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3. Mise en place de recommandations thérapeutiques pour la prise en charge des neutropénies fébriles chez les enfants atteints de cancer : expérience du RIFHOP

Author

Le Carrer, L., Saulpic, J., Dubrel, M., Serinet, M.O., Pacquement, H., Raimondo, G., Tabone, M.D., Trioche, P., Mesples, B., Furioli, J., Perdereau, S., Seaumes, H., Guillon, M., Guillaumat, C., Chavlon Demersay, A., Chevallier, B., Brethon, B., Ferry, C., Gouraud, F., Belloy, M., Bensaid, P., Dallot, C., Pellegrino, B., Sarda, H., Michon, J., and Dufour, C.

Published
2014
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7. High-temperature 3D-Reciprocal Space Mapping, phase transition and stress relaxation in pure zirconia

Author

Guinebretière, René, Gouraud, F., HUGER, Marc, Thune, Elsa, Örs, T., Michel, V., Castelnau, O., Arnaud, S., Blanc, N., Boudet, N., Axe 3 : organisation structurale multiéchelle des matériaux, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 4 : céramiques sous contraintes environnementales (SPCTS-AXE4), Axe 3 : organisation structurale multiéchelle des matériaux (SPCTS-AXE3), and DERORY, BEATRICE

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

Published
2017

8. Mesures par microdiffraction Laue de distributions de déformations élastiques au sein de briques de zircone

Author

Örs, T., Gouraud, F., Michel, V., HUGER, Marc, Micha, JS., Gey, N., Guinebretière, René, Castelnau, O., DERORY, BEATRICE, Axe 4 : céramiques sous contraintes environnementales (SPCTS-AXE4), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Axe 3 : organisation structurale multiéchelle des matériaux

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

National audience

Published
2017

9. Phase transitions and residual strains into high-zirconia containing industrial refractory blocks. An in-situ high-temperature x-ray diffraction study using synchrotron radiation

Author

Gouraud, F., HUGER, Marc, Thune, Elsa, Guinebretière, René, Örs, T., Michel, V., Castelnau, O., IRCER - Axe 4 : céramiques sous contraintes environnementales (IRCER-AXE4), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 3 : organisation structurale multiéchelle des matériaux, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), and DERORY, BEATRICE

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

Published
2016

10. Phase transitions and residual strains into high-zirconia containing industrial refractory blocks. An in-situ high-temperature x-ray diffraction

Author

Gouraud, F., Huger, Marc, Thune, Elsa, Guinebretière, René, Ors, T., Michel, V., Castelau, O., IRCER - Axe 4 : céramiques sous contraintes environnementales (IRCER-AXE4), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 3 : organisation structurale multiéchelle des matériaux, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), and DERORY, BEATRICE

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

Published
2016

11. Diffraction et diffusion des rayons X à très haute température sur la ligne BM02 à l’ESRF. Transition de phases et contraintes résiduelles dans la zircone pure

Author

Gouraud, F., Huger, Marc, Thune, Elsa, Guinebretière, René, Örs, T., Michel, V., Castelnau, O., Arnaud, S., Blanc, N., Boudet, N., IRCER - Axe 4 : céramiques sous contraintes environnementales (IRCER-AXE4), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 3 : organisation structurale multiéchelle des matériaux, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Société Française de Métallurgie et Matériaux, and DERORY, BEATRICE

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, [SPI.MAT]Engineering Sciences [physics]/Materials
Published
2016

12. Caractérisation expérimentale du comportement mécanique d’un réfractaire électrofondu à très haute teneur en zircone

Author

Gouraud, F., Zhang, Yang, Boussuge, Michel, Ryckelynck, David, Huger, Marc, Chotard, Thierry, Antou, Guy, Centre des Matériaux (MAT), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), IRCER - Axe 4 : céramiques sous contraintes environnementales (IRCER-AXE4), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and LMCPA

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT]Engineering Sciences [physics]/Materials
Published
2016

13. Etude par microdiffraction Laue des contraintes locales au sein de briques de zircone

Author

Ors, T., Guinebretière, René, Micha, J-S, Robach, O., Gey, N., Humbert, Michel, Gouraud, F., HUGER, Marc, Michel, V., Castelnau, O., Axe 3 : organisation structurale multiéchelle des matériaux, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'étude des textures et application aux matériaux (LETAM), Université Paul Verlaine - Metz (UPVM)-Centre National de la Recherche Scientifique (CNRS), Axe 4 : céramiques sous contraintes environnementales (SPCTS-AXE4), Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), and DERORY, BEATRICE

