Anna, Dobsinska, Veronika, Miranda, Nuno, Jimenez, Maria-Jose, Yonal-Hindilerden, Ipek, Wilson, Keith, Averbuch, Dina, Cesaro, Simone, Xhaard, Alienor, Knelange, Nina, Styczynski, Jan, Mikulska, Malgorzata, de la Camara, Rafael, Ljungman, Per, Tridello, Gloria, Pinana, Jose Luis, Ciceri, Fabio, Sengeloev, Henrik, Kulagin, Alexander, Mielke, Stephan, Yegin, Zeynep Arzu, Collin, Matthew, Einardottir, Sigrun, Lepretre, Sophie Ducastelle, Maertens, Johan, Campos, Antonio, Metafuni, Elisabetta, Pichler, Herbert, Folber, Frantisek, Solano, Carlos, Nicholson, Emma, Yueksel, Meltem Kurt, Carlson, Kristina, Aguado, Beatriz, Besley, Caroline, Byrne, Jenny, Heras, Immaculada, Dignan, Fiona, Kroeger, Nicolaus, Robin, Christine, Khan, Anjum, Lenhoff, Stig, Grassi, Anna, Dobsinska, Veronika, Miranda, Nuno, Jimenez, Maria-Jose, Yonal-Hindilerden, Ipek, Wilson, Keith, Averbuch, Dina, Cesaro, Simone, Xhaard, Alienor, Knelange, Nina, Styczynski, Jan, Mikulska, Malgorzata, and de la Camara, Rafael

Abstract

Introduction: COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. Methods: This study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic. Results: The median age was 50.3 years (min - max; 1.0 - 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min - max; 0.0 - 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 - 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 - 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022. Discussion: Although the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death.

Published
2023
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35. Achieving Molecular Remission before Allogeneic Stem Cell Transplantation in Adult Patients with Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: Impact on Relapse and Long-Term Outcome

Author

Lussana, Federico, Intermesoli, Tamara, Gianni, Francesca, Boschini, Cristina, Masciulli, Arianna, Spinelli, Orietta, Oldani, Elena, Tosi, Manuela, Grassi, Anna, Parolini, Margherita, Audisio, Ernesta, Cattaneo, Chiara, Raimondi, Roberto, Angelucci, Emanuele, Cavattoni, Irene Maria, Scattolin, Anna Maria, Cortelezzi, Agostino, Mannelli, Francesco, Ciceri, Fabio, Mattei, Daniele, Borlenghi, Erika, Terruzzi, Elisabetta, Romani, Claudio, Bassan, Renato, and Rambaldi, Alessandro

Published
2016
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37. Targeting mitochondrial impairment for the treatment of cardiovascular diseases: From hypertension to ischemia-reperfusion injury, searching for new pharmacological targets

Author

Todisco, Simona, primary, Musio, Biagia, additional, Pesce, Vito, additional, Cavalluzzi, Maria Maddalena, additional, Petrosillo, Giuseppe, additional, La Piana, Gianluigi, additional, Sgobba, Maria Noemi, additional, Schlosserová, Nikola, additional, Cafferati Beltrame, Lucas, additional, Di Lorenzo, Rosa, additional, Tragni, Vincenzo, additional, Marzulli, Domenico, additional, Guerra, Lorenzo, additional, De Grassi, Anna, additional, Gallo, Vito, additional, Volpicella, Mariateresa, additional, Palese, Luigi Leonardo, additional, Lentini, Giovanni, additional, and Pierri, Ciro Leonardo, additional

Published
2023
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38. Busulfan plus cyclophosphamide versus busulfan plus fludarabine as a preparative regimen for allogeneic haemopoietic stem-cell transplantation in patients with acute myeloid leukaemia: an open-label, multicentre, randomised, phase 3 trial

