RUNX1 gene alterations characterized by allelic preference in adult acute myeloid leukemia.

Thus, the observed loss and replacement of the wild-type RUNX1 runt domain could cause loss of the above-cited RUNX1-DNA and RUNX1-protein interactions. In this regard, in many predisposition syndromes, the disease progression (AML or MDS) generally occurs through a stepwise process involving the loss of the remaining wild-type allele and acquisition of additional cooperating mutations, whereas others appear to maintain the wild-type allele [[13]]. Germline mutations in the I RUNX1 i gene define a familial platelet disorder with a predisposition to myeloid malignancy (FPDMM). [Extracted from the article]