Subjects
[PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], [PHYS.COND] Physics [physics]/Condensed Matter [cond-mat], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

14. Residual Stresses in ZrO2 Based Refractory Bricks

Author

Ors, T., Robach, O., Gey, N., Micha, J.S., Guinebretière, René, Michel, V., Gouraud, F., Castelnau, O., Huger, Marc, Axe 3 : organisation structurale multiéchelle des matériaux, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 1 : procédés céramiques, and DERORY, BEATRICE

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

Published
2015

15. Influence of zirconia phase transformation on the thermo-mechanical behaviour of high zirconia refractories

Author

Gouraud, F., Antou, Guy, Guinebretière, René, Huger, Marc, Chotard, Thierry, Axe 1 : procédés céramiques (SPCTS-AXE1), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 3 : organisation structurale multiéchelle des matériaux, Axe 1 : procédés céramiques, and DERORY, BEATRICE

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

Published
2015

17. Understanding Microstructure/Properties Relationships Related to the Thermomechanical Behaviour of High Zirconia Refractories

Author

Patapy, Cédric, Gouraud, F., Huger, M., Guinebretiere, R., Chotard, T., Laboratoire Matériaux et Durabilité des constructions (LMDC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Goski, D. G. and Smith, J. D., Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)

Subjects
[SPI.GCIV]Engineering Sciences [physics]/Civil Engineering, high-temperature
Abstract

WOS:000348596100209; International audience; New compositions of refractory materials with a very high content of zirconia are being developed for the processing of glasses used in high technology industries. The use of these refractories requires good control of the manufacturing process to avoid critical flaws due to severe thermo-mechanical stresses. In this context, a first French national research program (NOREV 2007-2010)((1)) had as objectives to build numerical tools able to predict the mechanical behaviour of these materials during one of the critical phases of development, i.e. the controlled cooling process after solidification. The models developed during this program can be considered as robust concerning the thermal aspects. However, some improvements are needed from the mechanical aspects.

Published
2014

18. Infections fongiques hépato-spléniques chez des enfants neutropéniques

Author

A. Yver, Thierry Leblanc, A. Baruchel, G. Schaison, G. Leverger, and Gouraud F

Subjects
Gynecology, medicine.medical_specialty, Infectious Diseases, business.industry, Medicine, business
Abstract

Resume Il est rapporte 8 nouvelles observations d'infections fongiques hepatospleniques (IFHS) chez des enfants atteints de leucemie aigue. L'IFHS dans tous les cas est survenue au decours de la phase d'aplasie post chimiotherapie d'induction. Pendant l'aplasie 4 des enfants avaient eu une septicemie a levures documentee et tous avaient recu de l'amphotericine B. Le tableau clinique de CFHS associait principalement une fievre en sortie d'aplasie (8/8), une hepatomegalie sensible (6/8), une splenomegalie (6/8) et des signes digestifs non specifiques. Des images d'abces ont ete retrouvees dans tous les cas par l'echographie ou le scanner. Quatre enfants ont eu des prelevements biopsiques mais le diagnostic formel de la nature fungique des abces n'a pu etre fait que dans une seule observation. La guerison clinique et radiologique a ete obtenue dans 7 observations (1 enfant decede rapidement d'une rechute precoce de sa leucemie) par le traitement antifongique seul ou associe a une splenectomie dans 3 cas. L'association amphotericine B et 5 fluorocytosine a ete utilisee dans les 8 observations avec ensuite relais par un antifongique donne par voie orale : fluconazole (4), itraconazole (3), ketoconazole (2). La duree moyenne du traitement a ete de 6,5 mois. Les aspects cliniques, diagnostiques et therapeutiques des IFHS sont discutes a partir de ces observations et d'une revue de la litterature.