Author

Rambaldi, Alessandro, Grassi, Anna, Masciulli, Arianna, Boschini, Cristina, Micò, Maria Caterina, Busca, Alessandro, Bruno, Benedetto, Cavattoni, Irene, Santarone, Stella, Raimondi, Roberto, Montanari, Mauro, Milone, Giuseppe, Chiusolo, Patrizia, Pastore, Domenico, Guidi, Stefano, Patriarca, Francesca, Risitano, Antonio M, Saporiti, Giorgia, Pini, Massimo, Terruzzi, Elisabetta, Arcese, William, Marotta, Giuseppe, Carella, Angelo Michele, Nagler, Arnon, Russo, Domenico, Corradini, Paolo, Alessandrino, Emilio Paolo, Torelli, Giovanni Fernando, Scimè, Rosanna, Mordini, Nicola, Oldani, Elena, Marfisi, Rosa Maria, Bacigalupo, Andrea, and Bosi, Alberto

Published
2015
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39. Targeting mitochondrial impairment for the treatment of cardiovascular diseases: from hypertension to ischemia reperfusion injury, searching for new pharmacological targets

Author

Todisco, Simona, Musio, Biagia, Pesce, Vito, Cavalluzzi, Maria Maddalena, Petrosillo, Giuseppe, La Piana, Gianluigi, Sgobba, Maria Noemi, Schlosserová, Nikola, Cafferati Beltrame, Lucas, Di Lorenzo, Rosa, Tragni, Vincenzo, Marzulli, Domenico, Guerra, Lorenzo, De Grassi, Anna, Gallo, Vito, Volpicella, Mariateresa, Palese, Luigi Leonardo, Lentini, Giovanni, and Pierri, Ciro Leonardo

Subjects
Pharmacology, Drug-Repurposing, Mitochondrial permeability transition pore, Molecular modeling of mitochondrial proteins, Mitochondrial pyruvate carrier, Aquaporin, Cardiolipin, Cardiovascular diseases, Genomics, Hypertension, Ischemia reperfusion injury, Metabolomics, Mitochondrial carriers, Mitochondrial diseases, Mitochondrial dynamics, Mitochondrial dysfunction, Mitochondrial impairment, Mitochondrial metabolite transport system, Mitochondrial pharmacological targets, Mitochondrial targets for CVD treatments, Respiratory chain, Transcriptomics, Voltage-dependent anion channels, Biochemistry
Abstract

Mitochondria and mitochondrial proteins represent a group of promising pharmacological-target candidates in the search of new molecular targets and drugs to counteract the onset of hypertension and more in general cardiovascular diseases (CVDs). Indeed, several mitochondrial pathways result impaired in CVDs, showing ATP depletion and ROS production as common traits of cardiac tissue degeneration. Thus, targeting mitochondrial dysfunction in cardiomyocytes can represent a successful strategy to prevent heart failure. In this context, the identification of new pharmacological targets among mitochondrial proteins paves the way for the design of new selective drugs. Thanks to the advances in omics approaches, to a greater availability of mitochondrial crystallized protein structures and to the development of new computational approaches for protein 3D-modelling and drug-design, it is now possible to investigate in detail impaired mitochondrial pathways in CVDs. Furthermore, it is possible to design new powerful drugs able to hit the selected pharmacological targets in a highly selective way to rescue mitochondrial dysfunction and prevent cardiac tissue degeneration. The role of mitochondrial dysfunction in the onset of CVDs appears increasingly evident, as reflected by the impairment of proteins involved in lipid peroxidation, mitochondrial dynamics, respiratory chain complexes, and membrane polarization maintenance in CVD patients. Conversely, little is known about proteins responsible for the cross-talk between mitochondria and cytoplasm in cardiomyocytes. Mitochondrial transporters of the SLC25A family, in particular, are responsible for the translocation of nucleotides (e.g., ATP), amino acids (e.g., aspartate, glutamate, ornithine), organic acids (e.g. malate and 2-oxoglutarate), and other cofactors (e.g., inorganic phosphate, NAD

Published
2022

42. Carcik-CD19 Cells Expand In Vivo Toward a CD8+ Memory Phenotype and Their Persistence Is Associated with a Longer Duration of Response

Author

Rambaldi, Benedetta, primary, Galimberti, Stefania, additional, Rizzuto, Giuliana, additional, Magnani, Chiara Francesca, additional, Buracchi, Chiara, additional, Risca, Giulia, additional, Paredi, Martina, additional, Belotti, Daniela, additional, Moretti, Alex, additional, Ponzo, Marianna, additional, Tettamanti, Sarah, additional, Borleri, Gian Maria, additional, Meli, Cristian, additional, Paganessi, Muriel, additional, Zaninelli, Silvia, additional, Gotti, Elisa, additional, Capelli, Chiara, additional, Introna, Martino, additional, Lussana, Federico, additional, Gritti, Giuseppe, additional, Ferrari, Silvia, additional, Grassi, Anna, additional, Napolitano, Sara, additional, Balduzzi, Adriana, additional, Valsecchi, Maria Grazia, additional, Dastoli, Giuseppe, additional, Rambaldi, Alessandro, additional, Biondi, Andrea, additional, and Gaipa, Giuseppe, additional

Published
2022
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43. Training and Validation Cohorts for Predicting the Impact of High Molecular Risk Mutations after Allogeneic Stem Cell Transplantation in Myelofibrosis

Author

Finazzi, Maria Chiara, primary, Civini, Alessia, additional, Pavoni, Chiara, additional, Grassi, Anna, additional, Mico', Maria Caterina, additional, Algarotti, Alessandra, additional, Bellini, Marta, additional, Patriarca, Francesca, additional, Guglielmelli, Paola, additional, Luppi, Mario, additional, Rumi, Elisa, additional, Polverelli, Nicola, additional, Messina, Giuseppe, additional, Bregante, Stefania, additional, Milone, Giuseppe, additional, Imovilli, Annalisa, additional, Bruno, Benedetto, additional, Musso, Maurizio, additional, Santarone, Stella, additional, Pini, Massimo, additional, Pennisi, Martina, additional, Spinelli, Orietta, additional, Bonifazi, Francesca, additional, Rambaldi, Alessandro, additional, and Salmoiraghi, Silvia, additional

Published
2022
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44. Long-Term Analysis of an Open-Label, Multicentre, Randomized Phase 3 Trial Comparing Busulfan Plus Cyclophosphamide Versus Busulfan Plus Fludarabine As a Preparative Regimen for Allogeneic Stem-Cell Transplantation in Patients with Acute Myeloid Leukemia

Author

Cavallaro, Gianluca, primary, Grassi, Anna, additional, Pavoni, Chiara, additional, Mico', Maria Caterina, additional, Busca, Alessandro, additional, Cavattoni, Irene Maria, additional, Santarone, Stella, additional, Borghero, Carlo, additional, Olivieri, Attilio, additional, Milone, Giuseppe, additional, Chiusolo, Patrizia, additional, Musto, Pellegrino, additional, Saccardi, Riccardo, additional, Patriarca, Francesca, additional, Pane, Fabrizio, additional, Saporiti, Giorgia, additional, Rivela, Paolo, additional, Terruzzi, Elisabetta, additional, Cerretti, Raffaella, additional, Marotta, Giuseppe, additional, Carella, Angelo Michele, additional, Nagler, Arnon, additional, Russo, Domenico, additional, Corradini, Paolo, additional, Bernasconi, Paolo, additional, Iori, Anna Paola, additional, Castagna, Luca, additional, Mordini, Nicola, additional, Oldani, Elena, additional, Di Grazia, Carmen, additional, Bacigalupo, Andrea, additional, and Rambaldi, Alessandro, additional

Published
2022
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45. Final Results of Phase I/II Study of Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with B-Cell Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Author

Lussana, Federico, primary, Magnani, Chiara Francesca, additional, Gaipa, Giuseppe, additional, Galimberti, Stefania, additional, Gritti, Giuseppe, additional, Belotti, Daniela, additional, Napolitano, Sara, additional, Buracchi, Chiara, additional, Borleri, Gian Maria, additional, Rambaldi, Benedetta, additional, Rizzuto, Giuliana, additional, Grassi, Anna, additional, Paganessi, Muriel, additional, Ferrari, Silvia, additional, Tettamanti, Sarah, additional, Gazzaniga, Giovanni, additional, Capelli, Chiara, additional, Gotti, Elisa, additional, Introna, Martino, additional, Balduzzi, Adriana, additional, Valsecchi, Maria Grazia, additional, Dastoli, Giuseppe, additional, Rambaldi, Alessandro, additional, and Biondi, Andrea, additional