Published
1991
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20. [Macrophage activation syndrome and dysgammaglobulinemia. Role of the Epstein-Barr virus]

Author

François, B., Gouraud, F., Garbarg-Chenon, A., Despretz, P., Leverger, G., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Trousseau [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Male, Blotting, Southern, Herpesvirus 4, Human, Tumor Virus Infections, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Child, Preschool, Hypergammaglobulinemia, Humans, Macrophage Activation, Immunoglobulin A
Abstract

International audience; The case of a five-year-old boy with macrophage activation syndrome and Epstein-Barr virus infection is reported. Several unusual features were found, including an early major increase in IgA levels, persistent oligoclonal gammapathy, and delayed development of anti-EA antibodies accompanied with an increase in anti-VCA antibodies. Despite the negative family history, an immune deficit and Purilo syndrome are discussed as possible diagnoses in this child.

Published
1992

22. Three-Year Follow-Up of Hydroxyurea Treatment in Severely Ill Children with Sickle Cell Disease

Author

de Montalembert, M., primary, Belloy, M., additional, Bernaudin, F., additional, Gouraud, F., additional, Capdeville, R., additional, Mardini, R., additional, Philippe, N., additional, Jais, J. P., additional, Bardakdjian, J., additional, Ducrocq, R., additional, Maier-Redelsperger, M., additional, Elion, J., additional, Labie, D., additional, and Girot, R., additional

Published
1997
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24. Lead Mobilization Test in Children With Lead Poisoning: Validation of a 5-Hour Edetate Calcium Disodium Provocation Test

Author

Garnier R, Leverger G, Gouraud F, Dollfus C, Beauvais P, and Iniguez Jl

Subjects
medicine.medical_specialty, Pediatrics, Mobilization, business.industry, Urinary system, Public health, Provocation test, Reproducibility of Results, medicine.disease, Lead poisoning, Surgery, Lead Poisoning, Lead, El Niño, Pediatrics, Perinatology and Child Health, medicine, Humans, Chelation therapy, Child, Lead (electronics), business, Edetic Acid
Abstract

Since 1985, more than 400 new cases of childhood lead poisoning were diagnosed in Paris, France. The resurgence of lead poisoning is a major public health concern.1,2The treatment of these children with increased blood lead levels was consistent with the guidelines of the Centers for Disease Control and Prevention (CDC), Atlanta, Ga,2-4which recommend a lead mobilization test for patients with intermediate lead intoxication to determine which children would benefit from chelation therapy. However, performing 24-hour provocative tests in young children has proved difficult: urine collection is often incomplete, and hospitalization is often necessary. The aim of our study was to decrease the urinary collection period of provocative tests to 5 hours and to assess the validity of this shortened procedure. Patients and Methods.During a 17-month period between May 1989 and October 1990, 34 edetate calcium disodium (CaNa2EDTA) mobilization tests were attempted in 32

Published
1995
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26. [Lead poisoning in children. Apropos of 129 cases]

Author

Yver A, Leverger G, Jl, Iniguez, Gouraud F, Lamour C, Robert Garnier, Turbier C, Delour M, and Lasfargues G

Subjects
Lead Poisoning, Male, Humans, Dimercaprol, Female, Child, Edetic Acid, Chelating Agents
Abstract

One hundred and twenty nine children with chronic lead poisoning were followed from August 1985 to July 1989. Old lead paint was recognized as the contaminant source at home. Pica of paint flakes was the main mode of intoxication. Children were classified according to the Center for Disease Control 1985 as follows: class IV (39 cases), class III (45 cases), class II (30 cases), class I (15 cases). Nineteen of those in class IV had blood lead levels above 700 micrograms/l and received BAL + EDTA followed by EDTA alone for a mean of 4.6 +/- 3.5 courses. With this treatment, blood lead level decreases were 50 +/- 17%. Nine of these class IV children had an evaluation at last 3 months after the last chelation course: 5 became class I or II, and 2 class III with a negative provocative test. The remaining 20 children in class IV were given a mean of 2.7 +/- 1.4 courses of EDTA. Blood lead levels decreased by 52 +/- 15%; 11 children were evaluable at least 3 months after the last chelation course: 4 became class I, and 7 class II. Thus overall 80% of class IV moved under treatment to class I or II. Among those 45 children in class II, 30 underwent a provocative test and 24 one to three courses of EDTA: 8 were further studied: 3 became class I and 5 class II. Combination of screening, medical treatment and sociocultural approach led to avoid acute effects of severe chronic childhood lead poisoning. The efficacy of such an approach in preventing chronic effects has still to be evaluated.

27. Study of the plasticity induced by the zirconia phase transformation in high zirconia refractories

Author

Gouraud, F., Guy ANTOU, Germaneau, A., Doumalin, P., Dupré, J. -C, Huger, M., Chotard, T., Axe 1 : procédés céramiques (SPCTS-AXE1), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 1 : procédés céramiques, and DERORY, BEATRICE

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

28. Appropriate thresholds for accurate screening for β-thalassemias in the newborn period: results from a French center for newborn screening.

Author

Allaf B, Pondarre C, Allali S, De Montalembert M, Arnaud C, Barrey C, Benkerrou M, Benhaim P, Bensaid P, Brousse V, Dollfus C, Eyssette-Guerreau S, Galacteros F, Gajdos V, Garrec N, Guillaumat C, Guitton C, Monfort-Gouraud M, Gouraud F, Holvoet L, Ithier G, Kamdem A, Koehl B, Malric A, Missud F, Monier B, Odièvre MH, Joly P, Renoux C, Patin F, Pissard S, and Couque N

Subjects
France, Humans, Infant, Newborn, Reference Values, Hemoglobin A analysis, Neonatal Screening standards, beta-Thalassemia diagnosis
Abstract

Objectives: Newborn screening (NBS) for β-thalassemia is based on measuring the expression of the hemoglobin A (HbA) fraction. An absence or very low level of HbA at birth may indicate β-thalassemia. The difficulty is that the HbA fraction at birth is correlated with gestational age (GA) and highly variable between individuals. We used HbA expressed in multiples of the normal (MoM) to evaluate relevant thresholds for NBS of β-thalassemia., Methods: The chosen threshold (HbA≤0.25 MoM) was prospectively applied for 32 months in our regional NBS program for sickle cell disease, for all tests performed, to identify patients at risk of β-thalassemia. Reliability of this threshold was evaluated at the end of the study., Results: In all, 343,036 newborns were tested, and 84 suspected cases of β-thalassemia were detected by applying the threshold of HbA≤0.25 MoM. Among the n=64 cases with confirmatory tests, 14 were confirmed using molecular analysis as β-thalassemia diseases, 37 were confirmed as β-thalassemia trait and 13 were false-positive. Determination of the optimum threshold for β-thalassemia screening showed that HbA≤0.16 MoM had a sensitivity of 100% and a specificity of 95.3%, whatever the GA., Conclusions: NBS for β-thalassemia diseases is effective, regardless of the birth term, using the single robust threshold of HbA≤0.16 MoM. A higher threshold would also allow screening for carriers, which could be interesting when β-thalassemia constitutes a public health problem.

Published
2020
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29. Evolution of Thermal Microcracking in Refractory ZrO₂-SiO₂ after Application of External Loads at High Temperatures.

Author

Laquai R, Gouraud F, Müller BR, Huger M, Chotard T, Antou G, and Bruno G

Abstract

Zirconia-based cast refractories are widely used for glass furnace applications. Since they have to withstand harsh chemical as well as thermo-mechanical environments, internal stresses and microcracking are often present in such materials under operating conditions (sometimes in excess of 1700 °C). We studied the evolution of thermal (CTE) and mechanical (Young's modulus) properties as a function of temperature in a fused-cast refractory containing 94 wt.% of monoclinic ZrO₂ and 6 wt.% of a silicate glassy phase. With the aid of X-ray refraction techniques (yielding the internal specific surface in materials), we also monitored the evolution of microcracking as a function of thermal cycles (crossing the martensitic phase transformation around 1000 °C) under externally applied stress. We found that external compressive stress leads to a strong decrease of the internal surface per unit volume, but a tensile load has a similar (though not so strong) effect. In agreement with existing literature on β-eucryptite microcracked ceramics, we could explain these phenomena by microcrack closure in the load direction in the compression case, and by microcrack propagation (rather than microcrack nucleation) under tensile conditions.

Published
2019
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30. Assessment of blood enterovirus PCR testing in paediatric populations with fever without source, sepsis-like disease, or suspected meningitis: a prospective, multicentre, observational cohort study.