Published
2022
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47. Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients

Author

Introna, Martino, Lucchini, Giovanna, Dander, Erica, Galimberti, Stefania, Rovelli, Attilio, Balduzzi, Adriana, Longoni, Daniela, Pavan, Fabio, Masciocchi, Francesca, Algarotti, Alessandra, Micò, Caterina, Grassi, Anna, Deola, Sara, Cavattoni, Irene, Gaipa, Giuseppe, Belotti, Daniela, Perseghin, Paolo, Parma, Matteo, Pogliani, Enrico, Golay, Josee, Pedrini, Olga, Capelli, Chiara, Cortelazzo, Sergio, D’Amico, Giovanna, Biondi, Andrea, Rambaldi, Alessandro, and Biagi, Ettore

Published
2014
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48. Deconstructing SARS‐CoV‐2 neutralization: A modular molecular framework for computational design and comparison of antibodies and nanobodies targeting the spike RBD.

Author

Tragni, Vincenzo, Mercurio, Ivan, Paoletti, Diletta Pia, Onofrio, Angelo, Laera, Luna, Cafferati Beltrame, Lucas, Sgobba, Maria Noemi, Guerra, Lorenzo, Volpicella, Mariateresa, De Grassi, Anna, Elia, Gabriella, and Pierri, Ciro Leonardo

Subjects
SARS-CoV-2, IMMUNOGLOBULINS
Abstract

Since 2020 the COVID‐19 pandemic has led scientists to search for strategies to predict the transmissibility and virulence of new severe acute respiratory syndrome coronavirus 2 variants based on the estimation of the affinity of the spike receptor binding domain (RBD) for the human angiotensin‐converting enzyme 2 (ACE2) receptor and/or neutralizing antibodies. In this context, our lab developed a computational pipeline to quickly quantify the free energy of interaction at the spike RBD/ACE2 protein–protein interface, reflecting the incidence trend observed in the transmissibility/virulence of the investigated variants. In this new study, we used our pipeline to estimate the free energy of interaction between the RBD from 10 variants, and 14 antibodies (ab), or 5 nanobodies (nb), highlighting the RBD regions preferentially targeted by the investigated ab/nb. Our structural comparative analysis and interaction energy calculations allowed us to propose the most promising RBD regions to be targeted by future ab/nb to be designed by site‐directed mutagenesis of existing high‐affinity ab/nb, to increase their affinity for the target RBD region, for preventing spike‐RBD/ACE2 interactions and virus entry in host cells. Furthermore, we evaluated the ability of the investigated ab/nb to simultaneously interact with the three RBD located on the surface of the trimeric spike protein, which can alternatively be in up‐ or down‐ (all‐3‐up‐, all‐3‐down‐, 1‐up‐/2‐down‐, 2‐up‐/1‐down‐) conformations. [ABSTRACT FROM AUTHOR]

Published
2023
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50. RUNX1 gene alterations characterized by allelic preference in adult acute myeloid leukemia.

Author

Cumbo, Cosimo, Tota, Giuseppina, De Grassi, Anna, Anelli, Luisa, Zagaria, Antonella, Coccaro, Nicoletta, Tarantini, Francesco, Minervini, Crescenzio Francesco, Parciante, Elisa, Impera, Luciana, Conserva, Maria Rosa, Redavid, Immacolata, Mestice, Anna, Attolico, Immacolata, Pierri, Ciro Leonardo, Musto, Pellegrino, and Albano, Francesco

Subjects
ACUTE myeloid leukemia, RUNX proteins
Abstract

Thus, the observed loss and replacement of the wild-type RUNX1 runt domain could cause loss of the above-cited RUNX1-DNA and RUNX1-protein interactions. In this regard, in many predisposition syndromes, the disease progression (AML or MDS) generally occurs through a stepwise process involving the loss of the remaining wild-type allele and acquisition of additional cooperating mutations, whereas others appear to maintain the wild-type allele [[13]]. Germline mutations in the I RUNX1 i gene define a familial platelet disorder with a predisposition to myeloid malignancy (FPDMM). [Extracted from the article]

Published
2023
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