Author

Lafolie J, Labbé A, L'Honneur AS, Madhi F, Pereira B, Decobert M, Adam MN, Gouraud F, Faibis F, Arditty F, Marque-Juillet S, Guitteny MA, Lagathu G, Verdan M, Rozenberg F, Mirand A, Peigue-Lafeuille H, Henquell C, Bailly JL, and Archimbaud C

Subjects
Adolescent, Child, Child, Preschool, Emergency Service, Hospital, Enterovirus genetics, Enterovirus Infections virology, Female, Fever of Unknown Origin virology, France, Humans, Infant, Infant, Newborn, Male, Meningitis virology, Molecular Diagnostic Techniques methods, Prospective Studies, Sepsis virology, Blood virology, Enterovirus isolation & purification, Enterovirus Infections diagnosis, Fever of Unknown Origin diagnosis, Meningitis diagnosis, Polymerase Chain Reaction methods, Sepsis diagnosis
Abstract

Background: Enteroviruses are the most frequent cause of acute meningitis and are seen increasingly in sepsis-like disease and fever without source in the paediatric population. Detection of enterovirus in cerebrospinal fluid (CSF) specimens by PCR is the gold standard diagnostic test. Our aim was to assess a method of detecting enterovirus in blood specimens by PCR., Methods: We did a prospective, multicentre, observational study at 35 French paediatric and emergency departments in 16 hospitals. We recruited newborn babies (aged ≤28 days) and infants (aged >28 days to ≤2 years) with fever without source, sepsis-like disease, or suspected meningitis, and children (aged >2 years to ≤16 years) with suspected meningitis, who were admitted to a participating hospital. We used a standardised form to obtain demographic, clinical, and laboratory data, which were anonymised. Enterovirus PCR testing was done in blood and CSF specimens., Findings: Between June 1, 2015, and Oct 31, 2015, and between June 1, 2016, and Oct 31, 2016, we enrolled 822 patients, of whom 672 had enterovirus PCR testing done in blood and CSF specimens. Enterovirus was detected in 317 (47%) patients in either blood or CSF, or both (71 newborn babies, 83 infants, and 163 children). Detection of enterovirus was more frequent in blood samples than in CSF specimens of newborn babies (70 [99%] of 71 vs 62 [87%] of 71; p=0·011) and infants (76 [92%] of 83 vs 62 [75%] of 83; p=0·008), and was less frequent in blood samples than in CSF specimens of children (90 [55%] of 163 vs 148 [91%] of 163; p<0·0001). Detection of enterovirus was more frequent in blood samples than in CSF specimens of infants aged 2 years or younger with fever without source (55 [100%] of 55 vs 41 [75%] of 55; p=0·0002) or with sepsis-like disease (16 [100%] of 16 vs nine [56%] of 16; p=0·008). Detection of enterovirus was less frequent in blood than in CSF of patients with suspected meningitis (165 [67%] of 246 vs 222 [90%] of 246; p<0·0001)., Interpretation: Testing for enterovirus in blood by PCR should be an integral part of clinical practice guidelines for infants aged 2 years or younger. This testing could decrease the length of hospital stay and reduce exposure to antibiotics for low-risk patients admitted to the emergency department with febrile illness., Funding: University Hospital Clermont-Ferrand., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Published
2018
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31. [The sexualisation of the care relationship by the patient in gerontology].

Author

Gouraud F, Rexand-Galais F, Maillard B, and Delrieu H

Subjects
Aged, 80 and over, Female, Humans, Geriatric Nursing, Nurse-Patient Relations, Sexuality
Abstract

The expression of the sexuality of the ageing patient in the care setting, particularly when it concerns the genital area and involves the caregiver without he or she being aware, constitutes a critical situation for the geriatric teams. A psychodynamic reading of these situations is important for the caregiving teams in order to optimise the somatic treatment and to prevent the risk of an unsuitable reactive treatment. This article presents a clinical case as an example., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

Published
2018
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32. Isolated congenital asplenia: a French nationwide retrospective survey of 20 cases.

Author

Mahlaoui N, Minard-Colin V, Picard C, Bolze A, Ku CL, Tournilhac O, Gilbert-Dussardier B, Pautard B, Durand P, Devictor D, Lachassinne E, Guillois B, Morin M, Gouraud F, Valensi F, Fischer A, Puel A, Abel L, Bonnet D, and Casanova JL

Subjects
Adolescent, Adult, Child, Child, Preschool, Congenital Abnormalities diagnosis, Congenital Abnormalities epidemiology, Congenital Abnormalities genetics, Female, France epidemiology, Humans, Infant, Male, Middle Aged, Pedigree, Retrospective Studies, Young Adult, Spleen abnormalities
Abstract

Objective: To better describe the natural history, mode of inheritance, and the epidemiological and clinical features of isolated congenital asplenia, a rare and poorly understood primary immunodeficiency., Study Design: A French national retrospective survey was conducted in hospital pediatric departments. A definitive diagnosis of ICA was based on the presence of Howell-Jolly bodies, a lack of detectable spleen, and no detectable cardiovascular malformation., Results: The study included 20 patients (12 males and 8 females) from 10 kindreds neither related to each other nor consanguineous. The diagnosis of ICA was certain in 13 cases (65%) and probable in 7 cases (35%). Ten index cases led to diagnosis of 10 additional cases in relatives. Five cases were sporadic and 15 were familial, suggesting autosomal dominant inheritance. Median age was 12 months at first infection (range, 2-516 months), 11 months at diagnosis of asplenia (range, 0-510 months), and 9.9 years at last follow-up (range, 0.7-52 years). Fifteen patients sustained 18 episodes of invasive bacterial infection, caused mainly by Streptococcus pneumoniae (61%). Outcomes were poor, with 9 patients (45%) dying from fulminant infection., Conclusions: ICA is more common than was previously thought, with an autosomal dominant inheritance in at least some kindreds. Relatives of cases of ICA should be evaluated for ICA, as should children and young adults with invasive infection., (Copyright © 2011 Mosby, Inc. All rights reserved.)

Published
2011
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33. Management and successful desensitization in methotrexate-induced anaphylaxis.

Author

Bouchireb K, Dodille A, Ponvert C, Gouraud F, Dubrel M, and Brugières L

Subjects
Anaphylaxis drug therapy, Child, Humans, Methotrexate therapeutic use, Osteosarcoma complications, Osteosarcoma drug therapy, Anaphylaxis chemically induced, Desensitization, Immunologic methods, Drug Hypersensitivity prevention & control, Methotrexate adverse effects
Abstract

Anaphylactic/anaphylactoid reactions to methotrexate are rare. In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression. In such patients, desensitization may enable the patient to continue treatment with methotrexate. We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate. Skin tests with methotrexate were not performed because their diagnostic value is controversial. Desensitization with methotrexate was successful and allowed the patient to complete 12 additional courses of chemotherapy. Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis., ((c) 2008 Wiley-Liss, Inc.)

Published
2009
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34. [Transient myeloproliferative disorder in a neonate without Down syndrome].

Author

Adam M, Vincenot A, Gouraud F, Harvel C, Perot C, Portnoi MF, Andre-Kerneis E, Giraudier S, Leverger G, and Favier R

Subjects
Diseases in Twins, Down Syndrome genetics, Exons genetics, Follow-Up Studies, GATA1 Transcription Factor genetics, Gene Deletion, Humans, Infant, Newborn, Male, Mutation genetics, Remission, Spontaneous, Twins, Dizygotic, Infant, Premature, Infant, Premature, Diseases diagnosis, Myeloproliferative Disorders diagnosis
Abstract

We report a new case of transient myeloproliferative disorder (TMD) in a non Down syndrome neonate. The cytogenetic and molecular studies within from the blood blast cells identified a trisomy 21 and a partial deletion in exon 2 of the transcription factor GATA1. Spontaneous regression of the TMD was achieved at the age of 1 month as the clonal and molecular abnormalities. A survey by periodic cytological examinations of peripheral blood cells and GATA1 mutation analysis was instituted since three years and has not detected up to date acute leukaemia.

Published
2007

37. [A rare cause of neonatal exudative enteropathy: congenital Langerhans cell histiocytosis (histiocytosis X)].

Author

Carlier-Mercier L, Fontaine JL, Boccon-Gibod L, Girardet JP, Josset P, Gouraud F, and Pinturier MF

Subjects
Adrenal Cortex Hormones therapeutic use, Biopsy, Drug Therapy, Combination, Histiocytosis, Langerhans-Cell congenital, Humans, Infant, Newborn, Male, Protein-Losing Enteropathies drug therapy, Protein-Losing Enteropathies pathology, Vinblastine therapeutic use, Histiocytosis, Langerhans-Cell complications, Protein-Losing Enteropathies etiology
Abstract

A case of Langerhans cell histiocytosis is reported in a neonate. Intestinal involvement was especially diffuse and severe, presenting as a protein-losing enteropathy secondary to massive mucosal infiltration by histiocytic cells. The infant died at the age of 3 1/2 months despite therapy with corticosteroids and vinblastine then etoposide and interferon. Such an outcome confirmed the severity of forms with neonatal onset and digestive involvement.

Published
1992

39. [Isolated Candida albicans meningitis after treatment of B lymphoma].

Author

Damay M, Chevalier MC, Gouraud F, Jabado N, Varache C, Landman-Parker J, and Leverger G

Subjects
Adolescent, Amphotericin B therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Candidiasis cerebrospinal fluid, Candidiasis drug therapy, Fluconazole therapeutic use, Follow-Up Studies, Humans, Immunosuppression Therapy adverse effects, Male, Meningitis cerebrospinal fluid, Meningitis drug therapy, Neoplasm Recurrence, Local, Abdominal Neoplasms drug therapy, Antineoplastic Combined Chemotherapy Protocols adverse effects, Candidiasis etiology, Lymphoma, B-Cell drug therapy, Meningitis etiology
Abstract

A case of candida meningitis occurring in a child treated for a lymphoma is reported. Diagnosis was made with Candida albicans culture in the CSF. Blood cultures were negative. Cerebral CT scan was normal. No other localization was found. The child was successfully treated by amphotericin B (initially with 5-fluorocytosin). Fluconazole was continued orally later on. This case is noteworthy by the absence of other localization, the favourable evolution and its occurrence in childhood. The therapeutic attitude and prevention are discussed.

Published
1992

43. [Lead poisoning in children. Apropos of 129 cases].

Author

Yver A, Leverger G, Iniguez JL, Gouraud F, Lamour C, Garnier R, Turbier C, Delour M, and Lasfargues G

Subjects
Chelating Agents therapeutic use, Child, Dimercaprol therapeutic use, Edetic Acid therapeutic use, Female, Humans, Lead Poisoning diagnosis, Lead Poisoning drug therapy, Male, Lead Poisoning classification
Abstract

One hundred and twenty nine children with chronic lead poisoning were followed from August 1985 to July 1989. Old lead paint was recognized as the contaminant source at home. Pica of paint flakes was the main mode of intoxication. Children were classified according to the Center for Disease Control 1985 as follows: class IV (39 cases), class III (45 cases), class II (30 cases), class I (15 cases). Nineteen of those in class IV had blood lead levels above 700 micrograms/l and received BAL + EDTA followed by EDTA alone for a mean of 4.6 +/- 3.5 courses. With this treatment, blood lead level decreases were 50 +/- 17%. Nine of these class IV children had an evaluation at last 3 months after the last chelation course: 5 became class I or II, and 2 class III with a negative provocative test. The remaining 20 children in class IV were given a mean of 2.7 +/- 1.4 courses of EDTA. Blood lead levels decreased by 52 +/- 15%; 11 children were evaluable at least 3 months after the last chelation course: 4 became class I, and 7 class II. Thus overall 80% of class IV moved under treatment to class I or II. Among those 45 children in class II, 30 underwent a provocative test and 24 one to three courses of EDTA: 8 were further studied: 3 became class I and 5 class II. Combination of screening, medical treatment and sociocultural approach led to avoid acute effects of severe chronic childhood lead poisoning. The efficacy of such an approach in preventing chronic effects has still to be evaluated.

Published
1991

44. The comeback of lead poisoning.

Author

Gouraud F, Iniguez JL, Leverger G, Fontaine A, and Lasfargues G

Subjects
Follow-Up Studies, Humans, Paris epidemiology, Lead Poisoning epidemiology
Published
1991

46. [Treatment of pneumococcal infections in children].

Author

Olivier C and Gouraud F

Subjects
Ampicillin therapeutic use, Ampicillin Resistance, Cefotaxime therapeutic use, Drug Resistance, Microbial, Humans, Imipenem therapeutic use, Infant, Male, Streptococcus pneumoniae drug effects, Meningitis, Pneumococcal drug therapy
Published
1989

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